Search
Results: 320
Development of System Typology and Choice of Preferred Simulation Modelling Methods for DSS-Toolkit
Oleg Dmitriev
Jan 01, 2022
This paper formulated a position on the feasibility of developing and applying a highly developed simulation models of complex object within scope of justifying of managerial decisions. It selected a set of classification...
Published by: IGI Global Scientific Publishing
A generative model for age and income distribution
Abstract Each individual in society experiences an evolution of their income during their lifetime. Macroscopically, this dynamic creates a statistical relationship between age and income for each...
Inferring extrinsic noise from single-cell gene expression data using approximate Bayesian computation.
BACKGROUND: Gene expression is known to be an intrinsically stochastic process which can involve single-digit numbers of mRNA molecules in a cell at any given time. The modelling of such processes calls for the use of exact...
Human Computer Interaction During Clinical Decision Support With Electronic Health Records Improvement
Katerina Bolgova, Sergey Kovalchuk, Marina Balakhontceva, Nadezhda Zvartau, Oleg Metsker
Jan 01, 2020
This study investigated the most common challenges of human-computer interaction (HCI) while using electronic health records (EHR) based on the experience of a large Russian medical research center. The article presents the...
Published by: IGI Global Scientific Publishing
Behavioural deficits in transgenic mice expressing human truncated (1-120 amino acid) alpha-synuclein.
ALPHA-SYNUCLEIN dementia with Lewy bodies Memory neurodegeneration Transgenic mouse Age Factors Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2 Disease Models Animal Exploratory Behavior Gene Expression Regulation Humans Lewy Body Disease Male Maze Learning Mice Mice Inbred C57BL Mice Transgenic Peptide Fragments Prosencephalon RNA Messenger ALPHA-SYNUCLEIN
Evaluation of transabdominal and transperineal ultrasound-derived prostate specific antigen (PSA) density and clinical utility compared to MRI prostate volumes
Maria Pantelidou, Iztok Caglic, Anne George, Oleg Blyuss, Vincent J Gnanapragasam, Tristan Barrett
Sep 09, 2022
PURPOSE: To investigate the accuracy of surface-based ultrasound-derived PSA-density (US-PSAD) versus gold-standard MRI-PSAD as a risk-stratification tool. METHODS: Single-centre prospective study of patients undergoing MRI for...
MRI-derived radiomics model for baseline prediction of prostate cancer progression on active surveillance
Nikita Sushentsev, Leonardo Rundo, Oleg Blyuss, Vincent J. Gnanapragasam, Evis Sala, Tristan Barrett
Jun 21, 2021
Abstract: Nearly half of patients with prostate cancer (PCa) harbour low- or intermediate-risk disease considered suitable for active surveillance (AS). However, up to 44% of patients discontinue AS within the first five years...
MRI-derived radiomics model for baseline prediction of prostate cancer progression on active surveillance.
Nikita Sushentsev, Leonardo Rundo, Oleg Blyuss, Vincent J Gnanapragasam, Evis Sala, Tristan Barrett
Jun 04, 2021
Evaluation of transabdominal and transperineal ultrasound-derived prostate specific antigen (PSA) density and clinical utility compared to MRI prostate volumes
Maria Pantelidou, Iztok Caglic, Anne George, Oleg Blyuss, Vincent J Gnanapragasam, Tristan Barrett
Oct 12, 2022
PURPOSE: To investigate the accuracy of surface-based ultrasound-derived PSA-density (US-PSAD) versus gold-standard MRI-PSAD as a risk-stratification tool. METHODS: Single-centre prospective study of patients undergoing MRI for...
Block Copolymer Micelles for Photonic Fluids and Crystals.
Mikko Poutanen, Giulia Guidetti, Tina I Gröschel, Oleg V Borisov, Silvia Vignolini, Olli Ikkala, Andre H Gröschel
Dec 17, 2018
Block copolymer micelles (BCMs) are self-assembled nanoparticles in solution with a collapsed core and a brush-like stabilizing corona typically in the size range of tens of nanometers. Despite being widely studied in various...
Thoracic metastasis in advanced ovarian cancer
OBJECTIVE: To determine which computed tomography (CT) imaging features predict pleural malignancy in patients with advanced epithelial ovarian carcinoma (EOC) using video-assisted thoracic surgery (VATS), pathology, and...
Remobilization of dormant carbon from Siberian-Arctic permafrost during three past warming events.
Jannik Martens, Birgit Wild, Francesco Muschitiello, Matt O'Regan, Martin Jakobsson, Igor Semiletov, Oleg V Dudarev, Örjan Gustafsson
Oct 20, 2020
Carbon cycle models suggest that past warming events in the Arctic may have caused large-scale permafrost thaw and carbon remobilization, thus affecting atmospheric CO2 levels. However, observational records are sparse...
Integrative analysis of copy number and gene expression in breast cancer using formalin-fixed paraffin-embedded core biopsy tissue
Mahesh Iddawela, Oscar Rueda, Jenny Eremin, Oleg Eremin, Jed Cowley, Helena Earl, Carlos Caldas
Jan 16, 2018
Humans Breast Neoplasms Formaldehyde Paraffin Embedding Tissue Fixation Feasibility Studies Gene Expression Profiling Gene Dosage Adult Aged Middle Aged Female
Published by: BMC genomics
Integration of Machine Learning Methods to Dissect Genetically Imputed Transcriptomic Profiles in Alzheimer's Disease.
