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Results: 304
Sex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet.
Nirajan Shrestha, Steven D Melvin, Daniel R McKeating, Olivia J Holland, James SM Cuffe, Anthony V Perkins, Andrew J McAinch, Deanne H Hryciw
Sep 25, 2021
BACKGROUND: Linoleic acid (LA) is an essential polyunsaturated fatty acid (PUFA) that is required for foetal growth and development. Excess intake of LA can be detrimental for metabolic health due to its pro-inflammatory...
Linoleic Acid metabolite Offspring sex 3-Hydroxybutyric Acid Acetic Acid Adult Children Animals Animals Newborn Diet Diet High-Fat Female Lactation Linoleic Acid Lysine Male Maternal Nutritional Physiological Phenomena Plasma Pregnancy prenatal exposure delayed effects principal component analysis ROC Curve Rats Inbred WKY Sex Characteristics
Molecular and Functional Characterization of Pyramidal Cell Types in the Frontal Cortex of Mouse Brain
Prerana Shrestha
Jan 01, 0001
Mammalian neocortex is the most complex structure in the brain. Considered the seat of executive function, the neocortex subserves diverse cognitive processes such as decision-making, motor planning, sensory discrimination and...
Published by: Rockefeller University
Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation.
Defects in chromosome-microtubule attachment can cause chromosomal instability (CIN), frequently associated with infertility and aggressive cancers. Chromosome-microtubule attachment is mediated by a large macromolecular...
A new Himalayan crisis? Exploring transformative resilience pathways
This paper demonstrates that a new crisis has emerged in the Himalayas in recent years, as five decades of well-intentioned policy responses failed to tackle escalating environment and development challenges. It then suggests...
Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation.
Defects in chromosome-microtubule attachment can cause chromosomal instability (CIN), frequently associated with infertility and aggressive cancers. Chromosome-microtubule attachment is mediated by a large macromolecular...
Reduction of response time in transmissive optically addressed spatial light modulator using solution-based ZnO NP/PEDOT
Abstract: An optically addressed spatial light modulator (OASLM) works by using the intensity of a ‘write’ light to modulate the phase of a ‘read’ light. OASLM using ZnO nanoparticles (NPs) as a photoconductor is important to...
High-Resolution Electrochemical Transistors Defined by Mold-Guided Drying of PEDOT
Ion-sensitive transistors with nanoscale or microscale dimensions are promising for high-resolution electrophysiological recording and sensing. Technology that can pattern polymer functional materials directly from a solution...
Variety of Ordered Patterns in Donor-Acceptor Polymer Semiconductor Films Crystallized from Solution.
Shunpu Li, Jin Li, Youngtea Chun, Pawan K Shrestha, Xin Chang, Mike Pivnenko, Daping Chu
Apr 08, 2021
A huge challenge is to control the nucleation of crystallites/aggregates in the solution during polymer film formation to generate desired structures. In this work, we investigate crystallization of P(NDI2OD-T2), a...
Reduction of response time in transmissive optically addressed spatial light modulator (OASLM) using solution-based ZnO NP / PEDOT
Optically addressed spatial light modulator (OASLM) works by using the intensity of a 'write' light to modulate the phase of a 'read' light. OASLM using ZnO nanoparticles (NP) as photoconductor is important to holographic...
Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor.
Andras S Solt, Mark J Bostock, Binesh Shrestha, Prashant Kumar, Tony Warne, Christopher G Tate, Daniel Nietlispach
Jun 08, 2018
A complex conformational energy landscape determines G-protein-coupled receptor (GPCR) signalling via intracellular binding partners (IBPs), e.g., Gs and β-arrestin. Using 13C methyl methionine NMR for the β1-adrenergic...
Reduction of response time in transmissive optically addressed spatial light modulator using solution-based ZnO NP/PEDOT
Abstract: An optically addressed spatial light modulator (OASLM) works by using the intensity of a ‘write’ light to modulate the phase of a ‘read’ light. OASLM using ZnO nanoparticles (NPs) as a photoconductor is important to...
Disaster Diaries
Grace Mueller, Anna Barford, Helen Osborne, Kaajal Pradhan, Rachel Proefke, Soniya Shrestha, Andi M Pratiwi
Jan 12, 2023
Bianca Jupp, Jennifer E Murray, Emily R Jordan, Jing Xia, Meg Fluharty, Saurav Shrestha, Trevor W Robbins, Jeffrey W Dalley
Oct 27, 2015
Anxiety High responder Impulsivity psychostimulants Resource competition Social status Animals Behavior Addictive Cocaine Corpus Striatum Dopamine Dopamine Plasma Membrane Transport Proteins Dopamine Uptake Inhibitors Exploratory Behavior Male Protein Binding Rats Receptors Dopamine D2 Receptors Dopamine D3 Reinforcement psychology Self Administration Social Dominance
Coherence scale of magnetic fields generated in early time forward shocks of Gamma Ray Bursts
N Jordana-Mitjans, C G Mundell, R. J. Smith, C. Guidorzi, M. Marongiu, S. Kobayashi, A. Gomboc, M. Shrestha, I. A. Steele
Aug 31, 2021
We report the earliest-ever detection of optical polarization from a GRB forward shock (GRB 141220A), measured 129.5-204.3 s after the burst using the multi-colour RINGO3 optical polarimeter on the 2-m fully autonomous robotic...
