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A new reporter cell line for studies with proteasome inhibitors in Trypanosoma brucei.
A Trypanosoma brucei cell line is described that produces a visual readout of proteasome activity. The cell line contains an integrated transgene encoding an ubiquitin-green fluorescent protein (GFP) fusion polypeptide...
Distinct mRNA and protein interactomes highlight functional differentiation of major eIF4F-like complexes from Trypanosoma brucei.
Desgarraduras del cuerpo y degolladuras de la voz
B Epps
Aug 24, 2017
El mismo mar de todos los veranos de Esther Tusquets narra la tormentosa relación erótica y emocional de una mujer de la alta burguesía catalana, casada y desencantada, que ejerce de profesora de literatura, con una joven...
De-globalisation and decoupling
P Williamson
Feb 19, 2021
It has become fashionable to argue that the post-coronavirus world will see an acceleration in de-globalisation and decoupling and that companies will substantively re-localise their supply chains (Javorcik, 2020; McKinsey...
De la philosophie de la religion dans l’oeuvre de Landgrebe
Sylvain Camilleri
Apr 22, 2021
Nombreux sont les premiers disciples de Husserl à s’être intéressés de prèsà la religion. Landgrebe ne fait pas exception à la règle, même si j’entendsmontrer qu’il constitue plutôt un cas à part. Pourquoi donc ? Parce que...
Published by: Memorial University of Newfoundland
De la philosophie de la religion dans l’oeuvre de Landgrebe
Sylvain Camilleri
Apr 22, 2021
Nombreux sont les premiers disciples de Husserl à s’être intéressés de prèsà la religion. Landgrebe ne fait pas exception à la règle, même si j’entendsmontrer qu’il constitue plutôt un cas à part. Pourquoi donc ? Parce que...
Published by: Memorial University of Newfoundland
Time-dependent compactification to de Sitter space
Abstract: It is known that the Einstein gravitational field equations in D > 4 spacetime dimensions have no time-independent non-singular compactification solutions to de Sitter space if the D-dimensional stress tensor satisfies...
Infancy‐onset diabetes caused by de‐regulated
<scp>AMPylation</scp>
of the human endoplasmic reticulum chaperone
<scp>BiP</scp>
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Jan 27, 2023
Dysfunction of the endoplasmic reticulum (ER) in insulin‐producing beta cells results in cell loss and diabetes mellitus. Here we report on five individuals from three different consanguineous families with infancy‐onset...
Strong Cosmic Censorship and eigenvalue repulsions for rotating de Sitter black holes in higher-dimensions
Abstract
It has been established that Christodoulou’s formulation of Strong Cosmic Censorship (SCC) is violated by Reissner-Nordström-de Sitter black...
Intolerancia en Tiempos de Crisis: Hacia una Literatura Transgresora en El sitio de los sitios de Juan Goytisolo
Oscar Ivan Useche
Jan 01, 0001
Este artículo propone entender la novela de Goytisolo como una respuesta cultural a la crisis de los modelos de racionalidad occidental. Se estudian las dinámicas de descomposición social de la globalización y la aparición...
Juan Goytisolo globalization Sarajevo historical memory memoria historica globalizacion State of Siege fiction Modern Literature Spanish and Portuguese Language and Literature
Published by: Ursinus College
Nonlinear stability of two-layer shallow water flows with a free surface
The problem of two layers of immiscible fluid, bordered above by an unbounded layer of passive fluid and below by a flat bed, is formulated and discussed. The resulting equations are given by a first-order, four-dimensional...
Assessment of the effectiveness of physical activity interventions in the Brazilian Unified Health System.
Evelyn Helena Corgosinho Ribeiro, Leandro Martin Totaro Garcia, Emanuel Péricles Salvador, Evelyn Fabiana Costa, Douglas Roque Andrade, Maria do Rosario Dias de Oliveira Latorre, Alex Antonio Florindo
Sep 11, 2018
OBJECTIVE: To assess the effect of interventions on the levels of physical activity of healthy adults, users of the Brazilian Unified Health System and attended by the Family Health Strategy. METHODS: Non-randomized experimental...
