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Results: 52
Multi-Center Evaluation of the Fully Automated PCR-Based Idylla™ KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal Cancer.
Jérôme Solassol, Julie Vendrell, Bruno Märkl, Christian Haas, Beatriz Bellosillo, Clara Montagut, Matthew Smith, Brendan O'Sullivan, Nicky D'Haene, Marie Le Mercier, Morten Grauslund, Linea Cecilie Melchior, Emma Burt, Finbarr Cotter, Daniel Stieber, Fernando de Lander Schmitt, Valentina Motta, Calogero Lauricella, Richard Colling, Elizabeth Soilleux, Matteo Fassan, Claudia Mescoli, Christine Collin, Jean-Christophe Pagès, Peter Sillekens
Dec 20, 2019
Since the advent of monoclonal antibodies against epidermal growth factor receptor (EGFR) in colorectal cancer therapy, the determination of RAS mutational status is needed for therapeutic decision-making. Most prevalent in...
Exploring Communication and Networks Using Social Network Analysis
Programme management’s importance is increasing, particularly in the public sector, because of government promotion of PM. However, its novelty means PM is an under-researched organizational form.This is particularly the case...
Published by: IGI Global Scientific Publishing
Neogene Uplift and Magmatism of Anatolia
It is generally agreed that mantle dynamics have played a significant role in generating and maintaining the elevated topography of Anatolia during Neogene times. However, there is much debate about the relative importance of...
Using Parameter Constraints to Choose State Structures in Cost-Effectiveness Modelling.
BACKGROUND: This article addresses the choice of state structure in a cost-effectiveness multi-state model. Key model outputs, such as treatment recommendations and prioritisation of future research, may be sensitive to state...
Application of normalisation process theory in understanding implementation processes in primary care settings in the UK
Lisa Huddlestone, Jessica Turner, Helen Eborall, Nicky Hudson, Melanie Davies, Graham Martin
Jun 06, 2020
Abstract: Background: Normalisation Process Theory (NPT) provides a framework to understand how interventions are implemented, embedded, and integrated in healthcare settings. Previous reviews of published literature have...
IMPRoving Outcomes for children exposed to domestic ViolencE (IMPROVE)
Background Exposure to domestic violence and abuse (DVA) during childhood and adolescence increases the risk of negative outcomes across the...
Emma Howarth, Theresa HM Moore, Nicky J Welton, Natalia Lewis, Nicky Stanley, Harriet MacMillan, Alison Shaw, Marianne Hester, Peter Bryden, Gene Feder
Feb 17, 2020
Clinical Research Health Services Behavioral and Social Science Pediatric Mental Health Comparative Effectiveness Research 3.1 Primary prevention interventions to modify behaviours or promote wellbeing 8 Health and social care services research 6 Evaluation of treatments and therapeutic interventions 6.6 Psychological and behavioural 8.1 Organisation and delivery of services 3 Prevention of disease and conditions and promotion of well-being Mental Health 16 Peace Justice and Strong Institutions
Using Normalisation Process Theory (NPT) to develop an intervention to improve referral and uptake rates for self-management education for patients with type 2 diabetes in UK primary care.
Jessica Turner, Graham Martin, Nicky Hudson, Liz Shaw, Lisa Huddlestone, Christina Weis, Alison Northern, Sally Schreder, Melanie Davies, Helen Eborall
Sep 27, 2022
BACKGROUND: Referral and uptake rates of structured self-management education (SSME) for Type 2 diabetes (T2DM) in the UK are variable and relatively low. Research has documented contributing factors at patient, practitioner and...
Using Normalisation Process Theory (NPT) to develop an intervention to improve referral and uptake rates for self-management education for patients with type 2 diabetes in UK primary care.
Jessica Turner, Graham Martin, Nicky Hudson, Liz Shaw, Lisa Huddlestone, Christina Weis, Alison Northern, Sally Schreder, Melanie Davies, Helen Eborall
Oct 29, 2022
BACKGROUND: Referral and uptake rates of structured self-management education (SSME) for Type 2 diabetes (T2DM) in the UK are variable and relatively low. Research has documented contributing factors at patient, practitioner and...
Application of normalisation process theory in understanding implementation processes in primary care settings in the UK
Lisa Huddlestone, Jessica Turner, Helen Eborall, Nicky Hudson, Melanie Davies, Graham Martin
Apr 17, 2020
BACKGROUND:Normalisation Process Theory (NPT) provides a framework to understand how interventions are implemented, embedded, and integrated in healthcare settings. Previous reviews of published literature have examined the...
Published by: BMC family practice
Towards an ecological understanding of readiness to engage with interventions for children exposed to domestic violence and abuse
Emma Howarth, Theresa HM Moore, Nicky Stanley, Harriet L MacMillan, Gene Feder, Alison Shaw
Nov 12, 2018
Children who grow up in homes affected by domestic violence and abuse (DVA) are at risk of poor outcomes across the lifespan, yet there is limited evidence on the acceptability and effectiveness of interventions for them. A...
