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Results: 72
Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes
George Hindy, Gunnar Engström, Susanna C Larsson, Matthew Traylor, Hugh S Markus, Olle Melander, Marju Orho-Melander, Stroke Genetics Network (SiGN)
Jun 21, 2018
BACKGROUND AND PURPOSE: Statin therapy is associated with a lower risk of ischemic stroke supporting a causal role of low-density lipoprotein (LDL) cholesterol. However, more evidence is needed to answer the question whether LDL...
Cholesterol HDL Cholesterol LDL Polymorphism Single Nucleotide stroke Triglycerides Brain Ischemia Causality cerebral small vessel diseases Cholesterol HDL Cholesterol LDL Humans Intracranial Arteriosclerosis Intracranial Embolism Mendelian Randomization Analysis Multivariate Analysis Polymorphism Single Nucleotide stroke Triglycerides
Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults.
Tibor V Varga, Azra Kurbasic, Mattias Aine, Pontus Eriksson, Ashfaq Ali, George Hindy, Stefan Gustafsson, Jian'an Luan, Dmitry Shungin, Yan Chen, Christina-Alexandra Schulz, Peter M Nilsson, Göran Hallmans, Inês Barroso, Panos Deloukas, Claudia Langenberg, Robert A Scott, Nicholas J Wareham, Lars Lind, Erik Ingelsson, Olle Melander, Marju Orho-Melander, Frida Renström, Paul W Franks
Aug 15, 2017
BACKGROUND: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes...
Prospective cohort study Genetic epidemiology longitudinal analysis Morbidity single nucleotide polymorphism Total cholesterol Triglycerides Adult Aged Coronary Artery Disease Cross-Sectional Studies Female Genetic Loci Genome-Wide Association Study Genotype Humans Lipids Male Meta-Analysis as Topic Middle Aged Polymorphism Single Nucleotide Prospective Studies Sweden White People
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
Siddhartha Jaiswal, Pradeep Natarajan, Alexander J Silver, Christopher J Gibson, Alexander G Bick, Eugenia Shvartz, Marie McConkey, Namrata Gupta, Stacey Gabriel, Diego Ardissino, Usman Baber, Roxana Mehran, Valentin Fuster, John Danesh, Philippe Frossard, Danish Saleheen, Olle Melander, Galina K Sukhova, Donna Neuberg, Peter Libby, Sekar Kathiresan, Benjamin L Ebert
Nov 28, 2017
Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke
Marios K Georgakis, Rainer Malik, Harry Björkbacka, Tiberiu A Pana, Serkalem Demissie, Colby Ayers, Mohamed A Elhadad, Myriam Fornage, Alexa S Beiser, Emelia J Benjamin, Matthijs S Boekholdt, Gunnar Engström, Christian Herder, Ron C Hoogeveen, Wolfgang Koenig, Olle Melander, Marju Orho-Melander, Alexandru Schiopu, Martin Söderholm, Nick Wareham, Christie M Ballantyne, Annette Peters, Sudha Seshadri, Phyo Kyaw Myint, Jan Nilsson, James A de Lemos, Martin Dichgans
Sep 06, 2019
Testicular organoid generation by a novel in vitro three-layer gradient system.
A system that models the testicular microenvironment and spermatogonial stem-cell (SSC) niche in vitro has not been produced yet. Here, we developed and characterized a novel three-dimensional multilayer model, the Three-Layer...
3D culture De novo morphogenesis Germ Cells Seminiferous tubules-like structures Sertoli Cells Testicular organoid Animals Blood-Testis Barrier Cell Differentiation Interleukin-1alpha Male Organoids Rats Sprague-Dawley Seminiferous Tubules Sertoli Cells Spermatozoa Testis Tissue Engineering Tretinoin Tumor Necrosis Factor-alpha
Organic solar cells based on non-fullerene acceptors.
Organic solar cells (OSCs) have been dominated by donor:acceptor blends based on fullerene acceptors for over two decades. This situation has changed recently, with non-fullerene (NF) OSCs developing very quickly. The power...
Time Propagation and Spectroscopy of Fermionic Systems Using a Stochastic Technique.
