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Group A Streptococcus M1T1 Intracellular Infection of Primary Tonsil Epithelial Cells Dampens Levels of Secreted IL-8 Through the Action of SpyCEP.
Amelia T Soderholm, Timothy C Barnett, Othmar Korn, Tania Rivera-Hernandez, Lisa M Seymour, Benjamin L Schulz, Victor Nizet, Christine A Wells, Matthew J Sweet, Mark J Walker
Apr 14, 2021
Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and adults, with severe invasive disease and immune sequelae being an infrequent consequence. The ability of GAS to invade the host and...
IL-8 protease PrtS ScpC Streptococcus pyogenes intracellular infection Chemokines Cytokines Cytoplasm Epithelial Cells Gene Expression Host-Pathogen Interactions Humans Immunity Innate Interleukin-8 Male Palatine Tonsil Peptide Hormones Protein Transport Streptococcal Infections Streptococcus pyogenes Transcription Factors
Near critical, self-similar, blow-up solutions of the generalised Korteweg–de Vries equation
Pierluigi Amodio, Chris J. Budd, Othmar Koch, Vivi Rottschäfer, Giuseppina Settanni, Ewa Weinmüller
Jan 01, 2020
In this article we give a detailed asymptotic analysis of the near critical self-similar blowup solutions to the Generalised Korteweg–de Vries equation (GKdV). We compare this analysis to some careful numerical calculations....
Asymptotic analysis Blow-up solutions Generalised Korteweg–de Vries equation Numerical methods /dk/atira/pure/subjectarea/asjc/3100/3109 name=Statistical and Nonlinear Physics /dk/atira/pure/subjectarea/asjc/2600/2610 name=Mathematical Physics /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
Near critical, self-similar, blow-up solutions of the generalised Korteweg–de Vries equation
Pierluigi Amodio, Chris J. Budd, Othmar Koch, Vivi Rottschäfer, Giuseppina Settanni, Ewa Weinmüller
Jan 01, 2020
In this article we give a detailed asymptotic analysis of the near critical self-similar blowup solutions to the Generalised Korteweg–de Vries equation (GKdV). We compare this analysis to some careful numerical calculations....
Asymptotic analysis Blow-up solutions Generalised Korteweg–de Vries equation Numerical methods /dk/atira/pure/subjectarea/asjc/3100/3109 name=Statistical and Nonlinear Physics /dk/atira/pure/subjectarea/asjc/2600/2610 name=Mathematical Physics /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
Efficient Magnus-type integrators for solar energy conversion in Hubbard models
Winfried Auzinger, Juliette Dubois, Karsten Held, Harald Hofstätter, Tobias Jawecki, Anna Kauch, Othmar Koch, Karolina Kropielnicka, Pranav Singh, Clemens Watzenböck
Jan 31, 2022
Strongly interacting electrons in solids are generically described by Hubbardtype models, and the impact of solar light can be modeled by an additional time-dependence. This yields a finite dimensional system of ordinary...
Efficient Magnus-type integrators for solar energy conversion in Hubbard models
Winfried Auzinger, Juliette Dubois, Karsten Held, Harald Hofstätter, Tobias Jawecki, Anna Kauch, Othmar Koch, Karolina Kropielnicka, Pranav Singh, Clemens Watzenböck
Jan 31, 2022
Strongly interacting electrons in solids are generically described by Hubbardtype models, and the impact of solar light can be modeled by an additional time-dependence. This yields a finite dimensional system of ordinary...
Nanobodies mapped to cross-reactive and divergent epitopes on A(H7N9) influenza hemagglutinin using yeast display.
Tiziano Gaiotto, Walter Ramage, Christina Ball, Paul Risley, George Carnell, Nigel Temperton, Othmar G Engelhardt, Simon E Hufton
Apr 12, 2021
Influenza H7N9 virus continues to cause infections in humans and represents a significant pandemic risk. During the most recent 5th epidemic wave in 2016/17 two distinct lineages with increased human infections and wider...
