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High-frequency recombination between members of an LTR retrotransposon family during transposition bursts.
Retrotransposons containing long terminal repeats (LTRs) form a substantial fraction of eukaryotic genomes. The timing of past transposition can be estimated by quantifying the accumulation of mutations in initially identical...
Giant nonlinear optical activity of achiral origin in planar metasurfaces with quadratic and cubic nonlinearities
Shumei Chen, Franziska Zeuner, Martin Weismann, Bernhard Reinike, Guixin Li, Ventsislav Kolev Valev, Kok Wai Cheah, Nicolae Coriolan Panoiu, Thomas Zentgraf, Shuang Zhang
Apr 14, 2016
3D chirality is shown to be unnecessary for introducing strong circular dichroism for harmonic generations. Specifically, near-unity circular dichroism for both second-harmonic generation and third-harmonic generations is...
Giant nonlinear optical activity of achiral origin in planar metasurfaces with quadratic and cubic nonlinearities
Shumei Chen, Franziska Zeuner, Martin Weismann, Bernhard Reinike, Guixin Li, Ventsislav Kolev Valev, Kok Wai Cheah, Nicolae Coriolan Panoiu, Thomas Zentgraf, Shuang Zhang
Apr 14, 2016
3D chirality is shown to be unnecessary for introducing strong circular dichroism for harmonic generations. Specifically, near-unity circular dichroism for both second-harmonic generation and third-harmonic generations is...
Artificial Intelligence to Detect Papilledema from Ocular Fundus Photographs.
Dan Milea, Raymond P Najjar, Jiang Zhubo, Daniel Ting, Caroline Vasseneix, Xinxing Xu, Masoud Aghsaei Fard, Pedro Fonseca, Kavin Vanikieti, Wolf A Lagrèze, Chiara La Morgia, Carol Y Cheung, Steffen Hamann, Christophe Chiquet, Nicolae Sanda, Hui Yang, Luis J Mejico, Marie-Bénédicte Rougier, Richard Kho, Tran Thi Ha Chau, Shweta Singhal, Philippe Gohier, Catherine Clermont-Vignal, Ching-Yu Cheng, Jost B Jonas, Patrick Yu-Wai-Man, Clare L Fraser, John J Chen, Selvakumar Ambika, Neil R Miller, Yong Liu, Nancy J Newman, Tien Y Wong, Valérie Biousse, BONSAI Group
Apr 21, 2020
BACKGROUND: Nonophthalmologist physicians do not confidently perform direct ophthalmoscopy. The use of artificial intelligence to detect papilledema and other optic-disk abnormalities from fundus photographs has not been well...
Psychological and Mnemonic Benefits of Nostalgia for People with Dementia
Sanda Ismail, Gary Christopher, Emily Dodd, Tim Wildschut, Constantine Sedikides, Tom A Ingram, Roy W Jones, Krist A Noonan, Danielle Tingley, Richard Cheston
Sep 25, 2018
BACKGROUND: Studies with non-clinical populations show that nostalgia increases psychological resources, such as self-esteem and social connectedness.
OBJECTIVES: Our objectives were to find out if the benefits of...
Alzheimer's Disease Autobiographical memory Dementia immediate recall psychological adaptation /dk/atira/pure/subjectarea/asjc/2800/2800 name=General Neuroscience /dk/atira/pure/subjectarea/asjc/3200/3203 name=Clinical Psychology /dk/atira/pure/subjectarea/asjc/2700/2717 name=Geriatrics and Gerontology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Diabetic microcirculatory disturbances and pathologic erythropoiesis are provoked by deposition of amyloid-forming amylin in red blood cells and capillaries.
