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Results: 81
Association of faecal elastase 1 with non-fasting triglycerides in type 2 diabetes.
Wolfgang Rathmann, Burkhard Haastert, Jan Oscarsson, Niklas Berglind, Björn Lindkvist, Nicholas J Wareham
Apr 15, 2016
cardiovascular disease Chronic pancreatitis Faecal elastase 1 Pancreatic exocrine dysfunction Triglycerides Type 2 diabetes Aged Alcohol Drinking Case-Control Studies Diabetes mellitus Type 2 England Feces Female Glycated Hemoglobin Humans Hypertriglyceridemia LIPASE Male Middle Aged Pancreatic Elastase Pancreatic Function Tests Smoking Triglycerides
Sample size estimation using a latent variable model for mixed outcome co-primary, multiple primary and composite endpoints.
Mixed outcome endpoints that combine multiple continuous and discrete components are often employed as primary outcome measures in clinical trials. These may be in the form of co-primary endpoints, which conclude effectiveness...
Employing a latent variable framework to improve efficiency in composite endpoint analysis.
Composite endpoints that combine multiple outcomes on different scales are common in clinical trials, particularly in chronic conditions. In many of these cases, patients will have to cross a predefined responder threshold in...
Employing a latent variable framework to improve efficiency in composite endpoint analysis
Composite endpoints that combine multiple outcomes on different scales are common in clinical trials, particularly in chronic conditions. In many of these cases, patients will have to cross a predefined responder threshold in...
Improving the analysis of composite endpoints in rare disease trials
Background: Composite endpoints are recommended in rare diseases to increase power and/or to sufficiently capture complexity. Often, they are in the form of responder indices which contain a mixture of continuous and binary...
Increasing power in the analysis of responder endpoints in rheumatology
BACKGROUND: Composite responder endpoints feature frequently in rheumatology due to the multifaceted nature of many of these conditions. Current analysis methods used to analyse these endpoints discard much of the data used to...
Image Encoding Using Multi-Level DNA Barcodes with Nanopore Readout.
Deoxyribonucleic acid (DNA) nanostructure-based data encoding is an emerging information storage mode, offering rewritable, editable, and secure data storage. Herein, a DNA nanostructure-based storage method established on a...
It's about time
Thoughtful use of simplifying assumptions is crucial to make systems biology models tractable while still representative of the underlying biology. A useful simplification can elucidate the core dynamics of a system. A poorly...
It’s about time
Thoughtful use of simplifying assumptions is crucial to make systems biology models tractable while still representative of the underlying biology. A useful simplification can elucidate the core dynamics of a system. A poorly...
QuipuNet
Nanopore sensing is a versatile technique for the analysis of molecules on the single-molecule level. However, extracting information from data with established algorithms usually requires time-consuming checks by an experienced...
Spin Purification in Full-CI Quantum Monte Carlo via a First-Order Penalty Approach.
In this article, we demonstrate that a first-order spin penalty scheme can be efficiently applied to the Slater determinant based Full-CI Quantum Monte Carlo (FCIQMC) algorithm, as a practical route toward spin purification. Two...
Image Encoding Using Multi‐Level DNA Barcodes with Nanopore Readout
Abstract: Deoxyribonucleic acid (DNA) nanostructure‐based data encoding is an emerging information storage mode, offering rewritable, editable, and secure data storage. Herein, a DNA nanostructure‐based storage method...
RESEARCH ARTICLE RESEARCH ARTICLES DNA nanostructures encryption information storage Nanopores strand displacement
Published by: Small
Retail and Place Attractiveness
The opponents of big‐box entry argue that large retail establishments generate a variety of negative externalities. The advocates, on the contrary, argue that access to a large retail market not only delivers direct economic...
Published by: Geographical Analysis
The anti-GMO advocacy
Purpose: Public debates on the use of genetically modified organisms (GMOs) are strongly influenced by the nongovernmental organization (NGO)-led advocacy, most of which is harshly critical of genetic engineering. This...
