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Unselected Population Genetic Testing for Personalised Ovarian Cancer Risk Prediction
Faiza Gaba, Samuel Oxley, Xinting Liu, Xin Yang, Dhivya Chandrasekaran, Jatinderpal Kalsi, Antonis Antoniou, Lucy Side, Saskia Sanderson, Jo Waller, Munaza Ahmed, Andrew Wallace, Yvonne Wallis, Usha Menon, Ian Jacobs, Rosa Legood, Dalya Marks, Ranjit Manchanda
Apr 21, 2022
Unselected population-based personalised ovarian cancer (OC) risk assessments combining genetic, epidemiological and hormonal data have not previously been undertaken. We aimed to understand the attitudes, experiences and impact...
Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention
Faiza Gaba, Oleg Blyuss, Xinting Liu, Shivam Goyal, Nishant Lahoti, Dhivya Chandrasekaran, Margarida Kurzer, Jatinderpal Kalsi, Saskia Sanderson, Anne Lanceley, Munaza Ahmed, Lucy Side, Aleksandra Gentry-Maharaj, Yvonne Wallis, Andrew Wallace, Jo Waller, Craig Luccarini, Xin Yang, Joe Dennis, Alison Dunning, Andrew Lee, Antonis C. Antoniou, Rosa Legood, Usha Menon, Ian Jacobs, Ranjit Manchanda
May 16, 2020
Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC risk stratification of...
Open-circuit Air-gap Magnetic Field Calculation of Interior Permanent Magnet Synchronous Motor with V-shaped Segmented Skewed Poles Using Hybrid Analytical Method
Yuansheng An, Conggan Ma, Nic Zhang, Yue Guo, Michele Degano, Chris Gerada, Qiongyao Li, Shensen Zhou
Dec 31, 2021
Due to the local inhomogeneous magnetic saturation of the core of the interior permanent magnet synchronous motor (IPMSM), the magnetic field changes nonlinearly, which makes the analytical calculation of the magnetic field...
Hybrid analytical method V-shaped segmented skewed poles interior permanent magnet synchronous motor (IPMSM) magnetic bridge saturation open-circuit air-gap magnetic field (OC-AG-MF) /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
Dynamic transcriptional response of Saccharomyces cerevisiae cells to copper.
Copper is a crucial trace element for all living systems and any deficiency in copper homeostasis leads to the development of severe diseases in humans. The observation of extensive evolutionary conservation in copper...
Algorithms Cluster Analysis Computational Biology Copper Copper Transport Proteins Endocytosis Gene Deletion Gene Expression Regulation Fungal Homeostasis Homozygote Iron Mutation Oligonucleotide Array Sequence Analysis Phylogeny Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins sulfur Transcription Genetic Ubiquitin
Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention.
Faiza Gaba, Oleg Blyuss, Xinting Liu, Shivam Goyal, Nishant Lahoti, Dhivya Chandrasekaran, Margarida Kurzer, Jatinderpal Kalsi, Saskia Sanderson, Anne Lanceley, Munaza Ahmed, Lucy Side, Aleksandra Gentry-Maharaj, Yvonne Wallis, Andrew Wallace, Jo Waller, Craig Luccarini, Xin Yang, Joe Dennis, Alison Dunning, Andrew Lee, Antonis C Antoniou, Rosa Legood, Usha Menon, Ian Jacobs, Ranjit Manchanda
May 12, 2020
UNLABELLED: Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC risk...
A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene.
Caitlin T Fierheller, Laure Guitton-Sert, Wejdan M Alenezi, Timothée Revil, Kathleen K Oros, Yuandi Gao, Karine Bedard, Suzanna L Arcand, Corinne Serruya, Supriya Behl, Liliane Meunier, Hubert Fleury, Eleanor Fewings, Deepak N Subramanian, Javad Nadaf, Jeffrey P Bruce, Rachel Bell, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Jacek Majewski, Trevor J Pugh, Marc Tischkowitz, Paul A James, Ian G Campbell, Celia MT Greenwood, Jiannis Ragoussis, Jean-Yves Masson, Patricia N Tonin
Dec 22, 2021
BACKGROUND: Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination (HR) of DNA, could involve pathogenic variants...
