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Fine-scale computations for adaptive processing in the human brain
Adapting to the environment statistics by reducing brain responses to repetitive sensory information is key for efficient information processing. Yet, the fine-scale computations that support this adaptive processing in the...
Immunocapture of <i>Escherichia coli</i> in a fluoropolymer microcapillary array
Isabel P. Alves, Nuno Reis
Jan 25, 2019
This study presents novel experimental insights into the direct quantitation and immunocapture of bacteria cells in a fluoropolymer microcapillary array, using Escherichia coli as work model, a pathogen responsible for around...
Microfluidic smartphone quantitation of <i>Escherichia coli</i> in synthetic urine
Isabel P Alves, Nuno M Reis
Dec 01, 2019

In spite of the clinical need, there is a major gap in rapid diagnostics for identification and quantitation of E. coli and other pathogens, also regarded as the biggest bottleneck in the fight against the spread of...

Microfluidic smartphone quantitation of <i>Escherichia coli</i> in synthetic urine
Isabel P Alves, Nuno M Reis
Dec 01, 2019

In spite of the clinical need, there is a major gap in rapid diagnostics for identification and quantitation of E. coli and other pathogens, also regarded as the biggest bottleneck in the fight against the spread of...

Transparent, Hydrophobic Fluorinated Ethylene Propylene Offers Rapid, Robust, and Irreversible Passive Adsorption of Diagnostic Antibodies for Sensitive Optical Biosensing

Current literature data is scarce and somehow contradictory in respect to the suitability of "nonstick" fluoropolymer surfaces for immobilization of biomolecules. We have previously shown empirically that transparent Teflon...

Immunocapture of <i>Escherichia coli</i> in a fluoropolymer microcapillary array
Isabel P. Alves, Nuno Reis
Jan 25, 2019
This study presents novel experimental insights into the direct quantitation and immunocapture of bacteria cells in a fluoropolymer microcapillary array, using Escherichia coli as work model, a pathogen responsible for around...
Transparent, Hydrophobic Fluorinated Ethylene Propylene Offers Rapid, Robust, and Irreversible Passive Adsorption of Diagnostic Antibodies for Sensitive Optical Biosensing

Current literature data is scarce and somehow contradictory in respect to the suitability of "nonstick" fluoropolymer surfaces for immobilization of biomolecules. We have previously shown empirically that transparent Teflon...

Antibody Surface Coverage Drives Matrix Interference in Microfluidic Capillary Immunoassays

The performance of biosensors is often optimized in buffers, which brings inconsistencies during applications with biological samples. Current strategies for minimizing sample (matrix) interference are complex to automate and...

Fast prototyping using 3D printed templates and flexible fluoropolymer microcapillary films offers enhanced micromixing in immobilised (bio)catalytic reactions

Microreactors offer large surface-area-to-volume (SAV) ratios and short diffusion distances, yet, even at sub-millimetre space, there remains a level of mass transfer control of reactions. This can be minimised using passive...

Fast prototyping using 3D printed templates and flexible fluoropolymer microcapillary films offers enhanced micromixing in immobilised (bio)catalytic reactions

Microreactors offer large surface-area-to-volume (SAV) ratios and short diffusion distances, yet, even at sub-millimetre space, there remains a level of mass transfer control of reactions. This can be minimised using passive...

Sensitive optical detection of clinically relevant biomarkers in affordable microfluidic devices

One of the biggest challenges in miniaturization of optical immunoassays is the short light path distance of microchannels/microcapillaries. Protein biomarkers are often presented in circulating blood in the...

Sensitive optical detection of clinically relevant biomarkers in affordable microfluidic devices

One of the biggest challenges in miniaturization of optical immunoassays is the short light path distance of microchannels/microcapillaries. Protein biomarkers are often presented in circulating blood in the...

Antibody Surface Coverage Drives Matrix Interference in Microfluidic Capillary Immunoassays

The performance of biosensors is often optimized in buffers, which brings inconsistencies during applications with biological samples. Current strategies for minimizing sample (matrix) interference are complex to automate and...

Selective photocatalytic synthesis of benzaldehyde in microcapillaries with immobilized carbon nitride

Photocatalysis on microfluidic reactors can be an environmental-friendly strategy to conventional chemical synthesis methods to find selective and efficient processes to produce high value-added molecules. In this work, we...

Microcapillary film reactor outperforms single-bore mesocapillary reactors in continuous flow chemical reactions

Meso- and micro-flow reactors are routinely used in continuous flow chemistry, however the role of capillary diameter, D, on conversion and reaction rates is often overlooked during scale-up. Volume, pressured drop and...

Selective photocatalytic synthesis of benzaldehyde in microcapillaries with immobilized carbon nitride

Photocatalysis on microfluidic reactors can be an environmental-friendly strategy to conventional chemical synthesis methods to find selective and efficient processes to produce high value-added molecules. In this work, we...

Integrated Cu-Au stereo microelectrode arrays and microfluidic channels for the electrochemical detection of glucose

Noble and transition metal nanomaterials are widely used in glucose sensing. However, the fabrication of these sensors still suffers from complex nanomaterial synthesis process and unstable nanomaterial loading on sensing...

Label-free 1D microfluidic dipstick counting of microbial colonies and bacteriophage plaques

Counting viable bacterial cells and functional bacteriophage is fundamental to microbiology underpinning research, surveillance, biopharmaceuticals and diagnostics. Colony forming unit (CFU) and plaque forming unit (PFU)...

Label-free 1D microfluidic dipstick counting of microbial colonies and bacteriophage plaques

Counting viable bacterial cells and functional bacteriophage is fundamental to microbiology underpinning research, surveillance, biopharmaceuticals and diagnostics. Colony forming unit (CFU) and plaque forming unit (PFU)...

Photodegradation and ecotoxicology of acyclovir in water under UV254 and UV 254/H2O2 processes
The photochemical and ecotoxicological fate of acyclovir (ACY) through UV254 direct photolysis and in the presence of hydroxyl radicals (UV254/H2O2 process) were investigated in a microcapillary film (MCF) array photoreactor...

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