Augmented Hill-Climb increases reinforcement learning efficiency for language-based de novo molecule generation.
A plethora of AI-based techniques now exists to conduct de novo molecule generation that can devise molecules conditioned towards a particular endpoint in the context of drug design. One popular approach is using reinforcement...
Influence of bidding mechanism and spot market characteristics on market power of a large genco using hybrid DE/BBO
Generation company (Genco) bidding in an electricity market (EM) aims to maximize its profit under uncertain market characteristics and a regulated bidding mechanism. This paper addresses the strategic bidding for a large...
Determinantes de la movilidad ocupacional segmentada de los inmigrantes no comunitarios en España
La literatura sobre la integración económica de los inmigrantes ha destacado la existencia de un patrón de movilidad en forma de «U». En este artículo discutimos esta argumentación partiendo de las teorías de la segmentación del...
Economic Integration of Immigrants International Migration Labor Market Segmentation Segmented Occupational Mobility Spain Anthropology Social and Cultural Anthropology Sociology
Published by: Winthrop University
Le Diable dans la bibliothèque
Dans Thinking with Demons (1997), Stuart Clark a montré que la démonologie, cette composante essentielle de la pensée de la première modernité, n’était pas une affaire de spécialistes: ‘penser avec le diable’ était une activité...
Nonlinear stability of two-layer shallow water flows with a free surface
The problem of two layers of immiscible fluid, bordered above by an unbounded layer of passive fluid and below by a flat bed, is formulated and discussed. The resulting equations are given by a first-order, four-dimensional...
Order Reconstruction for Nematics on Squares with Isotropic Inclusions
We prove the existence of a well order reconstruction solution (WORS)-type Landau- de Gennes critical point on a square domain with an isotropic concentric square inclusion, with tangent boundary conditions on the outer...
Physical activity and preventable premature deaths from non-communicable diseases in Brazil.
Leandro Fórnias Machado de Rezende, Leandro Martin Totaro Garcia, Grégore Iven Mielke, Dong Hoon Lee, Edward Giovannucci, José Eluf-Neto
Dec 03, 2018
BACKGROUND: Studies on the impact of counterfactual scenarios of physical activity on premature deaths from non-communicable diseases (NCDs) are sparse in the literature. We estimated preventable premature deaths from NCDs...
The effect of ozone gas sterilization on the properties and cell compatibility of electrospun polycaprolactone scaffolds
Carolina Rediguieri, Paul De Bank, Maria Helena Ambrosio Zanin, Patrícia Leo, Natalia Neto Pereira Cerize, Adriano Marim de Oliveira, Terezinha Pinto
Jul 30, 2017
The growing area of tissue engineering has the potential to alleviate the shortage of tissues and organs for transplantation, and electrospun biomaterial scaffolds are extremely promising devices for translating engineered...
Christian de Duve, 1963
The Rockefeller University
Jan 01, 0001
Christian de Duve. The separation and characterization of subcellular particles.
Lecture delivered November 21, 1963
Posted with permission
Published by: Academic Press
Influence of bidding mechanism and spot market characteristics on market power of a large genco using hybrid DE/BBO
Generation company (Genco) bidding in an electricity market (EM) aims to maximize its profit under uncertain market characteristics and a regulated bidding mechanism. This paper addresses the strategic bidding for a large...
Order reconstruction for nematics on squares and hexagons
We construct an order reconstruction (OR-)type Landau-de Gennes critical point on a square domain of edge length 2λ, motivated by the well order reconstruction solution numerically reported in [S. Kralj and A. Majumdar, Proc....
Augmented Hill-Climb increases reinforcement learning efficiency for language-based de novo molecule generation.
A plethora of AI-based techniques now exists to conduct de novo molecule generation that can devise molecules conditioned towards a particular endpoint in the context of drug design. One popular approach is using reinforcement...
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