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Results: 423
Targeted long-read sequencing identifies missing pathogenic variants in unsolved Werner syndrome cases.
Danny E Miller, Lin Lee, Miranda Galey, Renuka Kandhaya-Pillai, Marc Tischkowitz, Deepak Amalnath, Avadh Vithlani, Koutaro Yokote, Hisaya Kato, Yoshiro Maezawa, Aki Takada-Watanabe, Minoru Takemoto, George M Martin, Evan E Eichler, Fuki M Hisama, Junko Oshima
May 11, 2022
BACKGROUND: Werner syndrome (WS) is an autosomal recessive progeroid syndrome caused by variants in WRN. The International Registry of Werner Syndrome has identified biallelic pathogenic variants in 179/188 cases of classical...
Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes.
Werner Syndrome (WS) and Bloom Syndrome (BS) are disorders of DNA damage repair caused by biallelic disruption of the WRN or BLM DNA helicases respectively. Both are commonly associated with insulin resistant diabetes, usually...
Efficient Adaptive Designs for Clinical Trials of Interventions for COVID-19.
Nigel Stallard, Lisa Hampson, Norbert Benda, Werner Brannath, Thomas Burnett, Tim Friede, Peter K Kimani, Franz Koenig, Johannes Krisam, Pavel Mozgunov, Martin Posch, James Wason, Gernot Wassmer, John Whitehead, S Faye Williamson, Sarah Zohar, Thomas Jaki
Jul 07, 2020
The COVID-19 pandemic has led to an unprecedented response in terms of clinical research activity. An important part of this research has been focused on randomized controlled clinical trials to evaluate potential therapies for...
Efficient Adaptive Designs for Clinical Trials of Interventions for COVID-19.
Nigel Stallard, Lisa Hampson, Norbert Benda, Werner Brannath, Thomas Burnett, Tim Friede, Peter K Kimani, Franz Koenig, Johannes Krisam, Pavel Mozgunov, Martin Posch, James Wason, Gernot Wassmer, John Whitehead, S Faye Williamson, Sarah Zohar, Thomas Jaki
Aug 02, 2021
The COVID-19 pandemic has led to an unprecedented response in terms of clinical research activity. An important part of this research has been focused on randomized controlled clinical trials to evaluate potential therapies for...
Pandemic research Adaptive trial SARS-CoV-2 group sequential design Platform trial Multi-arm multi-stage
Published by: Statistics in biopharmaceutical research
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D. Upton, Sonja Loges, Nicholas W. Morrell, Werner Seeger, Ralph T. Schermuly
Jan 28, 2022
Abstract: Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e....
Very Large Array Radio Study of a Sample of Nearby X-Ray and Optically Bright Early-type Galaxies
Abstract
Many massive early-type galaxies host central radio sources and hot X-ray atmospheres indicating the presence of radio-mechanical active galactic nucleus (AGN) feedback....
Romana Grossová, Norbert Werner, Francesco Massaro, Kiran Lakhchaura, Tomáš Plšek, Krisztina Gabányi, Kamlesh Rajpurohit, Rebecca EA Canning, Paul Nulsen, Ewan O’Sullivan, Steven W Allen, Andrew Fabian
Jan 28, 2022
Very Large Array Radio Study of a Sample of Nearby X-Ray and Optically Bright Early-type Galaxies
Abstract
Many massive early-type galaxies host central radio sources and hot X-ray atmospheres indicating the presence of radio-mechanical active galactic nucleus (AGN) feedback....
Romana Grossová, Norbert Werner, Francesco Massaro, Kiran Lakhchaura, Tomáš Plšek, Krisztina Gabányi, Kamlesh Rajpurohit, Rebecca EA Canning, Paul Nulsen, Ewan O’Sullivan, Steven W Allen, Andrew Fabian
Feb 09, 2022
Monographs of the RIMR. Vol. 13, 1920
The Rockefeller University
Jan 01, 0001
The Early Stages of Tabanidae (Horse-flies) by Werner Marchand
Published by: The Rockefeller Institute for Medical Research
The Meaningfulness of Knowledge for the Design of Sustainable AI
A growing number of business processes can be characterized as knowledge-intensive. The ability to speed up the necessary transfer of knowledge between individuals in business processes can lead to a huge competitive advantage...
Published by: IGI Global Scientific Publishing
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2.
Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D Upton, Sonja Loges, Nicholas W Morrell, Werner Seeger, Ralph T Schermuly
Sep 25, 2021
Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e., monocrotaline and...
Published by: Communications biology
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2.
Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul Upton, Sonja Loges, Nicholas Morrell, Werner Seeger, Ralph T Schermuly
Oct 26, 2021
Published by: Communications biology
Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.
Oleg Pak, Susan Scheibe, Azadeh Esfandiary, Mareike Gierhardt, Akylbek Sydykov, Angela Logan, Athanasios Fysikopoulos, Florian Veit, Matthias Hecker, Florian Kroschel, Karin Quanz, Alexandra Erb, Katharina Schäfer, Mirja Fassbinder, Nasim Alebrahimdehkordi, Hossein A Ghofrani, Ralph T Schermuly, Ralf P Brandes, Werner Seeger, Michael P Murphy, Norbert Weissmann, Natascha Sommer
Jun 18, 2018
Increased mitochondrial reactive oxygen species (ROS), particularly superoxide have been suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced pulmonary hypertension (PH) and right ventricular...
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D. Upton, Sonja Loges, Nicholas W. Morrell, Werner Seeger, Ralph T. Schermuly
Aug 26, 2021
Abstract: Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e....
Time Propagation and Spectroscopy of Fermionic Systems Using a Stochastic Technique.
We present a stochastic method for solving the time-dependent Schrödinger equation, generalizing a ground state full configuration interaction quantum Monte Carlo method. By performing the time integration in the complex plane...
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2.
Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D Upton, Sonja Loges, Nicholas W Morrell, Werner Seeger, Ralph T Schermuly
Jan 28, 2022
Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e., monocrotaline and...
A hidden Markov model for describing turbostratic disorder applied to carbon blacks and graphene
A mathematical framework is presented to represent turbostratic disorder in materials like carbon blacks, smectites and twisted n-layer graphene. In particular, the set of all possible disordered layers, including rotated...
A hidden Markov model for describing turbostratic disorder applied to carbon blacks and graphene
A mathematical framework is presented to represent turbostratic disorder in materials like carbon blacks, smectites and twisted n-layer graphene. In particular, the set of all possible disordered layers, including rotated...
Addressing Sustainability of Sanitation Systems
Recently, a technical draft of the international standard ISO/DIS 30500 for non-sewered sanitation systems has been developed (publication expected for 2018). Its innovative feature is the inclusion of sustainable aspects. This...
IT Policy & Standardization Computer Science and Information Technology IT Policy and Standardization
Published by: IGI Global Scientific Publishing
Resolution of Low-Energy States in Spin-Exchange Transition-Metal Clusters
Polynuclear transition-metal (PNTM) clusters owe their catalytic activity to numerous energetically low-lying spin states and stable oxidation states. The characterization of their electronic structure represents one of the...
Linguistic Distances in Dialectometric Intensity Estimation
Dialectometric intensity estimation as introduced in Rumpf etal. (2009) and Pickl and Rumpf (2011, 2012) is a method for the unsupervised generation of maps visualizing geolinguistic data on the level of linguistic...
Hareth Al-Janabi, Job Van Exel, Werner Brouwer, Caroline Trotter, Linda Glennie, Laurie Hannigan, Joanna Coast
Sep 21, 2015
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