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Results: 7327
Genomic survey of Clostridium difficile reservoirs in the East of England implicates environmental contamination of wastewater treatment plants by clinical lineages.
Danesh Moradigaravand, Theodore Gouliouris, Catherine Ludden, Sandra Reuter, Dorota Jamrozy, Beth Blane, Plamena Naydenova, Kim Judge, Sani H Aliyu, Nazreen F Hadjirin, Mark A Holmes, Estée Török, Nicholas M Brown, Julian Parkhill, Sharon Peacock
May 22, 2018
There is growing evidence that patients with Clostridiumdifficile-associated diarrhoea often acquire their infecting strain before hospital admission. Wastewater is known to be a potential source of surface water that is...
Clostridium difficile One Health genomic epidemiology wastewater treatment plants Bayes Theorem Clostridioides difficile Cross-Sectional Studies DNA Bacterial Diarrhea England Genome Bacterial Genomics Humans Multilocus Sequence Typing Retrospective Studies Sequence Analysis DNA Waste Management Wastewater
Simultaneous Nasal Carriage by Methicillin-Resistant and Methicillin Susceptible Staphylococcus aureus of Lineage ST398 in a Live Pig Transporter.
Paula Gómez, Carmen Aspiroz, Nazreen F Hadjirin, Daniel Benito, Myriam Zarazaga, Carmen Torres, Mark A Holmes
Aug 07, 2020
Methicillin-resistant Staphylococcus aureus (MRSA) sequence type (ST)398 is a livestock associated (LA) lineage with zoonotic potential, especially in humans with live pig contact. The objective of this study was to characterize...
Streptococcus suis contains multiple phase-variable methyltransferases that show a discrete lineage distribution.
John M Atack, Lucy A Weinert, Alexander W Tucker, Asma U Husna, Thomas M Wileman, Nazreen F Hadjirin, Ngo T Hoa, Julian Parkhill, Duncan J Maskell, Patrick J Blackall, Michael P Jennings
Dec 06, 2018
Alleles Animals DNA Methylation DNA Modification Methylases DNA Bacterial Epigenesis Genetic Escherichia coli Gene Expression Regulation Bacterial genetic variation Genome Bacterial Methyltransferases Microsatellite Repeats Oligonucleotides Phenotype Regulon Streptococcal Infections Streptococcus suis Swine
Mechanisms of β-lactam resistance of Streptococcus uberis isolated from bovine mastitis cases.
Scott McDougall, Laura Clausen, Hye-Jeong Ha, Isobel Gibson, Mark Bryan, Nazreen Hadjirin, Elizabeth Lay, Claire Raisen, Xiaoliang Ba, Olivier Restif, Julian Parkhill, Mark A Holmes
Jan 23, 2020
A number of veterinary clinical pathology laboratories in New Zealand have been reporting emergence of increased minimum in inhibitory concentrations for β-lactams in the common clinical bovine mastitis pathogen Streptococcus...
Penicillin binding proteins Streptococcus uberis β-lactam resistance Amino Acid Substitution Animals Anti-Bacterial Agents Bacterial Proteins Cattle Female Genome-Wide Association Study Mastitis Bovine Microbial Sensitivity Tests New Zealand Oxacillin Penicillin-Binding Proteins Phylogeny Polymorphism Single Nucleotide Streptococcus beta-Lactam Resistance
Comparison of two chromogenic media for the detection of vancomycin-resistant enterococcal carriage by nursing home residents.
Theodore Gouliouris, Beth Blane, Hayley J Brodrick, Kathy E Raven, Kirsty E Ambridge, Angela D Kidney, Nazreen F Hadjirin, M Estée Török, Direk Limmathurotsakul, Sharon J Peacock
May 13, 2016
detection Enterococcus faecium Selectivity sensitivity VRE Vancomycin-Resistant Enterococci Bacteriological Techniques Carrier State Chromogenic Compounds Culture Media Enterococcus faecalis Enterococcus faecium Feces Gram-Positive Bacterial Infections Humans Nursing Homes Prospective Studies Sensitivity and Specificity Vancomycin-Resistant Enterococci
f-scLVM
Florian Buettner, Naruemon Pratanwanich, Davis J McCarthy, John C Marioni, Oliver Stegle
Mar 26, 2018
Single-cell RNA-sequencing (scRNA-seq) allows studying heterogeneity in gene expression in large cell populations. Such heterogeneity can arise due to technical or biological factors, making decomposing sources of variation...
Gene set annotations Single-cell RNA-seq Sparse factor analysis Animals Computer Simulation Databases as Topic Factor Analysis Statistical Gene Expression Regulation Mice Models Theoretical Mouse embryonic stem cells Neurons Reproducibility of Results Sequence Analysis RNA Single-Cell Analysis Software
Synthesis and characterization of fluorinated β-ketoiminate zinc precursors and their utility in the AP-MOCVD growth of ZnO
Andrew L. Johnson, Samuel D. Cosham, Gabriele Kociok-Kohn, Jeff A. Hamilton, Michael S. Hill, Kieran C. Molloy, Remi Castaing
Sep 01, 2015
A novel family of zinc bis beta-ketoiminate complexes 2b-2h have been synthesized by reaction of the isolated free ligands (1a-h) with dimethylzinc. The isolated zinc complexes were characterized by elemental analysis, NMR...
