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Metastasis in breast cancer significantly increases morbidity and mortality. The 5-year survival rate reduces from 90% for localised disease to about 20% once metastasis has taken place. The phosphoinositide 3-kinase/Akt...
Retrospective analysis assessing the spatial and temporal distribution of paediatric acute respiratory tract infections in Ho Chi Minh City, Vietnam.
Nhan Thi Ho, Corinne Thompson, Le Nguyen Thanh Nhan, Hoang Minh Tu Van, Nguyen Thanh Dung, Phuc Tran My, Vo Minh Quang, Ngo Ngoc Quang Minh, Tran Anh Tuan, Nguyen Thanh Hung, Ha Manh Tuan, Nguyen Van Vinh Chau, Marcel Wolbers, Guy E Thwaites, Marc Choisy, Stephen Baker
Apr 10, 2019
BACKGROUND: Acute respiratory tract infections (ARIs) are the leading cause of morbidity and mortality in young children in low/middle-income countries. Using routine hospital data, we aimed to examine the spatial distribution...
acute respiratory infections lower respiratory infections Pediatrics spatial distribution Temporal patterns upper respiratory infections Acute Disease Adolescent Child Child Preschool Female Hospitalization Hospitals Pediatric Humans Incidence Infant Infant Newborn Male Respiratory Tract Infections Retrospective Studies Risk Factors Seasons Spatio-Temporal Analysis Vietnam weather
No Clinical Benefit of Empirical Antimicrobial Therapy for Pediatric Diarrhea in a High-Usage, High-Resistance Setting.
Vu Thuy Duong, Ha Thanh Tuyen, Pham Van Minh, James I Campbell, Hoang Le Phuc, Tran Do Hoang Nhu, Le Thi Phuong Tu, Tran Thi Hong Chau, Le Thi Quynh Nhi, Nguyen Thanh Hung, Nguyen Minh Ngoc, Nguyen Thi Thanh Huong, Lu Lan Vi, Corinne N Thompson, Guy E Thwaites, Ruklanthi de Alwis, Stephen Baker
Apr 10, 2019
BACKGROUND: Pediatric diarrheal disease presents a major public health burden in low- to middle-income countries. The clinical benefits of empirical antimicrobial treatment for diarrhea are unclear in settings that lack reliable...
Campylobacter Shigella Antimicrobial resistance disease outcome Fluoroquinolones multidrug resistance nontyphoidal Salmonella pediatric diarrhea Adolescent Anti-Bacterial Agents Campylobacter Child Child Preschool Cross-Sectional Studies Diarrhea Drug Resistance Multiple Bacterial Feces Female Humans Infant Male Microbial Sensitivity Tests prevalence Prospective Studies salmonella Shigella Treatment Outcome Vietnam
A universal genome sequencing method for rotavirus A from human fecal samples which identifies segment reassortment and multi-genotype mixed infection.
Tran Thi Ngoc Dung, Pham Thanh Duy, October M Sessions, Uma K Sangumathi, Voong Vinh Phat, Pham Thi Thanh Tam, Nguyen Thi Nguyen To, Tran My Phuc, Tran Thi Hong Chau, Nguyen Ngoc Minh Chau, Ngoc Nguyen Minh, Guy E Thwaites, Maia A Rabaa, Stephen Baker
Apr 10, 2019
BACKGROUND: Genomic characterization of rotavirus (RoV) has not been adopted at large-scale due to the complexity of obtaining sequences for all 11 segments, particularly when feces are used as starting material. METHODS: To...
A Double-blind, Randomized, Placebo-controlled Trial of Lactobacillus acidophilus for the Treatment of Acute Watery Diarrhea in Vietnamese Children.