Cancer-predisposing gene DNA Repair Fanci Familial aggregation of cancer Fanconi anaemia pathway Hereditary cancer ovarian cancer Protein expression Tissue microarray Whole exome sequencing BRCA1 Protein BRCA2 Protein Breast Neoplasms Canada Fanconi Anemia Complementation Group Proteins Female Genetic Predisposition to Disease Humans Male Ovarian Neoplasms
Dynamic transcriptional response of Saccharomyces cerevisiae cells to copper
Abstract: Copper is a crucial trace element for all living systems and any deficiency in copper homeostasis leads to the development of severe diseases in humans. The observation of extensive evolutionary conservation in copper...
Open-circuit Air-gap Magnetic Field Calculation of Interior Permanent Magnet Synchronous Motor with V-shaped Segmented Skewed Poles Using Hybrid Analytical Method
Yuansheng An, Conggan Ma, Nic Zhang, Yue Guo, Michele Degano, Chris Gerada, Qiongyao Li, Shensen Zhou
Dec 31, 2021
Due to the local inhomogeneous magnetic saturation of the core of the interior permanent magnet synchronous motor (IPMSM), the magnetic field changes nonlinearly, which makes the analytical calculation of the magnetic field...
Hybrid analytical method V-shaped segmented skewed poles interior permanent magnet synchronous motor (IPMSM) magnetic bridge saturation open-circuit air-gap magnetic field (OC-AG-MF) /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
Unselected Population Genetic Testing for Personalised Ovarian Cancer Risk Prediction
Faiza Gaba, Samuel Oxley, Xinting Liu, Xin Yang, Dhivya Chandrasekaran, Jatinderpal Kalsi, Antonis Antoniou, Lucy Side, Saskia Sanderson, Jo Waller, Munaza Ahmed, Andrew Wallace, Yvonne Wallis, Usha Menon, Ian Jacobs, Rosa Legood, Dalya Marks, Ranjit Manchanda
Jun 29, 2022
Unselected population-based personalised ovarian cancer (OC) risk assessments combining genetic, epidemiological and hormonal data have not previously been undertaken. We aimed to understand the attitudes, experiences and impact...
Optic Chiasm Morphometric Changes in Multiple Sclerosis
Sophisticated volume measurements of brain structures on magnetic resonance imaging (MRI) may improve specificity in determining long-term progression of multiple sclerosis (MS), but these techniques are laborious. The optic...
Techniques for Selecting the Optimal Parameters of One-Class Support Vector Machine Classifier for Reduced Samples
Usually, the One-Class Support Vector Machine (OC-SVM) requires a large dataset for modeling effectively the target class independently to other classes. For finding the OC-SVM model, the available dataset is subdivided into two...
Published by: IGI Global Scientific Publishing
Facing the "new normal"
Naomi A Fineberg, Luca Pellegrini, David Wellsted, Natalie Hall, Ornella Corazza, Valentina Giorgetti, Dorotea Cicconcelli, Elena Theofanous, Nick Sireau, David Adam, Samuel R Chamberlain, Keith R Laws
Aug 16, 2021
BACKGROUND: Re-establishing societal norms in the wake of the COVID-19 pandemic will be important for restoring public mental health and psychosocial wellbeing as well as economic recovery. We investigated the impact on...
Molecular Genetic Characteristics of <i>FANCI</i>, a Proposed New Ovarian Cancer Predisposing Gene.
Caitlin T Fierheller, Wejdan M Alenezi, Corinne Serruya, Timothée Revil, Setor Amuzu, Karine Bedard, Deepak N Subramanian, Eleanor Fewings, Jeffrey P Bruce, Stephenie Prokopec, Luigi Bouchard, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Marc Tischkowitz, Ian G Campbell, Trevor J Pugh, Celia M T Greenwood, Jiannis Ragoussis, Patricia N Tonin
Mar 28, 2023
FANCI was recently identified as a new candidate ovarian cancer (OC)-predisposing gene from the genetic analysis of carriers of FANCI c.1813C>T; p.L605F in OC families. Here, we aimed to investigate the molecular...
ovarian cancer Hereditary cancer Whole exome sequencing TCGA Fanci Fanconi Anemia Pathway Cancer Predisposing Gene Humans Ovarian Neoplasms Genetic Predisposition to Disease Molecular Biology Mutation Genes BRCA2 Female Fanconi Anemia Complementation Group Proteins
Published by: Genes
Do Power and Commitment Impart Organizational Citizenship Behavior?
Shaping the behavior of the employees determines one of the crucial duties of the organizations. Mobilizing power and getting commitment from individuals is the foundation for effective organizational citizenship behavior (OCB)....
