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Results: 267
Light-responsive self-assembly of a cationic azobenzene surfactant at high concentration.
Camille Blayo, Elaine A Kelly, Judith E Houston, Nikul Khunti, Nathan P Cowieson, Rachel C Evans
Nov 03, 2020
The formation of high-concentration mesophases by a cationic azobenzene photosurfactant is described for the first time. Using a combination of polarised optical microscopy and small-angle X-ray scattering, optically...
The spatial biology of transcription and translation in rapidly growing Escherichia coli.
Single-molecule fluorescence provides high resolution spatial distributions of ribosomes and RNA polymerase (RNAP) in live, rapidly growing Escherichia coli. Ribosomes are more strongly segregated from the nucleoids (chromosomal...
Challenges of analysing stochastic gene expression in bacteria using single-cell time-lapse experiments.
Stochastic gene expression causes phenotypic heterogeneity in a population of genetically identical bacterial cells. Such non-genetic heterogeneity can have important consequences for the population fitness, and therefore cells...
Synthetic Micrographs of Bacteria (SyMBac) allows accurate segmentation of bacterial cells using deep neural networks.
BACKGROUND: Deep-learning-based image segmentation models are required for accurate processing of high-throughput timelapse imaging data of bacterial cells. However, the performance of any such model strictly depends on the...
microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells.
Reema Roshan, Ashwani Choudhary, Aksheev Bhambri, Bhawani Bakshi, Tanay Ghosh, Beena Pillai
Aug 04, 2017
BACKGROUND: Polyglutamine diseases constitute a class of neurodegenerative disorders associated with expansion of the cytosine-adenine-guanine (CAG) triplet, in protein coding genes. Expansion of a polyglutamine tract in the...
Bacterial persisters are a stochastically formed subpopulation of low-energy cells.
Sylvie Manuse, Yue Shan, Silvia J Canas-Duarte, Somenath Bakshi, Wei-Sheng Sun, Hirotada Mori, Johan Paulsson, Kim Lewis
Jun 14, 2021
Persisters represent a small subpopulation of non- or slow-growing bacterial cells that are tolerant to killing by antibiotics. Despite their prominent role in the recalcitrance of chronic infections to antibiotic therapy, the...
Quantification of very low-abundant proteins in bacteria using the HaloTag and epi-fluorescence microscopy.
Alessia Lepore, Hannah Taylor, Dirk Landgraf, Burak Okumus, Sebastián Jaramillo-Riveri, Lorna McLaren, Somenath Bakshi, Johan Paulsson, M El Karoui
Aug 19, 2019
Cell biology is increasingly dependent on quantitative methods resulting in the need for microscopic labelling technologies that are highly sensitive and specific. Whilst the use of fluorescent proteins has led to major...
Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells.
Burak Okumus, Dirk Landgraf, Ghee Chuan Lai, Somenath Bakshi, Juan Carlos Arias-Castro, Sadik Yildiz, Dann Huh, Raul Fernandez-Lopez, Celeste N Peterson, Erdal Toprak, Meriem El Karoui, Johan Paulsson
Jan 31, 2020
Many key regulatory proteins in bacteria are present in too low numbers to be detected with conventional methods, which poses a particular challenge for single-cell analyses because such proteins can contribute greatly to...
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
Qin Qin Huang, Howard H. F. Tang, Shu Mei Teo, Danny Mok, Scott C. Ritchie, Artika P. Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J. Holt, Chiea Chuen Khor, Peter D. Sly, Patrick G. Holt, Kathryn E. Holt, Michael Inouye
Jul 28, 2020
Abstract: Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting...
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk.
Qin Qin Huang, Howard HF Tang, Shu Mei Teo, Danny Mok, Scott C Ritchie, Artika P Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J Holt, Chiea Chuen Khor, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
Aug 25, 2020
Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting myeloid...