Synthesis and characterization of fluorinated β-ketoiminate zinc precursors and their utility in the AP-MOCVD growth of ZnO
Andrew L. Johnson, Samuel D. Cosham, Gabriele Kociok-Kohn, Jeff A. Hamilton, Michael S. Hill, Kieran C. Molloy, Remi Castaing
Sep 01, 2015
A novel family of zinc bis beta-ketoiminate complexes 2b-2h have been synthesized by reaction of the isolated free ligands (1a-h) with dimethylzinc. The isolated zinc complexes were characterized by elemental analysis, NMR...
One Health Genomic Surveillance of Escherichia coli Demonstrates Distinct Lineages and Mobile Genetic Elements in Isolates from Humans versus Livestock.
Catherine Ludden, Kathy E Raven, Dorota Jamrozy, Theodore Gouliouris, Beth Blane, Francesc Coll, Marcus de Goffau, Plamena Naydenova, Carolyne Horner, Juan Hernandez-Garcia, Paul Wood, Nazreen Hadjirin, Milorad Radakovic, Nicholas M Brown, Mark Holmes, Julian Parkhill, Sharon J Peacock
Feb 07, 2019
Livestock have been proposed as a reservoir for drug-resistant Escherichia coli that infect humans. We isolated and sequenced 431 E. coli isolates (including 155 extended-spectrum β-lactamase [ESBL]-producing isolates) from...
ESBL Escherichia coli Antimicrobial resistance Genomics Livestock Animals Computational Biology Cross-Sectional Studies Drug Resistance Bacterial England Epidemiological Monitoring Escherichia coli Escherichia coli Infections Genes Bacterial genetic variation Genomics Humans Interspersed Repetitive Sequences Livestock Meat One Health prevalence Sequence Analysis DNA whole genome sequencing
Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen
Truncation of GdpP mediates β-lactam resistance in clinical isolates of Staphylococcus aureus.
Xiaoliang Ba, Lajos Kalmar, Nazreen F Hadjirin, Heidrun Kerschner, Petra Apfalter, Fiona J Morgan, Gavin K Paterson, Samantha L Girvan, Rui Zhou, Ewan M Harrison, Mark A Holmes
Feb 05, 2019
OBJECTIVES: High-level β-lactam resistance in MRSA is mediated in the majority of strains by a mecA or mecC gene. In this study, we identified 10 mec gene-negative MRSA human isolates from Austria and 11 bovine isolates from the...
Homer F. Swift, 1920
The Rockefeller University
Jan 01, 0001
Homer F. Swift, M.D. Trench Fever
Lecture delivered January 10th, 1920
Published by: J.B. Lippincott Company
Genomic Surveillance of Enterococcus faecium Reveals Limited Sharing of Strains and Resistance Genes between Livestock and Humans in the United Kingdom.
Theodore Gouliouris, Kathy E Raven, Catherine Ludden, Beth Blane, Jukka Corander, Carolyne S Horner, Juan Hernandez-Garcia, Paul Wood, Nazreen F Hadjirin, Milorad Radakovic, Mark A Holmes, Marcus de Goffau, Nicholas M Brown, Julian Parkhill, Sharon J Peacock
Dec 03, 2018
Vancomycin-resistant Enterococcus faecium (VREfm) is a major cause of nosocomial infection and is categorized as high priority by the World Health Organization global priority list of antibiotic-resistant bacteria. In the past...
Enterococcus faecium One Health genome sequencing Livestock vancomycin resistant vancomycin-resistant Animals Anti-Bacterial Agents Cross-Sectional Studies Drug Resistance Multiple Bacterial Enterococcus faecium Epidemiological Monitoring Farms Genome Bacterial Genotype Gram-Positive Bacterial Infections Humans Livestock Meat Products Microbial Sensitivity Tests Phylogeny Polymorphism Single Nucleotide prevalence Swine United Kingdom Vancomycin Resistance Vancomycin-Resistant Enterococci Wastewater whole genome sequencing
A One Health Study of the Genetic Relatedness of Klebsiella pneumoniae and Their Mobile Elements in the East of England.
Catherine Ludden, Danesh Moradigaravand, Dorota Jamrozy, Theodore Gouliouris, Beth Blane, Plamena Naydenova, Juan Hernandez-Garcia, Paul Wood, Nazreen Hadjirin, Milorad Radakovic, Charles Crawley, Nicholas M Brown, Mark Holmes, Julian Parkhill, Sharon J Peacock
Sep 06, 2019
BACKGROUND: Klebsiella pneumoniae is a human, animal, and environmental commensal and a leading cause of nosocomial infections, which are often caused by multiresistant strains. We evaluate putative sources of K. pneumoniae that...
