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Results: 350
Derivation of nociceptive sensory neurons from hiPSCs with early patterning and temporally controlled NEUROG2 overexpression.
William Plumbly, Nikolaos Patikas, Sarah F Field, Stefanie Foskolou, Emmanouil Metzakopian
Jan 04, 2023
Despite development of protocols to differentiate human pluripotent stem cells (hPSCs), those used to produce sensory neurons remain difficult to replicate and result in heterogenous populations. There is a growing clinical...
Single-Cell Transcriptomics of Parkinson's Disease Human In Vitro Models Reveals Dopamine Neuron-Specific Stress Responses.
Hugo JR Fernandes, Nikolaos Patikas, Stefanie Foskolou, Sarah F Field, Jong-Eun Park, Meg L Byrne, Andrew R Bassett, Emmanouil Metzakopian
Sep 25, 2020
cholesterol biosynthesis Dopamine neurons ER stress Felodipine Human iPSC Oxidative Stress PD GWAS Parkinson's Disease SNCA-A53T Single-cell transcriptomics Cell Differentiation Cell Respiration Cholesterol Chromatin Assembly and Disassembly Dopaminergic Neurons Down-Regulation Endoplasmic reticulum stress Gene Expression Profiling Genome-Wide Association Study Glycolysis Humans Induced Pluripotent Stem Cells Models Biological Oxidative Phosphorylation Oxidative Stress Parkinson Disease Proteasome Endopeptidase Complex Regression Analysis Signal Transduction Single-Cell Analysis Stress Physiological Synapses Transcriptome Ubiquitin Up-Regulation
Automatic Mapping of Physical Urban Problems Using Remotely Sensed Imagery
Nikolaos Lempesis
Jan 01, 2023
While big cities are expected to exercise cost-effective, evidence-based planning, many are under reactive management, facing simultaneous problems and limited resources. This project develops a proof-of-concept workflow for the...
Published by: IGI Global Scientific Publishing
CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death.
A Framework to Identify Influences of Environmental Legislation on Corporate Green Intellectual Capital, Innovation, and Environmental Performance
The aim of this paper is to examine the Porter hypothesis which defines that environmental regulations, under certain circumstances, could have positive effects on corporate environmental and economic performance. The majority...
Policy & Reform Business and Management Business Ethics and Law Government and Law Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
A Framework to Identify Influences of Environmental Legislation on Corporate Green Intellectual Capital, Innovation, and Environmental Performance
The aim of this paper is to examine the Porter hypothesis which defines that environmental regulations, under certain circumstances, could have positive effects on corporate environmental and economic performance. The majority...
Published by: IGI Global Scientific Publishing
Top quark production at the Tevatron at NNLO.
We present results for top quark production at the Tevatron including next-to-nextto-
leading order (NNLO) soft-gluon corrections. We show the stability of the cross section
with respect to kinematics choice and scale when the...
Published by: HEP, Cavendish Laboratory, University of Cambridge
Pension scheme redesign and wealth redistribution between the members and sponsor
The redesign of defined benefit pension schemes usually results in a substantial redistribution of wealth between age cohorts of members, pensioners, and the sponsor. This is the first study to quantify the redistributive...
Should Investors Include Bitcoin in Their Portfolios? A Portfolio Theory Approach
Many papers in recent years have examined the benefits of adding alternative assets to traditional portfolios containing stocks and bonds. Bitcoin has emerged as a new alternative investment for investors which has attracted...
Charged Higgs production with a top quark at the LHC.
Nikolaos Kidonakis
Feb 08, 2010
I discuss charged Higgs production via the process bg ! tH− at the LHC. I
show that the cross section is dominated by soft-gluon corrections and I provide
results for its dependence on the charged Higgs mass and on the scale...
Published by: HEP, Cavendish Laboratory, University of Cambridge
Taxation, Pension Schemes and Stakeholder Wealth
Although tax relief on pensions is a controversial area of government expenditure, this is the first study of the tax effects for a real world defined benefit pension scheme. First, we estimate the tax and national insurance...
Forecasts combinations for intermittent demand
Intermittent demand is characterised by infrequent demand arrivals, where many periods have zero demand, coupled with varied demand sizes. The dual source of variation renders forecasting for intermittent demand a very...
