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Approaches and advances in the genetic causes of autoimmune disease and their implications
Genome-wide association studies are transformative in revealing the polygenetic basis of common diseases, with autoimmune diseases leading the charge. Although the field is just over 10 years old, advances in understanding the...
Health-related quality of life after traumatic brain injury
Daphne C Voormolen, Suzanne Polinder, Nicole von Steinbuechel, Yan Feng, Lindsay Wilson, Mark Oppe, Juanita A Haagsma, CENTER-TBI Participants and Investigators
Nov 10, 2020
PURPOSE: The Quality of Life after Brain Injury overall scale (QOLIBRI-OS) measures health-related quality of life (HRQoL) after traumatic brain injury (TBI). The aim of this study was to derive value sets for the QOLIBRI-OS in...
Health utilities Health-related quality of life Quality of life after brain injury overall scale (QOLIBRI-OS) Traumatic brain injury Value set Adolescent Adult Aged Brain Injuries Traumatic Female Humans Italy Male Middle Aged Netherlands Quality of life Surveys and Questionnaires United Kingdom Young Adult
Golden Eye
File systems are important sources of intelligence information and digital evidence. They have long attracted the interest of researchers in recovering files that are deleted from a hard disk. Existing file recovery studies rely...
Published by: IGI Global Scientific Publishing
Balancing Identity
Derek Bolton
Jun 10, 2021
Scholarship on ontological security (OS), the security of being, reveals how national narratives delineate communities within which individuals have OS and how the corresponding self-interest in upholding these narratives...
Validation of the online prediction tool PREDICT v. 2.0 in the Dutch breast cancer population.
MC van Maaren, CD van Steenbeek, PDP Pharoah, A Witteveen, GS Sonke, LJA Strobbe, PMP Poortmans, S Siesling
Jan 30, 2018
BACKGROUND: PREDICT version 2.0 is increasingly used to estimate prognosis in breast cancer. This study aimed to validate this tool in specific prognostic subgroups in the Netherlands. METHODS: All operated women with...
Breast Cancer overall survival PREDICT Population-based study Prediction model validation Adult Aged Antineoplastic Agents Hormonal Area Under Curve Biomarkers Tumor Breast Neoplasms Chemotherapy Adjuvant Chi-Square Distribution Clinical Decision-Making Decision Support Techniques Female Humans Mastectomy Middle Aged Neoplasm Grading Neoplasm Staging Netherlands Patient Selection Precision Medicine Predictive Value of Tests ROC Curve Receptors Estrogen Registries Reproducibility of Results Risk Factors Time Factors Treatment Outcome
The unbearable lightness of being? Reconfiguring the moral underpinnings and sources of ontological security
Derek Bolton
Jul 31, 2023
While ontological security (OS) studies have gone through a recent evolution, shifting toward psychoanalytic and existential accounts of anxiety, this article argues there remains a deficient engagement with the affective...
Outcome prediction of head and neck squamous cell carcinoma by MRI radiomic signatures.
Steven W Mes, Floris HP van Velden, Boris Peltenburg, Carel FW Peeters, Dennis E Te Beest, Mark A van de Wiel, Joost Mekke, Doriene C Mulder, Roland M Martens, Jonas A Castelijns, Frank A Pameijer, Remco de Bree, Ronald Boellaard, C René Leemans, Ruud H Brakenhoff, Pim de Graaf
Jun 04, 2021
OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) shows a remarkable heterogeneity between tumors, which may be captured by a variety of quantitative features extracted from diagnostic images, termed radiomics. The aim...
Factor Analysis Head and Neck Neoplasms Magnetic Resonance Imaging Prognosis Aged Area Under Curve Biomarkers Comorbidity Disease-Free Survival Factor Analysis Statistical Female Head and Neck Neoplasms Humans Kaplan-Meier Estimate Magnetic Resonance Imaging Male Middle Aged Neoplasm Recurrence Local Observer Variation Prognosis Radiometry Reproducibility of Results Retrospective Studies Squamous Cell Carcinoma of Head and Neck Treatment Outcome
Balancing Identity
Derek Bolton
Jun 10, 2021
Scholarship on ontological security (OS), the security of being, reveals how national narratives delineate communities within which individuals have OS and how the corresponding self-interest in upholding these narratives...
Genome-Wide Meta-Analysis Identifies Variants in DSCAM and PDLIM3 That Correlate with Efficacy Outcomes in Metastatic Renal Cell Carcinoma Patients Treated with Sunitinib.
