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Results: 32
Carrier fluid temperature data in vertical ground heat exchangers with a varying pipe separation.
The dataset in this article is related to shallow geothermal energy systems, which efficiently provide renewable heating and cooling to buildings, and specifically to the performance of the vertical ground heat exchangers (GHE)...
Understanding student behavior in a flipped classroom
The flipped classroom has been increasingly employed as a pedagogical strategy in the higher education classroom. This approach commonly involves pre-class learning activities that are delivered online through learning...
Scientists advise, ministers decide?
COVID-19 has been a transformational crisis, uprooting everyday lives and causing some of the most significant health, social, and economic challenges in recent memory. Similarly, coronavirus has also forced significant...
Ground-source heat pump systems
Ground-source heat pump systems are renewable and highly efficient HVAC systems that utilise the ground to exchange heat via ground heat exchangers (GHEs). This study developed a detailed 3D finite element model for...
Scientists advise, ministers decide?
COVID-19 has been a transformational crisis, uprooting everyday lives and causing some of the most significant health, social, and economic challenges in recent memory. Similarly, coronavirus has also forced significant...
Indigenous youth and international conservation law
Abstract: The principle of intergenerational equity plays a fundamental role in international conservation law. In this article, we analyse in how far the principle is applied with regard to indigenous youth. By scrutinizing the...
Impact of simplifications on numerical modelling of the shallow subsurface at city-scale and implications for shallow geothermal potential.
Anthropogenic infrastructures in the shallow subsurface, such as heated basements, tunnels or shallow geothermal systems, are known to increase ground temperatures, particularly in urban areas. Numerical modelling helps inform...
Prolonged depletion of antioxidant capacity after ultraendurance exercise
The purpose of this study was to examine the short- and long-term (up to 1 month) effects of an ultraendurance running event on redox homeostasis. Markers of oxidative stress and antioxidant capacity in peripheral blood were...
Prolonged depletion of antioxidant capacity after ultraendurance exercise
The purpose of this study was to examine the short- and long-term (up to 1 month) effects of an ultraendurance running event on redox homeostasis. Markers of oxidative stress and antioxidant capacity in peripheral blood were...
The effect of lamotrigine and other antiepileptic drugs on respiratory rhythm generation in the pre-Bötzinger complex.
OBJECTIVE: Lamotrigine and other sodium-channel blocking agents are among the most commonly used antiepileptic drugs (AEDs). Because other sodium channel blockers, such as riluzole, can severely alter respiratory rhythm...
Visualizing genome and systems biology
Georgios A Pavlopoulos, Dimitris Malliarakis, Nikolas Papanikolaou, Theodosis Theodosiou, Anton J Enright, Ioannis Iliopoulos
Jan 22, 2018
"Α picture is worth a thousand words." This widely used adage sums up in a few words the notion that a successful visual representation of a concept should enable easy and rapid absorption of large amounts of information....
Synchronised oscillations in growing cell populations are explained by demographic noise
Kit Yates, Enrico Gavagnin, Tim Rogers, Matthew Simpson, Nikolas Haass, Sean Vittadello, Gency Gunasingh
Feb 20, 2021
Understanding synchrony in growing populations is important for applications as diverse as epidemiology and cancer treatment. Recent experiments employing fluorescent reporters in melanoma cell lines have uncovered growing...
Synchronised oscillations in growing cell populations are explained by demographic noise
Kit Yates, Enrico Gavagnin, Tim Rogers, Matthew Simpson, Nikolas Haass, Sean Vittadello, Gency Gunasingh
Feb 20, 2021
Understanding synchrony in growing populations is important for applications as diverse as epidemiology and cancer treatment. Recent experiments employing fluorescent reporters in melanoma cell lines have uncovered growing...
Information flow, cell types and stereotypy in a full olfactory connectome.
Philipp Schlegel, Alexander Shakeel Bates, Tomke Stürner, Sridhar R Jagannathan, Nikolas Drummond, Joseph Hsu, Laia Serratosa Capdevila, Alexandre Javier, Elizabeth C Marin, Asa Barth-Maron, Imaan FM Tamimi, Feng Li, Gerald M Rubin, Stephen M Plaza, Marta Costa, Gregory SXE Jefferis
Jul 02, 2021
The hemibrain connectome provides large-scale connectivity and morphology information for the majority of the central brain of Drosophila melanogaster. Using this data set, we provide a complete description of the Drosophila...
Genetic Basis of Inherited Retinal Disease in a Molecularly Characterized Cohort of More Than 3000 Families from the United Kingdom.
Nikolas Pontikos, Gavin Arno, Neringa Jurkute, Elena Schiff, Rola Ba-Abbad, Samantha Malka, Ainoa Gimenez, Michalis Georgiou, Genevieve Wright, Monica Armengol, Hannah Knight, Menachem Katz, Mariya Moosajee, Patrick Yu-Wai-Man, Anthony T Moore, Michel Michaelides, Andrew R Webster, Omar A Mahroo
Jan 04, 2021
PURPOSE: In a large cohort of molecularly characterized inherited retinal disease (IRD) families, we investigated proportions with disease attributable to causative variants in each gene. DESIGN: Retrospective study of...
Information flow, cell types and stereotypy in a full olfactory connectome
Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping.