Portfolio management with cryptocurrencies:
This paper contributes to the literature on cryptocurrencies, portfolio management and estimation risk by comparing the performance of naïve diversification, Markowitz diversification and the advanced Black-Litterman model with...
Doc2KG
Nick Bassiliades, Nikolaos Stylianou, Danai Vlachava, Ioannis Konstantinidis, Vassilios Peristeras
Jan 01, 2022
Document Management Systems (DMS) are used for decades to store large amounts of information in textual form. Their technology paradigm is based on storing vast quantities of textual information enriched with metadata to support...
Published by: IGI Global Scientific Publishing
Nominal rigidities equilibria in a non-Ricardian economy
Nikolaos Kokonas
Dec 01, 2016
I consider a cash-in-advance economy with nominal price rigidities. Nominal interest rates are the cost of liquidity and fiscal policy sets nominal transfers that affect the distribution of wealth. Under a fiscal policy...
Taxation, Pension Schemes and Stakeholder Wealth
Although tax relief on pensions is a controversial area of government expenditure, this is the first study of the tax effects for a real world defined benefit pension scheme. First, we estimate the tax and national insurance...
Next-to-next-to-leading order soft and virtual corrections for QCD, Higgs and SUSY processes.
Nikolaos Kidonakis
Feb 08, 2010
I review recent advances in the calculation of higher-order soft-gluon corrections for
a variety of QCD, Higgs, and SUSY processes in hadron colliders. A unified approach
and master formulas for next-to-next-to-leading order...
Published by: HEP, Cavendish Laboratory, University of Cambridge
Nominal rigidities equilibria in a non-Ricardian economy
Nikolaos Kokonas
Dec 01, 2016
I consider a cash-in-advance economy with nominal price rigidities. Nominal interest rates are the cost of liquidity and fiscal policy sets nominal transfers that affect the distribution of wealth. Under a fiscal policy...
Public acceptability of population-level interventions to reduce alcohol consumption
Public acceptability influences policy action, but the most acceptable policies are not always the most effective. This discrete choice experiment provides a novel investigation of the acceptability of different interventions to...
Two loop and N loop eikonal vertex corrections.
Nikolaos Kidonakis
Feb 15, 2010
I present calculations of two-loop vertex corrections with massive and
massless partons in the eikonal approximation. I show that the n-loop
result for the UV poles can be given in terms of the one-loop calculation.
Published by: HEP, Cavendish Laboratory, University of Cambridge
The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons.
Marianna Tolve, Ayse Ulusoy, Nikolaos Patikas, K Ushna S Islam, Gabriela O Bodea, Ece Öztürk, Bianca Broske, Astrid Mentani, Antonia Wagener, Karen MJ van Loo, Stefan Britsch, Pengtao Liu, Walid T Khaled, Emmanouil Metzakopian, Stephan L Baader, Donato A Di Monte, Sandra Blaess
Sep 16, 2021
Midbrain dopaminergic (mDA) neurons are diverse in their projection targets, effect on behavior, and susceptibility to neurodegeneration. Little is known about the molecular mechanisms establishing this diversity during...
ALPHA-SYNUCLEIN Behavior circuits development Dopaminergic Neurons iPSCs MOUSE neurodegeneration neuronal diversity Transcription factor Animals Behavior Animal Brain Dopamine Dopaminergic Neurons Humans Induced Pluripotent Stem Cells Male Mice Mice Knockout Repressor Proteins Substantia Nigra Transcriptome Ventral Tegmental Area ALPHA-SYNUCLEIN
Harmful Diversification
Alternative assets have become as important as equities and fixed income in the
portfolios of major investors, and so their diversification properties are also
important. However, adding five alternative assets (real...
portfolios of major investors, and so their diversification properties are also
important. However, adding five alternative assets (real...
Optimal vs Naïve Diversification in Cryptocurrencies
This paper contributes to the literature on cryptocurrencies by examining the performance of naïve (1/N) and optimal (Markowitz) diversification in a portfolio of four popular cryptocurrencies. We employ weekly data with weekly...
When marketing and manufacturing departments integrate
Although the effect of marketing-manufacturing integration on new product development (NPD) performance has been extensively studied, the question about how this integration is affected during the different stages of NPD remains...
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