Meta HM Diekstra, Jesse J Swen, Loes FM van der Zanden, Sita H Vermeulen, Epie Boven, Ron HJ Mathijssen, Koya Fukunaga, Taisei Mushiroda, Fumiya Hongo, Egbert Oosterwijk, Anne Cambon-Thomsen, Daniel Castellano, Achim Fritsch, Jesus Garcia Donas, Cristina Rodriguez-Antona, Rob Ruijtenbeek, Marius T Radu, Tim Eisen, Kerstin Junker, Max Roessler, Ulrich Jaehde, Tsuneharu Miki, Stefan Böhringer, Michiaki Kubo, Lambertus ALM Kiemeney, Henk-Jan Guchelaar
Jul 24, 2022
Individual response to sunitinib in metastatic renal cell carcinoma (mRCC) patients is highly variable. Earlier, sunitinib outcome was related to single nucleotide polymorphisms (SNPs) in CYP3A5 and ABCB1. Our aim is to provide...
An open toolkit for tracking open science partnership implementation and impact.
E Richard Gold, Sarah E Ali-Khan, Liz Allen, Lluis Ballell, Manoel Barral-Netto, David Carr, Damien Chalaud, Simon Chaplin, Matthew S Clancy, Patricia Clarke, Robert Cook-Deegan, AP Dinsmore, Megan Doerr, Lisa Federer, Steven A Hill, Neil Jacobs, Antoine Jean, Osmat Azzam Jefferson, Chonnettia Jones, Linda J Kahl, Thomas M Kariuki, Sophie N Kassel, Robert Kiley, Elizabeth Robboy Kittrie, Bianca Kramer, Wen Hwa Lee, Emily MacDonald, Lara M Mangravite, Elizabeth Marincola, Daniel Mietchen, Jennifer C Molloy, Mark Namchuk, Brian A Nosek, Sébastien Paquet, Claude Pirmez, Annabel Seyller, Malcolm Skingle, S Nicole Spadotto, Sophie Staniszewska, Mike Thelwall
Jan 27, 2020
Serious concerns about the way research is organized collectively are increasingly being raised. They include the escalating costs of research and lower research productivity, low public trust in researchers to report the truth...
How does safety netting for lung cancer symptoms help patients to reconsult appropriately? A qualitative study.
Georgia B Black, Sandra van Os, Cristina Renzi, Fiona Walter, Willie Hamilton, Katriina L Whitaker
Aug 05, 2022
BACKGROUND: Safety netting in primary care is considered an important intervention for managing diagnostic uncertainty. This is the first study to examine how patients understand and interpret safety netting advice around...
η2-SO2 Linkage Photoisomer of an Osmium Coordination Complex.
Jacqueline M Cole, Jose de J Velazquez-Garcia, David J Gosztola, SuYin Grass Wang, Yu-Sheng Chen
Oct 18, 2018
We report the discovery of an η2-SO2 linkage photoisomer in the osmium pentaammine coordination complex, [Os(NH3)5(SO2)][Os(NH3)5(HSO3)]Cl4 (1). Its dark- and light-induced crystal structures are determined via synchrotron X-ray...
Prognostic effect of cytoreductive nephrectomy in synchronous metastatic renal cell carcinoma
Tobias Klatte, Kate Fife, Sarah J Welsh, Manavi Sachdeva, James N Armitage, Tevita 'Aho, Antony C Riddick, Athena Matakidou, Tim Eisen, Grant D Stewart
Feb 23, 2018
PURPOSE: To test the hypothesis that cytoreductive nephrectomy (CN) improves overall survival (OS) of patients with synchronous metastatic renal cell carcinoma (mRCC), who subsequently receive targeted therapies (TT). METHODS...
Nephrectomy Pazopanib Prognosis Sunitinib survival Aged Anilides Antibodies Monoclonal Antineoplastic Agents Carcinoma Renal Cell Cohort Studies Combined Modality Therapy Cytoreduction Surgical Procedures Female Humans Indazoles Indoles Kaplan-Meier Estimate Kidney Neoplasms Liver Neoplasms Lung Neoplasms Male Middle Aged Molecular Targeted Therapy Neoplasm Metastasis Nephrectomy Nivolumab Probability Prognosis Proportional Hazards Models Pyridines Pyrimidines Pyrroles Retrospective Studies Sex Factors Sulfonamides Sunitinib Survival Rate Thrombocytosis
Taking care of our future doctors
Rebecca Jacob, Tsz-Yan Li, Zoe Martin, Amanda Burren, Peter Watson, Rhian Kant, Richard Davies, Diana F Wood
Jun 19, 2020
BACKGROUND: Studies suggest medical students experience high levels of mental distress during training but are less likely, than other students, to access care due to stigma and concerns regarding career progression. In...