Published by: IGI Global Scientific Publishing
Promiscuous and Selective
Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific
Background: In a mammalian host, the cell surface of African trypanosomes is protected by a monolayer of a single variant surface glycoprotein (VSG). The VSG is central to antigenic variation; one VSG gene is expressed at any...
Verifying community-wide exposure to endocrine disruptors in personal care products – In quest for metabolic biomarkers of exposure via in vitro studies and wastewater-based epidemiology
This study aimed to identify human specific metabolites of selected known or suspected endocrine disruptors (EDCs), mainly UV filters, used in personal care and consumer products whose metabolism has hardly been explored and...
Endocrine disruptor Environment EPIDEMIOLOGY exposure Personal care product UV filter Wastewater /dk/atira/pure/subjectarea/asjc/2300/2302 name=Ecological Modelling /dk/atira/pure/subjectarea/asjc/2300/2312 name=Water Science and Technology /dk/atira/pure/subjectarea/asjc/2300/2311 name=Waste Management and Disposal /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution
Cost-effectiveness of Population-Based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 Mutation Testing in Unselected General Population Women.
Ranjit Manchanda, Shreeya Patel, Vladimir S Gordeev, Antonis C Antoniou, Shantel Smith, Andrew Lee, John L Hopper, Robert J Macinnis, Clare Turnbull, Susan J Ramus, Simon A Gayther, Paul DP Pharoah, Usha Menon, Ian Jacobs, Rosa Legood
Jan 12, 2018
BACKGROUND: The cost-effectiveness of population-based panel testing for high- and moderate-penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We evaluate the cost-effectiveness of population-based...
Adult Aged Aged 80 and over BRCA1 Protein BRCA2 Protein Breast Neoplasms Cost-Benefit Analysis DNA Mutational Analysis Decision Support Techniques Fanconi Anemia Complementation Group N Protein Fanconi Anemia Complementation Group Proteins Female Genetic Testing Humans Incidence Mammography Middle Aged Mutation Ovarian Neoplasms RNA Helicases United Kingdom United States
Pancreas deficiency modifies bone development in the ovine fetus near term.
Hormones have an important role in the regulation of fetal growth and development, especially in response to nutrient availability in utero. Using micro-CT and an electromagnetic three-point bend test, this study examined the...
Pancreas deficiency modifies bone development in the ovine fetus near term.
Stuart A Lanham, Dominique Blache, Richard OC Oreffo, Abigail L Fowden, Alison J Forhead
Jan 06, 2022
Hormones have an important role in the regulation of fetal growth and development, especially in response to nutrient availability in utero. Using micro-CT and an electromagnetic three-point bend test, this study examined the...
Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury.
Anna K Uryga, Mandy O J Grootaert, Abel M Garrido, Sebnem Oc, Kirsty Foote, Joel Chappell, Alison Finigan, Francesca Rossiello, Fabrizio d'Adda di Fagagna, Dimitra Aravani, Helle F Jorgensen, Martin R Bennett
Jun 22, 2021
Accumulation of vascular smooth muscle cells (VSMCs) is a hallmark of multiple vascular pathologies, including following neointimal formation after injury and atherosclerosis. However, human VSMCs in advanced atherosclerotic...
Published by: Communications biology
Sex- and bone-specific responses in bone structure to exogenous leptin and leptin receptor antagonism in the ovine fetus.
Miles J De Blasio, Stuart A Lanham, Dominique Blache, Richard OC Oreffo, Abigail L Fowden, Alison J Forhead
Apr 27, 2018
Widespread expression of leptin and its receptor in developing cartilage and bone suggests that leptin may regulate bone growth and development in the fetus. Using microcomputed tomography, this study investigated the effects of...
Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury.
Anna K Uryga, Mandy OJ Grootaert, Abel M Garrido, Sebnem Oc, Kirsty Foote, Joel Chappell, Alison Finigan, Francesca Rossiello, Fabrizio d'Adda di Fagagna, Dimitra Aravani, Helle F Jorgensen, Martin R Bennett
Apr 15, 2021
Accumulation of vascular smooth muscle cells (VSMCs) is a hallmark of multiple vascular pathologies, including following neointimal formation after injury and atherosclerosis. However, human VSMCs in advanced atherosclerotic...
Animals Atherosclerosis Cell Proliferation Cells Cultured Cellular Senescence DNA Damage Disease Models Animal Humans Inflammation Male Mice Mice Inbred C57BL Mice Knockout Microfilament Proteins Muscle Proteins Muscle Smooth Vascular Myocytes Smooth Muscle Neointima Telomere Telomeric Repeat Binding Protein 2
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