Nirmal Verma, Miao Liu, Han Ly, Analia Loria, Kenneth S Campbell, Heather Bush, Philip A Kern, Pedro A Jose, Heinrich Taegtmeyer, Donald M Bers, Sanda Despa, Larry B Goldstein, Andrew J Murray, Florin Despa
Jul 29, 2019
In the setting of type-2 diabetes, there are declines of structural stability and functionality of blood capillaries and red blood cells (RBCs), increasing the risk for microcirculatory disturbances. Correcting hyperglycemia is...
amylin Erythropoiesis Hypoxia microvascular disease type-2 diabetes Adult Amyloid Animals Diabetes mellitus Type 2 Diabetic Angiopathies Disease Models Animal Eicosanoids Erythrocytes Erythropoiesis Erythropoietin Female Humans Islet Amyloid Polypeptide Kidney Male Microcirculation Microvessels Middle Aged Rats Retrospective Studies
Transcription cofactor GRIP1 differentially affects myeloid cell-driven neuroinflammation and response to IFN-β therapy.
Sanda Mimouna, David A Rollins, Gayathri Shibu, Bowranigan Tharmalingam, Dinesh K Deochand, Xi Chen, David Oliver, Yurii Chinenov, Inez Rogatsky
Dec 07, 2020
Macrophages (MФ) and microglia (MG) are critical in the pathogenesis of multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE). Glucocorticoids (GCs) and interferon β (IFN-β) are frontline...
Psychological and Mnemonic Benefits of Nostalgia for People with Dementia
Sanda Ismail, Gary Christopher, Emily Dodd, Tim Wildschut, Constantine Sedikides, Tom A Ingram, Roy W Jones, Krist A Noonan, Danielle Tingley, Richard Cheston
Sep 25, 2018
BACKGROUND: Studies with non-clinical populations show that nostalgia increases psychological resources, such as self-esteem and social connectedness.
OBJECTIVES: Our objectives were to find out if the benefits of...
Alzheimer's Disease Autobiographical memory Dementia immediate recall psychological adaptation /dk/atira/pure/subjectarea/asjc/2800/2800 name=General Neuroscience /dk/atira/pure/subjectarea/asjc/3200/3203 name=Clinical Psychology /dk/atira/pure/subjectarea/asjc/2700/2717 name=Geriatrics and Gerontology /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas.
Nirmal Verma, Gopal Viswanathan Velmurugan, Edric Winford, Han Coburn, Deepak Kotiya, Noah Leibold, Laura Radulescu, Sanda Despa, Kuey C Chen, Linda J Van Eldik, Peter T Nelson, Donna M Wilcock, Gregory A Jicha, Ann M Stowe, Larry B Goldstein, David K Powel, Jeffrey H Walton, Manuel F Navedo, Matthew A Nystoriak, Andrew J Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Florin Despa
Jan 04, 2023
The association of circulating amylin with β-amyloid in familial Alzheimer's disease.
Han Ly, Nirmal Verma, Savita Sharma, Deepak Kotiya, Sanda Despa, Erin L Abner, Peter T Nelson, Gregory A Jicha, Donna M Wilcock, Larry B Goldstein, Rita Guerreiro, José Brás, Angela J Hanson, Suzanne Craft, Andrew J Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Aesg, Florin Despa
Feb 19, 2021
INTRODUCTION: This study assessed the hypothesis that circulating human amylin (amyloid-forming) cross-seeds with amyloid beta (Aβ) in early Alzheimer's disease (AD). METHODS: Evidence of amylin-AD pathology interaction was...
Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas.
Nirmal Verma, Gopal Viswanathan Velmurugan, Edric Winford, Han Coburn, Deepak Kotiya, Noah Leibold, Laura Radulescu, Sanda Despa, Kuey C Chen, Linda J Van Eldik, Peter T Nelson, Donna M Wilcock, Gregory A Jicha, Ann M Stowe, Larry B Goldstein, David K Powel, Jeffrey H Walton, Manuel F Navedo, Matthew A Nystoriak, Andrew J Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Florin Despa
Feb 09, 2023
Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.
