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Results: 37
MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.
Karol Kaiser, Ahram Jang, Petra Kompanikova, Melody P Lun, Jan Prochazka, Ondrej Machon, Neil Dani, Michaela Prochazkova, Benoit Laurent, Daniel Gyllborg, Renee van Amerongen, Ryann M Fame, Suhasini Gupta, Feizhen Wu, Roger A Barker, Ivana Bukova, Radislav Sedlacek, Zbynek Kozmik, Ernest Arenas, Maria K Lehtinen, Vitezslav Bryja
Apr 28, 2021
Choroid Plexus Epithelium Meis1 Meis2 Morphogenesis WNT5A Animals Brain CRISPR-Cas Systems Cell Line Choroid Plexus Epithelial Cells Epithelium Female Fourth Ventricle HEK293 Cells Humans Mice Mice Knockout Myeloid Ecotropic Viral Integration Site 1 Protein Promoter Regions Genetic Receptor Tyrosine Kinase-like Orphan Receptors Signal Transduction Wnt-5a Protein
Use of rituximab in SARS-CoV-2-positive renal transplant recipient with EBV reactivation and probable haemophagocytic lymphohistiocytosis.
We present a case of a rapid clinical recovery in a critically ill kidney transplant recipient with SARS-CoV-2 positivity, Epstein-Barr virus (EBV) reactivation and probable secondary hemophagocytic lymphohistiocytosis (HLH)...
Use of rituximab in SARS-CoV-2-positive renal transplant recipient with EBV reactivation and probable haemophagocytic lymphohistiocytosis.
We present a case of a rapid clinical recovery in a critically ill kidney transplant recipient with SARS-CoV-2 positivity, Epstein-Barr virus (EBV) reactivation and probable secondary hemophagocytic lymphohistiocytosis (HLH)...
Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2
TRPM2 (transient receptor potential cation channel, subfamily M, member 2) is a nonselective cation channel involved in the response to oxidative stress and in inflammation. Its role in autoimmune and neurodegenerative...
Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2
TRPM2 (transient receptor potential cation channel, subfamily M, member 2) is a nonselective cation channel involved in the response to oxidative stress and in inflammation. Its role in autoimmune and neurodegenerative...
If You're Happy, I'm Happy
An increasing body of research has addressed what a tourism experience is and how it should best be measured and managed. One conclusion has been to recommend observational methods such as facial expression analysis. The chapter...
Business and Management Hospitality Travel and Tourism Management Hospitality Travel & Tourism Management Social Sciences and Humanities Media and Communications
Published by: IGI Global Scientific Publishing
Norm Augmented Reinforcement Learning Agents With Synthesized Normative Rules
The dynamic deontic (DD) is a norm synthesis framework that extracts normative rules from reinforcement learning (RL), however it was not designed to be applied in agent coordination. This study proposes a norm augmented...
Published by: IGI Global Scientific Publishing
Three ancient hormonal cues co-ordinate shoot branching in a moss.
Yoan Coudert, Wojtek Palubicki, Karin Ljung, Ondrej Novak, Ottoline Leyser, C Jill Harrison
Jun 26, 2015
Physcomitrella apical dominance branching developmental biology gametophyte plant biology Stem Cells Biological Transport Body Patterning Bryopsida Cytokinins Gene Expression Regulation Plant Indoleacetic Acids Lactones Models Biological Morphogenesis Mutation Plant Epidermis Plant Growth Regulators Plant Proteins Plant Shoots Plants Genetically Modified
Machine learning potentials for complex aqueous systems made simple
Significance
Understanding complex materials, in particular those with solid–liquid interfaces, such as water on surfaces or under confinement, is a key challenge for technological and...
Christoph Schran, Fabian L Thiemann, Patrick Rowe, Erich A Müller, Ondrej Marsalek, Angelos Michaelides
Sep 16, 2021
Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics.
Danyang Zhang, Remigijus Lape, Saher A Shaikh, Bianka K Kohegyi, Jake F Watson, Ondrej Cais, Terunaga Nakagawa, Ingo H Greger
Apr 17, 2023
AMPA glutamate receptors (AMPARs) mediate excitatory neurotransmission throughout the brain. Their signalling is uniquely diversified by brain region-specific auxiliary subunits, providing an opportunity for the development of...