Systematics of the α′ expansion in F-theory
Abstract: Extracting reliable low-energy information from string compactifications notoriously requires a detailed understanding of the UV sensitivity of the corresponding effective field theories. Despite past efforts in...
C-F Bond Activation of P(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> By Ruthenium Dihydride Complexes
The major product of the reaction between Ru(IMe4)2(PPh3)2H2 (1; IMe4 = 1,3,4,5-tetramethylimidazol-2-ylidene) and P(C6F5)3 (PCF)...
C-F Bond Activation of P(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> By Ruthenium Dihydride Complexes
The major product of the reaction between Ru(IMe4)2(PPh3)2H2 (1; IMe4 = 1,3,4,5-tetramethylimidazol-2-ylidene) and P(C6F5)3 (PCF)...
Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis
Nazreen F. Hadjirin, Eric L. Miller, Gemma G. R. Murray, Phung L. K. Yen, Ho D. Phuc, Thomas M. Wileman, Juan Hernandez-Garcia, Susanna M. Williamson, Julian Parkhill, Duncan J. Maskell, Rui Zhou, Nahuel Fittipaldi, Marcelo Gottschalk, A. W. ( Dan) Tucker, Ngo Thi Hoa, John J. Welch, Lucy A. Weinert
Sep 08, 2021
Abstract: Background: Antimicrobial resistance (AMR) is among the gravest threats to human health and food security worldwide. The use of antimicrobials in livestock production can lead to emergence of AMR, which can have direct...
Experimental and computational studies of the copper borate complexes [(NHC)Cu(HBEt<sub>3</sub>)] and [(NHC)Cu(HB(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>)]
Lee R. Collins, Nasir A. Rajabi, Stuart A. Macgregor, Mary F. Mahon, Michael K. Whittlesey
Dec 05, 2016
The synthesis of the Cu-borate complexes [(6Mes)Cu(HBR3)] featuring the unusual [HBEt3]− (5) and [HB(C6F5)3]− (6) ligands is described. Experimental...
Cross-Module Enoylreduction in the Azalomycin F Polyketide Synthase.
Guifa Zhai, Wenyan Wang, Wei Xu, Guo Sun, Chaoqun Hu, Xiangming Wu, Zisong Cong, Liang Deng, Yanrong Shi, Peter F Leadlay, Heng Song, Kui Hong, Zixin Deng, Yuhui Sun
Oct 19, 2020
The colinearity of canonical modular polyketide synthases, which creates a direct link between multienzyme structure and the chemical structure of the biosynthetic end-product, has become a cornerstone of knowledge-based genome...
Systematics of the α′ expansion in F-theory
Extracting reliable low-energy information from string compactifications
notoriously requires a detailed understanding of the UV sensitivity of the
corresponding effective field theories. Despite past efforts in...
Experimental and computational studies of the copper borate complexes [(NHC)Cu(HBEt<sub>3</sub>)] and [(NHC)Cu(HB(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>)]
Lee R. Collins, Nasir A. Rajabi, Stuart A. Macgregor, Mary F. Mahon, Michael K. Whittlesey
Dec 05, 2016
The synthesis of the Cu-borate complexes [(6Mes)Cu(HBR3)] featuring the unusual [HBEt3]− (5) and [HB(C6F5)3]− (6) ligands is described. Experimental...
Clinical significance of prostate (18)F-labelled fluorodeoxyglucose uptake on positron emission tomography/computed tomography
AIM: To determine the significance and need for investigation of incidental prostatic uptake in men undergoing (18)F-labelled fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for other...
Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus.
Gerrit Koop, Manouk Vrieling, Daniel ML Storisteanu, Laurence SC Lok, Tom Monie, Glenn van Wigcheren, Claire Raisen, Xiaoliang Ba, Nicholas Gleadall, Nazreen Hadjirin, Arjen J Timmerman, Jaap A Wagenaar, Heleen M Klunder, J Ross Fitzgerald, Ruth Zadoks, Gavin K Paterson, Carmen Torres, Andrew S Waller, Anette Loeffler, Igor Loncaric, Armando E Hoet, Karin Bergström, Luisa De Martino, Constança Pomba, Hermínia de Lencastre, Karim Ben Slama, Haythem Gharsa, Emily J Richardson, Edwin R Chilvers, Carla de Haas, Kok van Kessel, Jos AG van Strijp, Ewan M Harrison, Mark A Holmes
Jun 19, 2018
Bicomponent pore-forming leukocidins are a family of potent toxins secreted by Staphylococcus aureus, which target white blood cells preferentially and consist of an S- and an F-component. The S-component recognizes a receptor...
F-Actin nucleated on chromosomes coordinates their capture by microtubules in oocyte meiosis.
Capture of each and every chromosome by spindle microtubules is essential to prevent chromosome loss and aneuploidy. In somatic cells, astral microtubules search and capture chromosomes forming lateral attachments to...
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