Nicole Prutsch, Elisabeth Gurnhofer, Tobias Suske, Huan Chang Liang, Michaela Schlederer, Simone Roos, Lawren C Wu, Ingrid Simonitsch-Klupp, Andrea Alvarez-Hernandez, Christoph Kornauth, Dario A Leone, Jasmin Svinka, Robert Eferl, Tanja Limberger, Astrid Aufinger, Nitesh Shirsath, Peter Wolf, Thomas Hielscher, Christina Sternberg, Fritz Aberger, Johannes Schmoellerl, Dagmar Stoiber, Birgit Strobl, Ulrich Jäger, Philipp B Staber, Florian Grebien, Richard Moriggl, Mathias Müller, Giorgio G Inghirami, Takaomi Sanda, A Thomas Look, Suzanne D Turner, Lukas Kenner, Olaf Merkel
Nov 06, 2018
TYK2 is a member of the JAK family of tyrosine kinases that is involved in chromosomal translocation-induced fusion proteins found in anaplastic large cell lymphomas (ALCL) that lack rearrangements activating the anaplastic...
Anaplastic Lymphoma Kinase Animals Apoptosis Cell Line Tumor Cell Survival Gene Expression Regulation Neoplastic Humans Lymphoma Large-Cell Anaplastic Mice Myeloid Cell Leukemia Sequence 1 Protein Phosphorylation Protein Kinase Inhibitors Protein-Tyrosine Kinases STAT1 Transcription Factor STAT3 Transcription Factor Signal Transduction TYK2 Kinase Translocation Genetic
Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status
Rebecca Ritte, Annekatrin Lukanova, Franco Berrino, Laure Dossus, Anne Tjønneland, Anja Olsen, Thure Filskov Overvad, Kim Overvad, Françoise Clavel-Chapelon, Agnès Fournier, Guy Fagherazzi, Sabine Rohrmann, Birgit Teucher, Heiner Boeing, Krasimira Aleksandrova, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Sabina Sieri, Salvatore Panico, Rosario Tumino, Paolo Vineis, José Ramón Quirós, Genevieve Buckland, Maria-José Sánchez, Pilar Amiano, María-Dolores Chirlaque, Eva Ardanaz, Malin Sund, Per Lenner, Bas Bueno-de-Mesquita, Carla H van Gils, Petra Hm Peeters, Sanda Krum-Hansen, Inger Torhild Gram, Eiliv Lund, Kay-Tee Khaw, Nick Wareham, Naomi E Allen, Timothy J Key, Isabelle Romieu, Sabina Rinaldi, Afshan Siddiq, David Cox, Elio Riboli, Rudolf Kaaks
Jun 04, 2012
The Sustainable Materials Roadmap
Maria-Magdalena Titirici, Sterling Baird, Taylor Sparks, Shirley M Yang, Agi Brandt-Talbot, Omid Hosseinaei, David Paul Harper, Richard Parker, Silvia Vignolini, Lars Berglund, Yuanyuan Li, Huai-Ling Gao, Li-Bo Mao, Shuhong Yu, Noel Díez, Guillermo Alvarez.ferrero, Marta Sevilla Solis, Petra Szilagyi, Connor Stubbs, Joshua Worch, Yunping Huang, Christine Luscombe, Koon-yang Lee, Hui Luo, Jim Platts, Devendra Tiwari, Dmitry Kovalevskiy, David Fermin, Heather Au, Hande Alptekin, Maria Crespo Ribadeneyra, Valeska Ting, Tim-Patrick Fellinger, Jesus Barrio-hermida, Olivia Westhead, Claudie Roy, Ifan Stephens, Sabina Alexandra Nicolae, Saurav Sarma, Rose Oates, Chen Gang Wang, Zibiao Li, Xian Jun Loh, Rupert J Myers, Niko Heeren, Alice Grégoire, Clément Périssé, Xiaoying Zhao, Yael Vodovotz, Becky Earley, Goran Finnveden, Anna Björklund, Gavin Harper, Allan Walton, Paul A Anderson
Aug 09, 2022
