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Results: 62
The benefit of minocycline on negative symptoms in early-phase psychosis in addition to standard care - extent and mechanism (BeneMin)
Danuta M Lisiecka, John Suckling, Thomas RE Barnes, Imran B Chaudhry, Paola Dazzan, Nusrat Husain, Peter B Jones, Eileen M Joyce, Stephen M Lawrie, Rachel Upthegrove, Bill Deakin
May 01, 2018
BACKGROUND: Negative symptoms of psychosis do not respond to the traditional therapy with first- or second-generation antipsychotics and are among main causes of a decrease in quality of life observed in individuals suffering...
Clinical Protocols Double-Blind Method Humans Magnetic Resonance Imaging Minocycline Neuroprotective Agents Outcome Assessment Health Care Psychotic Disorders
Published by: Trials
A review of published spoligotype data indicates the diversity of Mycobacterium tuberculosis from India is under-represented in global databases.
BACKGROUND: Mycobacterium tuberculosis (MTBC) lineages differ in clinical presentation, virulence, transmission, drug resistance and immunological responses. Despite having the largest burden of tuberculosis (TB) in the world...
Deconstructing depression and negative symptoms of schizophrenia; differential and longitudinal immune correlates, and response to minocycline treatment.
Carl R Krynicki, Paola Dazzan, Carmine M Pariante, Nicholas M Barnes, Rachel C Vincent, Alex Roberts, Annalisa Giordano, Andrew Watson, John Suckling, Thomas RE Barnes, Nusrat Husain, Peter B Jones, Eileen Joyce, Stephen M Lawrie, Shôn Lewis, Bill Deakin, Rachel Upthegrove, BeneMin Study team
Nov 20, 2020
BACKGROUND: Immune dysfunction has been implicated in negative symptoms of schizophrenia and also in depression. These disorders are frequently co-morbid, with some symptoms such as anhedonia and apathy common to both. The...
Properties of isolated red pulp macrophages from mouse spleen
[No abstract available]
Published by: Rockefeller University
Algae Involved Generation of Compost
This research investigated the potential application of blue-green algae to improve the quality of composts generated from multiple waste streams including- fly ash, fish waste, and sludge from a local wastewater treatment...
Diversifying Representations of Female Scientists on Social Media
In the absence of real-life role models, women scientists portrayed in the media enable young women to imagine themselves as future scientists. Both traditional media and social media have the potential to provide role...
Alexandra A Phillips, Catherine R Walsh, Korie A Grayson, Camilla E Penney, Fatima Husain
Aug 01, 2022
Algae Involved Generation of Compost
This research investigated the potential application of blue-green algae to improve the quality of composts generated from multiple waste streams including- fly ash, fish waste, and sludge from a local wastewater treatment...
Mechanisms Underlying Motivational Dysfunction in Schizophrenia
Negative symptoms are a debilitating feature of schizophrenia which are often resistant to pharmacological intervention. The mechanisms underlying them remain poorly understood, and diagnostic methods rely on phenotyping through...
The Graded Fate of Unattended Stimulus Representations in Visuospatial Working Memory.
As in visual perception, information can be selected for prioritized processing at the expense of unattended representations in visual working memory (VWM). However, what is not clear is whether and how this prioritization...
The benefit of minocycline on negative symptoms of schizophrenia in patients with recent-onset psychosis (BeneMin)
Bill Deakin, John Suckling, Thomas RE Barnes, Kelly Byrne, Imran B Chaudhry, Paola Dazzan, Richard J Drake, Annalisa Giordano, Nusrat Husain, Peter B Jones, Eileen Joyce, Emma Knox, Carl Krynicki, Stephen M Lawrie, Shôn Lewis, Danuta M Lisiecka-Ford, Naghmeh Nikkheslat, Carmine M Pariante, Richard Smallman, Andrew Watson, Steven Cr Williams, Rachel Upthegrove, Graham Dunn, BeneMin Study team
Dec 10, 2018
BACKGROUND: The antibiotic minocycline has neuroprotective and anti-inflammatory properties that could prevent or reverse progressive neuropathic changes implicated in recent-onset schizophrenia. In the BeneMin study, we aimed...
Long-term strategies to control COVID-19 in low and middle-income countries
Rajiv Chowdhury, Shammi Luhar, Nusrat Khan, Sohel Reza Choudhury, Imran Matin, Oscar H. Franco
Sep 10, 2020
Abstract: In low and middle-income countries (LMICs), strict social distancing measures (e.g., nationwide lockdown) in response to the COVID-19 pandemic are unsustainable in the long-term due to knock-on socioeconomic and...