We present a stochastic method for solving the time-dependent Schrödinger equation, generalizing a ground state full configuration interaction quantum Monte Carlo method. By performing the time integration in the complex plane...
Organic solar cells based on non-fullerene acceptors.
Organic solar cells (OSCs) have been dominated by donor:acceptor blends based on fullerene acceptors for over two decades. This situation has changed recently, with non-fullerene (NF) OSCs developing very quickly. The power...
Published by: Nat Mater
Self-organising human gonads generated by a Matrigel-based gradient system.
Elizabeth Oliver, João Pedro Alves-Lopes, Femke Harteveld, Rod T Mitchell, Elisabet Åkesson, Olle Söder, Jan-Bernd Stukenborg
Nov 25, 2021
BACKGROUND: Advances in three-dimensional culture technologies have led to progression in systems used to model the gonadal microenvironment in vitro. Despite demonstrating basic functionality, tissue organisation is often...
Primary Human Testicular Cells Self-Organize into Organoids with Testicular Properties.
Yoni Baert, Joery De Kock, João P Alves-Lopes, Olle Söder, Jan-Bernd Stukenborg, Ellen Goossens
Dec 11, 2019
So far, successful de novo formation of testicular tissue followed by complete spermatogenesis in vitro has been achieved only in rodents. Our findings reveal that primary human testicular cells are able to self-organize into...
immunofluorescence inhibin B in vitro spermatogenesis Organoid Scaffold secretome Spermatogonia Testis Testosterone whole mount Biomarkers Cell Culture Techniques Cells Cultured Cytokines Gene Expression Hormones Humans Male Organogenesis Organoids Spermatogenesis Stem Cell Niche Testis Tissue Scaffolds
Waist circumference and a body shape index and prostate cancer risk and mortality.
Sylvia HJ Jochems, Angela M Wood, Christel Häggström, Marju Orho-Melander, Pär Stattin, Tanja Stocks
Apr 28, 2021
We recently found a negative association between body mass index (BMI) and the risk of localised prostate cancer (PCa), no association with advanced PCa, and a positive association with PCa-specific mortality. In a 15%...
Height, body mass index and prostate cancer risk and mortality by way of detection and cancer risk category.
Sylvia HJ Jochems, Pär Stattin, Christel Häggström, Bengt Järvholm, Marju Orho-Melander, Angela M Wood, Tanja Stocks
Oct 07, 2020
Obesity is a risk factor for advanced, but not localised, prostate cancer (PCa), and for poor prognosis. However, the detection of localised PCa through asymptomatic screening might influence these associations. We investigated...
Association between blood pressure and BMI with bladder cancer risk and mortality in 340,000 men in three Swedish cohorts.
Stanley Teleka, Sylvia HJ Jochems, Christel Häggström, Angela M Wood, Bengt Järvholm, Marju Orho-Melander, Fredrik Liedberg, Tanja Stocks
Mar 09, 2021
BACKGROUND: The relation between obesity, blood pressure (BP) and bladder cancer (BC) risk and mortality remains unclear, partially due to potential confounding by smoking, the strongest risk factor for BC, and not accounting...
Priorities for research on equity and health
Piroska Östlin, Ted Schrecker, Ritu Sadana, Josiane Bonnefoy, Lucy Gilson, Clyde Hertzman, Michael P Kelly, Tord Kjellstrom, Ronald Labonté, Olle Lundberg, Carles Muntaner, Jennie Popay, Gita Sen, Ziba Vaghri
Mar 04, 2021
Piroska Östlin and colleagues argue that a paradigm shift is needed to keep the focus on health equity within the social determinants of health research agenda.
Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Aurora Perez-Cornago, Francesca L Crowe, Paul N Appleby, Kathryn E Bradbury, Angela M Wood, Marianne Uhre Jakobsen, Laura Johnson, Carlotta Sacerdote, Marinka Steur, Elisabete Weiderpass, Anne Mette L Würtz, Tilman Kühn, Verena Katzke, Antonia Trichopoulou, Anna Karakatsani, Carlo La Vecchia, Giovanna Masala, Rosario Tumino, Salvatore Panico, Ivonne Sluijs, Guri Skeie, Liher Imaz, Dafina Petrova, J Ramón Quirós, Sandra Milena Colorado Yohar, Paula Jakszyn, Olle Melander, Emily Sonestedt, Jonas Andersson, Maria Wennberg, Dagfinn Aune, Elio Riboli, Matthias B Schulze, Emanuele Di Angelantonio, Nicholas J Wareham, John Danesh, Nita G Forouhi, Adam S Butterworth, Timothy J Key
May 07, 2021
BACKGROUND: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of...
