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Chronic subdural haematoma
Peter Hutchinson is supported by a Research Professorship from the National Institute for Health Research (NIHR), the NIHR Cambridge Biomedical Research Centre, a European Union Seventh Framework Program grant (CENTER-TBI; grant...
3D printed customised external cranial plate in a patient with syndrome of trephined
Mee H., Greasley S., Whiting G., Harkin C., Oliver G., Marsden D., Andrews R., Sireau S., Price RD., Anwar F., Timofeev IS., Hutchinson PJ., White PA., Helmy A.
Nov 22, 2021
Abstract: Background: Syndrome of the trephined is a well-recognised phenomenon that occurs in patients following a craniectomy. It is associated with several symptoms, including headaches, motor impairments, cognitive disorders...
Debate
The number of people presenting at gender clinics is increasing worldwide. Many people undergo a gender transition with subsequent improved psychological well-being (Paediatrics, 2014, 134, 696). However, some people choose...
gender dysphoria Gender Identity Therapy /dk/atira/pure/subjectarea/asjc/2700/2735 name=Pediatrics, Perinatology, and Child Health /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Comparing International Approaches to Safeguarding Children
Child maltreatment is a complex global problem which remains difficult to study and address. Over the last decade, we have seen considerable interest by governments globally in learning the lessons from different countries and...
Global reorganization of the nuclear landscape in senescent cells.
Tamir Chandra, Philip Andrew Ewels, Stefan Schoenfelder, Mayra Furlan-Magaril, Steven William Wingett, Kristina Kirschner, Jean-Yves Thuret, Simon Andrews, Peter Fraser, Wolf Reik
Jul 15, 2019
Cellular senescence has been implicated in tumor suppression, development, and aging and is accompanied by large-scale chromatin rearrangements, forming senescence-associated heterochromatic foci (SAHF). However, how the...
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.
Gabriel Balmus, Delphine Larrieu, Ana C Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J Geisler, Christopher J Lelliott, Jacqueline K White, Natasha A Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J Adams, Stephen P Jackson
Feb 09, 2018
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, but devastating genetic disease characterized by segmental premature aging, with cardiovascular disease being the main cause of death. Cells from HGPS patients accumulate...
Improving the coverage of credible sets in Bayesian genetic fine-mapping
Genome Wide Association Studies (GWAS) have successfully identified thousands of loci associated with human diseases. Bayesian genetic fine-mapping studies aim to identify the specific causal variants within GWAS loci...
Debate
The number of people presenting at gender clinics is increasing worldwide. Many people undergo a gender transition with subsequent improved psychological well-being (Paediatrics, 2014, 134, 696). However, some people choose...
gender dysphoria Gender Identity Therapy /dk/atira/pure/subjectarea/asjc/2700/2735 name=Pediatrics, Perinatology, and Child Health /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Improved long-term survival with subdural drains following evacuation of chronic subdural haematoma
Background
Chronic subdural haematoma (CSDH) is a common condition that is effectively managed by burrhole drainage but requires repeat surgery in a significant minority of patients. The Cambridge Chronic Subdural Haematoma...
Fine-mapping genetic associations.
Whilst thousands of genetic variants have been associated with human traits, identifying the subset of those variants that are causal requires a further 'fine-mapping' step. We review the basic fine-mapping approach, which is...
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