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THE "INDIFFERENCE-ke CONSTRUCTION" IN MODERN CONVERSATIONAL PERSIAN
Nima Sadat-Tehrani
Aug 01, 2013
This paper deals with a construction in Persian called here the Indifference-ke
Construction (or IKC). This construction has the structure A ke B, where A is a clause (minimally a verb), ke is a particle, and B is a verb, a...
Published by: Atlantic Provinces Linguistic Association
The influence of comorbid depression and overweight status on peripheral inflammation and cortisol levels.
Anna P McLaughlin, Naghmeh Nikkheslat, Caitlin Hastings, Maria A Nettis, Melisa Kose, Courtney Worrell, Zuzanna Zajkowska, Nicole Mariani, Daniela Enache, Giulia Lombardo, Linda Pointon, NIMA Consortium, Philip Cowen, Jonathan Cavanagh, Neil Harrison, Edward Bullmore, Carmine M Pariante, Valeria Mondelli
Feb 24, 2021
BACKGROUND: Depression and overweight are each associated with abnormal immune system activation. We sought to disentangle the extent to which depressive symptoms and overweight status contributed to increased inflammation and...
Iron and hepcidin as risk factors in atherosclerosis
Tessel E Galesloot, Luc L Janss, Stephen Burgess, Lambertus ALM Kiemeney, Martin den Heijer, Jacqueline de Graaf, Suzanne Holewijn, Beben Benyamin, John B Whitfield, Dorine W Swinkels, Sita H Vermeulen
Sep 29, 2016
BACKGROUND: Previous reports suggested a role for iron and hepcidin in atherosclerosis. Here, we evaluated the causality of these associations from a genetic perspective via (i) a Mendelian randomization (MR) approach, (ii)...
Who is worthy of my commitment now?
Purpose: The paper aims to investigate the dynamics of individuals' multiple commitments in the internship context by answering two questions: How do interns' commitment to different stakeholders change over time? And what...
THE "INDIFFERENCE-ke CONSTRUCTION" IN MODERN CONVERSATIONAL PERSIAN
Nima Sadat-Tehrani
Aug 01, 2013
This paper deals with a construction in Persian called here the Indifference-ke
Construction (or IKC). This construction has the structure A ke B, where A is a clause (minimally a verb), ke is a particle, and B is a verb, a...
Published by: Atlantic Provinces Linguistic Association
High extracellular phosphate increases platelet polyphosphate content.
Platelet-derived extracellular polyphosphate (PolyP) is a major mediator of thrombosis. PolyP is a linear chain of inorganic phosphate (Pi) and is stored in platelet dense granules. Pi enters cells from the extracellular fluid...
Who is worthy of my commitment now?
Purpose: The paper aims to investigate the dynamics of individuals' multiple commitments in the internship context by answering two questions: How do interns' commitment to different stakeholders change over time? And what...
Aptamer-based Field-Effect Biosensor for Tenofovir Detection
Nima Aliakbarinodehi, Pawan Jolly, Nikhil Bhalla, Anna Miodek, Giovanni de Micheli, Pedro Estrela, Sandro Carrara
Mar 15, 2017
During medical treatment it is critical to maintain the circulatory concentration of drugs within their therapeutic range. A novel biosensor is presented in this work to address the lack of a reliable point-of-care drug...
Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism
Samuel Furse, Adam J. Watkins, Nima Hojat, James Smith, Huw E. L. Williams, Davide Chiarugi, Albert Koulman
Feb 05, 2021
Abstract: In this paper we present an investigation of parental-diet-driven metabolic programming in offspring using a novel computational network analysis tool. The impact of high paternal carbohydrate intake on offsprings’...
Aptamer-based Field-Effect Biosensor for Tenofovir Detection
Nima Aliakbarinodehi, Pawan Jolly, Nikhil Bhalla, Anna Miodek, Giovanni de Micheli, Pedro Estrela, Sandro Carrara
Mar 15, 2017
During medical treatment it is critical to maintain the circulatory concentration of drugs within their therapeutic range. A novel biosensor is presented in this work to address the lack of a reliable point-of-care drug...
Griscelli Syndrome Type 2 Sine Albinism
Yuta Ohishi, Sandra Ammann, Vahid Ziaee, Katharina Strege, Miriam Groß, Carla Vazquez Amos, Mohammad Shahrooei, Parisa Ashournia, Anahita Razaghian, Gillian M. Griffiths, Stephan Ehl, Mitsunori Fukuda, Nima Parvaneh
Dec 24, 2020
Griscelli syndrome type 2 (GS-2) is an inborn error of immunity characterized by partial albinism and episodes of hemophagocytic lymphohistiocytosis (HLH). It is caused by RAB27A mutations that encode RAB27A, a member of the Rab...
Supramaximal calcium signaling triggers procoagulant platelet formation.
Nima Abbasian, Sarah L Millington-Burgess, Shirom Chabra, Jean-Daniel Malcor, Matthew T Harper
Dec 13, 2019
Procoagulant platelets promote thrombin generation during thrombosis. Platelets become procoagulant in an all-or-nothing manner. We investigated how distinct Ca2+ signaling between platelet subpopulations commits some platelets...