Tran Thi Hong Chau, Nguyen Ngoc Minh Chau, Nhat Thanh Hoang Le, Hao Chung The, Phat Voong Vinh, Nguyen Thi Nguyen To, Nguyen Minh Ngoc, Ha Manh Tuan, Tang Le Chau Ngoc, Marion-Eliette Kolader, Jeremy J Farrar, Marcel Wolbers, Guy E Thwaites, Stephen Baker, Oxford-Vietnam Probiotics Study Group
Aug 02, 2019
Novel multiplex real-time PCR assays reveal a high prevalence of diarrhoeagenic Escherichia coli pathotypes in healthy and diarrhoeal children in the south of Vietnam
Vu Thuy Duong, Le Thi Phuong Tu, Ha Thanh Tuyen, Le Thi Quynh Nhi, James I. Campbell, Pham Van Minh, Hoang Le Phuc, Tran Thi Hong Chau, Nguyen Minh Ngoc, Lu Lan Vi, Claire Jenkins, Iruka Okeke, Ellen Higginson, Stephen Baker
Jul 03, 2020
Abstract: Background: Diarrhoeagenic Escherichia coli (DEC) infections are common in children in low-middle income countries (LMICs). However, detecting the various DEC pathotypes is complex as they cannot be differentiated by...
Novel multiplex real-time PCR assays reveal a high prevalence of diarrhoeagenic Escherichia coli pathotypes in healthy and diarrhoeal children in the south of Vietnam.
Vu Thuy Duong, Le Thi Phuong Tu, Ha Thanh Tuyen, Le Thi Quynh Nhi, James I Campbell, Pham Van Minh, Hoang Le Phuc, Tran Thi Hong Chau, Nguyen Minh Ngoc, Lu Lan Vi, Claire Jenkins, Iruka Okeke, Ellen Higginson, Stephen Baker
Sep 21, 2020
BACKGROUND: Diarrhoeagenic Escherichia coli (DEC) infections are common in children in low-middle income countries (LMICs). However, detecting the various DEC pathotypes is complex as they cannot be differentiated by classical...
co-infection Diarrhoea children EAEC EHEC EIEC EPEC ETEC Healthy children Multiplex real-time PCR Adolescent Child Child Preschool Diarrhea Enteropathogenic Escherichia coli Escherichia coli Infections Female Humans Infant Infant Newborn Male Multiplex Polymerase Chain Reaction prevalence Real-Time Polymerase Chain Reaction Sensitivity and Specificity Vietnam Virulence Factors Bordetella
Pathogenic Escherichia coli Possess Elevated Growth Rates under Exposure to Sub-Inhibitory Concentrations of Azithromycin.
Tran Tuan-Anh, Ha Thanh Tuyen, Nguyen Ngoc Minh Chau, Nguyen Duc Toan, Tran Hanh Triet, Le Minh Triet, Nguyen Hoang Thu Trang, Nguyen Thi Nguyen To, Josefin Bartholdson Scott, Hao Chung The, Duy Pham Thanh, Hannah Clapham, Stephen Baker
Dec 07, 2020
Antimicrobial resistance (AMR) has been identified by the World Health Organization (WHO) as one of the ten major threats to global health. Advances in technology, including whole-genome sequencing, have provided new insights...
Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children's hospital.
Nguyen Duc Toan, Thomas C Darton, Nguyen Hoang Thien Huong, Le Thanh Hoang Nhat, To Nguyen Thi Nguyen, Ha Thanh Tuyen, Le Quoc Thinh, Nguyen Kien Mau, Pham Thi Thanh Tam, Cam Ngoc Phuong, Le Nguyen Thanh Nhan, Ngo Ngoc Quang Minh, Ngo Minh Xuan, Tang Chi Thuong, Nguyen Thanh Hung, Christine Boinett, Stephen Reece, Abhilasha Karkey, Jeremy N Day, Stephen Baker
Apr 17, 2023
Sepsis is a major cause of neonatal mortality and children born in low- and middle-income countries (LMICs) are at greater risk of severe neonatal infections than those in higher-income countries. Despite this disparity, there...
Published by: PLOS global public health
Pathogenic Escherichia coli Possess Elevated Growth Rates under Exposure to Sub-Inhibitory Concentrations of Azithromycin
Tran Tuan-Anh, Ha Thanh Tuyen, Nguyen Ngoc Minh Chau, Nguyen Duc Toan, Tran Hanh Triet, Le Minh Triet, Nguyen Hoang Thu Trang, Nguyen Thi Nguyen To, Josefin Bartholdson Scott, Hao Chung The, Duy Pham Thanh, Hannah Clapham, Stephen Baker
Oct 29, 2020
Antimicrobial resistance (AMR) has been identified by the World Health Organization (WHO) as one of the ten major threats to global health. Advances in technology, including whole-genome sequencing, have provided new insights...