Nanobodies mapped to cross-reactive and divergent epitopes on A(H7N9) influenza hemagglutinin using yeast display
Tiziano Gaiotto, Walter Ramage, Christina Ball, Paul Risley, George W. Carnell, Nigel Temperton, Othmar G. Engelhardt, Simon E. Hufton
Feb 04, 2021
Abstract: Influenza H7N9 virus continues to cause infections in humans and represents a significant pandemic risk. During the most recent 5th epidemic wave in 2016/17 two distinct lineages with increased human infections and...
A high prevalence of blaOXA-48 in Klebsiella (Raoultella) ornithinolytica and related species in hospital wastewater in South West England
Marjorie J Gibbon, Natacha Couto, Sophia David, Ruth Barden, Richard Standerwick, Kishore Jagadeesan, Hollie Birkwood, Punyawee Dulyayangkul, Matthew B Avison, Andrew Kannan, Dan Kibbey, Tim Craft, Samia Habib, Harry A Thorpe, Jukka Corander, Barbara Kasprzyk-Hordern, Edward J Feil
Dec 31, 2021
Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae (Kpne) has gained...
A high prevalence of blaOXA-48 in Klebsiella (Raoultella) ornithinolytica and related species in hospital wastewater in South West England
Marjorie J Gibbon, Natacha Couto, Sophia David, Ruth Barden, Richard Standerwick, Kishore Jagadeesan, Hollie Birkwood, Punyawee Dulyayangkul, Matthew B Avison, Andrew Kannan, Dan Kibbey, Tim Craft, Samia Habib, Harry A Thorpe, Jukka Corander, Barbara Kasprzyk-Hordern, Edward J Feil
Dec 31, 2021
Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae (Kpne) has gained...
Nanobodies mapped to cross-reactive and divergent epitopes on A(H7N9) influenza hemagglutinin using yeast display.
Tiziano Gaiotto, Walter Ramage, Christina Ball, Paul Risley, George W Carnell, Nigel Temperton, Othmar G Engelhardt, Simon E Hufton
Aug 16, 2022
Influenza H7N9 virus continues to cause infections in humans and represents a significant pandemic risk. During the most recent 5th epidemic wave in 2016/17 two distinct lineages with increased human infections and wider...
Amino Acid Sequence Animals Antibodies Neutralizing Antibodies Viral Binding Sites Birds Epitopes Hemagglutinin Glycoproteins Influenza Virus Humans Influenza A virus H7N9 Subtype Influenza in Birds Influenza Human Models Molecular Peptide Library Protein Binding Protein Conformation Protein Interaction Domains and Motifs Saccharomyces cerevisiae Single-Domain Antibodies
Large-Scale Mapping of Moiré Superlattices by Hyperspectral Raman Imaging.
Kai-Qiang Lin, Johannes Holler, Jonas M Bauer, Philipp Parzefall, Marten Scheuck, Bo Peng, Tobias Korn, Sebastian Bange, John M Lupton, Christian Schüller
Jul 28, 2021
Moiré superlattices can induce correlated-electronic phases in twisted van der Waals materials: strongly correlated quantum phenomena emerge, such as superconductivity and the Mott-insulating state. However, moiré superlattices...
Building Something with the Raspberry Pi
Richard Kordel
Jan 01, 0001
In 2017 Ryan Korn and I submitted a grant proposal in the annual Harrisburg University President's Grant process. Our proposal was to partner with a local high school to install a classroom of 20 Raspberry Pi's, along with the...
Raspberry Pi Student Research technology programming showcase Databases and Information Systems Data Science Graphics and Human Computer Interfaces Other Computer Sciences Programming Languages and Compilers software engineering Systems Architecture
Published by: Harrisburg University of Science and Technology
Moiré phonons in twisted MoSe 2 –WSe 2 heterobilayers and their correlation with interlayer excitons
Philipp Parzefall, Johannes Holler, Marten Scheuck, Andreas Beer, Kai-Qiang Lin, Bo Peng, Bartomeu Monserrat, Philipp Nagler, Michael Kempf, Tobias Korn, Christian Schüller
Jul 28, 2021
Abstract: We report about the investigation of twisted MoSe2 homo- and MoSe2–WSe2 heterobilayers by means of low-frequency Raman spectroscopy (LFRS) and low-temperature micro photoluminescence (µPL). In room-temperature LFRS...
Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis
Abstract The sympathetic nervous system has been evolutionary selected to respond to stress and activates haematopoietic stem cells via noradrenergic signals. However, the pathways preserving...
Claire Fielding, Andrés García-García, Claudia Korn, Stephen Gadomski, Zijian Fang, Juan L Reguera, José A Pérez-Simón, Berthold Göttgens, Simón Méndez-Ferrer
Jan 28, 2022
Enhanced waterlogging tolerance in barley by manipulation of expression of the N-end rule pathway E3 ligase PROTEOLYSIS6.
Guillermina M Mendiondo, Daniel J Gibbs, Miriam Szurman-Zubrzycka, Arnd Korn, Julietta Marquez, Iwona Szarejko, Miroslaw Maluszynski, John King, Barry Axcell, Katherine Smart, Francoise Corbineau, Michael J Holdsworth
Jul 29, 2020
Increased tolerance of crops to low oxygen (hypoxia) during flooding is a key target for food security. In Arabidopsis thaliana (L.) Heynh., the N-end rule pathway of targeted proteolysis controls plant responses to hypoxia by...
ERFVIIs N-end rule PRT6 targeted proteolysis waterlogging Adaptation Physiological Alleles Amino Acid Sequence Chlorophyll Cysteine Darkness Gene Expression Regulation Plant Genes Plant Genome Plant germination Hordeum Mutation Phenotype Plant Leaves Plant Proteins Plants Genetically Modified Protein Stability Real-Time Polymerase Chain Reaction Seeds Substrate Specificity Ubiquitin-Protein Ligases water
Moiré phonons in twisted MoSe2-WSe2 heterobilayers and their correlation with interlayer excitons
Abstract
We report about the investigation of twisted MoSe2 homo- and MoSe2 –WSe2 heterobilayers by means of...
P Parzefall, J Holler, M Scheuck, A Beer, KQ Lin, B Peng, B Monserrat, P Nagler, M Kempf, T Korn, C Schüller
Jul 28, 2021
Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis.
Claire Fielding, Andrés García-García, Claudia Korn, Stephen Gadomski, Zijian Fang, Juan L Reguera, José A Pérez-Simón, Berthold Göttgens, Simón Méndez-Ferrer
Feb 28, 2022
The sympathetic nervous system has been evolutionary selected to respond to stress and activates haematopoietic stem cells via noradrenergic signals. However, the pathways preserving haematopoietic stem cell quiescence and...
Deterministic programming of human pluripotent stem cells into microglia facilitates studying their role in health and disease.
Anna M Speicher, Lisanne Korn, Júlia Csatári, Laura Gonzalez-Cano, Michael Heming, Christian Thomas, Christina B Schroeter, David Schafflick, Xiaolin Li, Lukas Gola, Alexander Engler, Thilo Kaehne, Ludovic Vallier, Sven G Meuth, Gerd Meyer Zu Hörste, Stjepana Kovac, Heinz Wiendl, Hans R Schöler, Matthias Pawlowski
Nov 17, 2022
Microglia, the resident immune cells of the central nervous system (CNS), are derived from yolk-sac macrophages that populate the developing CNS during early embryonic development. Once established, the microglia population is...
Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes.
Andrés García-García, Claudia Korn, María García-Fernández, Olivia Domingues, Javier Villadiego, Daniel Martín-Pérez, Joan Isern, José A Bejarano-García, Jacques Zimmer, José A Pérez-Simón, Juan J Toledo-Aral, Tatiana Michel, Matti S Airaksinen, Simón Méndez-Ferrer
Dec 07, 2018
Hematopoietic stem and progenitor cells (HSPCs) and leukocytes circulate between the bone marrow (BM) and peripheral blood following circadian oscillations. Autonomic sympathetic noradrenergic signals have been shown to regulate...
