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Results: 59
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.
Stephan C Collins, Anna Mikhaleva, Katarina Vrcelj, Valerie E Vancollie, Christel Wagner, Nestor Demeure, Helen Whitley, Meghna Kannan, Rebecca Balz, Lauren FE Anthony, Andrew Edwards, Hervé Moine, Jacqueline K White, David J Adams, Alexandre Reymond, Christopher J Lelliott, Caleb Webber, Binnaz Yalcin
Feb 04, 2021
Brain morphogenesis is an important process contributing to higher-order cognition, however our knowledge about its biological basis is largely incomplete. Here we analyze 118 neuroanatomical parameters in 1,566 mutant mouse...
Cost-effectiveness of cognitive therapy as an early intervention for post-traumatic stress disorder in children and adolescents
James Shearer, Nestor Papanikolaou, Richard Meiser-Stedman, Anna McKinnon, Tim Dalgleish, Patrick Smith, Clare Dixon, Sarah Byford
Apr 13, 2018
BACKGROUND: Untreated post-traumatic stress disorder (PTSD) in children and adolescents is associated with a considerable economic burden on the health system, families and society. Recent research has demonstrated the potential...
economic evaluation Cognitive Therapy Post-traumatic stress disorder Adolescent Child Cognitive Behavioral Therapy Cost-Benefit Analysis Early Medical Intervention Female Follow-Up Studies Humans Male Models Econometric Outcome Assessment Health Care Quality-Adjusted Life Years Stress Disorders Post-Traumatic
Cannabis-dependent adolescents show differences in global reward-associated network topology
Adolescence may be a period of increased vulnerability to the onset of drug misuse and addiction due to changes in developing brain networks that support cognitive and reward processing. Cannabis is a widely misused illicit drug...
Magnetoencephalography of frontotemporal dementia
Behavioural variant frontotemporal dementia is a neurodegenerative disorder with dysfunction and atrophy of the frontal lobes leading to changes in personality, behaviour, empathy, social conduct and insight, with relative...
What's "up"? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy.
This study seeks to confirm whether lesions in posterior regions of the brain involved in visuo-spatial processing are of functional relevance to the processing of words with spatial meaning. We investigated whether patients...
The tricellular vertex-specific adhesion molecule Sidekick facilitates polarised cell intercalation during Drosophila axis extension.
Tara M Finegan, Nathan Hervieux, Alexander Nestor-Bergmann, Alexander G Fletcher, Guy B Blanchard, Bénédicte Sanson
Jan 06, 2020
In epithelia, tricellular vertices are emerging as important sites for the regulation of epithelial integrity and function. Compared to bicellular contacts, however, much less is known. In particular, resident proteins at...
The tricellular vertex-specific adhesion molecule Sidekick facilitates polarised cell intercalation during Drosophila axis extension.
Tara M Finegan, Nathan Hervieux, Alexander Nestor-Bergmann, Alexander G Fletcher, Guy B Blanchard, Bénédicte Sanson
Nov 11, 2019
In epithelia, tricellular vertices are emerging as important sites for the regulation of epithelial integrity and function. Compared to bicellular contacts, however, much less is known. In particular, resident proteins at...
The tricellular vertex-specific adhesion molecule Sidekick facilitates polarised cell intercalation during Drosophila axis extension
Tara M. Finegan, Nathan Hervieux, Alexander Nestor-Bergmann, Alexander G. Fletcher, Guy B. Blanchard, Bénédicte Sanson
Dec 05, 2019
In epithelia, tricellular vertices are emerging as important sites for the regulation of epithelial integrity and function. Compared to bicellular contacts, however, much less is known. In particular, resident proteins at...
Genomic and temporal analyses of Mycobacterium bovis in southern Brazil.
Rudielle de Arruda Rodrigues, Flábio Ribeiro Araújo, Alberto Martín Rivera Dávila, Rodrigo Nestor Etges, Julian Parkhill, Andries J van Tonder
Jun 21, 2021
Mycobacterium bovis is a causal agent of bovine tuberculosis (bTB), one of the most important diseases currently facing the cattle industry worldwide. Tracing the source of M. bovis infections of livestock is an important tool...
Differential effects of Down's syndrome and Alzheimer's neuropathology on default mode connectivity.
Liam R Wilson, Deniz Vatansever, Tiina Annus, Guy B Williams, Young T Hong, Tim D Fryer, Peter J Nestor, Anthony J Holland, Shahid H Zaman
Jul 10, 2019
Down's syndrome is a chromosomal disorder that invariably results in both intellectual disability and Alzheimer's disease neuropathology. However, only a limited number of studies to date have investigated intrinsic brain...
Alzheimer's Disease Down's syndrome anti-correlation Default mode network functional connectivity Memory Adult Alzheimer Disease Amyloid Aniline Compounds Carbon Radioisotopes Cerebral Cortex Connectome Cross-Sectional Studies Down Syndrome Female Humans Magnetic Resonance Imaging Male Middle Aged Positron-Emission Tomography Radiopharmaceuticals Thiazoles
Decoupling the Roles of Cell Shape and Mechanical Stress in Orienting and Cueing Epithelial Mitosis.