The sustainable materials roadmap
M Titirici, SG Baird, TD Sparks, SM Yang, A Brandt-Talbot, O Hosseinaei, DP Harper, RM Parker, S Vignolini, LA Berglund, Y Li, HL Gao, LB Mao, SH Yu, N Díez, GA Ferrero, M Sevilla, PÁ Szilágyi, CJ Stubbs, JC Worch, Y Huang, CK Luscombe, KY Lee, H Luo, MJ Platts, D Tiwari, D Kovalevskiy, DJ Fermin, H Au, H Alptekin, M Crespo-Ribadeneyra, VP Ting, TP Fellinger, J Barrio, O Westhead, C Roy, IEL Stephens, SA Nicolae, SC Sarma, RP Oates, CG Wang, Z Li, XJ Loh, RJ Myers, N Heeren, A Grégoire, C Périssé, X Zhao, Y Vodovotz, B Earley, G Finnveden, A Björklund, GDJ Harper, A Walton, PA Anderson
Aug 10, 2022
The sustainable materials roadmap
Magda Titirici, Sterling G Baird, Taylor D Sparks, Shirley Min Yang, Agnieszka Brandt-Talbot, Omid Hosseinaei, David P Harper, Richard M Parker, Silvia Vignolini, Lars A Berglund, Yuanyuan Li, Huai-Ling Gao, Li-Bo Mao, Shu-Hong Yu, Noel Díez, Guillermo A Ferrero, Marta Sevilla, Petra Ágota Szilágyi, Connor J Stubbs, Joshua C Worch, Yunping Huang, Christine K Luscombe, Koon-yang Lee, Hui Luo, M J Platts, Devendra Tiwari, Dmitry Kovalevskiy, David J Fermin, Heather Au, Hande Alptekin, Maria Crespo-Ribadeneyra, Valeska P Ting, Tim-Patrick Fellinger, Jesús Barrio, Olivia Westhead, Claudie Roy, Ifan E L Stephens, Sabina Alexandra Nicolae, Saurav Ch Sarma, Rose P Oates, Chen-Gang Wang, Zibiao Li, Xian Jun Loh, Rupert J Myers, Niko Heeren, Alice Grégoire, Clément Périssé, Xiaoying Zhao, Yael Vodovotz, Becky Earley, Göran Finnveden, Anna Björklund, Gavin D J Harper, Allan Walton, Paul A Anderson
Aug 04, 2022
Abstract: Over the past 150 years, our ability to produce and transform engineered materials has been responsible for our current high standards of living, especially in developed economies. However, we must carefully think of...
Published by: IOP Publishing
The Sustainable Materials Roadmap
Maria-Magdalena Titirici, Sterling Baird, Taylor Sparks, Shirley M Yang, Agi Brandt-Talbot, Omid Hosseinaei, David Paul Harper, Richard Parker, Silvia Vignolini, Lars Berglund, Yuanyuan Li, Huai-Ling Gao, Li-Bo Mao, Shuhong Yu, Noel Díez, Guillermo Alvarez.ferrero, Marta Sevilla Solis, Petra Szilagyi, Connor Stubbs, Joshua Worch, Yunping Huang, Christine Luscombe, Koon-yang Lee, Hui Luo, Jim Platts, Devendra Tiwari, Dmitry Kovalevskiy, David Fermin, Heather Au, Hande Alptekin, Maria Crespo Ribadeneyra, Valeska Ting, Tim-Patrick Fellinger, Jesus Barrio-hermida, Olivia Westhead, Claudie Roy, Ifan Stephens, Sabina Alexandra Nicolae, Saurav Sarma, Rose Oates, Chen Gang Wang, Zibiao Li, Xian Jun Loh, Rupert J Myers, Niko Heeren, Alice Grégoire, Clément Périssé, Xiaoying Zhao, Yael Vodovotz, Becky Earley, Goran Finnveden, Anna Björklund, Gavin Harper, Allan Walton, Paul A Anderson
Aug 04, 2022
