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Results: 17
EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome.
Shengjiang Tan, Laëtitia Kermasson, Angela Hoslin, Pekka Jaako, Alexandre Faille, Abraham Acevedo-Arozena, Etienne Lengline, Dana Ranta, Maryline Poirée, Odile Fenneteau, Hubert Ducou le Pointe, Stefano Fumagalli, Blandine Beaupain, Patrick Nitschké, Christine Bôle-Feysot, Jean-Pierre de Villartay, Christine Bellanné-Chantelot, Jean Donadieu, Caroline Kannengiesser, Alan J Warren, Patrick Revy
May 15, 2019
Adolescent Animals Cells Cultured DNA Mutational Analysis Disease Models Animal Disease Susceptibility Female Genome-Wide Association Study Humans Infant Male Mice Mice Transgenic Models Molecular Mutation Pedigree Peptide Elongation Factors Peptide Initiation Factors Phenotype Protein Conformation Ribonucleoprotein U5 Small Nuclear Shwachman-Diamond Syndrome Structure-Activity Relationship whole genome sequencing
The role of habit in compulsivity.
Claire M Gillan, Trevor W Robbins, Barbara J Sahakian, Odile A van den Heuvel, Guido van Wingen
Jan 06, 2016
MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints.
Andrea Vergallo, Simone Lista, Yuhai Zhao, Pablo Lemercier, Stefan J Teipel, Marie-Claude Potier, Marie-Odile Habert, Bruno Dubois, Walter J Lukiw, Harald Hampel, INSIGHT-preAD study group, Alzheimer Precision Medicine Initiative (APMI)
Jan 27, 2021
There is substantial experimental evidence for dysregulation of several microRNA (miRNA) expression levels in Alzheimer's disease (AD). MiRNAs modulate critical brain intracellular signaling pathways and are associated with AD...
Brain circuitry of compulsivity.
Odile A van den Heuvel, Guido van Wingen, Carles Soriano-Mas, Pino Alonso, Samuel R Chamberlain, Takashi Nakamae, Damiaan Denys, Anna E Goudriaan, Dick J Veltman
Jan 07, 2016
Anxiety Compulsivity Cortico-striato-thalamico-cortical circuits Limbic Neuroimaging Animals Antipsychotic Agents Anxiety Brain Cognition Cognitive Behavioral Therapy Combined Modality Therapy Compulsive Behavior Compulsive Personality Disorder Humans Limbic System Models Neurological Nerve Net Neurogenesis Neuronal Plasticity Obsessive-Compulsive Disorder
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Irina Kufareva, Benoit Bestgen, Paul Brear, Renaud Prudent, Béatrice Laudet, Virginie Moucadel, Mohamed Ettaoussi, Celine F Sautel, Isabelle Krimm, Matthias Engel, Odile Filhol, Marc Le Borgne, Thierry Lomberget, Claude Cochet, Ruben Abagyan
Dec 06, 2019
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by...
In Depth Exploration of the Alternative Proteome of Drosophila melanogaster.
Bertrand Fabre, Sebastien A Choteau, Carine Duboé, Carole Pichereaux, Audrey Montigny, Dagmara Korona, Michael Deery, Mylène Camus, Christine Brun, Odile Burlet-Schiltz, Steve Russell, Jean-Philippe Combier, Kathryn S Lilley, Serge Plaza
Jun 17, 2022
Recent studies have shown that hundreds of small proteins were occulted when protein-coding genes were annotated. These proteins, called alternative proteins, have failed to be annotated notably due to the short length of their...
In Depth Exploration of the Alternative Proteome of Drosophila melanogaster.
Bertrand Fabre, Sebastien A Choteau, Carine Duboé, Carole Pichereaux, Audrey Montigny, Dagmara Korona, Michael J Deery, Mylène Camus, Christine Brun, Odile Burlet-Schiltz, Steven Russell, Jean-Philippe Combier, Kathryn S Lilley, Serge Plaza
Jul 20, 2022
Recent studies have shown that hundreds of small proteins were occulted when protein-coding genes were annotated. These proteins, called alternative proteins, have failed to be annotated notably due to the short length of their...
A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease.
Pradeep J Nathan, S Babli Millais, Alex Godwood, Odile Dewit, David M Cross, Janet Liptrot, Bharat Ruparelia, Stephen Paul Jones, Geor Bakker, Paul T Maruff, Gregory A Light, Alastair JH Brown, Malcolm Peter Weir, Miles Congreve, Tim Tasker
Feb 23, 2022
Genomic characterization of novel Neisseria species
Kanny Diallo, Jenny MacLennan, Odile B. Harrison, Chisomo Msefula, Samba O. Sow, Doumagoum M. Daugla, Errin Johnson, Caroline Trotter, Calman A. MacLennan, Julian Parkhill, Ray Borrow, Brian M. Greenwood, Martin C. J. Maiden
Sep 23, 2020
Abstract: Of the ten human-restricted Neisseria species two, Neisseria meningitidis, and Neisseria gonorrhoeae, cause invasive disease: the other eight are carried asymptomatically in the pharynx, possibly modulating...