A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index.
Julia J Schubert, Mattia Veronese, Tim D Fryer, Roido Manavaki, Manfred G Kitzbichler, Maria A Nettis, Valeria Mondelli, Carmine M Pariante, Edward T Bullmore, NIMA Consortium, Federico E Turkheimer
Feb 24, 2021
BACKGROUND: Immune mechanisms have been implicated in the pathogenesis of depression. Translocator protein (TSPO)-targeted positron emission tomography (PET) has been used to assess neuroinflammation in major depressive...
No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing.
John J Cole, Alison McColl, Robin Shaw, Mary-Ellen Lynall, Philip J Cowen, Peter de Boer, Wayne C Drevets, Neil Harrison, Carmine Pariante, Linda Pointon, NIMA Consortium, Carl Goodyear, Edward Bullmore, Jonathan Cavanagh
Jun 04, 2021
The increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation forthe variance in this heterogeneous condition. Peripheral blood...
Optimized Photometric Redshifts for the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS)
Dritan Kodra, Brett H. Andrews, Jeffrey A. Newman, Steven L. Finkelstein, Adriano Fontana, Nimish Hathi, Mara Salvato, Tommy Wiklind, Stijn Wuyts, Adam Broussard, Nima Chartab, Christopher Conselice, M. C. Cooper, Avishai Dekel, Mark Dickinson, Henry C. Ferguson, Eric Gawiser, Norman A. Grogin, Kartheik Iyer, Jeyhan Kartaltepe, Susan Kassin, Anton M. Koekemoer, David C. Koo, Ray A. Lucas, Kameswara Bharadwaj Mantha, Daniel H. McIntosh, Bahram Mobasher, Camilla Pacifici, Pablo G. Pérez-González, Paola Santini
Jan 04, 2023
We present the first comprehensive release of photometric redshifts (photo- z's) from the Cosmic Assembly Near-Infrared Deep Extragalactic Legacy Survey (CANDELS) team. We use statistics based upon the Quantile-Quantile (Q-Q)...
Optimized Photometric Redshifts for the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS)
Dritan Kodra, Brett H. Andrews, Jeffrey A. Newman, Steven L. Finkelstein, Adriano Fontana, Nimish Hathi, Mara Salvato, Tommy Wiklind, Stijn Wuyts, Adam Broussard, Nima Chartab, Christopher Conselice, M. C. Cooper, Avishai Dekel, Mark Dickinson, Henry C. Ferguson, Eric Gawiser, Norman A. Grogin, Kartheik Iyer, Jeyhan Kartaltepe, Susan Kassin, Anton M. Koekemoer, David C. Koo, Ray A. Lucas, Kameswara Bharadwaj Mantha, Daniel H. McIntosh, Bahram Mobasher, Camilla Pacifici, Pablo G. Pérez-González, Paola Santini
Jan 04, 2023
We present the first comprehensive release of photometric redshifts (photo- z's) from the Cosmic Assembly Near-Infrared Deep Extragalactic Legacy Survey (CANDELS) team. We use statistics based upon the Quantile-Quantile (Q-Q)...
Griscelli Syndrome Type 2 Sine Albinism
Yuta Ohishi, Sandra Ammann, Vahid Ziaee, Katharina Strege, Miriam Groß, Carla Vazquez Amos, Mohammad Shahrooei, Parisa Ashournia, Anahita Razaghian, Gillian M Griffiths, Stephan Ehl, Mitsunori Fukuda, Nima Parvaneh
Jan 18, 2021
Griscelli syndrome type 2 (GS-2) is an inborn error of immunity characterized by partial albinism and episodes of hemophagocytic lymphohistiocytosis (HLH). It is caused by RAB27A mutations that encode RAB27A, a member of the Rab...
Leukocytes Mononuclear Cell Line COS Cells Animals Humans Albinism Piebaldism rab GTP-Binding Proteins Adaptor Proteins Signal Transducing Membrane Proteins Binding Sites Mutation Missense Adolescent Child Child Preschool Infant Infant Newborn Female Male Lymphohistiocytosis Hemophagocytic rab27 GTP-Binding Proteins Primary Immunodeficiency Diseases Chlorocebus aethiops
Comparative omics and feeding manipulations in chicken indicate a shift of the endocrine role of visceral fat towards reproduction.
Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth.
Alessio Lepore, Pui Man Choy, Nathan CW Lee, Maria Annunziata Carella, Rosy Favicchio, Marco A Briones-Orta, Shannon S Glaser, Gianfranco Alpini, Clive D'Santos, Reuben M Tooze, Mihaela Lorger, Wing-Kin Syn, Athanasios Papakyriakou, Georgios Giamas, Concetta Bubici, Salvatore Papa
Sep 15, 2021
BACKGROUND AND AIMS: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive type of liver cancer in urgent need of treatment options. Aberrant activation of the c-Jun N-terminal kinase (JNK) pathway is a key feature in ICC...