American institutionalism Complexity reduction Discourse failure GMO NGO /dk/atira/pure/subjectarea/asjc/2200/2207 name=Control and Systems Engineering /dk/atira/pure/subjectarea/asjc/1700/1701 name=Computer Science (miscellaneous) /dk/atira/pure/subjectarea/asjc/2600/2614 name=Theoretical Computer Science /dk/atira/pure/subjectarea/asjc/3300/3301 name=Social Sciences (miscellaneous) /dk/atira/pure/subjectarea/asjc/2200/2201 name=Engineering (miscellaneous)
Differential Effects of Iron Chelates vs. Iron Salts on Induction of Pro-Oncogenic Amphiregulin and Pro-Inflammatory COX-2 in Human Intestinal Adenocarcinoma Cell Lines.
Agata Tarczykowska, Niklas Engström, Darja Dobermann, Jonathan Powell, Nathalie Scheers
Apr 05, 2023
Neural evidence of motivational conflict between social values
Motivational interdependence is an organizing principle in Schwartz’s circumplex model of social values, which has received abundant cross-cultural support. We used fMRI to test whether motivational relations between social...
Linking Diversity and Mental Health
Niklas Schulte, Friedrich M Götz, Fabienne Partsch, Tim Goldmann, Lea Smidt, Bertolt Meyer
Jul 14, 2020
Diversity and psychological health issues at the workplace are pressing issues in today's organizations. However, research linking two fields is scant. To bridge this gap, drawing from team faultline research, social...
Differential Effects of Iron Chelates vs. Iron Salts on Induction of Pro-Oncogenic Amphiregulin and Pro-Inflammatory COX-2 in Human Intestinal Adenocarcinoma Cell Lines.
Agata Tarczykowska, Niklas Engström, Darja Dobermann, Jonathan Powell, Nathalie Scheers
Apr 17, 2023
We previously showed that two iron compounds that are orally ingested by humans, namely ferric EDTA and ferric citrate, can induce an oncogenic growth factor (amphiregulin) in human intestinal epithelial adenocarcinoma cell...
Iron IL-6 IGF1R COX-2 amphiregulin IFNGR1 ferric pyrophosphate Cell Line Humans Adenocarcinoma Iron Compounds Ferric Compounds Salts Edetic Acid Interleukin-6 Iron Chelating Agents Signal Transduction STAT Transcription Factors Cyclooxygenase 2 Janus Kinases Biomarkers
Published by: International journal of molecular sciences
Digital Data Storage Using DNA Nanostructures and Solid-State Nanopores.
Solid-state nanopores are powerful tools for reading the three-dimensional shape of molecules, allowing for the translation of molecular structure information into electric signals. Here, we show a high-resolution integrated...
The anti-GMO advocacy
Purpose: Public debates on the use of genetically modified organisms (GMOs) are strongly influenced by the nongovernmental organization (NGO)-led advocacy, most of which is harshly critical of genetic engineering. This...
American institutionalism Complexity reduction Discourse failure GMO NGO /dk/atira/pure/subjectarea/asjc/2200/2207 name=Control and Systems Engineering /dk/atira/pure/subjectarea/asjc/1700/1701 name=Computer Science (miscellaneous) /dk/atira/pure/subjectarea/asjc/2600/2614 name=Theoretical Computer Science /dk/atira/pure/subjectarea/asjc/3300/3301 name=Social Sciences (miscellaneous) /dk/atira/pure/subjectarea/asjc/2200/2201 name=Engineering (miscellaneous)
Multilocus species trees show the recent adaptive radiation of the mimetic heliconius butterflies.
Krzysztof M Kozak, Niklas Wahlberg, Andrew FE Neild, Kanchon K Dasmahapatra, James Mallet, Chris D Jiggins
Apr 22, 2015
Neural coding of human values is underpinned by brain areas representing the core self in the cortical midline region
The impact of human values on our choices depends on their nature. Self-Transcendence values motivate us to act for the benefit of others and care for the environment. Self-Enhancement values motivate us to act for our...
Neural evidence of motivational conflict between social values
Motivational interdependence is an organizing principle in Schwartz’s circumplex model of social values, which has received abundant cross-cultural support. We used fMRI to test whether motivational relations between social...
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