Chris Wallace, Antony J Cutler, Nikolas Pontikos, Marcin L Pekalski, Oliver S Burren, Jason D Cooper, Arcadio Rubio García, Ricardo C Ferreira, Hui Guo, Neil M Walker, Deborah J Smyth, Stephen S Rich, Suna Onengut-Gumuscu, Stephen J Sawcer, Maria Ban, Sylvia Richardson, John A Todd, Linda S Wicker
Jun 19, 2015
Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior.
Yang He, Bas Brouwers, Hesong Liu, Hailan Liu, Katherine Lawler, Edson Mendes de Oliveira, Dong-Kee Lee, Yongjie Yang, Aaron R Cox, Julia M Keogh, Elana Henning, Rebecca Bounds, Aliki Perdikari, Vikram Ayinampudi, Chunmei Wang, Meng Yu, Longlong Tu, Nan Zhang, Na Yin, Junying Han, Nikolas A Scarcelli, Zili Yan, Kristine M Conde, Camille Potts, Jonathan C Bean, Mengjie Wang, Sean M Hartig, Lan Liao, Jianming Xu, Inês Barroso, Jacek Mokrosinski, Yong Xu, I Sadaf Farooqi
Jan 04, 2023
Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor (5-HT2CR) in weight regulation and behavior. Using exome sequencing of...
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization.
Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D Kouyos, John A Robinson, Huldrych F Günthard, Andreas Plückthun, Alexandra Trkola
Jan 07, 2022
The V3 loop of the HIV-1 envelope (Env) protein elicits a vigorous, but largely non-neutralizing antibody response directed to the V3-crown, whereas rare broadly neutralizing antibodies (bnAbs) target the V3-base. Challenging...
Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior
Yang He, Bas Brouwers, Hesong Liu, Hailan Liu, Katherine Lawler, Edson Mendes de Oliveira, Dong-Kee Lee, Yongjie Yang, Aaron R. Cox, Julia M. Keogh, Elana Henning, Rebecca Bounds, Aliki Perdikari, Vikram Ayinampudi, Chunmei Wang, Meng Yu, Longlong Tu, Nan Zhang, Na Yin, Junying Han, Nikolas A. Scarcelli, Zili Yan, Kristine M. Conde, Camille Potts, Jonathan C. Bean, Mengjie Wang, Sean M. Hartig, Lan Liao, Jianming Xu, Inês Barroso, Jacek Mokrosinski, Yong Xu, I. Sadaf Farooqi
Jan 19, 2023
Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor (5-HT2CR) in weight regulation and behavior. Using exome sequencing of...
Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior.
Yang He, Bas Brouwers, Hesong Liu, Hailan Liu, Katherine Lawler, Edson Mendes de Oliveira, Dong-Kee Lee, Yongjie Yang, Aaron R Cox, Julia M Keogh, Elana Henning, Rebecca Bounds, Aliki Perdikari, Vikram Ayinampudi, Chunmei Wang, Meng Yu, Longlong Tu, Nan Zhang, Na Yin, Junying Han, Nikolas A Scarcelli, Zili Yan, Kristine M Conde, Camille Potts, Jonathan C Bean, Mengjie Wang, Sean M Hartig, Lan Liao, Jianming Xu, Inês Barroso, Jacek Mokrosinski, Yong Xu, I Sadaf Farooqi
Jan 22, 2023
Enhanced Efficacy of Aurora Kinase Inhibitors in G2/M Checkpoint Deficient TP53 Mutant Uterine Carcinomas Is Linked to the Summation of LKB1–AKT–p53 Interactions
Katherine N. Lynch, Joyce F. Liu, Nikolas Kesten, Kin-Hoe Chow, Aniket Shetty, Ruiyang He, Mosammat Faria Afreen, Liping Yuan, Ursula A. Matulonis, Whitfield B. Growdon, Michael G. Muto, Neil S. Horowitz, Colleen M. Feltmate, Michael J. Worley, Ross S. Berkowitz, Christopher P. Crum, Bo R. Rueda, Sarah J. Hill
May 04, 2021
Uterine carcinoma (UC) is the most common gynecologic malignancy in the United States. TP53 mutant UCs cause a disproportionate number of deaths due to limited therapies for these tumors and the lack of mechanistic understanding...
Enhanced Efficacy of Aurora Kinase Inhibitors in G2/M Checkpoint Deficient TP53 Mutant Uterine Carcinomas Is Linked to the Summation of LKB1-AKT-p53 Interactions.
Katherine N Lynch, Joyce F Liu, Nikolas Kesten, Kin-Hoe Chow, Aniket Shetty, Ruiyang He, Mosammat Faria Afreen, Liping Yuan, Ursula A Matulonis, Whitfield B Growdon, Michael G Muto, Neil S Horowitz, Colleen M Feltmate, Michael J Worley, Ross S Berkowitz, Christopher P Crum, Bo R Rueda, Sarah J Hill
Jul 07, 2021
Uterine carcinoma (UC) is the most common gynecologic malignancy in the United States. TP53 mutant UCs cause a disproportionate number of deaths due to limited therapies for these tumors and the lack of mechanistic understanding...
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization.
Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D Kouyos, John A Robinson, Huldrych F Günthard, Andreas Plückthun, Alexandra Trkola
Nov 22, 2021
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