Alexander Nestor-Bergmann, Georgina A Stooke-Vaughan, Georgina K Goddard, Tobias Starborg, Oliver E Jensen, Sarah Woolner
May 01, 2019
Distinct mechanisms involving cell shape and mechanical force are known to influence the rate and orientation of division in cultured cells. However, uncoupling the impact of shape and force in tissues remains challenging....
Developing a roadmap to improve trial delivery for under-served groups
Miles D. Witham, Eleanor Anderson, Camille Carroll, Paul M. Dark, Kim Down, Alistair S. Hall, Joanna Knee, Rebecca H. Maier, Gail A. Mountain, Gary Nestor, Laurie Oliva, Sarah R. Prowse, Amanda Tortice, James Wason, Lynn Rochester
Aug 01, 2020
Abstract: Background: Participants in clinical research studies often do not reflect the populations for which healthcare interventions are needed or will be used. Enhancing representation of under-served groups in clinical...
Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome
Elijah Mak, Anastasia Bickerton, Concepcion Padilla, Madeleine J Walpert, Tiina Annus, Liam R Wilson, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, Bradley T Christian, Benjamin L Handen, William E Klunk, David K Menon, Peter J Nestor, Shahid H Zaman, Anthony J Holland
May 23, 2019
Ensuring that COVID-19 research is inclusive
Miles D Witham, Eleanor Anderson, Camille B Carroll, Paul M Dark, Kim Down, Alistair S Hall, Joanna Knee, Eamonn R Maher, Rebecca H Maier, Gail A Mountain, Gary Nestor, John T O'Brien, Laurie Oliva, James Wason, Lynn Rochester
Nov 09, 2020
Objective: To provide guidance to researchers, funders, regulators and study delivery teams to ensure that research on COVID-19 is inclusive, particularly of groups disproportionately affected by COVID-19 and who may have been...
Developing a roadmap to improve trial delivery for under-served groups
Miles D. Witham, Eleanor Anderson, Camille Carroll, Paul M. Dark, Kim Down, Alistair S. Hall, Joanna Knee, Rebecca H. Maier, Gail A. Mountain, Gary Nestor, Laurie Oliva, Sarah R. Prowse, Amanda Tortice, James Wason, Lynn Rochester
Aug 02, 2021
Abstract: Background: Participants in clinical research studies often do not reflect the populations for which healthcare interventions are needed or will be used. Enhancing representation of under-served groups in clinical...
Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline.
Two new Linear B tablets and an enigmatic find from Bronze Age Pylos (Palace of Nestor)
Abstract
This article presents two newly-discovered fragments of Linear B tablets from recent excavations at the site of Ano Englianos, Bronze Age Pylos, along with a third...
Rotation Curves in z ∼ 1–2 Star-forming Disks
S. H. Price, T. T. Shimizu, R. Genzel, H. Übler, N. M. Förster Schreiber, L. J. Tacconi, R. T. Coogan, D. Lutz, S. Wuyts, E. Wisnioski, A. Nestor, A. Sternberg, A. Burkert, R. Bender, A. Contursi, R. Herrera-Camus, M.-j. Lee, T. Naab, R. Neri, A. Renzini, R. Saglia, A. Schruba, K. Schuster
Dec 01, 2021
We present a follow-up analysis examining the dynamics and structures of 41 massive, large star-forming galaxies at z ∼ 0.67 − 2.45 using both ionized and molecular gas kinematics. We fit the galaxy dynamics with models...
Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome
Elijah Mak, Monika Grigorova, Jessica Beresford-Webb, Maura Malpetti, Madeline Walpert, Stephanie Brown, Elizabeth Jones, Isabel Clare, Young T Hong, Tim D Fryer, Jonathan P Coles, Franklin I Aigbirhio, David K Menon, Peter J Nestor, Anthony J Holland, Shahid H Zaman
Oct 26, 2020
Positron emission tomography imaging of glucose hypometabolism and amyloid deposition are two well-established methods to evaluate preclinical changes in Alzheimer's disease and people with Down syndrome. However, the use of...
RC100
A. Nestor Shachar, S. H. Price, N. M. Förster Schreiber, R. Genzel, T. T. Shimizu, L. J. Tacconi, H. Übler, A. Burkert, R. I. Davies, A. Dekel, R. Herrera-Camus, L. L. Lee, D. Liu, D. Lutz, T. Naab, R. Neri, A. Renzini, R. Saglia, K. F. Schuster, A. Sternberg, E. Wisnioski, S. Wuyts
Feb 28, 2023
We analyze Hα or CO rotation curves extending out to several galaxy effective radii for 100 massive, large, star-forming disk galaxies (SFGs) across the peak of cosmic galaxy star formation (z ∼ 0.6-2.5), more than doubling...
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