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Florence Demenais, Patricia Margaritte-Jeannin, Kathleen C Barnes, William OC Cookson, Janine Altmüller, Wei Ang, R Graham Barr, Terri H Beaty, Allan B Becker, John Beilby, Hans Bisgaard, Unnur Steina Bjornsdottir, Eugene Bleecker, Klaus Bønnelykke, Dorret I Boomsma, Emmanuelle Bouzigon, Christopher E Brightling, Myriam Brossard, Guy G Brusselle, Esteban Burchard, Kristin M Burkart, Andrew Bush, Moira Chan-Yeung, Kian Fan Chung, Alexessander Couto Alves, John A Curtin, Adnan Custovic, Denise Daley, Johan C de Jongste, Blanca E Del-Rio-Navarro, Kathleen M Donohue, Liesbeth Duijts, Celeste Eng, Johan G Eriksson, Martin Farrall, Yuliya Fedorova, Bjarke Feenstra, Manuel A Ferreira, Australian Asthma Genetics Consortium (AAGC) collaborators, Maxim B Freidin, Zofia Gajdos, Jim Gauderman, Ulrike Gehring, Frank Geller, Jon Genuneit, Sina A Gharib, Frank Gilliland, Raquel Granell, Penelope E Graves, Daniel F Gudbjartsson, Tari Haahtela, Susan R Heckbert, Dick Heederik, Joachim Heinrich, Markku Heliövaara, John Henderson, Blanca E Himes, Hiroshi Hirose, Joel N Hirschhorn, Albert Hofman, Patrick Holt, Jouke Hottenga, Thomas J Hudson, Jennie Hui, Medea Imboden, Vladimir Ivanov, Vincent WV Jaddoe, Alan James, Christer Janson, Marjo-Riitta Jarvelin, Deborah Jarvis, Graham Jones, Ingileif Jonsdottir, Pekka Jousilahti, Michael Kabesch, Mika Kähönen, David B Kantor, Alexandra S Karunas, Elza Khusnutdinova, Gerard H Koppelman, Anita L Kozyrskyj, Eskil Kreiner, Michiaki Kubo, Rajesh Kumar, Ashish Kumar, Mikko Kuokkanen, Lies Lahousse, Tarja Laitinen, Catherine Laprise, Mark Lathrop, Susanne Lau, Young-Ae Lee, Terho Lehtimäki, Sébastien Letort, Albert M Levin, Guo Li, Liming Liang, Laura R Loehr, Stephanie J London, Daan W Loth, Ani Manichaikul, Ingo Marenholz, Fernando J Martinez, Melanie C Matheson, Rasika A Mathias, Kenji Matsumoto, Hamdi Mbarek, Wendy L McArdle, Mads Melbye, Erik Melén, Deborah Meyers, Sven Michel, Hamida Mohamdi, Arthur W Musk, Rachel A Myers, Maartje AE Nieuwenhuis, Emiko Noguchi, George T O'Connor, Ludmila M Ogorodova, Cameron D Palmer, Aarno Palotie, Julie E Park, Craig E Pennell, Göran Pershagen, Alexey Polonikov, Dirkje S Postma, Nicole Probst-Hensch, Valery P Puzyrev, Benjamin A Raby, Olli T Raitakari, Adaikalavan Ramasamy, Stephen S Rich, Colin F Robertson, Isabelle Romieu, Muhammad T Salam, Veikko Salomaa, Vivi Schlünssen, Robert Scott, Polina A Selivanova, Torben Sigsgaard, Angela Simpson, Valérie Siroux, Lewis J Smith, Maria Solodilova, Marie Standl, Kari Stefansson, David P Strachan, Bruno H Stricker, Atsushi Takahashi, Philip J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Carla MT Tiesler, Dara G Torgerson, Tatsuhiko Tsunoda, André G Uitterlinden, Ralf JP van der Valk, Amaury Vaysse, Sailaja Vedantam, Andrea von Berg, Erika von Mutius, Judith M Vonk, Johannes Waage, Nick J Wareham, Scott T Weiss, Wendy B White, Magnus Wickman, Elisabeth Widén, Gonneke Willemsen, L Keoki Williams, Inge M Wouters, James J Yang, Jing Hua Zhao, Miriam F Moffatt, Carole Ober, Dan L Nicolae
Jan 21, 2020
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We...