Autoimmune Diseases Butyrophilins CD4-Positive T-Lymphocytes Cathepsin H Child Child Development Child Preschool Datasets as Topic Fetal Blood Gene Expression Profiling Gene Expression Regulation Developmental Gene Regulatory Networks Genetic Predisposition to Disease Genome-Wide Association Study HLA-C Antigens Humans Hypersensitivity Infant Infant Newborn Mendelian Randomization Analysis Myeloid Cells Oligonucleotide Array Sequence Analysis Polymorphism Single Nucleotide Prospective Studies Quantitative Trait Loci
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
Qin Qin Huang, Howard H. F. Tang, Shu Mei Teo, Danny Mok, Scott C. Ritchie, Artika P. Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J. Holt, Chiea Chuen Khor, Peter D. Sly, Patrick G. Holt, Kathryn E. Holt, Michael Inouye
Jul 28, 2021
Abstract: Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting...
Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator.
David T Riglar, David L Richmond, Laurent Potvin-Trottier, Andrew A Verdegaal, Alexander D Naydich, Somenath Bakshi, Emanuele Leoncini, Lorena G Lyon, Johan Paulsson, Pamela A Silver
Dec 11, 2019
Synthetic gene oscillators have the potential to control timed functions and periodic gene expression in engineered cells. Such oscillators have been refined in bacteria in vitro, however, these systems have lacked the...
Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator
David T. Riglar, David L. Richmond, Laurent Potvin-Trottier, Andrew A. Verdegaal, Alexander D. Naydich, Somenath Bakshi, Emanuele Leoncini, Lorena G. Lyon, Johan Paulsson, Pamela A. Silver
Apr 27, 2021
Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator
David T. Riglar, David L. Richmond, Laurent Potvin-Trottier, Andrew A. Verdegaal, Alexander D. Naydich, Somenath Bakshi, Emanuele Leoncini, Lorena G. Lyon, Johan Paulsson, Pamela A. Silver
Oct 10, 2020
Abstract: Synthetic gene oscillators have the potential to control timed functions and periodic gene expression in engineered cells. Such oscillators have been refined in bacteria in vitro, however, these systems have lacked the...
Acute otitis externa
Matthew E Smith, John C Hardman, Nishchay Mehta, Gareth H Jones, Rishi Mandavia, Caroline Anderson, Maha Khan, Aula Abdelaziz, Bakir Al-Dulaimy, Nikul Amin, Rajesh Anmolsingh, Bilal Anwar, Manohar Bance, Katherine Belfield, Mahmood Bhutta, Ruaridh Buchanan, Deepak Chandrasekharan, Michael Chu, Srikanth Chundu, Katherine Conroy, Gemma Crundwell, Mat Daniel, Jessica Daniels, Sujata De, Sian Dobbs, Jayesh Doshi, Matthew Farr, Tanjinah Ferdous, Eleni Fragkouli, Simon Freeman, Samit Ghosh, Emma Gosnell, S Alam Hannan, Elliot Heward, Faisal Javed, Deepa John, Helen Nicholls, Anand V Kasbekar, Haroon Khan, Hammad Khan, Sadie Khwaja, Bhik Kotecha, Madhankumar Krishnan, Nirmal Kumar, Tamara Lamb, Hannah Lancer, Joseph G Manjaly, Marcos Martinez Del Pero, Fiona McClenaghan, Kristijonas Milinis, Nina Mistry, Hassan Mohammed, Elizabeth Morris, Stephen Morris-Jones, Jessica Padee, Surojit Pal, Sanjay Patel, Agamemnon Pericleous, Asad Qayyum, Maral Rouhani, Haroon Saeed, Mirusanthan Santhiyapillai, Kay Seymour, Sunil Sharma, Richard Siau, Arvind Singh, Emma Stapleton, Kate Stephenson, Gill Stynes, Bharathi Subramanian, Neil Summerfield, Chloe Swords, Aaron Trinidade, Antonia Tse, Emmanuel Twumasi, Harmony Ubhi, Samit Unadkat, Ananth Vijendren, Joe Wasson, Glen Watson, Glennis Williams, Janet Wilson, Alexander Yao, Ahmed Youssef, Simon K W Lloyd, James R Tysome
Jun 14, 2021
Objective
Evidence for the management of acute otitis externa (AOE) is limited, with unclear diagnostic criteria and variably reported outcome measures that may not reflect key stakeholder priorities. We aimed to develop...