Modifiable causes of premature death in middle-age in Western Europe
David C Muller, Neil Murphy, Mattias Johansson, Pietro Ferrari, Konstantinos K Tsilidis, Marie-Christine Boutron-Ruault, Francoise Clavel, Laureen Dartois, Kuanrong Li, Rudolf Kaaks, Cornelia Weikert, Manuela Bergmann, Heiner Boeing, Anne Tjønneland, Kim Overvad, M Luisa Redondo, Antonio Agudo, Elena Molina-Portillo, Jone M Altzibar, Lluís Cirera, Eva Ardanaz, Kay-Tee Khaw, Nicholas J Wareham, Timothy J Key, Ruth C Travis, Christina Bamia, Philippos Orfanos, Antonia Trichopoulou, Domenico Palli, Valeria Pala, Rosario Tumino, Paolo Vineis, Salvatore Panico, H Bas Bueno-De-Mesquita, WM Monique Verschuren, Ellen A Struijk, Petra H Peeters, Gunnar Engström, Olle Melander, Malin Sund, Elisabete Weiderpass, Guri Skeie, Eiliv Lund, Teresa Norat, Marc Gunter, Elio Riboli, Paul Brennan
Dec 04, 2017
Natriuretic peptides and integrated risk assessment for cardiovascular disease
Natriuretic Peptides Studies Collaboration, Peter Willeit, Stephen Kaptoge, Paul Welsh, Adam Butterworth, Rajiv Chowdhury, Sarah Spackman, Lisa Pennells, Pei Gao, Stephen Burgess, Daniel Freitag, Michael Sweeting, Angela Wood, Nancy Cook, Suzanne Judd, Stella Trompet, Vijay Nambi, Michael Olsen, Brendan Everett, Frank Kee, Johan Ärnlöv, Veikko Salomaa, Daniel Levy, Jussi Kauhanen, Jari Laukkanen, Maryam Kavousi, Toshiharu Ninomiya, Juan-Pablo Casas, Lori Daniels, Lars Lind, Caroline Kistorp, Jens Rosenberg, Thomas Mueller, Speranza Rubattu, Demosthenes Panagiotakos, Oscar Franco, James de Lemos, Andreas Luchner, Jorge Kizer, Stefan Kiechl, Jukka Salonen, S Goya Wannamethee, Rudolf de Boer, Børge Nordestgaard, Jonas Andersson, Torben Jørgensen, Olle Melander, Christie Ballantyne, Christopher DeFilippi, Paul Ridker, Mary Cushman, Wayne Rosamond, Simon Thompson, Vilmundur Gudnason, Naveed Sattar, John Danesh, Emanuele Di Angelantonio
Sep 20, 2016
Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA.
Mathilde Gersel Wegmann, Rikke Beck Jensen, Ajay Thankamony, Jan Frystyk, Edna Roche, Hilary Hoey, Jeremy Kirk, Guftar Shaikh, Sten-A Ivarsson, Olle Söder, David B Dunger, Anders Juul
Nov 19, 2019
BACKGROUND: Some children born small for gestational age (SGA) experience supra-physiological insulin-like growth factor-I (IGF-I) concentrations during GH treatment. However, measurements of total IGF-I concentrations may not...
Adiposity in Children Born Small for Gestational Age Is Associated With β-Cell Function, Genetic Variants for Insulin Resistance, and Response to Growth Hormone Treatment.