Animals Antineoplastic Agents Bile Duct Neoplasms Carcinogenesis Cell Line Tumor Cholangiocarcinoma Female Gene Knockdown Techniques Humans MAP Kinase Signaling System Mice Mice Inbred NOD Mice SCID Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase 9 NIMA-Interacting Peptidylprolyl Isomerase Phosphorylation RNA Small Interfering Tretinoin Tumor Burden Xenograft Model Antitumor Assays
Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression.
Athina R Aruldass, Manfred G Kitzbichler, Sarah E Morgan, Sol Lim, Mary-Ellen Lynall, Lorinda Turner, Petra Vertes, Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer’s Disease (NIMA), Jonathan Cavanagh, Phil Cowen, Carmine M Pariante, Neil A Harrison, Edward T Bullmore
Aug 23, 2021
OBJECTIVE: There is increasing evidence for a subgroup of major depressive disorder (MDD) associated with heightened peripheral blood inflammatory markers. In this study, we aimed to understand the mechanistic brain-immune axis...
Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth.
Adi L Tarca, Bálint Ármin Pataki, Roberto Romero, Marina Sirota, Yuanfang Guan, Rintu Kutum, Nardhy Gomez-Lopez, Bogdan Done, Gaurav Bhatti, Thomas Yu, Gaia Andreoletti, Tinnakorn Chaiworapongsa, DREAM Preterm Birth Prediction Challenge Consortium, Sonia S Hassan, Chaur-Dong Hsu, Nima Aghaeepour, Gustavo Stolovitzky, Istvan Csabai, James C Costello
Jun 25, 2021
Identification of pregnancies at risk of preterm birth (PTB), the leading cause of newborn deaths, remains challenging given the syndromic nature of the disease. We report a longitudinal multi-omics study coupled with a DREAM...
Aptamers collaborative competition human transcriptome arrays Machine Learning plasma proteomics predictive modeling preterm labor and delivery spontaneous preterm birth whole blood transcriptomics Adult Asymptomatic Diseases Biomarkers Blood Proteins Cell-Free Nucleic Acids Crowdsourcing Female Gestational Age Humans Infant Newborn Longitudinal Studies pre-eclampsia Pregnancy premature birth Proteomics ROC Curve Transcriptome
Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system
Khalil S. Rawji, Adam M.H. Young, Tanay Ghosh, Nathan J. Michaels, Reza Mirzaei, Janson Kappen, Kathleen L. Kolehmainen, Nima Alaeiilkhchi, Brian Lozinski, Manoj K. Mishra, Annie Pu, Weiwen Tang, Salma Zein, Deepak K. Kaushik, Michael B. Keough, Jason R. Plemel, Fiona Calvert, Andrew J. Knights, Daniel J. Gaffney, Wolfram Tetzlaff, Robin J. M. Franklin, V. Wee Yong
Jun 06, 2020
Abstract: Remyelination following CNS demyelination restores rapid signal propagation and protects axons; however, its efficiency declines with increasing age. Both intrinsic changes in the oligodendrocyte progenitor cell...
Adrenal-permissive HSD3B1 genetic inheritance and risk of estrogen-driven postmenopausal breast cancer.
Megan L Kruse, Mona Patel, Jeffrey McManus, Yoon-Mi Chung, Xiuxiu Li, Wei Wei, Peter S Bazeley, Fumihiko Nakamura, Aimalie Hardaway, Erinn Downs, Sarat Chandarlapaty, Mathew Thomas, Halle Cf Moore, George T Budd, WH Wilson Tang, Stanley L Hazen, Aaron Bernstein, Serena Nik-Zainal, Jame Abraham, Nima Sharifi
Nov 25, 2021
BACKGROUNDGenetics of estrogen synthesis and breast cancer risk has been elusive. The 1245A→C missense-encoding polymorphism in HSD3B1, which is common in White populations, is functionally adrenal permissive and increases...
Inflammatory biomarkers in Alzheimer's disease plasma.
Angharad R Morgan, Samuel Touchard, Claire Leckey, Caroline O'Hagan, Alejo J Nevado-Holgado, NIMA Consortium, Frederik Barkhof, Lars Bertram, Olivier Blin, Isabelle Bos, Valerija Dobricic, Sebastiaan Engelborghs, Giovanni Frisoni, Lutz Frölich, Silvey Gabel, Peter Johannsen, Petronella Kettunen, Iwona Kłoszewska, Cristina Legido-Quigley, Alberto Lleó, Pablo Martinez-Lage, Patrizia Mecocci, Karen Meersmans, José Luis Molinuevo, Gwendoline Peyratout, Julius Popp, Jill Richardson, Isabel Sala, Philip Scheltens, Johannes Streffer, Hikka Soininen, Mikel Tainta-Cuezva, Charlotte Teunissen, Magda Tsolaki, Rik Vandenberghe, Pieter Jelle Visser, Stephanie Vos, Lars-Olof Wahlund, Anders Wallin, Sarah Westwood, Henrik Zetterberg, Simon Lovestone, B Paul Morgan, Annex: NIMA–Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer's Disease
Jul 23, 2019
INTRODUCTION: Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a "Holy Grail" of AD research and intensively sought; however, there are no well-established plasma markers. METHODS: A hypothesis-led...
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