Novel multiplex real-time PCR assays reveal a high prevalence of diarrhoeagenic Escherichia coli pathotypes in healthy and diarrhoeal children in the south of Vietnam
Vu Thuy Duong, Le Thi Phuong Tu, Ha Thanh Tuyen, Le Thi Quynh Nhi, James I. Campbell, Pham Van Minh, Hoang Le Phuc, Tran Thi Hong Chau, Nguyen Minh Ngoc, Lu Lan Vi, Claire Jenkins, Iruka Okeke, Ellen Higginson, Stephen Baker
Jul 05, 2021
Abstract: Background: Diarrhoeagenic Escherichia coli (DEC) infections are common in children in low-middle income countries (LMICs). However, detecting the various DEC pathotypes is complex as they cannot be differentiated by...
Antibiotic use and prescription and its effects on Enterobacteriaceae in the gut in children with mild respiratory infections in Ho Chi Minh City, Vietnam. A prospective observational outpatient study.
Ngo Ngoc Quang Minh, Pham Van Toi, Le Minh Qui, Le Binh Bao Tinh, Nguyen Thi Ngoc, Le Thi Ngoc Kim, Nguyen Hanh Uyen, Vu Thi Ty Hang, Nguyen Thi Thuy Chinh B'Krong, Nguyen Thi Tham, Thai Dang Khoa, Huynh Duy Khuong, Pham Quynh Vi, Nguyen Ngoc Hong Phuc, Le Thi Minh Vien, Thomas Pouplin, Doan Van Khanh, Pham Nguyen Phuong, Phung Khanh Lam, Heiman FL Wertheim, James I Campbell, Stephen Baker, Christopher M Parry, Juliet E Bryant, Constance Schultsz, Nguyen Thanh Hung, Menno D de Jong, H Rogier van Doorn
Jan 11, 2021
BACKGROUND AND OBJECTIVES: Treatment guidelines do not recommend antibiotic use for acute respiratory infections (ARI), except for streptococcal pharyngitis/tonsillitis and pneumonia. However, antibiotics are prescribed...
Amoxicillin Anti-Bacterial Agents Cephalosporins Child Child Preschool Chromatography High Pressure Liquid Drug Prescriptions Drug Resistance Bacterial Enterobacteriaceae Female Follow-Up Studies Gastrointestinal Microbiome Humans Infant Male Outpatients Prospective Studies Respiratory Tract Infections Severity of Illness Index Vietnam
Hospital-acquired colonization and infections in a Vietnamese intensive care unit.
Duong Bich Thuy, James Campbell, Le Thanh Hoang Nhat, Nguyen Van Minh Hoang, Nguyen Van Hao, Stephen Baker, Ronald B Geskus, Guy E Thwaites, Nguyen Van Vinh Chau, C Louise Thwaites
Apr 10, 2019
Data concerning intensive care unit (ICU)-acquired bacterial colonization and infections are scarce from low and middle-income countries (LMICs). ICU patients in these settings are at high risk of becoming colonized and infected...
An age-stratified serosurvey against purified Salmonella enterica serovar Typhi antigens in the Lao People´s Democratic Republic.
Lisa Hefele, Antony P Black, Trinh Van Tan, Nguyen Tri Minh, Nguyen Duc Hoang, Siriphone Virachith, Claude P Muller, Judith M Hübschen, Paula Russell, Josefin Bartholdson Scott, Chau Nguyen Ngoc Minh, Tran Vu Thieu Nga, Stephen Baker
Jan 28, 2022
The epidemiology of typhoid fever in Lao People`s Democratic Republic is poorly defined. Estimating the burden of typhoid fever in endemic countries is complex due to the cost and limitations of population-based surveillance;...
An age-stratified serosurvey against purified Salmonella enterica serovar Typhi antigens in the Lao People´s Democratic Republic.
Lisa Hefele, Antony P Black, Trinh Van Tan, Nguyen Tri Minh, Nguyen Duc Hoang, Siriphone Virachith, Claude P Muller, Judith M Hübschen, Paula Russell, Josefin Bartholdson Scott, Chau Nguyen Ngoc Minh, Tran Vu Thieu Nga, Stephen Baker
Jan 05, 2022
The epidemiology of typhoid fever in Lao People`s Democratic Republic is poorly defined. Estimating the burden of typhoid fever in endemic countries is complex due to the cost and limitations of population-based surveillance;...
