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Using the <i>Mus musculus</i> hybrid zone to assess covariation and genetic architecture of limb bone lengths
Two subspecies of the house mouse, Mus musculus domesticus and Mus musculus musculus, meet in a narrow contact zone across Europe. Mice in the hybrid zone are highly admixed, representing the full range of mixed ancestry from...
Using the <i>Mus musculus</i> hybrid zone to assess covariation and genetic architecture of limb bone lengths
Two subspecies of the house mouse, Mus musculus domesticus and Mus musculus musculus, meet in a narrow contact zone across Europe. Mice in the hybrid zone are highly admixed, representing the full range of mixed ancestry from...
Insights from structural studies of the cardiovirus 2A protein.
Cardioviruses are single-stranded RNA viruses of the family Picornaviridae. In addition to being the first example of internal ribosome entry site (IRES) utilization, cardioviruses also employ a series of alternative translation...
Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus.
Christopher Hill, Georgia Cook, Sawsan Napthine, Anuja Kibe, Katherine Brown, Neva Caliskan, Andrew Firth, Stephen Graham, Ian Brierley
Oct 11, 2021
The 2A protein of Theiler's murine encephalomyelitis virus (TMEV) acts as a switch to stimulate programmed -1 ribosomal frameshifting (PRF) during infection. Here, we present the X-ray crystal structure of TMEV 2A and define how...
Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch.
Chris H Hill, Lukas Pekarek, Sawsan Napthine, Anuja Kibe, Andrew E Firth, Stephen C Graham, Neva Caliskan, Ian Brierley
Jan 04, 2022
Hypoxia and tissue destruction in pulmonary TB.
Moerida Belton, Sara Brilha, Roido Manavaki, Francesco Mauri, Kuldip Nijran, Young T Hong, Neva H Patel, Marcin Dembek, Liku Tezera, Justin Green, Rachel Moores, Franklin Aigbirhio, Adil Al-Nahhas, Tim D Fryer, Paul T Elkington, Jon S Friedland
Jun 03, 2016
Tuberculosis Adult Biopsy Cell Hypoxia Cells Cultured Collagenases Epithelial Cells Female Gene Expression Regulation Humans Hypoxia-Inducible Factor 1 alpha Subunit Lung MACROPHAGES Male Matrix Metalloproteinase 1 Microscopy Confocal Middle Aged Mycobacterium tuberculosis Positron Emission Tomography Computed Tomography RNA Messenger Respiratory Mucosa Tuberculosis Pulmonary Up-Regulation Young Adult