Search
Results: 47
A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity.
Adriana Ordóñez, Juan Pérez, Lu Tan, Jennifer A Dickens, Neda Motamedi-Shad, James A Irving, Imran Haq, Ugo Ekeowa, Stefan J Marciniak, Elena Miranda, David A Lomas
May 18, 2018
Mutant Z α1-antitrypsin (E342K) accumulates as polymers within the endoplasmic reticulum (ER) of hepatocytes predisposing to liver disease, whereas low levels of circulating Z α1-antitrypsin lead to emphysema by loss of...
Liver Disease Monoclonal antibody scFv intrabody serpin polymer Animals Base Sequence COS Cells Chlorocebus aethiops Endoplasmic Reticulum Humans Immunoblotting Intracellular Space Kinetics Leukocyte Elastase Mice Inbred BALB C Molecular Sequence Data Mutation Polymerization Protease Inhibitors Single-Chain Antibodies alpha 1-Antitrypsin
Factors contributing to the experience of shame and shame management
Previous research has firmly established that some individuals experience shame more frequently than others. This study employed a cross-sectional design to explore factors that are related to the experience of shame. In this...
Acceptance of shame and embarrassment
Objectives: The ability to accept painful feelings is associated with decreased distress and better functioning. We set out to design an instrument that specifically measures acceptance of shame and embarrassment, as this may be...
Factors contributing to the experience of shame and shame management
Previous research has firmly established that some individuals experience shame more frequently than others. This study employed a cross-sectional design to explore factors that are related to the experience of shame. In this...
Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years.
Acceptance of shame and embarrassment
Objectives: The ability to accept painful feelings is associated with decreased distress and better functioning. We set out to design an instrument that specifically measures acceptance of shame and embarrassment, as this may be...
Understanding Places Exploration and Visitation via Human Mobility Mining
Spatial-temporal data is widely available because of advancement in location acquisition technologies (GPS, GSM, Wifi, etc.) over past decades. This spatial-temporal data can easily be used to leverage user's trajectories...
Published by: IGI Global Scientific Publishing
KIR in Allogeneic Hematopoietic Stem Cell Transplantation
Adèle Dhuyser, Alice Aarnink, Michaël Pérès, Jyothi Jayaraman, Neda Nemat-Gorgani, Marie Thérèse Rubio, John Trowsdale, James Traherne
Mar 01, 2022
Allogeneic hematopoietic stem cell transplantation (aHSCT) is a lifesaving therapy for hematological malignancies. For years, a fully matched HLA donor was a requisite for the procedure. However, new immunosuppressive strategies...
Alemtuzumab CARE-MS II 5-year follow-up
Alasdair J Coles, Jeffrey A Cohen, Edward J Fox, Gavin Giovannoni, Hans-Peter Hartung, Eva Havrdova, Sven Schippling, Krzysztof W Selmaj, Anthony Traboulsee, D Alastair S Compston, David H Margolin, Karthinathan Thangavelu, Madalina C Chirieac, Darlene Jody, Panos Xenopoulos, Richard J Hogan, Michael A Panzara, Douglas L Arnold, CARE-MS II and CAMMS03409 Investigators
Dec 11, 2017
OBJECTIVE: To evaluate 5-year efficacy and safety of alemtuzumab in patients with active relapsing-remitting multiple sclerosis and inadequate response to prior therapy. METHODS: In the 2-year Comparison of Alemtuzumab and Rebif...
Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years.
Monèm Jemni, Rashid Zaman, Frederick Robert Carrick, Neil David Clarke, Michel Marina, Lindsay Bottoms, Jagdeep Singh Matharoo, Roger Ramsbottom, Norman Hoffman, Shad James Groves, Yaodong Gu, Ferman Konukman
Apr 17, 2023
The aim of this review was to explore the relevant neurobiology and the association between peripheral levels of brain-derived neurotrophic factor (BDNF) and acute and short to long-term exercise regimes, as well as its relation...
