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Pilot study to establish a prospective neonatal cohort
BACKGROUND: Genetic risk variants and preterm birth are early and potent risk factors for later neuropsychiatric disorders. To understand the interrelationships between these factors, a large-scale genetic study of very preterm...
Affect-Driven Learning of Robot Behaviour for Collaborative Human-Robot Interactions.
Collaborative interactions require social robots to share the users' perspective on the interactions and adapt to the dynamics of their affective behaviour. Yet, current approaches for affective behaviour generation in robots...
Biosensors for screening kinase inhibitors
For successful drug discovery it is important to understand the fundamentals of the underlying causes and consequences of the diseases for which the drug is being developed. One such physiological process in eukaryotic cells is...
Contribution of de novo and inherited rare CNVs to very preterm birth.
Hilary S Wong, Megan Wadon, Alexandra Evans, George Kirov, Neena Modi, Michael C O'Donovan, Anita Thapar
Feb 14, 2020
BACKGROUND: The genomic contribution to adverse health sequelae in babies born very preterm (<32 weeks' gestation) is unknown. We conducted an investigation of rare CNVs in infants born very preterm as part of a study to...
The shaken realist
Abstract: Bernard Williams thought that philosophy should address real human concerns felt beyond academic philosophy. But what wider concerns are addressed by Ethics and the Limits of Philosophy, a book he introduces as being...
Exploiting the signatures of nanoplasmon-exciton coupling on proton sensitive insulator-semiconductor devices for drug discovery applications
Multimodal sensing methods have a great promise in biosensing applications as they can measure independently several properties that characterise the biomolecular interaction to be detected as well as providing inherent on-chip...
Introduction to biosensors
Biosensors are nowadays ubiquitous in biomedical diagnosis as well as a wide range of other areas such as point-of-care monitoring of treatment and disease progression, environmental monitoring, food control, drug discovery...
Semiconductor technology in protein kinase research and drug discovery
Since the discovery of protein kinase activity in 1954, close to 600 kinases have been discovered that have crucial roles in cell physiology. In several pathological conditions, aberrant protein kinase activity leads to abnormal...
Protein phosphorylation analysis based on proton release detection
Phosphorylation is the most important post-translational modification of proteins in eukaryotic cells and it is catalysed by enzymes called kinases. The balance between protein phosphorylation and dephosphorylation is critical...
Protein phosphorylation detection using dual-mode field-effect devices and nanoplasmonic sensors
Phosphorylation by kinases is an important post-translational modification of proteins. It is a critical control for the regulation of vital cellular activities, and its dysregulation is implicated in several diseases. A common...
Protein phosphorylation detection using dual-mode field-effect devices and nanoplasmonic sensors
Phosphorylation by kinases is an important post-translational modification of proteins. It is a critical control for the regulation of vital cellular activities, and its dysregulation is implicated in several diseases. A common...
Introduction to biosensors
Biosensors are nowadays ubiquitous in biomedical diagnosis as well as a wide range of other areas such as point-of-care monitoring of treatment and disease progression, environmental monitoring, food control, drug discovery...
A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank
Beate Leppert, Louise A. C. Millard, Lucy Riglin, George Davey Smith, Anita Thapar, Kate Tilling, Esther Walton, Evie Stergiakouli
May 11, 2020
Psychiatric disorders are highly heritable and associated with a wide variety of social adversity and physical health problems. Using genetic liability (rather than phenotypic measures of disease) as a proxy for psychiatric...
/dk/atira/pure/subjectarea/asjc/1100/1105 name=Ecology, Evolution, Behavior and Systematics /dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology /dk/atira/pure/subjectarea/asjc/1300/1311 name=Genetics /dk/atira/pure/subjectarea/asjc/2700/2716 name=Genetics(clinical) /dk/atira/pure/subjectarea/asjc/1300/1306 name=Cancer Research /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Exploiting the signatures of nanoplasmon-exciton coupling on proton sensitive insulator-semiconductor devices for drug discovery applications
Multimodal sensing methods have a great promise in biosensing applications as they can measure independently several properties that characterise the biomolecular interaction to be detected as well as providing inherent on-chip...
A simple non-parametric method for resolving merged doublet lines
Doublet line emission and absorption are common in astronomical sources (e.g. [OIII], [O II], NaD, MgII). In many cases, complex kinematics in the emitting source can cause the doublet lines to merge, making characterization...
Understanding cost-utility analysis studies in the trauma and orthopaedic surgery literature.
Cost-utility analysis (CUA) studies are becoming increasingly important due to the need to reduce healthcare spending, especially in the field of trauma and orthopaedics.There is an increasing need for trauma and orthopaedic...
Biosensors for screening kinase inhibitors
For successful drug discovery it is important to understand the fundamentals of the underlying causes and consequences of the diseases for which the drug is being developed. One such physiological process in eukaryotic cells is...
A cross-disorder MR-pheWAS of 5 major psychiatric disorders in UK Biobank
Beate Leppert, Louise A. C. Millard, Lucy Riglin, George Davey Smith, Anita Thapar, Kate Tilling, Esther Walton, Evie Stergiakouli
May 11, 2020
Psychiatric disorders are highly heritable and associated with a wide variety of social adversity and physical health problems. Using genetic liability (rather than phenotypic measures of disease) as a proxy for psychiatric...
/dk/atira/pure/subjectarea/asjc/1100/1105 name=Ecology, Evolution, Behavior and Systematics /dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology /dk/atira/pure/subjectarea/asjc/1300/1311 name=Genetics /dk/atira/pure/subjectarea/asjc/2700/2716 name=Genetics(clinical) /dk/atira/pure/subjectarea/asjc/1300/1306 name=Cancer Research /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Perioperative management of patients with rheumatoid arthritis undergoing orthopaedic surgery.
Rheumatoid arthritis is an autoimmune disease which is characterised by systemic inflammation. In the recent decades, the advent of disease modifying anti-rheumatic drugs have reduced the need for orthopaedic procedures....
Implementing Agile Methodology Techniques in Automobile Industry
Nikhil Kranthi Datrika
Jan 01, 0001
Automotive industries have continued to expand, as they cut on costs by regulating efficiency, grow and make profits. The factors that have continued to change the industry include marketplace growth, outsourcing for product...
Agile automobile industry Human Resources Management Interpersonal and Small Group Communication Management Information Systems Management Sciences and Quantitative Methods
Published by: Harrisburg University of Science and Technology
Aptamer-based Field-Effect Biosensor for Tenofovir Detection
Nima Aliakbarinodehi, Pawan Jolly, Nikhil Bhalla, Anna Miodek, Giovanni de Micheli, Pedro Estrela, Sandro Carrara
Mar 15, 2017
During medical treatment it is critical to maintain the circulatory concentration of drugs within their therapeutic range. A novel biosensor is presented in this work to address the lack of a reliable point-of-care drug...
Plasmonic ruler on field-effect devices for kinase drug discovery applications
Nikhil Bhalla, Nello Formisano, Anna Miodek, Aditya Jain, Mirella Di Lorenzo, Giordano Pula, Pedro Estrela
Sep 15, 2015
Protein kinases are cellular switches that mediate phosphorylation of proteins. Abnormal phosphorylation of proteins is associated with lethal diseases such as cancer. In the pharmaceutical industry, protein kinases have become...
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