Ajay Thankamony, Rikke Beck Jensen, Susan M O'Connell, Felix Day, Jeremy Kirk, Malcolm Donaldson, Sten A Ivarsson, Olle Söder, Edna Roche, Hilary Hoey, Ken K Ong, David B Dunger, Anders Juul
Nov 20, 2015
Absorptiometry Photon Adiposity Body composition Body Height Child Child Preschool Female genetic variation Genotype Glucose Human Growth Hormone Humans Infant Newborn Infant Small for Gestational Age Insulin Insulin Resistance Insulin-Like Growth Factor I Insulin-Secreting Cells Male Pancreatic Function Tests Recombinant Proteins Treatment Outcome
Genetic markers of insulin sensitivity and insulin secretion are associated with spontaneous postnatal growth and response to growth hormone treatment in short SGA children
Rikke Beck Jensen, Ajay Thankamony, Felix Day, Robert A Scott, Claudia Langenberg, Jeremy Kirk, Malcolm Donaldson, Sten-A Ivarsson, Olle Söder, Edna Roche, Hilary Hoey, Anders Juul, Ken K Ong, David B Dunger
Aug 07, 2015
Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition.
Sofia Christakoudi, Artemisia Kakourou, Georgios Markozannes, Ioanna Tzoulaki, Elisabete Weiderpass, Paul Brennan, Marc Gunter, Christina C Dahm, Kim Overvad, Anja Olsen, Anne Tjønneland, Marie-Christine Boutron-Ruault, Anne-Laure Madika, Gianluca Severi, Verena Katzke, Tilman Kühn, Manuela M Bergmann, Heiner Boeing, Anna Karakatsani, Georgia Martimianaki, Paschalis Thriskos, Giovanna Masala, Sabina Sieri, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Antonio Agudo, Daniel Redondo-Sánchez, Sandra M Colorado-Yohar, Olatz Mokoroa, Olle Melander, Tanja Stocks, Christel Häggström, Sophia Harlid, Bas Bueno-de-Mesquita, Carla H van Gils, Roel CH Vermeulen, Kay-Tee Khaw, Nicholas J Wareham, Tammy YN Tong, Heinz Freisling, Mattias Johansson, Hannah Lennon, Dagfinn Aune, Elio Riboli, Dimitrios Trichopoulos, Antonia Trichopoulou, Konstantinos K Tsilidis
Jul 22, 2019
Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident...
Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts.
Louise Brunkwall, Yan Chen, George Hindy, Gull Rukh, Ulrika Ericson, Inês Barroso, Ingegerd Johansson, Paul W Franks, Marju Orho-Melander, Frida Renström
Jul 26, 2019
BACKGROUND: The consumption of sugar-sweetened beverages (SSBs), which has increased substantially during the last decades, has been associated with obesity and weight gain. OBJECTIVE: Common genetic susceptibility to obesity...
BMI Sweden Gene-lifestyle interaction genetic risk score Sugar-sweetened beverage Beverages Body Mass Index Carbonated Beverages Cohort Studies Confounding Factors Epidemiologic Cross-Sectional Studies Diet Records Dietary Carbohydrates Female Fruit and Vegetable Juices Genetic Association Studies Genetic Loci Genetic Predisposition to Disease Humans Male Middle Aged Nutrigenomics Nutrition Surveys obesity Overweight Polymorphism Single Nucleotide Prospective Studies Self Report Sweden
Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study.
Karina Meidtner, Clara Podmore, Janine Kröger, Yvonne T van der Schouw, Benedetta Bendinelli, Claudia Agnoli, Larraitz Arriola, Aurelio Barricarte, Heiner Boeing, Amanda J Cross, Courtney Dow, Kim Ekblom, Guy Fagherazzi, Paul W Franks, Marc J Gunter, José María Huerta, Paula Jakszyn, Mazda Jenab, Verena A Katzke, Timothy J Key, Kay Tee Khaw, Tilman Kühn, Cecilie Kyrø, Francesca Romana Mancini, Olle Melander, Peter M Nilsson, Kim Overvad, Domenico Palli, Salvatore Panico, J Ramón Quirós, Miguel Rodríguez-Barranco, Carlotta Sacerdote, Ivonne Sluijs, Magdalena Stepien, Anne Tjonneland, Rosario Tumino, Nita G Forouhi, Stephen J Sharp, Claudia Langenberg, Matthias B Schulze, Elio Riboli, Nicholas J Wareham
Jun 04, 2018
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