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Irina Kufareva, Benoit Bestgen, Paul Brear, Renaud Prudent, Béatrice Laudet, Virginie Moucadel, Mohamed Ettaoussi, Celine F Sautel, Isabelle Krimm, Matthias Engel, Odile Filhol, Marc Le Borgne, Thierry Lomberget, Claude Cochet, Ruben Abagyan
Nov 03, 2020
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by...
Adenosine Triphosphate Binding Sites Casein Kinase II Catalytic Domain Cell Line Tumor Cell Movement Cell Proliferation Crystallography X-Ray Holoenzymes Humans Kinetics Molecular Docking Simulation Peptides Phosphorylation Protein Kinase Inhibitors Protein Subunits Substrate Specificity Surface Plasmon Resonance
Hierarchical genomic analysis of carried and invasive serogroup A Neisseria meningitidis during the 2011 epidemic in Chad
Kanny Diallo, Kadija Gamougam, Doumagoum M Daugla, Odile B Harrison, James E Bray, Dominique A Caugant, Jay Lucidarme, Caroline Louise Trotter, Musa Hassan-King, James M Stuart, Olivier Manigart, Brian M Greenwood, Martin CJ Maiden
Aug 11, 2017
Published by: BioMed Central
Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.
Ismail Syed, Jennifer Lee, Pedro M Moraes-Vieira, Cynthia J Donaldson, Alexandra Sontheimer, Pratik Aryal, Kerry Wellenstein, Matthew J Kolar, Andrew T Nelson, Dionicio Siegel, Jacek Mokrosinski, I Sadaf Farooqi, Juan Juan Zhao, Mark M Yore, Odile D Peroni, Alan Saghatelian, Barbara B Kahn
Aug 08, 2019
FAHFA GLP-1 receptor GPR40 glucose-insulin homeostasis human islets Insulin Secretion palmitic acid hydroxystearic acid Type 2 diabetes Adiposity Animals Eating Glucose HEK293 Cells Homeostasis Humans Inflammation Insulin Resistance Mice Inbred C57BL Palmitic Acid Receptors G-Protein-Coupled Stearic Acids
Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk
Nasim Mavaddat, Antonis C. Antoniou, Thea M. Mooij, Maartje J. Hooning, Bernadette A. Heemskerk-Gerritsen, Catherine Noguès, Marion Gauthier-Villars, Olivier Caron, Paul Gesta, Pascal Pujol, Alain Lortholary, Daniel Barrowdale, Debra Frost, D. Gareth Evans, Louise Izatt, Julian Adlard, Ros Eeles, Carole Brewer, Marc Tischkowitz, Alex Henderson, Jackie Cook, Diana Eccles, Klaartje van Engelen, Marian J. E. Mourits, Margreet G. E. M. Ausems, Linetta B. Koppert, John L. Hopper, Esther M. John, Wendy K. Chung, Irene L. Andrulis, Mary B. Daly, Saundra S. Buys, Javier Benitez, Trinidad Caldes, Anna Jakubowska, Jacques Simard, Christian F. Singer, Yen Tan, Edith Olah, Marie Navratilova, Lenka Foretova, Anne-Marie Gerdes, Marie-José Roos-Blom, Flora E. Van Leeuwen, Brita Arver, Håkan Olsson, Rita K. Schmutzler, Christoph Engel, Karin Kast, Kelly-Anne Phillips, Mary Beth Terry, Roger L. Milne, David E. Goldgar, Matti A. Rookus, Nadine Andrieu, Douglas F. Easton, Lilian Laborde, Emmanuel Breysse, Dominique Stoppa-Lyonnet, Bruno Buecher, Emmanuelle Fourme-Mouret, Jean-Pierre Fricker, Christine Lasset, Valérie Bonadona, Pascaline Berthet, Laurence Faivre, Elisabeth Luporsi, Véronique Mari, Laurence Gladieff, Hagay Sobol, François Eisinger, Michel Longy, Catherine Dugast, Chrystelle Colas, Isabelle Coupier, Carole Corsini, Philippe Vennin, Claude Adenis, Tan Dat Nguyen, Capucine Delnatte, Julie Tinat, Isabelle Tennevet, Jean-Marc Limacher, Christine Maugard, Yves-Jean Bignon, Liliane Demange, Clotilde Penet, Hélène Dreyfus, Odile Cohen-Haguenauer, Laurence Venat-Bouvet, Dominique Leroux, Hélène Zattara-Cannoni, Sandra Fert-Ferrer, Odile Bera, Steve Ellis, F. B. L. Hogervorst, J. M. Collée, C. J. van Asperen, A. R. Mensenkamp, M. G. E. M. Ausems, H. E. J. Meijers-Heijboer, K. van Engelen, M. J. Blok, J. C. Oosterwijk, J. Verloop, E. van den Broek
Jan 15, 2021
Abstract: Background: The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be...
Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk
Nasim Mavaddat, Antonis C. Antoniou, Thea M. Mooij, Maartje J. Hooning, Bernadette A. Heemskerk-Gerritsen, Catherine Noguès, Marion Gauthier-Villars, Olivier Caron, Paul Gesta, Pascal Pujol, Alain Lortholary, Daniel Barrowdale, Debra Frost, D. Gareth Evans, Louise Izatt, Julian Adlard, Ros Eeles, Carole Brewer, Marc Tischkowitz, Alex Henderson, Jackie Cook, Diana Eccles, Klaartje van Engelen, Marian J. E. Mourits, Margreet G. E. M. Ausems, Linetta B. Koppert, John L. Hopper, Esther M. John, Wendy K. Chung, Irene L. Andrulis, Mary B. Daly, Saundra S. Buys, Javier Benitez, Trinidad Caldes, Anna Jakubowska, Jacques Simard, Christian F. Singer, Yen Tan, Edith Olah, Marie Navratilova, Lenka Foretova, Anne-Marie Gerdes, Marie-José Roos-Blom, Flora E. Van Leeuwen, Brita Arver, Håkan Olsson, Rita K. Schmutzler, Christoph Engel, Karin Kast, Kelly-Anne Phillips, Mary Beth Terry, Roger L. Milne, David E. Goldgar, Matti A. Rookus, Nadine Andrieu, Douglas F. Easton, Lilian Laborde, Emmanuel Breysse, Dominique Stoppa-Lyonnet, Bruno Buecher, Emmanuelle Fourme-Mouret, Jean-Pierre Fricker, Christine Lasset, Valérie Bonadona, Pascaline Berthet, Laurence Faivre, Elisabeth Luporsi, Véronique Mari, Laurence Gladieff, Hagay Sobol, François Eisinger, Michel Longy, Catherine Dugast, Chrystelle Colas, Isabelle Coupier, Carole Corsini, Philippe Vennin, Claude Adenis, Tan Dat Nguyen, Capucine Delnatte, Julie Tinat, Isabelle Tennevet, Jean-Marc Limacher, Christine Maugard, Yves-Jean Bignon, Liliane Demange, Clotilde Penet, Hélène Dreyfus, Odile Cohen-Haguenauer, Laurence Venat-Bouvet, Dominique Leroux, Hélène Zattara-Cannoni, Sandra Fert-Ferrer, Odile Bera, Steve Ellis, F. B. L. Hogervorst, J. M. Collée, C. J. van Asperen, A. R. Mensenkamp, M. G. E. M. Ausems, H. E. J. Meijers-Heijboer, K. van Engelen, M. J. Blok, J. C. Oosterwijk, J. Verloop, E. van den Broek
Jun 06, 2020
Abstract: Background: The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be...
Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings.
Eva Velthorst, Josephine Mollon, Robin M Murray, Lieuwe de Haan, Inez Myin Germeys, David C Glahn, Celso Arango, Els van der Ven, Marta Di Forti, Miguel bernardo, Sinan Guloksuz, Philippe Delespaul, Gisela Mezquida, Silvia Amoretti, Julio Bobes, Pilar A Saiz, María Paz García-Portilla, José Luis Santos, Estela Jiménez-López, Julio Sanjuan, Eduardo J Aguilar, Manuel Arrojo, Angel Carracedo, Gonzalo López, Javier González-Peñas, Mara Parellada, Cem Atbaşoğlu, Meram Can Saka, Alp Üçok, Köksal Alptekin, Berna Akdede, Tolga Binbay, Vesile Altınyazar, Halis Ulaş, Berna Yalınçetin, Güvem Gümüş-Akay, Burçin Cihan Beyaz, Haldun Soygür, Eylem Şahin Cankurtaran, Semra Ulusoy Kaymak, Nadja P Maric, Marina M Mihaljevic, Sanja Andric Petrovic, Tijana Mirjanic, Cristina Marta Del-Ben, Laura Ferraro, Charlotte Gayer-Anderson, Peter B Jones, Hannah E Jongsma, James B Kirkbride, Caterina La Cascia, Antonio Lasalvia, Sarah Tosato, Pierre-Michel Llorca, Paulo Rossi Menezes, Craig Morgan, Diego Quattrone, Marco Menchetti, Jean-Paul Selten, Andrei Szöke, Ilaria Tarricone, Andrea Tortelli, Philip McGuire, Lucia Valmaggia, Matthew J Kempton, Mark van der Gaag, Anita Riecher-Rössler, Rodrigo A Bressan, Neus Barrantes-Vidal, Barnaby Nelson, Patrick McGorry, Chris Pantelis, Marie-Odile Krebs, Stephan Ruhrmann, Gabriele Sachs, Bart PF Rutten, Jim van Os, Behrooz Z Alizadeh, Therese van Amelsvoort, Agna A Bartels-Velthuis, Richard Bruggeman, Nico J van Beveren, Jurjen J Luykx, Wiepke Cahn, Claudia JP Simons, Rene S Kahn, Frederike Schirmbeck, Ruud van Winkel, EU-GEI High Risk Study, Abraham Reichenberg
Nov 24, 2020