Carlo Maj, Tiago Azevedo, Valentina Giansanti, Oleg Borisov, Giovanna Maria Dimitri, Simeon Spasov, Alzheimer’s Disease Neuroimaging Initiative, Pietro Lió, Ivan Merelli
Dec 06, 2019
Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.
Michal Wegrzynowicz, Dana Bar-On, Laura Calo', Oleg Anichtchik, Mariangela Iovino, Jing Xia, Sergey Ryazanov, Andrei Leonov, Armin Giese, Jeffrey W Dalley, Christian Griesinger, Uri Ashery, Maria Grazia Spillantini
Jun 06, 2020
Parkinson's disease (PD) is characterized by the presence of α-synuclein aggregates known as Lewy bodies and Lewy neurites, whose formation is linked to disease development. The causal relation between α-synuclein aggregates and...
ALPHA-SYNUCLEIN Anle138b mouse model Parkinson’s disease Striatum Substantia Nigra dSTORM Animals Cell Death Disease Models Animal Dopaminergic Neurons Gait Mice Mice Transgenic Motor Activity Parkinson Disease protein aggregation Pathological Substantia Nigra Tyrosine 3-Monooxygenase ALPHA-SYNUCLEIN
Integrative analysis of copy number and gene expression in breast cancer using formalin-fixed paraffin-embedded core biopsy tissue
Mahesh Iddawela, Oscar Rueda, Jenny Eremin, Oleg Eremin, Jed Cowley, Helena M Earl, Carlos Caldas
Jul 12, 2017
BACKGROUND: An absence of reliable molecular markers has hampered individualised breast cancer treatments, and a major limitation for translational research is the lack of fresh tissue. There are, however, abundant banks of...
Density modification of cryo-EM maps.
Density modification uses expectations about features of a map such as a flat solvent and expected distributions of density in the region of the macromolecule to improve individual Fourier terms representing the map. This...
Comparative performance of MRI-derived PRECISE scores and delta-radiomics models for the prediction of prostate cancer progression in patients on active surveillance.
Nikita Sushentsev, Leonardo Rundo, Oleg Blyuss, Tatiana Nazarenko, Aleksandr Suvorov, Vincent J Gnanapragasam, Evis Sala, Tristan Barrett
Jan 04, 2022
Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.
Cynthia Tallant, Erica Valentini, Oleg Fedorov, Lois Overvoorde, Fleur M Ferguson, Panagis Filippakopoulos, Dmitri I Svergun, Stefan Knapp, Alessio Ciulli
Feb 03, 2015
Virulence and antimicrobial resistance genes are enriched in the plasmidome of clinical Escherichia coli isolates compared with wastewater isolates from western Kenya.
Sifuna Anthony Wawire, Oleg N Reva, Thomas J O'Brien, Wendy Figueroa, Victor Dinda, William A Shivoga, Martin Welch
Mar 15, 2021
Many low-middle income countries in Africa have poorly-developed infectious disease monitoring systems. Here, we employed whole genome sequencing (WGS) to investigate the presence/absence of antimicrobial resistance (AMR) and...
Comparative performance of MRI-derived PRECISE scores and delta-radiomics models for the prediction of prostate cancer progression in patients on active surveillance.
CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice.
Laura Caló, Eric Hidari, Michal Wegrzynowicz, Jeffrey W Dalley, Bernard L Schneider, Martyna Podgajna, Oleg Anichtchik, Emma Carlson, David Klenerman, Maria Grazia Spillantini
Jan 12, 2021
A Reversible Phase Transition for Sodium Insertion in Anatase TiO<sub>2</sub>
Wei Li, Mika Fukunishi, Benjamin Morgan, Olaf Borkiewicz, Karena Chapman, Valérie Pralong, Antoine Maignan, Oleg Lebedev, Jiwei Ma, Henri Groult, Shinichi Komaba, Damien Dambournet
Feb 28, 2017
Anatase TiO2 is a potential negative electrode for sodium-ion batteries. The
sodium storage mechanism is, however, still under debate, yet its comprehension is required to optimize the electrochemical properties....
sodium storage mechanism is, however, still under debate, yet its comprehension is required to optimize the electrochemical properties....
Impact of Solution Chemistry on Growth and Structural Features of Mo-Substituted Spinel Iron Oxides
Chérazade Haouari, Alexander G. Squires, Romain Berthelot, Lorenzo Stievano, Moulay Tahar Sougrati, Benjamin J. Morgan, Oleg I. Lebedev, Antonella Iadecola, Olaf J. Borkiewicz, Damien Dambournet
May 17, 2021
The effect of crystallizing solution chemistry on the chemistry of subsequently as-grown materials was investigated for Mo-substituted iron oxides prepared by thermally activated co-precipitation. In the presence of Mo ions...
|
|< |
< |
1 |