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The Clinical and Public Health Challenges of Diabetes Prevention
In an Editorial accompanying PLOS Medicine's Special Issue on Diabetes Prevention, Guest Editors Nicholas Wareham and William Herman discuss some of the challenges for researchers and policy makers in developing effective and...
Nicolas Sarkozy's legitimization of the Front National
Aurelien Mondon
Feb 01, 2013
In the 'poor' result achieved by Jean-Marie Le Pen in the 2007 presidential elections, many commentators saw the demise of the Front National. However, when asked by a journalist whether it was the end of her father's political...
Nicolas Sarkozy's legitimization of the Front National
Aurelien Mondon
Feb 01, 2013
In the 'poor' result achieved by Jean-Marie Le Pen in the 2007 presidential elections, many commentators saw the demise of the Front National. However, when asked by a journalist whether it was the end of her father's political...
Predicting admissions and time spent in hospital over a decade in a population-based record linkage study
EPIDEMIOLOGY HEALTH SERVICES ADMINISTRATION & MANAGEMENT Public Health Adult Age Factors Aged Body Mass Index Demography Educational Status Female Health Behavior Hospitalization Hospitals Humans Length of Stay Life Style Logistic Models Male Middle Aged Patient Admission Prospective Studies Risk Factors Sex Factors Smoking Social Class United Kingdom
Life's simple 7 and calcific aortic valve stenosis incidence in apparently healthy men and women.
Nicolas Perrot, S Matthijs Boekholdt, Patrick Mathieu, Nicholas J Wareham, Kay-Tee Khaw, Benoit J Arsenault
Nov 20, 2018
BACKGROUND: Calcific aortic valve stenosis (CAVS) is the most prevalent heart valve disease in Western societies. The American Heart Association 2020 Strategic Impact Goals introduced the concept of ideal cardiovascular health...
Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes
Jakie Guertin, Yannick Kaiser, Hasanga Manikpurage, Nicolas Perrot, Raphaëlle Bourgeois, Christian Couture, Nicholas J Wareham, Yohan Bossé, Philippe Pibarot, Erik SG Stroes, Patrick Mathieu, Marie-Annick Clavel, Sébastien Thériault, S Matthijs Boekholdt, Benoit J Arsenault
Jul 26, 2021
BACKGROUND: Elevated Lp(a) (Lipoprotein(a)) levels are associated with coronary artery disease (CAD), ischemic stroke (IS), and calcific aortic valve stenosis (CAVS). Studies investigating the association between Lp(a) levels...
Physical activity and dietary behaviour in a population-based sample of British 10-year old children: the SPEEDY study (Sport, Physical activity and Eating behaviour
Towards a Multidimensional Ontology Model for DIH-Based Organisations
Digital innovation hubs are of utmost importance when they sustain cooperation in innovative technological domains like the cyber-physical system. In this paper, the authors introduce, in the first part, a DIH ontology that they...
Published by: IGI Global Scientific Publishing
Knowledge Transfer in Information Security Capacity Building for Community-Based Organizations
Community-based organizations (CBOs) in the health and human services sector handle very sensitive client information, such as psychiatric, HIV testing, criminal justice, and financial records. With annual revenue often in the...
Published by: IGI Global Scientific Publishing
Species-specific contribution of volumetric growth and tissue convergence to posterior body elongation in vertebrates.
Ben Steventon, Fernando Duarte, Ronan Lagadec, Sylvie Mazan, Jean-François Nicolas, Estelle Hirsinger
Mar 21, 2016
QSAR Analysis for the Inhibition of the Mutagenic Activity by Anthocyanin Derivatives
Flavonoid compounds modulate the cytochrome P450 3A4 enzyme activity and inhibit the mutagenic activity of mammalian cells, preventing carcinogen activation and cellular DNA damage. In this work, the quantitative...
Published by: IGI Global Scientific Publishing
Trajectory and uniqueness of mutational signatures in yeast mutators.
Sophie Loeillet, Mareike Herzog, Fabio Puddu, Patricia Legoix, Sylvain Baulande, Stephen P Jackson, Alain G Nicolas
Aug 28, 2020
The acquisition of mutations plays critical roles in adaptation, evolution, senescence, and tumorigenesis. Massive genome sequencing has allowed extraction of specific features of many mutational landscapes but it remains...
Pol zeta dynamics of mutation accumulation Loss of Heterozygosity mutational profiles mutator genes Acetyltransferases BRCA1 Protein BRCA2 Protein Breast Neoplasms Carcinogenesis DNA Damage DNA-Directed DNA Polymerase Diploidy Female Flap Endonucleases Genome Fungal Humans Loss of Heterozygosity Membrane Proteins Mutation Peroxiredoxins Rad51 Recombinase Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins whole genome sequencing
Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk
Benoit J Arsenault, William Pelletier, Yannick Kaiser, Nicolas Perrot, Christian Couture, Kay-Tee Khaw, Nicholas J Wareham, Yohan Bossé, Philippe Pibarot, Erik SG Stroes, Patrick Mathieu, Sébastien Thériault, S Matthijs Boekholdt
Mar 31, 2020
IMPORTANCE: Elevated lipoprotein(a) (Lp[a]) levels are associated with atherosclerotic cardiovascular diseases. The association between high Lp(a) levels and human longevity phenotypes is, however, controversial. OBJECTIVE: To...