Published by: Nature Communications
CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD
Ondrej Cerny, Camilla Godlee, Romina Tocci, Nancy E. Cross, Haoran Shi, James C. Williamson, Eric Alix, Paul J. Lehner, David W. Holden
Aug 11, 2021
The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. This requires the...
Answering Why and When?
Ali Selamat, Najwa Jamaludin, Farhan Mohamed, Vei Chan, Mohd Sunar, Ondrej Krejcar, Andres Iglesias
Jan 01, 2023
Immersive analytics (IA) is a fast-growing research field that concerns improving and facilitating human sense making and data understanding through an immersive experience. Understanding the suitable application scenario that...
Published by: IGI Global Scientific Publishing
CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.
Ondrej Cerny, Camilla Godlee, Romina Tocci, Nancy E Cross, Haoran Shi, James C Williamson, Eric Alix, Paul J Lehner, David W Holden
Aug 27, 2021
The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. This requires the...
Do Images of Biskyrmions Show Type-II Bubbles?
James C Loudon, Alison C Twitchett-Harrison, David Cortés-Ortuño, Max T Birch, Luke A Turnbull, Aleš Štefančič, Feodor Y Ogrin, Erick O Burgos-Parra, Nicholas Bukin, Angus Laurenson, Horia Popescu, Marijan Beg, Ondrej Hovorka, Hans Fangohr, Paul A Midgley, Geetha Balakrishnan, Peter D Hatton
Feb 14, 2019
The intense research effort investigating magnetic skyrmions and their applications for spintronics has yielded reports of more exotic objects including the biskyrmion, which consists of a bound pair of counter-rotating vortices...
CD36 maintains the gastric mucosa and associates with gastric disease.
Miriam Jacome-Sosa, Zhi-Feng Miao, Vivek S Peche, Edward F Morris, Ramkumar Narendran, Kathryn M Pietka, Dmitri Samovski, Hei-Yong G Lo, Terri Pietka, Andrea Varro, Latisha Love-Gregory, James R Goldenring, Ondrej Kuda, Eric R Gamazon, Jason C Mills, Nada A Abumrad
Nov 02, 2021
The gastric epithelium is often exposed to injurious elements and failure of appropriate healing predisposes to ulcers, hemorrhage, and ultimately cancer. We examined the gastric function of CD36, a protein linked to disease and...
CD36 maintains the gastric mucosa and associates with gastric disease.
Miriam Jacome-Sosa, Zhi-Feng Miao, Vivek S Peche, Edward F Morris, Ramkumar Narendran, Kathryn M Pietka, Dmitri Samovski, Hei-Yong G Lo, Terri Pietka, Andrea Varro, Latisha Love-Gregory, James R Goldenring, Ondrej Kuda, Eric R Gamazon, Jason C Mills, Nada A Abumrad
Jan 06, 2022
The gastric epithelium is often exposed to injurious elements and failure of appropriate healing predisposes to ulcers, hemorrhage, and ultimately cancer. We examined the gastric function of CD36, a protein linked to disease and...
Neutron Radiation Dose Measurements in a Scanning Proton Therapy Room
Vladimir Mares, Jad Farah, Marijke De Saint-Hubert, Szymon Domański, Carles Domingo, Martin Dommert, Magdalena Kłodowska, Katarzyna Krzempek, Michał Kuć, Immaculada Martínez-Rovira, Edyta Michaś, Natalia Mojżeszek, Łukasz Murawski, Ondrej Ploc, Maite Romero-Expósito, Marco Tisi, François Trompier, Olivier Van Hoey, Laurent Van Ryckeghem, Marek Wielunski, Roger M Harrison, Liliana Stolarczyk, Pawel Olko
Jul 28, 2022
PURPOSE: This study aims to characterize the neutron radiation field inside a scanning proton therapy treatment room including the impact of different pediatric patient sizes. MATERIALS AND METHODS: Working Group 9 of the...
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer.
Caryn S Ross-Innes, Rory Stark, Andrew E Teschendorff, Kelly A Holmes, H Raza Ali, Mark J Dunning, Gordon D Brown, Ondrej Gojis, Ian O Ellis, Andrew R Green, Simak Ali, Suet-Feung Chin, Carlo Palmieri, Carlos Caldas, Jason S Carroll
Nov 08, 2017
Oestrogen receptor-α (ER) is the defining and driving transcription factor in the majority of breast cancers and its target genes dictate cell growth and endocrine response, yet genomic understanding of ER function has been...