Application of normalisation process theory in understanding implementation processes in primary care settings in the UK
Lisa Huddlestone, Jessica Turner, Helen Eborall, Nicky Hudson, Melanie Davies, Graham Martin
Mar 16, 2021
Abstract: Background: Normalisation Process Theory (NPT) provides a framework to understand how interventions are implemented, embedded, and integrated in healthcare settings. Previous reviews of published literature have...
Application of normalisation process theory in understanding implementation processes in primary care settings in the UK
Lisa Huddlestone, Jessica Turner, Helen Eborall, Nicky Hudson, Melanie Davies, Graham Martin
Apr 14, 2020
BACKGROUND: Normalisation Process Theory (NPT) provides a framework to understand how interventions are implemented, embedded, and integrated in healthcare settings. Previous reviews of published literature have examined the...
What is the optimal management of potentially resectable stage III-N2 NSCLC? Results of a fixed-effects network meta-analysis and economic modelling.
Matthew Evison, Ross Maconachie, Toby Mercer, Caitlin H Daly, Nicky J Welton, Shahzeena Aslam, Doug West, Neal Navani
Apr 17, 2023
INTRODUCTION: There is a critical need to understand the optimal treatment regimen in patients with potentially resectable stage III-N2 nonsmall cell lung cancer (NSCLC). METHODS: A systematic review of randomised controlled...
Recapture or precapture? Fallibility of standard capture-recapture methods in the presence of referrals between sources.
Hayley E Jones, Matthew Hickman, Nicky J Welton, Daniela De Angelis, Ross J Harris, AE Ades
Aug 16, 2018
Capture-recapture methods, largely developed in ecology, are now commonly used in epidemiology to adjust for incomplete registries and to estimate the size of difficult-to-reach populations such as problem drug users....
Bias log-linear models model selection parameter identifiability prevalence estimation problem drug use Bias Data Collection Data Interpretation Statistical England Epidemiologic Research Design Humans Linear Models Models Statistical Population Density Referral and Consultation Substance-Related Disorders
Multilevel and Quasi Monte Carlo Methods for the Calculation of the Expected Value of Partial Perfect Information.
Wei Fang, Zhenru Wang, Michael B Giles, Chris H Jackson, Nicky J Welton, Christophe Andrieu, Howard Thom
Jan 28, 2022
The expected value of partial perfect information (EVPPI) provides an upper bound on the value of collecting further evidence on a set of inputs to a cost-effectiveness decision model. Standard Monte Carlo estimation of EVPPI is...
Hope, Agency, and the Lived Experience of Violence
Lisa Arai, Ali Shaw, Gene Feder, Emma Howarth, Harriet MacMillan, Theresa HM Moore, Nicky Stanley, Alison Gregory
Jul 25, 2019
There is a large body of research on the impact of domestic violence and abuse (DVA) on children, mostly reporting survey data and focusing largely on psychological outcomes. Qualitative research on the views of children has the...
18F-FDG PET and perfusion SPECT in the diagnosis of Alzheimer and Lewy body dementias.
John T O'Brien, Michael J Firbank, Christopher Davison, Nicky Barnett, Claire Bamford, Cam Donaldson, Kirsty Olsen, Karl Herholz, David Williams, Jim Lloyd
Apr 13, 2015
18F-FDG PET Alzheimer’s disease HMPAO SPECT dementia with Lewy bodies Diagnosis sensitivity specificity Aged Aged 80 and over Alzheimer Disease Brain Female Fluorodeoxyglucose F18 Humans Lewy Body Disease Male Neuropsychological Tests Perfusion Positron-Emission Tomography Prospective Studies Technetium Tc 99m Exametazime Tomography Emission-Computed Single-Photon
Illicit and pharmaceutical drug consumption estimated via wastewater analysis. Part B: Placing back-calculations in a formal statistical framework
Hayley E Jones, Matthew Hickman, Barbara Kasprzyk-Hordern, Nicky J . Welton, David R. Baker, A. E Ades
Jul 15, 2014
Concentrations of metabolites of illicit drugs in sewage water can be measured with great accuracy and precision, thanks to the development of sensitive and robust analytical methods. Based on assumptions about factors including...
Illicit and pharmaceutical drug consumption estimated via wastewater analysis. Part B: Placing back-calculations in a formal statistical framework
Hayley E Jones, Matthew Hickman, Barbara Kasprzyk-Hordern, Nicky J . Welton, David R. Baker, A. E Ades
Jul 15, 2014
Concentrations of metabolites of illicit drugs in sewage water can be measured with great accuracy and precision, thanks to the development of sensitive and robust analytical methods. Based on assumptions about factors including...
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