Animals Bone Marrow Cells Cell Adhesion Cell Movement Cells Cultured Chemotaxis Cholinergic Agents Circadian Rhythm Endothelium Vascular Female Glial Cell Line-Derived Neurotrophic Factor Receptors Hematopoietic Stem Cells Leukocytes Male Mice Mice Inbred C57BL Mice Knockout Parasympathetic Nervous System Receptors Adrenergic beta-2 Receptors Adrenergic beta-3 Receptors G-Protein-Coupled sympathetic nervous system
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging.
Ya-Hsuan Ho, Raquel Del Toro, José Rivera-Torres, Justyna Rak, Claudia Korn, Andrés García-García, David Macías, Cristina González-Gómez, Alberto Del Monte, Monika Wittner, Amie K Waller, Holly R Foster, Carlos López-Otín, Randall S Johnson, Claus Nerlov, Cedric Ghevaert, William Vainchenker, Fawzia Louache, Vicente Andrés, Simón Méndez-Ferrer
Jun 20, 2019
Hutchinson-Gilford progeria aging Hematopoietic stem cell lymphoid microenvironment myeloid niche Adrenergic Agonists aging aging Premature Animals Bone Marrow Cell Differentiation Cell Encapsulation Cell Proliferation Disease Models Animal Hematopoietic Stem Cells Humans Interleukin-6 Megakaryocytes Mice Myeloid Cells Nitric Oxide Synthase Type I progeria Receptors Adrenergic beta-2 Signal Transduction Stem Cell Niche
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
Simon Renders, Arthur Flohr Svendsen, Jasper Panten, Nicolas Rama, Maria Maryanovich, Pia Sommerkamp, Luisa Ladel, Anna Rita Redavid, Benjamin Gibert, Seka Lazare, Benjamin Ducarouge, Katharina Schönberger, Andreas Narr, Manon Tourbez, Bertien Dethmers-Ausema, Erik Zwart, Agnes Hotz-Wagenblatt, Dachuan Zhang, Claudia Korn, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Simon Mendez-Ferrer, Mathias Heikenwälder, Maik Brune, Daniel Klimmeck, Leonid Bystrykh, Paul S. Frenette, Patrick Mehlen, Gerald de Haan, Nina Cabezas-Wallscheid, Andreas Trumpp
Jan 27, 2021
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1.
Simon Renders, Arthur Flohr Svendsen, Jasper Panten, Nicolas Rama, Maria Maryanovich, Pia Sommerkamp, Luisa Ladel, Anna Rita Redavid, Benjamin Gibert, Seka Lazare, Benjamin Ducarouge, Katharina Schönberger, Andreas Narr, Manon Tourbez, Bertien Dethmers-Ausema, Erik Zwart, Agnes Hotz-Wagenblatt, Dachuan Zhang, Claudia Korn, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Simon Mendez-Ferrer, Mathias Heikenwälder, Maik Brune, Daniel Klimmeck, Leonid Bystrykh, Paul S Frenette, Patrick Mehlen, Gerald de Haan, Nina Cabezas-Wallscheid, Andreas Trumpp
Jan 20, 2021
The Gaia-ESO survey
E Stonkute, SE Koposov, LM Howes, S Feltzing, CC Worley, G Gilmore, GR Ruchti, G Kordopatis, S Randich, T Zwitter, T Bensby, A Bragaglia, R Smiljanic, MT Costado, G Tautvaišiene, AR Casey, AJ Korn, AC Lanzafame, E Pancino, E Franciosini, A Hourihane, P Jofré, C Lardo, J Lewis, L Magrini, L Monaco, L Morbidelli, GG Sacco, L Sbordone
Jul 25, 2016
The $\textit{Gaia}$-ESO Survey
L Spina, S Randich, L Magrini, RD Jeffries, ED Friel, GG Sacco, E Pancino, R Bonito, L Bravi, E Franciosini, A Klutsch, D Montes, G Gilmore, A Vallenari, T Bensby, A Bragaglia, E Flaccomio, SE Koposov, AJ Korn, AC Lanzafame, R Smiljanic, A Bayo, G Carraro, AR Casey, MT Costado, F Damiani, P Donati, A Frasca, A Hourihane, P Jofré, J Lewis, K Lind, L Monaco, L Morbidelli, L Prisinzano, SG Sousa, CC Worley, S Zaggia
May 04, 2017
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