Published by: PLOS ONE
Acute otitis externa
Matthew E Smith, John C Hardman, Nishchay Mehta, Gareth H Jones, Rishi Mandavia, Caroline Anderson, Maha Khan, Aula Abdelaziz, Bakir Al-Dulaimy, Nikul Amin, Rajesh Anmolsingh, Bilal Anwar, Manohar Bance, Katherine Belfield, Mahmood Bhutta, Ruaridh Buchanan, Deepak Chandrasekharan, Michael Chu, Srikanth Chundu, Katherine Conroy, Gemma Crundwell, Mat Daniel, Jessica Daniels, Sujata De, Sian Dobbs, Jayesh Doshi, Matthew Farr, Tanjinah Ferdous, Eleni Fragkouli, Simon Freeman, Samit Ghosh, Emma Gosnell, S Alam Hannan, Elliot Heward, Faisal Javed, Deepa John, Helen Nicholls, Anand V Kasbekar, Haroon Khan, Hammad Khan, Sadie Khwaja, Bhik Kotecha, Madhankumar Krishnan, Nirmal Kumar, Tamara Lamb, Hannah Lancer, Joseph G Manjaly, Marcos Martinez Del Pero, Fiona McClenaghan, Kristijonas Milinis, Nina Mistry, Hassan Mohammed, Elizabeth Morris, Stephen Morris-Jones, Jessica Padee, Surojit Pal, Sanjay Patel, Agamemnon Pericleous, Asad Qayyum, Maral Rouhani, Haroon Saeed, Mirusanthan Santhiyapillai, Kay Seymour, Sunil Sharma, Richard Siau, Arvind Singh, Emma Stapleton, Kate Stephenson, Gill Stynes, Bharathi Subramanian, Neil Summerfield, Chloe Swords, Aaron Trinidade, Antonia Tse, Emmanuel Twumasi, Harmony Ubhi, Samit Unadkat, Ananth Vijendren, Joe Wasson, Glen Watson, Glennis Williams, Janet Wilson, Alexander Yao, Ahmed Youssef, Simon KW Lloyd, James R Tysome, INTEGRATE (The UK ENT Trainee Research Network)
Jul 19, 2021
OBJECTIVE: Evidence for the management of acute otitis externa (AOE) is limited, with unclear diagnostic criteria and variably reported outcome measures that may not reflect key stakeholder priorities. We aimed to develop 1) a...
Acute otitis externa
Matthew E. Smith, John C. Hardman, Nishchay Mehta, Gareth H. Jones, Rishi Mandavia, Caroline Anderson, Maha Khan, Aula Abdelaziz, Bakir Al-Dulaimy, Nikul Amin, Rajesh Anmolsingh, Bilal Anwar, Manohar Bance, Katherine Belfield, Mahmood Bhutta, Ruaridh Buchanan, Deepak Chandrasekharan, Michael Chu, Srikanth Chundu, Katherine Conroy, Gemma Crundwell, Mat Daniel, Jessica Daniels, Sujata De, Sian Dobbs, Jayesh Doshi, Matthew Farr, Tanjinah Ferdous, Eleni Fragkouli, Simon Freeman, Samit Ghosh, Emma Gosnell, S. Alam Hannan, Elliot Heward, Faisal Javed, Deepa John, Helen Nicholls, Anand V. Kasbekar, Haroon Khan, Hammad Khan, Sadie Khwaja, Bhik Kotecha, Madhankumar Krishnan, Nirmal Kumar, Tamara Lamb, Hannah Lancer, Joseph G. Manjaly, Marcos Martinez Del Pero, Fiona McClenaghan, Kristijonas Milinis, Nina Mistry, Hassan Mohammed, Elizabeth Morris, Stephen Morris-Jones, Jessica Padee, Surojit Pal, Sanjay Patel, Agamemnon Pericleous, Asad Qayyum, Maral Rouhani, Haroon Saeed, Mirusanthan Santhiyapillai, Kay Seymour, Sunil Sharma, Richard Siau, Arvind Singh, Emma Stapleton, Kate Stephenson, Gill Stynes, Bharathi Subramanian, Neil Summerfield, Chloe Swords, Aaron Trinidade, Antonia Tse, Emmanuel Twumasi, Harmony Ubhi, Samit Unadkat, Ananth Vijendren, Joe Wasson, Glen Watson, Glennis Williams, Janet Wilson, Alexander Yao, Ahmed Youssef, Simon K. W. Lloyd, James R. Tysome, on behalf of INTEGRATE (The UK ENT Trainee Research Network)
May 20, 2021
Objective: Evidence for the management of acute otitis externa (AOE) is limited, with unclear diagnostic criteria and variably reported outcome measures that may not reflect key stakeholder priorities. We aimed to develop 1) a...
Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH
Na Zhu, Emilia M. Swietlik, Carrie L. Welch, Michael W. Pauciulo, Jacob J. Hagen, Xueya Zhou, Yicheng Guo, Johannes Karten, Divya Pandya, Tobias Tilly, Katie A. Lutz, Jennifer M. Martin, Carmen M. Treacy, Erika B. Rosenzweig, Usha Krishnan, Anna W. Coleman, Claudia Gonzaga-Jauregui, Allan Lawrie, Richard C. Trembath, Martin R. Wilkins, Nicholas W. Morrell, Yufeng Shen, Stefan Gräf, William C. Nichols, Wendy K. Chung, Russel Hirsch, R. James White, Marc Simon, David Badesch, Erika Rosenzweig, Charles Burger, Murali Chakinala, Thenappan Thenappan, Greg Elliott, Robert Simms, Harrison Farber, Robert Frantz, Jean Elwing, Nicholas Hill, Dunbar Ivy, James Klinger, Steven Nathan, Ronald Oudiz, Ivan Robbins, Robert Schilz, Terry Fortin, Jeffrey Wilt, Delphine Yung, Eric Austin, Ferhaan Ahmad, Nitin Bhatt, Tim Lahm, Adaani Frost, Zeenat Safdar, Zia Rehman, Robert Walter, Fernando Torres, Sahil Bakshi, Stephen Archer, Rahul Argula, Christopher Barnett, Raymond Benza, Ankit Desai, Veeranna Maddipati, Harm J. Bogaard, Colin Church, Gerry Coghlin, Robin Condliffe, Mélanie Eyries, Henning Gall, Stefano Ghio, Barbara Girerd, Simon Holden, Luke Howard, Marc Humbert, David G. Kiely, Gabor Kovacs, Jim Lordan, Rajiv D. Machado, Robert V. MacKenzie Ross, Colm McCabe, Shahin Moledina, David Montani, Horst Olschewski, Christopher J. Penkett, Joanna Pepke-Zaba, Laura Price, Christopher J. Rhodes, Werner Seeger, Florent Soubrier, Laura Southgate, Jay Suntharalingam, Andrew J. Swift, Mark R. Toshner, Anton Vonk Noordegraaf, John Wharton, Jim Wild, Stephen John Wort
Jun 04, 2021
Abstract: Background: Pulmonary arterial hypertension (PAH) is a lethal vasculopathy characterized by pathogenic remodeling of pulmonary arterioles leading to increased pulmonary pressures, right ventricular hypertrophy, and...
Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH
Na Zhu, Emilia M. Swietlik, Carrie L. Welch, Michael W. Pauciulo, Jacob J. Hagen, Xueya Zhou, Yicheng Guo, Johannes Karten, Divya Pandya, Tobias Tilly, Katie A. Lutz, Jennifer M. Martin, Carmen M. Treacy, Erika B. Rosenzweig, Usha Krishnan, Anna W. Coleman, Claudia Gonzaga-Juaregui, Allan Lawrie, Richard C. Trembath, Martin R. Wilkins, Nicholas W. Morrell, Yufeng Shen, Stefan Gräf, William C. Nichols, Wendy K. Chung, Russel Hirsch, R. James White, Marc Simon, David Badesch, Erika Rosenzweig, Charles Burger, Murali Chakinala, Thenappan Thenappan, Greg Elliott, Robert Simms, Harrison Farber, Robert Frantz, Jean Elwing, Nicholas Hill, Dunbar Ivy, James Klinger, Steven Nathan, Ronald Oudiz, Ivan Robbins, Robert Schilz, Terry Fortin, Jeffrey Wilt, Delphine Yung, Eric Austin, Ferhaan Ahmad, Nitin Bhatt, Tim Lahm, Adaani Frost, Zeenat Safdar, Zia Rehman, Robert Walter, Fernando Torres, Sahil Bakshi, Stephen Archer, Rahul Argula, Christopher Barnett, Raymond Benza, Ankit Desai, Veeranna Maddipati, Harm J. Bogaard, Colin Church, Gerry Coghlin, Robin Condliffe, Mélanie Eyries, Henning Gall, Stefano Ghio, Barbara Girerd, Simon Holden, Luke Howard, Marc Humbert, David G. Kiely, Gabor Kovacs, Jim Lordan, Rajiv D. Machado, Robert V. MacKenzie Ross, Colm McCabe, Shahin Moledina, David Montani, Horst Olschewski, Christopher J. Penkett, Joanna Pepke-Zaba, Laura Price, Christopher J. Rhodes, Werner Seeger, Florent Soubrier, Laura Southgate, Jay Suntharalingam, Andrew J. Swift, Mark R. Toshner, Anton Vonk Noordegraaf, John Wharton, Jim Wild, Stephen John Wort
May 10, 2021
Abstract: Background: Pulmonary arterial hypertension (PAH) is a lethal vasculopathy characterized by pathogenic remodeling of pulmonary arterioles leading to increased pulmonary pressures, right ventricular hypertrophy, and...
Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH
Na Zhu, Emilia M. Swietlik, Carrie L. Welch, Michael W. Pauciulo, Jacob J. Hagen, Xueya Zhou, Yicheng Guo, Johannes Karten, Divya Pandya, Tobias Tilly, Katie A. Lutz, Jennifer M. Martin, Carmen M. Treacy, Erika B. Rosenzweig, Usha Krishnan, Anna W. Coleman, Claudia Gonzaga-Jauregui, Allan Lawrie, Richard C. Trembath, Martin R. Wilkins, Nicholas W. Morrell, Yufeng Shen, Stefan Gräf, William C. Nichols, Wendy K. Chung, Russel Hirsch, R. James White, Marc Simon, David Badesch, Erika Rosenzweig, Charles Burger, Murali Chakinala, Thenappan Thenappan, Greg Elliott, Robert Simms, Harrison Farber, Robert Frantz, Jean Elwing, Nicholas Hill, Dunbar Ivy, James Klinger, Steven Nathan, Ronald Oudiz, Ivan Robbins, Robert Schilz, Terry Fortin, Jeffrey Wilt, Delphine Yung, Eric Austin, Ferhaan Ahmad, Nitin Bhatt, Tim Lahm, Adaani Frost, Zeenat Safdar, Zia Rehman, Robert Walter, Fernando Torres, Sahil Bakshi, Stephen Archer, Rahul Argula, Christopher Barnett, Raymond Benza, Ankit Desai, Veeranna Maddipati, Harm J. Bogaard, Colin Church, Gerry Coghlin, Robin Condliffe, Mélanie Eyries, Henning Gall, Stefano Ghio, Barbara Girerd, Simon Holden, Luke Howard, Marc Humbert, David G. Kiely, Gabor Kovacs, Jim Lordan, Rajiv D. Machado, Robert V. MacKenzie Ross, Colm McCabe, Shahin Moledina, David Montani, Horst Olschewski, Christopher J. Penkett, Joanna Pepke-Zaba, Laura Price, Christopher J. Rhodes, Werner Seeger, Florent Soubrier, Laura Southgate, Jay Suntharalingam, Andrew J. Swift, Mark R. Toshner, Anton Vonk Noordegraaf, John Wharton, Jim Wild, Stephen John Wort
Jun 22, 2021
Abstract: Background: Pulmonary arterial hypertension (PAH) is a lethal vasculopathy characterized by pathogenic remodeling of pulmonary arterioles leading to increased pulmonary pressures, right ventricular hypertrophy, and...