Severe conservation risks of roads on apex predators
Abstract The global expansion of road networks threatens apex predator conservation and ecosystem functioning. This occurs through wildlife-vehicle collisions, habitat loss and fragmentation...
Itxaso Quintana, Edgar F Cifuentes, Jeffrey A Dunnink, María Ariza, Daniela Martínez-Medina, Felipe M Fantacini, Bibek R Shrestha, Freddie-Jeanne Richard
Feb 21, 2022
Accommodation-Free Head Mounted Display with Comfortable 3D Perception and an Enlarged Eye-box.
Pawan K Shrestha, Matt J Pryn, Jia Jia, Jhen-Si Chen, Hector Navarro Fructuoso, Atanas Boev, Qing Zhang, Daping Chu
Mar 13, 2020
An accommodation-free displays, also known as Maxwellian displays, keep the displayed image sharp regardless of the viewer's focal distance. However, they typically suffer from a small eye-box and limited effective field of view...
Markers of serotonergic function in the orbitofrontal cortex and dorsal raphé nucleus predict individual variation in spatial-discrimination serial reversal learning.
Rebecca L Barlow, Johan Alsiö, Bianca Jupp, Rebecca Rabinovich, Saurav Shrestha, Angela C Roberts, Trevor W Robbins, Jeffrey W Dalley
Mar 04, 2015
Animals Citalopram Conditioning Operant discrimination Psychological Dorsal Raphe Nucleus Dose-Response Relationship Drug Gene Expression Male Monoamine Oxidase Piperazines Prefrontal Cortex Protein Binding RNA Messenger Rats Reinforcement psychology Reversal Learning Serotonin Selective Serotonin Reuptake Inhibitors Space Perception Tryptophan Hydroxylase
Conformational plasticity of ligand-bound and ternary GPCR complexes studied by 19F NMR of the β1-adrenergic receptor.
J Niclas Frei, Richard W Broadhurst, Mark J Bostock, Andras Solt, Andrew JY Jones, Florian Gabriel, Aditi Tandale, Binesh Shrestha, Daniel Nietlispach
Jan 13, 2020
Targeted modification of the Per2 clock gene alters circadian function in mPer2luciferase (mPer2Luc) mice.
Martin R Ralph, Shu-Qun Shi, Carl H Johnson, Pavel Houdek, Tenjin C Shrestha, Priya Crosby, John S O'Neill, Martin Sládek, Adam R Stinchcombe, Alena Sumová
Jul 21, 2021
Modification of the Per2 clock gene in mPer2Luc reporter mice significantly alters circadian function. Behavioral period in constant dark is lengthened, and dissociates into two distinct components in constant light. Rhythms...
Conformational plasticity of ligand-bound and ternary GPCR complexes studied by 19F NMR of the β1-adrenergic receptor.
J Niclas Frei, Richard W Broadhurst, Mark J Bostock, Andras Solt, Andrew J Y Jones, Florian Gabriel, Aditi Tandale, Binesh Shrestha, Daniel Nietlispach
Mar 06, 2020
G-protein-coupled receptors (GPCRs) are allosteric signaling proteins that transmit an extracellular stimulus across the cell membrane. Using 19F NMR and site-specific labelling, we investigate the response of the cytoplasmic...
Published by: Nature Communications
Conformational plasticity of ligand-bound and ternary GPCR complexes studied by 19 F NMR of the β 1 -adrenergic receptor
J. Niclas Frei, Richard W. Broadhurst, Mark J. Bostock, Andras Solt, Andrew J. Y. Jones, Florian Gabriel, Aditi Tandale, Binesh Shrestha, Daniel Nietlispach
Feb 02, 2021
Abstract: G-protein-coupled receptors (GPCRs) are allosteric signaling proteins that transmit an extracellular stimulus across the cell membrane. Using 19F NMR and site-specific labelling, we investigate the response of the...
Severe conservation risks of roads on apex predators.
Itxaso Quintana, Edgar F Cifuentes, Jeffrey A Dunnink, María Ariza, Daniela Martínez-Medina, Felipe M Fantacini, Bibek R Shrestha, Freddie-Jeanne Richard
Mar 28, 2022
The global expansion of road networks threatens apex predator conservation and ecosystem functioning. This occurs through wildlife-vehicle collisions, habitat loss and fragmentation, reduced genetic connectivity and increased...
Coherence scale of magnetic fields generated in early time forward shocks of Gamma Ray Bursts
N Jordana-Mitjans, C G Mundell, R. J. Smith, C. Guidorzi, M. Marongiu, S. Kobayashi, A. Gomboc, M. Shrestha, I. A. Steele
Aug 31, 2021
We report the earliest-ever detection of optical polarization from a GRB forward shock (GRB 141220A), measured 129.5-204.3 s after the burst using the multi-colour RINGO3 optical polarimeter on the 2-m fully autonomous robotic...
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