Base Sequence Breast Neoplasms Cell Line Tumor Drug Resistance Neoplasm Female Gene Expression Regulation Neoplastic Hepatocyte Nuclear Factor 3-alpha Humans Neoplasm Metastasis Prognosis Protein Binding Receptors Estrogen Regulatory Sequences Nucleic Acid Survival Analysis Tamoxifen Treatment Outcome
Suppression of xylan endotransglycosylase PtxtXyn10A affects cellulose microfibril angle in secondary wall in aspen wood.
Marta Derba-Maceluch, Tatsuya Awano, Junko Takahashi, Jessica Lucenius, Christine Ratke, Inkeri Kontro, Marta Busse-Wicher, Ondrej Kosik, Ryo Tanaka, Anders Winzéll, Åsa Kallas, Joanna Leśniewska, Fredrik Berthold, Peter Immerzeel, Tuula T Teeri, Ines Ezcurra, Paul Dupree, Ritva Serimaa, Ewa J Mellerowicz
Aug 17, 2015
Populus endotransglycosylase growth stresses hybrid aspen Secondary cell wall wood formation xylan xylanase Arabidopsis Cell Wall Cellulose Chimera Gene Expression Regulation Plant Hydrolysis Microfibrils Multigene Family Plant Proteins Plants Genetically Modified Populus Wood Xylans Xylem Xylosidases
Mapping the developing human immune system across organs.
Chenqu Suo, Emma Dann, Issac Goh, Laura Jardine, Vitalii Kleshchevnikov, Jong-Eun Park, Rachel A Botting, Emily Stephenson, Justin Engelbert, Zewen Kelvin Tuong, Krzysztof Polanski, Nadav Yayon, Chuan Xu, Ondrej Suchanek, Rasa Elmentaite, Cecilia Domínguez Conde, Peng He, Sophie Pritchard, Mohi Miah, Corina Moldovan, Alexander S Steemers, Pavel Mazin, Martin Prete, Dave Horsfall, John C Marioni, Menna R Clatworthy, Muzlifah Haniffa, Sarah A Teichmann
Jun 13, 2022
Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine...
Distinct microbial and immune niches of the human colon.
Kylie R James, Tomas Gomes, Rasa Elmentaite, Nitin Kumar, Emily L Gulliver, Hamish W King, Mark D Stares, Bethany R Bareham, John R Ferdinand, Velislava N Petrova, Krzysztof Polański, Samuel C Forster, Lorna B Jarvis, Ondrej Suchanek, Sarah Howlett, Louisa K James, Joanne L Jones, Kerstin B Meyer, Menna R Clatworthy, Kourosh Saeb-Parsy, Trevor D Lawley, Sarah A Teichmann
Jan 23, 2020
Gastrointestinal microbiota and immune cells interact closely and display regional specificity; however, little is known about how these communities differ with location. Here, we simultaneously assess microbiota and single...
Changing climate both increases and decreases European river floods
Gunter Bloschl, Julia Hall, Alberto Viglione, Rui A. P. Perdigao, Juraj Parajka, Bruno Merz, David Lun, Berit Arheimer, Guiseppe T. Aronica, Ardian Bilibashi, Milon Bohac, Ognjen Bonacci, Marco Borga, Ivan Canjevac, Attilio Castellarin, Giovanni B. Chirico, Pierluigi Claps, Natalia Frolova, Daniele Ganora, Liudmyla Gorbachova, Ali Gul, Jamie Hannaford, Shaun Harrigan, Maria Kireeva, Andrea Kiss, Thomas Kjeldsen, Silvia Kohnova, Jarkko J. Koskela, Ondrej Ledvinka, Neil Macdonald, Maria Mavrova-Guirguinova, Luis Mediero, Ralf Merz, Peter Molnar, Alberto Montanari, Conor Murphy, Marzena Osuch, Valeryia Ovcharuk, Ivan Radevski, Jose L. Salinas, Eric Sauquet, Mojca Sraj, Jan Szolgay, Elena Volpi, Donna Wilson, Klodian Zaimi, Nenad Zivkovic
Sep 05, 2019
Climate change has led to concerns about increasing river floods resulting from the greater water-holding capacity of a warmer atmosphere 1. These concerns are reinforced by evidence of increasing economic losses...
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