Genetic determinants of risk in pulmonary arterial hypertension
Christopher J Rhodes, Ken Batai, Marta Bleda, Matthias Haimel, Laura Southgate, Marine Germain, Michael W Pauciulo, Charaka Hadinnapola, Jurjan Aman, Barbara Girerd, Amit Arora, Jo Knight, Ken B Hanscombe, Jason H Karnes, Marika Kaakinen, Henning Gall, Anna Ulrich, Lars Harbaum, Inês Cebola, Jorge Ferrer, Katie Lutz, Emilia M Swietlik, Ferhaan Ahmad, Philippe Amouyel, Stephen L Archer, Rahul Argula, Eric D Austin, David Badesch, Sahil Bakshi, Christopher Barnett, Raymond Benza, Nitin Bhatt, Harm J Bogaard, Charles D Burger, Murali Chakinala, Colin Church, John G Coghlan, Robin Condliffe, Paul A Corris, Cesare Danesino, Stéphanie Debette, C Gregory Elliott, Jean Elwing, Melanie Eyries, Terry Fortin, Andre Franke, Robert P Frantz, Adaani Frost, Joe GN Garcia, Stefano Ghio, Hossein-Ardeschir Ghofrani, J Simon R Gibbs, John Harley, Hua He, Nicholas S Hill, Russel Hirsch, Arjan C Houweling, Luke S Howard, Dunbar Ivy, David G Kiely, James Klinger, Gabor Kovacs, Tim Lahm, Matthias Laudes, Rajiv D Machado, Robert V MacKenzie Ross, Keith Marsolo, Lisa J Martin, Shahin Moledina, David Montani, Steven D Nathan, Michael Newnham, Andrea Olschewski, Horst Olschewski, Ronald J Oudiz, Willem H Ouwehand, Andrew J Peacock, Joanna Pepke-Zaba, Zia Rehman, Ivan Robbins, Dan M Roden, Erika B Rosenzweig, Ghulam Saydain, Laura Scelsi, Robert Schilz, Werner Seeger, Christian M Shaffer, Robert W Simms, Marc Simon, Olivier Sitbon, Jay Suntharalingam, Haiyang Tang, Alexander Y Tchourbanov, Thenappan Thenappan, Fernando Torres, Mark R Toshner, Carmen M Treacy, Anton Vonk Noordegraaf, Quinten Waisfisz, Anna K Walsworth, Robert E Walter, John Wharton, R James White, Jeffrey Wilt, Stephen J Wort, Delphine Yung, Allan Lawrie, Marc Humbert, Florent Soubrier, David-Alexandre Trégouët, Inga Prokopenko, Richard Kittles, Stefan Gräf, William C Nichols, Richard C Trembath, Ankit A Desai, Nicholas W Morrell, Martin R Wilkins, UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium
Jan 08, 2019
BACKGROUND: Rare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic variation to disease risk and natural history is poorly characterised. We tested for genome-wide association for...