Rigid analytic quantum groups and quantum Arens-Michael envelopes
Nicolas Dupré
Aug 19, 2019
We introduce a rigid analytification of the quantized coordinate algebra of a semisimple algebraic group and a quantized Arens-Michael envelope of the enveloping algebra of the corresponding Lie algebra, working over a...
Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans
Nicolas Perrot, Sébastien Thériault, Sidwell Rigade, Hao Yu Chen, Christian Dina, Andreas Martinsson, S Matthijs Boekholdt, Romain Capoulade, Thierry Le Tourneau, David Messika-Zeitoun, James C Engert, Nicholas J Wareham, Marie-Annick Clavel, Philippe Pibarot, J Gustav Smith, Jean Jacques Schott, Patrick Mathieu, Yohan Bossé, George Thanassoulis, Benoit J Arsenault
Jul 10, 2020
Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has been shown to predict calcific aortic valve stenosis (CAVS) outcomes. Our objective was to test the association between plasma Lp-PLA2 activity and...
Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans.
Nicolas Perrot, Sébastien Thériault, Sidwell Rigade, Hao Yu Chen, Christian Dina, Andreas Martinsson, S Matthijs Boekholdt, Romain Capoulade, Thierry Le Tourneau, David Messika-Zeitoun, James C Engert, Nicholas J Wareham, Marie-Annick Clavel, Philippe Pibarot, J Gustav Smith, Jean Jacques Schott, Patrick Mathieu, Yohan Bossé, George Thanassoulis, Benoit J Arsenault
Jul 14, 2020
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has been shown to predict calcific aortic valve stenosis (CAVS) outcomes. Our objective was to test the association between plasma Lp-PLA2 activity and...
Aortic stenosis Coronary Artery Disease 1-Alkyl-2-acetylglycerophosphocholine Esterase Aged Aged 80 and over Aortic Valve aortic valve stenosis Biomarkers Calcinosis Case-Control Studies Europe Female Genetic Association Studies Genetic Predisposition to Disease Humans Male Meta-Analysis as Topic Phenotype Polymorphism Single Nucleotide Risk Assessment Risk Factors Up-Regulation
Personalised prevention of type 2 diabetes.
Nicholas J Wareham
Sep 29, 2022
It is well established from clinical trials that behavioural interventions can halve the risk of progression from prediabetes to type 2 diabetes but translating this evidence of efficacy into effective real-world interventions...
Environmental Policy in International Shipping
Lori Katelyn Wareham
Aug 22, 2017
Shipping is a main method of transportation for goods internationally, and is also a sizeable contributor towards global emissions produced annually. The International Maritime Organization (IMO) which is a specialized agency...
Engineering Ocean and Naval Architectural Engineering focus stream in Political Science Engineering Naval Architecture Environmental Policy EEDI IMO Technology innovation marine
Published by: Memorial University of Newfoundland
The divergence history of European blue mussel species reconstructed from Approximate Bayesian Computation
Christelle Fraïsse, Camille Roux, Pierre-Alexandre Gagnaire, Jonathan Romiguier, Nicolas Faivre, John J Welch, Nicolas Bierne
Oct 18, 2018
Genome-scale diversity data are increasingly available in a variety of biological systems, and can be used to reconstruct the past evolutionary history of species divergence. However, extracting the full demographic information...
Fixing France's broken social model?
Susan Milner
Sep 01, 2012
Taking as its starting point the programme and campaign of Nicolas Sarkozy in the presidential election of 2007 around the ‘value of work’, this article reviews and assesses the main reforms undertaken during the period of his...
Fixing France's broken social model?
Susan Milner
Sep 01, 2012
Taking as its starting point the programme and campaign of Nicolas Sarkozy in the presidential election of 2007 around the ‘value of work’, this article reviews and assesses the main reforms undertaken during the period of his...
Multi-Omics and Genome-Scale Modeling Reveal a Metabolic Shift During C. elegans Aging.
Janna Hastings, Abraham Mains, Bhupinder Virk, Nicolas Rodriguez, Sharlene Murdoch, Juliette Pearce, Sven Bergmann, Nicolas Le Novère, Olivia Casanueva
Jul 01, 2019
In this contribution, we describe a multi-omics systems biology study of the metabolic changes that occur during aging in Caenorhabditis elegans. Sampling several time points from young adulthood until early old age, our study...
Environmental Policy in International Shipping
Lori Katelyn Wareham
Aug 22, 2017
Shipping is a main method of transportation for goods internationally, and is also a sizeable contributor towards global emissions produced annually. The International Maritime Organization (IMO) which is a specialized agency...
Engineering;Ocean and Naval Architectural Engineering; focus stream in Political Science Engineering, Naval Architecture, Environmental Policy, EEDI, IMO, technology, innovation, marine
Published by: Memorial University of Newfoundland
Embodying a Virtual Agent in a Self-Driving Car
Clarisse Lawson-Guidigbe, Nicolas Louveton, Kahina Amokrane-Ferka, Benoît Le Blanc, Jean-Marc André
Jan 01, 2023
This article considers the visual appearance of a virtual agent designed to take over the driving task in a highly automated car, to answer the question of which visual appearance is appropriate for a virtual agent in a driving...
Published by: IGI Global Scientific Publishing
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