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Ecological selectivity and the evolution of mammalian substrate preference across the K–Pg boundary
Abstract: The Cretaceous–Paleogene (K–Pg) mass extinction 66 million years ago was characterized by a worldwide ecological catastrophe and rapid species turnover. Large‐scale devastation of forested environments resulting from...
Published by: Ecology and Evolution
Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases.
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic contents to lysosomes for degradation. Genetic studies have revealed extensive links between autophagy and neurodegenerative disease, and...
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Dinosaur diversification rates were not in decline prior to the K-Pg boundary
Determining the tempo and mode of non-avian dinosaur extinction is one of the most contentious issues in palaeobiology. Extensive disagreements remain over whether their extinction was catastrophic and geologically instantaneous...
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DIA label-free proteomic analysis of murine bone-marrow-derived macrophages.
Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We provide a complete step-by-step protocol describing sample preparation...
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Dinosaur diversification rates were not in decline prior to the K-Pg boundary
Determining the tempo and mode of non-avian dinosaur extinction is one of the most contentious issues in palaeobiology. Extensive disagreements remain over whether their extinction was catastrophic and geologically instantaneous...
Published by:
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
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Cultural Values and Its Influence on the Enactment of Leadership in Public Sector Organisations
Pg Idris
Oct 01, 2021
This research contributes to our understanding of leadership in public sector organisations by examining the influence of national culture on the enactment of public sector leadership in the context of Brunei. It followed a...
Trans-myocardial Extraction of Endothelin-1 Correlates with Increased Microcirculatory Resistance following Percutaneous Coronary Intervention.
OBJECTIVE: Coronary microvascular dysfunction (CMD) can complicate successful percutaneous coronary intervention (PCI). The potent endogenous vasoconstrictor peptide Endothelin-1 (ET-1) may be an important mediator. To...
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Effects of Growth Rate on Peptidoglycan Crosslink Density of E. coli Using Fluorescent Labeling
Morgan Olszewski
Jan 01, 0001
Peptidoglycan (PG) is a polymer composed of polysaccharides and crosslinked peptide chains found in bacterial cell walls. It helps to protect the cell from environmental stress and maintain cell morphology throughout its life...
Respected Winthrop Student Veteran Passes Away
Winthrop University
Jan 01, 0001
Cpl. Ryan Holdaway transferred to Winthrop's College of Business Administration. He was a respected member of the veterans community. Respected Winthrop University student Cpl.
Published by: Winthrop University
Circulating levels of angiogenic factors and their association with preeclampsia among pregnant women at Mulago National Referral Hospital in Uganda.
Preeclampsia (PE) is a major cause of maternal and new-born morbidity and mortality. Angiogenic factors contribute a major role in the vascular dysfunction associated with PE. We investigated the circulating levels of vascular...
Published by: PLOS ONE
Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration.
Julio C Rojas, Ping Wang, Adam M Staffaroni, Carolin Heller, Yann Cobigo, Amy Wolf, Sheng-Yang M Goh, Peter A Ljubenkov, Hilary W Heuer, Jamie C Fong, Joanne B Taylor, Eliseo Veras, Linan Song, Andreas Jeromin, David Hanlon, Lili Yu, Arvind Khinikar, Rajeev Sivasankaran, Agnieszka Kieloch, Marie-Anne Valentin, Anna M Karydas, Laura L Mitic, Rodney Pearlman, John Kornak, Joel H Kramer, Bruce L Miller, Kejal Kantarci, David S Knopman, Neill Graff-Radford, Leonard Petrucelli, Rosa Rademakers, David J Irwin, Murray Grossman, Eliana Marisa Ramos, Giovanni Coppola, Mario F Mendez, Yvette Bordelon, Bradford C Dickerson, Nupur Ghoshal, Edward D Huey, Ian R Mackenzie, Brian S Appleby, Kimiko Domoto-Reilly, Ging-Yuek R Hsiung, Arthur W Toga, Sandra Weintraub, Daniel I Kaufer, Diana Kerwin, Irene Litvan, Chiadikaobi U Onyike, Alexander Pantelyat, Erik D Roberson, Maria C Tartaglia, Tatiana Foroud, Weiping Chen, Julie Czerkowicz, Danielle L Graham, John C van Swieten, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, James B Rowe, Mario Masellis, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonça, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris R Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Sandro Sorbi, David M Cash, Rhian S Convery, Martina Bocchetta, Martha Foiani, Caroline V Greaves, Georgia Peakman, Lucy Russell, Imogen Swift, Emily Todd, Jonathan D Rohrer, Bradley F Boeve, Howard J Rosen, Adam L Boxer, ALLFTD and GENFI consortia
Apr 13, 2021
OBJECTIVE: We tested the hypothesis that plasma neurofilament light chain (NfL) identifies asymptomatic carriers of familial frontotemporal lobar degeneration (FTLD)-causing mutations at risk of disease progression. METHODS...
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Evolution and dispersal of snakes across the Cretaceous-Paleogene mass extinction.
Mass extinctions have repeatedly shaped global biodiversity. The Cretaceous-Paleogene (K-Pg) mass extinction caused the demise of numerous vertebrate groups, and its aftermath saw the rapid diversification of surviving mammals...
Published by: Nature Communications
Saharan dust electrification perceived by a triangle of atmospheric electricity stations in Southern Portugal
Atmospheric Electric Potential Gradient (PG) measurements were carried out in three sites forming a triangular array in Southern Portugal. The campaign was performed during the summer, characterized by Saharan dust outbreaks;...
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