Female Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Genotyping Techniques HLA-DP alpha-Chains HLA-DP beta-Chains Humans Male Middle Aged Polymorphism Single Nucleotide pulmonary arterial hypertension Risk Assessment SOXF Transcription Factors Signal Transduction Survival Analysis
Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
N Barban, R Jansen, R de Vlaming, A Vaez, JJ Mandemakers, FC Tropf, X Shen, JF Wilson, DI Chasman, IM Nolte, V Tragante, SW van der Laan, JRB Perry, A Kong, BIOS Consortium, TS Ahluwalia, E Albrecht, L Yerges-Armstrong, G Atzmon, K Auro, K Ayers, A Bakshi, D Ben-Avraham, K Berger, A Bergman, L Bertram, LF Bielak, G Bjornsdottir, MJ Bonder, L Broer, M Bui, C Barbieri, A Cavadino, JE Chavarro, C Turman, MP Concas, HJ Cordell, G Davies, P Eibich, N Eriksson, T Esko, J Eriksson, F Falahi, JF Felix, MA Fontana, L Franke, I Gandin, AJ Gaskins, C Gieger, EP Gunderson, X Guo, C Hayward, C He, E Hofer, H Huang, PK Joshi, S Kanoni, R Karlsson, S Kiechl, A Kifley, A Kluttig, P Kraft, V Lagou, C Lecoeur, J Lahti, R Li-Gao, PA Lind, T Liu, E Makalic, C Mamasoula, L Matteson, H Mbarek, PF McArdle, G McMahon, SFW Meddens, E Mihailov, M Miller, SA Missmer, C Monnereau, PJ van der Most, R Myhre, MA Nalls, T Nutile, IP Kalafati, E Porcu, I Prokopenko, KB Rajan, J Rich-Edwards, CA Rietveld, A Robino, LM Rose, R Rueedi, KA Ryan, Y Saba, D Schmidt, JA Smith, L Stolk, E Streeten, A Tönjes, G Thorleifsson, S Ulivi, J Wedenoja, J Wellmann, P Willeit, J Yao, L Yengo, JH Zhao, W Zhao, DV Zhernakova, N Amin, H Andrews, B Balkau, N Barzilai, S Bergmann, G Biino, H Bisgaard, K Bønnelykke, DI Boomsma, JE Buring, H Campbell, S Cappellani, M Ciullo, SR Cox, F Cucca, D Toniolo, G Davey-Smith, IJ Deary, G Dedoussis, P Deloukas, CM van Duijn, EJC de Geus, JG Eriksson, DA Evans, JD Faul, CF Sala, P Froguel, P Gasparini, G Girotto, H-J Grabe, KH Greiser, PJF Groenen, HG de Haan, J Haerting, TB Harris, AC Heath, K Heikkilä, A Hofman, G Homuth, EG Holliday, J Hopper, E Hyppönen, B Jacobsson, VWV Jaddoe, M Johannesson, A Jugessur, M Kähönen, E Kajantie, SLR Kardia, B Keavney, I Kolcic, P Koponen, P Kovacs, F Kronenberg, Z Kutalik, M La Bianca, G Lachance, WG Iacono, S Lai, T Lehtimäki, DC Liewald, Lifelines Cohort Study, CM Lindgren, Y Liu, R Luben, M Lucht, R Luoto, P Magnus, PKE Magnusson, NG Martin, M McGue, R McQuillan, SE Medland, C Meisinger, D Mellström, A Metspalu, M Traglia, L Milani, P Mitchell, GW Montgomery, D Mook-Kanamori, R de Mutsert, EA Nohr, C Ohlsson, J Olsen, KK Ong, L Paternoster, A Pattie, BWJH Penninx, M Perola, PA Peyser, M Pirastu, O Polasek, C Power, J Kaprio, LJ Raffel, K Räikkönen, O Raitakari, PM Ridker, SM Ring, K Roll, I Rudan, D Ruggiero, D Rujescu, V Salomaa, D Schlessinger, H Schmidt, R Schmidt, N Schupf, J Smit, R Sorice, TD Spector, JM Starr, D Stöckl, K Strauch, M Stumvoll, MA Swertz, U Thorsteinsdottir, AR Thurik, NJ Timpson, JY Tung, AG Uitterlinden, S Vaccargiu, J Viikari, V Vitart, H Völzke, P Vollenweider, D Vuckovic, J Waage, GG Wagner, JJ Wang, NJ Wareham, DR Weir, G Willemsen, J Willeit, AF Wright, KT Zondervan, K Stefansson, RF Krueger, JJ Lee, DJ Benjamin, D Cesarini, PD Koellinger, M den Hoed, H Snieder, MC Mills
Nov 30, 2016
The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric...
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