Clinical features, antimicrobial susceptibility patterns and genomics of bacteria causing neonatal sepsis in a children's hospital in Vietnam
Nguyen Duc Toan, Thomas C Darton, Christine J Boinett, James I Campbell, Abhilasha Karkey, Evelyne Kestelyn, Le Quoc Thinh, Nguyen Kien Mau, Pham Thi Thanh Tam, Le Nguyen Thanh Nhan, Ngo Ngoc Quang Minh, Cam Ngoc Phuong, Nguyen Thanh Hung, Ngo Minh Xuan, Tang Chi Thuong, Stephen Baker
Apr 10, 2019
INTRODUCTION: The clinical syndrome of neonatal sepsis, comprising signs of infection, septic shock and organ dysfunction in infants ≤4 weeks of age, is a frequent sequel to bloodstream infection and mandates urgent...
Antimicrobial resistance clinical features Genomics neonates outcomes Sepsis Anti-Infective Agents Bacteria Drug Resistance Multiple Bacterial Female Hospitals Pediatric Humans Infant Infant Newborn Linear Models Male Microbial Sensitivity Tests Neonatal Sepsis Phylogeny Prospective Studies Research Design Vietnam whole genome sequencing
Technological Factors Affecting Communication Quality at Ho Chi Minh City University of Industry and Trade
In the current era of technological explosion, applications are widely adopted and continuously improved, significantly impacting the education sector and creating a high demand for training within educational institutions. This...
Published by: IGI Global Scientific Publishing
Tumour microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients.
Hoang NH Tran, Trang Nguyen Hoang Thu, Phu Huu Nguyen, Chi Nguyen Vo, Khanh Van Doan, Chau Nguyen Ngoc Minh, Ngoc Tuan Nguyen, Van Ngoc Duc Ta, Khuong An Vu, Thanh Danh Hua, To Nguyen Thi Nguyen, Tan Trinh Van, Trung Pham Duc, Ba Lap Duong, Phuc Minh Nguyen, Vinh Chuc Hoang, Duy Thanh Pham, Guy E Thwaites, Lindsay J Hall, Daniel J Slade, Stephen Baker, Vinh Hung Tran, Hao Chung The
Nov 28, 2022
Perturbations in the gut microbiome have been associated with colorectal cancer (CRC), with the colonic overabundance of Fusobacterium nucleatum shown as the most consistent marker. Despite its significance in the promotion of...
Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children's hospital.
Nguyen Duc Toan, Thomas C Darton, Nguyen Hoang Thien Huong, Le Thanh Hoang Nhat, To Nguyen Thi Nguyen, Ha Thanh Tuyen, Le Quoc Thinh, Nguyen Kien Mau, Pham Thi Thanh Tam, Cam Ngoc Phuong, Le Nguyen Thanh Nhan, Ngo Ngoc Quang Minh, Ngo Minh Xuan, Tang Chi Thuong, Nguyen Thanh Hung, Christine Boinett, Stephen Reece, Abhilasha Karkey, Jeremy N Day, Stephen Baker
Sep 02, 2022
Sepsis is a major cause of neonatal mortality and children born in low- and middle-income countries (LMICs) are at greater risk of severe neonatal infections than those in higher-income countries. Despite this disparity, there...
Patient Safety Infant Mortality Hematology Sepsis Pediatric Clinical Research Infectious Diseases Perinatal Period - Conditions Originating in Perinatal Period 4.1 Discovery and preclinical testing of markers and technologies 4 Detection screening and diagnosis Infection Inflammatory and immune system 3 Good Health and Well Being
Assessing gut microbiota perturbations during the early phase of infectious diarrhea in Vietnamese children.
Hao Chung The, Paola Florez de Sessions, Song Jie, Duy Pham Thanh, Corinne N Thompson, Chau Nguyen Ngoc Minh, Collins Wenhan Chu, Tuan-Anh Tran, Nicholas R Thomson, Guy E Thwaites, Maia A Rabaa, Martin Hibberd, Stephen Baker
Apr 10, 2019
Diarrheal diseases remain the second most common cause of mortality in young children in developing countries. Efforts have been made to explore the impact of diarrhea on bacterial communities in the human gut, but a thorough...
