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Results: 78798
Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub.
Sarah Louise Latty, Jiro Sakai, Lee Hopkins, Brett Verstak, Teresa Paramo, Nils A Berglund, Eugenia Cammarota, Pietro Cicuta, Nicholas J Gay, Peter J Bond, David Klenerman, Clare E Bryant
Mar 23, 2018
Infection and tissue damage induces assembly of supramolecular organizing centres (SMOCs)), such as the Toll-like receptor (TLR) MyDDosome, to co-ordinate inflammatory signaling. SMOC assembly is thought to drive digital...
The Contribution of Building-Integrated Photovoltaics (BIPV) to the Concept of Nearly Zero-Energy Cities in Europe
The main purpose of this paper is to investigate the contributions of building-integrated photovoltaic (BIPV) systems to the notion of nearly zero-energy cities in the capitals of the European Union member states (EU), Norway...
Balancing a budget or running a deficit? The offset regime of carbon removal and solar geoengineering under a carbon budget
Abstract: The idea of the carbon budget is a powerful conceptual tool to define and quantify the climate challenge. Whilst scientists present the carbon budget as the geophysical foundation for global net-zero targets, the...
Balancing a budget or running a deficit? The offset regime of carbon removal and solar geoengineering under a carbon budget
Abstract: The idea of the carbon budget is a powerful conceptual tool to define and quantify the climate challenge. Whilst scientists present the carbon budget as the geophysical foundation for global net-zero targets, the...
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL.
Ali Al-Behadili, Jay P Uhler, Anna-Karin Berglund, Bradley Peter, Mara Doimo, Aurelio Reyes, Sjoerd Wanrooij, Massimo Zeviani, Maria Falkenberg
Nov 13, 2018
The role of Ribonuclease H1 (RNase H1) during primer removal and ligation at the mitochondrial origin of light-strand DNA synthesis (OriL) is a key, yet poorly understood, step in mitochondrial DNA maintenance. Here, we...
A general carbonyl alkylative amination for tertiary amine synthesis.
The ubiquity of tertiary alkylamines in pharmaceutical and agrochemical agents, natural products and small-molecule biological probes1,2 has stimulated efforts towards their streamlined synthesis3-9. Arguably the most robust...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Visibility of 4-covers of elliptic curves
Let C be a 4-cover of an elliptic curve E, written as a quadric intersection in P^3. Let E' be another elliptic curve with 4-torsion isomorphic to that of E. We show how to write down the 4-cover C' of E' with the property that...
A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo.
Nils Burger, Angela Logan, Tracy A Prime, Amin Mottahedin, Stuart T Caldwell, Thomas Krieg, Richard C Hartley, Andrew M James, Michael P Murphy
Oct 07, 2021
Coenzyme Q (CoQ) is an essential cofactor, primarily found in the mitochondrial inner membrane where it functions as an electron carrier in the respiratory chain, and as a lipophilic antioxidant. The redox state of the CoQ pool...
Challenge-Based Learning in Higher Education
Cecilia Christersson, Margareta Melin, Pär Widén, Nils Ekelund, Jonas Christensen, Nina Lundegren, Patricia Staaf
Jan 01, 2022
Higher education institutions (HEIs) have a pivotal role in fulfilling the social dimension of sustainability and contributing to a complex changing society. To meet these challenges, Malmö University has in interdisciplinary...
Published by: IGI Global Scientific Publishing
Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19.
The majority of COVID-19 survivors experience long-term neuropsychiatric symptoms such as fatigue, sleeping difficulties, depression and anxiety. We propose that neuroimmune cross-talk via inflammatory cytokines such as...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
Trusting the trust machine
Information systems research emphasizes that blockchain requires trust in the technology itself. However, we lack knowledge on the applicability of established trust cues to blockchain technology. Thus, this paper's objective...
Distributed Ledger End Users Human-Computer-Interaction Trustworthiness /dk/atira/pure/subjectarea/asjc/1400/1404 name=Management Information Systems /dk/atira/pure/subjectarea/asjc/1700/1710 name=Information Systems /dk/atira/pure/subjectarea/asjc/1700/1705 name=Computer Networks and Communications /dk/atira/pure/subjectarea/asjc/1400/1406 name=Marketing /dk/atira/pure/subjectarea/asjc/1800/1802 name=Information Systems and Management /dk/atira/pure/subjectarea/asjc/3300/3309 name=Library and Information Sciences /dk/atira/pure/subjectarea/asjc/1700/1702 name=Artificial Intelligence
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
A case study in estimating avionics availability from field reliability data
Ettore Settanni, Linda B. Newnes, Nils E. Thenent, Daniel Bumblauskas, Glenn Parry, Yee Mey Goh
Jun 01, 2016
Under incentivized contractual mechanisms such as availability-based contracts, the support service provider and its customer must share a common understanding of equipment reliability baselines. Emphasis is typically placed...
Field evaluation of DNA detection of human filarial and malaria parasites using mosquito excreta/feces.
Corrado Minetti, Nils Pilotte, Michael Zulch, Tiago Canelas, Edward J Tettevi, Francis BD Veriegh, Mike Yaw Osei-Atweneboana, Steven A Williams, Lisa J Reimer
Apr 20, 2020
We recently developed a superhydrophobic cone-based method for the collection of mosquito excreta/feces (E/F) for the molecular xenomonitoring of vector-borne parasites showing higher throughput compared to the traditional...
Correcting the Mean-Variance Dependency for Differential Variability Testing Using Single-Cell RNA Sequencing Data.
Bayesian immune activation single-cell RNA sequencing statistics transcriptional noise variability Animals Biological Variation Population CD4-Positive T-Lymphocytes Cell Differentiation Cell Lineage Computer Simulation Gene Expression Regulation Immunity Lymphocyte Activation Mice Mice Inbred C57BL Models Theoretical Sequence Analysis RNA Single-Cell Analysis Transcriptome
Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System.
Respiratory complex I is an essential metabolic enzyme that uses the energy from NADH oxidation and ubiquinone reduction to translocate protons across an energy transducing membrane and generate the proton motive force for ATP...
Structural basis for a complex I mutation that blocks pathological ROS production
Sentiment Analysis on Movie Reviews Dataset Using Support Vector Machines and Ensemble Learning
The internet makes it easier for people to connect to each other and has become a platform to express ideas and share information with the world. The growth of the internet has indirectly led to the development of social...
Published by: IGI Global Scientific Publishing
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