Published by: Frontiers in Physiology
Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung
Determine Intraday Trading Currency's Trend Framework Evidence From Machine Learning Techniques
Inzamam Khan, Wajid Ahmed, Shafqat Shad, Chandan Kumar, Muhammad Usman, Milad Jasemi, Khuarm Shafi
Jan 01, 2024
The purpose of this study is to determine the intraday hourly trading trends of currencies using predictive modeling techniques. The study encompasses two distinct intraday time intervals of 30 minutes and 1 hour, analyzing...
Published by: IGI Global Scientific Publishing
Monocytes Latently Infected with Human Cytomegalovirus Evade Neutrophil Killing.
Elizabeth Elder, Benjamin Krishna, James Williamson, Yusuf Aslam, Neda Farahi, Alexander Wood, Veronika Romashova, Kate Roche, Eain Murphy, Edwin Chilvers, Paul J Lehner, John Sinclair, Emma Poole
Feb 01, 2019
One site of latency of human cytomegalovirus (HCMV) in vivo is in undifferentiated cells of the myeloid lineage. Although latently infected cells are known to evade host T cell responses by suppression of T cell effector...
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity.
Sarah R Walmsley, Cristin Print, Neda Farahi, Carole Peyssonnaux, Randall S Johnson, Thorsten Cramer, Anastasia Sobolewski, Alison M Condliffe, Andrew S Cowburn, Nicola Johnson, Edwin R Chilvers
Mar 13, 2020
Neutrophils are key effector cells of the innate immune response and are required to migrate and function within adverse microenvironmental conditions. These inflammatory sites are characterized by low levels of oxygen and...
Animals Apoptosis Blotting Western Cell Survival Chemokine CCL4 Cytokines DNA Primers DNA-Binding Proteins Enzyme-Linked Immunosorbent Assay Gliotoxin Humans Hypoxia Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1 alpha Subunit Macrophage Inflammatory Proteins Mice Mice Knockout Mixed Function Oxygenases NF-kappa B p50 Subunit Neutrophils Nuclear Proteins Oligonucleotide Array Sequence Analysis Oligonucleotides Polymerase Chain Reaction Protein Binding Repressor Proteins Sesquiterpenes Transcription Factors
Comparison of NK alloreactivity prediction models based on KIR-MHC interactions in haematopoietic stem cell transplantation
Adèle Dhuyser, Thomas Remen, Michaël Pérès, Vitalina Chamberlain-Evans, Neda Nemat-Gorgani, Arnaud Campidelli, Sandra Clément, Marie Thérèse Rubio, John Trowsdale, Alice Aarnink, James Traherne
Apr 12, 2023
immunology KIR MHC HLA alloreactivity PREDICTION natural killer (NK) allogeneic stem cell transplantation Donor Selection
Published by: Frontiers Media S.A.
Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung.
Hollow-core Optical Fiber Gas Lasers (HOFGLAS)
A. V. Vasudevan Nampoothiri, Andrew M. Jones, Coralie Fourcade Dutin, Chenchen Mao, Neda Dadashzadeh, Bastian Baumgart, Yingying Wang, M. Alharbi, T. Bradley, Neil Campbell, F. Benabid, Brian R. Washburn, Kristan L. Corwin, Wolfgang Rudolph
Jul 01, 2012
The development of hollow core photonic crystal fibers with low losses over a broad spectral region in the near IR enabled the demonstration of a novel laser type - Hollow-core Optical Fiber Gas Laser (HOFGLAs). The laser...
Comparison of NK alloreactivity prediction models based on KIR-MHC interactions in haematopoietic stem cell transplantation.
KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors.
Claudia Alicata, Elham Ashouri, Neda Nemat-Gorgani, Lisbeth A Guethlein, Wesley M Marin, Sudan Tao, Lorenzo Moretta, Jill A Hollenbach, John Trowsdale, James A Traherne, Abbas Ghaderi, Peter Parham, Paul J Norman
May 29, 2020
Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands....
KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors
Claudia Alicata, Elham Ashouri, Neda Nemat-Gorgani, Lisbeth A. Guethlein, Wesley M. Marin, Sudan Tao, Lorenzo Moretta, Jill A. Hollenbach, John Trowsdale, James A. Traherne, Abbas Ghaderi, Peter Parham, Paul J. Norman
Apr 16, 2020
Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands....
|
|< |
< |
1 |