Bifidobacterium Fusobacterium developing country Diarrhea enterotype Microbiome Oral microbiome Bacteria Bacterial Physiological Phenomena Biodiversity Cluster Analysis Diarrhea Infantile Dysbiosis dysentery Feces Female Gastrointestinal Microbiome Gastrointestinal Tract Humans Infant Male RNA Ribosomal 16S Risk Factors Vietnam
Factors associated with a low prevalence of exclusive breastfeeding during hospital stay in urban and semi-rural areas of southern Vietnam.
Quynh-Nhi Thi Le, Khanh-Lam Phung, Van-Thuy Thi Nguyen, Katherine L Anders, Minh-Nguyet Nguyen, Diem-Tuyet Thi Hoang, Thuy-Tien Thi Bui, Vinh-Chau Van Nguyen, Guy E Thwaites, Cameron Simmons, Stephen Baker
Apr 10, 2019
BACKGROUND: There is a paucity of data regarding risk factors associated with suboptimal breastfeeding practices in urbanized areas of low-middle income countries (LMICs). METHODS: Through a large prospective birth cohort, which...
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam.
Kathryn E Holt, Paul McAdam, Phan Vuong Khac Thai, Nguyen Thuy Thuong Thuong, Dang Thi Minh Ha, Nguyen Ngoc Lan, Nguyen Huu Lan, Nguyen Thi Quynh Nhu, Hoang Thanh Hai, Vu Thi Ngoc Ha, Guy Thwaites, David J Edwards, Artika P Nath, Kym Pham, David B Ascher, Jeremy Farrar, Chiea Chuen Khor, Yik Ying Teo, Michael Inouye, Maxine Caws, Sarah J Dunstan
Sep 05, 2018
To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of 1,635 isolates and compared these with 3,144 isolates...
The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants
Ruklanthi de Alwis, Le Thi Phuong Tu, Nhi Le Thi Quynh, Corinne N Thompson, Katherine L Anders, Nguyen Thi Van Thuy, Nguyen Trong Hieu, Lu Lan Vi, Nguyen Van Vinh Chau, Vu Thuy Duong, Tran Thi Hong Chau, Ha Thanh Tuyen, Tran Vu Thieu Nga, Pham Van Minh, Trinh Van Tan, Trang Nguyen Hoang Thu, Tran Do Hoang Nhu, Guy E Thwaites, Cameron Simmons, Stephen Baker
Apr 09, 2019
BACKGROUND: Nontyphoidal Salmonella (NTS) organisms are a major cause of gastroenteritis and bacteremia, but little is known about maternally acquired immunity and natural exposure in infant populations residing in areas where...
Prognostic models for 9 month mortality in tuberculous meningitis
Le Thi Phuong Thao, A Dorothee Heemskerk, Ronald B Geskus, Nguyen Thi Hoang Mai, Dang Thi Minh Ha, Tran Thi Hong Chau, Nguyen Hoan Phu, Nguyen Van Vinh Chau, Maxine Caws, Nguyen Huu Lan, Do Dang Anh Thu, Nguyen Thuy Thuong Thuong, Jeremy Day, Jeremy J Farrar, M Estee Torok, Nguyen Duc Bang, Guy E Thwaites, Marcel Wolbers
May 02, 2018
Tumour microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients.
Hoang NH Tran, Trang Nguyen Hoang Thu, Phu Huu Nguyen, Chi Nguyen Vo, Khanh Van Doan, Chau Nguyen Ngoc Minh, Ngoc Tuan Nguyen, Van Ngoc Duc Ta, Khuong An Vu, Thanh Danh Hua, To Nguyen Thi Nguyen, Tan Trinh Van, Trung Pham Duc, Ba Lap Duong, Phuc Minh Nguyen, Vinh Chuc Hoang, Duy Thanh Pham, Guy E Thwaites, Lindsay J Hall, Daniel J Slade, Stephen Baker, Vinh Hung Tran, Hao Chung The
Oct 29, 2022
Perturbations in the gut microbiome have been associated with colorectal cancer (CRC), with the colonic overabundance of Fusobacterium nucleatum shown as the most consistent marker. Despite its significance in the promotion of...
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