Chromosome contacts in activated T cells identify autoimmune disease candidate genes
OS Burren, AR garcia, B-M javierre, DB Rainbow, J Cairns, NJ cooper, JJ Lambourne, E schofield, X dopico, RC Ferreira, R coulson, F Burden, SP rowlston, K Downes, S Wingett, M Frontini, WH Ouwehand, P Fraser, M Spivakov, JA Todd, LS Wicker, AJ Cutler, CE Wallace
Sep 05, 2017
How does safety netting for lung cancer symptoms help patients to reconsult appropriately? A qualitative study.
Georgia B Black, Sandra van Os, Cristina Renzi, Fiona Walter, Willie Hamilton, Katriina L Whitaker
Jul 21, 2022
BACKGROUND: Safety netting in primary care is considered an important intervention for managing diagnostic uncertainty. This is the first study to examine how patients understand and interpret safety netting advice around...
Scheduling nab-paclitaxel combined with gemcitabine as first-line treatment for metastatic pancreatic adenocarcinoma.
PG Corrie, W Qian, B Basu, JW Valle, S Falk, C Lwuji, H Wasan, D Palmer, M Scott-Brown, J Wadsley, S Arif, J Bridgewater, D Propper, R Gillmore, A Gopinathan, R Skells, P Bundi, R Brais, K Dalchau, L Bax, A Chhabra, A Machin, A Dayim, K McAdam, S Cummins, L Wall, R Ellis, A Anthoney, J Evans, YT Ma, C Isherwood, A Neesse, D Tuveson, DI Jodrell
May 11, 2020
BACKGROUND: Nab-paclitaxel plus gemcitabine (nabP+gemcitabine) offers modest survival gains for patients with metastatic pancreatic ductal adenocarcinoma (PDAC). Sequential scheduling of nabP+gemcitabine in a PDAC mouse model...
Metastatic chromophobe renal cell carcinoma treated with targeted therapies
E Colomba, G Le Teuff, T Eisen, GD Stewart, K Fife, J Larkin, A Biondo, L Pickering, A Srinivasan, H Boyle, L Derosa, CN Sternberg, F Recine, C Ralph, C Saldana, P Barthelemy, JC Bernhard, H Gurney, G Verhoest, E Vauleon, P Bigot, J Berger, C Pfister, G Gravis, J-M Rodier, S Culine, A Caty, F Rolland, F Priou, B Escudier, L Albiges
Jul 31, 2017
$\textbf{Background}$
Treatment of non–clear cell renal cell carcinoma (RCC) remains controversial despite several recent prospective studies of targeted therapies (TT). Often Vascular Endothelial growth Factor (VEGF) and...
Treatment and outcomes of UK and German patients with relapsed intracranial germ cell tumors following uniform first-line therapy
MJ Murray, S Bailey, K Heinemann, J Mann, UK Göbel, F Saran, JP Hale, G Calaminus, JC Nicholson
Jul 17, 2017
We aimed to retrospectively assess treatments/outcomes, including the value of high-dose-chemotherapy and autologous-stem-cell-rescue (HDC + AuSCR) and re-irradiation, in a large, European patient-cohort with relapsed...
Advanced Hodgkin lymphoma in the East of England
James Russell, Angela Collins, Alexis Fowler, Mamatha Karanth, Chandan Saha, Suzanne Docherty, Joseph Padayatty, Kyaw Maw, Isabel Lentell, Lisa Cooke, Andrew Hodson, Nimish Shah, Shalal Sadullah, Nicholas Grigoropoulos, Wendi Qian, Amy A Kirkwood, Benjamin J Uttenthal, Peter Johnson, George A Follows
Mar 15, 2021
Treatment with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) or escalated(e)-BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisolone) remains the international...
ABVD Advanced stage Escalated BEACOPP Hodgkin lymphoma Real-world data Response-adapted therapy Adolescent Adult Antineoplastic Combined Chemotherapy Protocols Bleomycin Clinical Trials as Topic Combined Modality Therapy cyclophosphamide Dacarbazine Doxorubicin England Etoposide Female Follow-Up Studies Hematopoietic Stem Cell Transplantation Hodgkin Disease Humans Kaplan-Meier Estimate Male Middle Aged Multicenter Studies as Topic prednisone Pregnancy Pregnancy Complications Neoplastic Procarbazine Progression-Free Survival Retrospective Studies Treatment Outcome Vinblastine Vincristine Young Adult
The unbearable lightness of being? Reconfiguring the moral underpinnings and sources of ontological security
Derek Bolton
Jul 31, 2023
While ontological security (OS) studies have gone through a recent evolution, shifting toward psychoanalytic and existential accounts of anxiety, this article argues there remains a deficient engagement with the affective...
Approximating Generalized Network Design under (Dis)economies of Scale with Applications to Energy Efficiency
In a generalized network design (GND) problem, a set of resources are assigned (non-exclusively) to multiple requests. Each request contributes its weight to the resources it uses and the total load on a resource is then...
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