Effect of Social Presence on Behavioral Intention to Social Commerce Through Online Social Capital
This research aims to observe how social presence influences online social capital and the behavioral intention of social commerce (s-commerce). The online survey with a structured questionnaire is used to collect data and...
Published by: IGI Global Scientific Publishing
Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease.
Jonathan Tay, Robin G Morris, Anil M Tuladhar, Masud Husain, Frank-Erik de Leeuw, Hugh S Markus
Jun 03, 2020
OBJECTIVE: To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. METHODS: Analyses used two prospective cohort studies of SVD: St. George's Cognition and Neuroimaging in...
Differential relationships between apathy and depression with white matter microstructural changes and functional outcomes.
Matthew J Hollocks, Andrew J Lawrence, Rebecca L Brookes, Thomas R Barrick, Robin G Morris, Masud Husain, Hugh S Markus
Sep 15, 2015
Long-term strategies to control COVID-19 in low and middle-income countries
Rajiv Chowdhury, Shammi Luhar, Nusrat Khan, Sohel Reza Choudhury, Imran Matin, Oscar H Franco
Aug 26, 2020
In low and middle-income countries (LMICs), strict social distancing measures (e.g., nationwide lockdown) in response to the COVID-19 pandemic are unsustainable in the long-term due to knock-on socioeconomic and psychological...
covid-19 Exit plan Local lockdown Low and middle-income countries Mitigation Non-pharmacological interventions Rolling lockdown Zonal lockdown Betacoronavirus covid-19 Communicable Disease Control coronavirus Coronavirus Infections Humans masks Pandemics Pneumonia Viral Public Health Quarantine SARS-CoV-2 Social Isolation
Long-term strategies to control COVID-19 in low and middle-income countries
Rajiv Chowdhury, Shammi Luhar, Nusrat Khan, Sohel Reza Choudhury, Imran Matin, Oscar H. Franco
Jul 28, 2021
Abstract: In low and middle-income countries (LMICs), strict social distancing measures (e.g., nationwide lockdown) in response to the COVID-19 pandemic are unsustainable in the long-term due to knock-on socioeconomic and...
Mechanisms Underlying Motivational Dysfunction in Schizophrenia.
Negative symptoms are a debilitating feature of schizophrenia which are often resistant to pharmacological intervention. The mechanisms underlying them remain poorly understood, and diagnostic methods rely on phenotyping through...
Stochastic Resilience in Operations Management Using Ito Diffusion and Gamma Catastrophe Processes
This study introduces a novel Ito diffusion model for operations management, addressing the challenge of maintaining resilience in supply chains and production networks against unpredictable disruptions. The model incorporates a...
Published by: IGI Global Scientific Publishing
OBITUARY (2007-2010)
Riaz-ul Islam
Dec 14, 2019
The Department of History (General), University of Karachi will always be indebted to the galaxy of great scholars and exemplary teachers who contributed their selfless services for the uplift of the department and promotion of...
Published by: Department of History, University of Karachi
Apathy is associated with large-scale white matter network disruption in small vessel disease.
Jonathan Tay, Anil M Tuladhar, Matthew J Hollocks, Rebecca L Brookes, Daniel J Tozer, Thomas R Barrick, Masud Husain, Frank-Erik de Leeuw, Hugh S Markus
Jan 16, 2019
OBJECTIVE: To investigate whether white matter network disruption underlies the pathogenesis of apathy, but not depression, in cerebral small vessel disease (SVD). METHODS: Three hundred thirty-one patients with SVD from the...
Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease
Jonathan Tay, Robin G Morris, Anil M Tuladhar, Masud Husain, Frank-Erik de Leeuw, Hugh S Markus
Jul 14, 2020
Objective: To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. Methods: Analyses used two prospective cohort studies of SVD: St. George’s Cognition and Neuroimaging in...
Published by: BMJ Publishing Group
Aging Increases Prosocial Motivation for Effort.
Patricia L Lockwood, Ayat Abdurahman, Anthony S Gabay, Daniel Drew, Marin Tamm, Masud Husain, Matthew AJ Apps
May 20, 2021
Social cohesion relies on prosociality in increasingly aging populations. Helping other people requires effort, yet how willing people are to exert effort to benefit themselves and others, and whether such behaviors shift across...
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