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Results: 20
Validation of the online prediction tool PREDICT v. 2.0 in the Dutch breast cancer population.
MC van Maaren, CD van Steenbeek, PDP Pharoah, A Witteveen, GS Sonke, LJA Strobbe, PMP Poortmans, S Siesling
Jan 30, 2018
BACKGROUND: PREDICT version 2.0 is increasingly used to estimate prognosis in breast cancer. This study aimed to validate this tool in specific prognostic subgroups in the Netherlands. METHODS: All operated women with...
Breast Cancer overall survival PREDICT Population-based study Prediction model validation Adult Aged Antineoplastic Agents Hormonal Area Under Curve Biomarkers Tumor Breast Neoplasms Chemotherapy Adjuvant Chi-Square Distribution Clinical Decision-Making Decision Support Techniques Female Humans Mastectomy Middle Aged Neoplasm Grading Neoplasm Staging Netherlands Patient Selection Precision Medicine Predictive Value of Tests ROC Curve Receptors Estrogen Registries Reproducibility of Results Risk Factors Time Factors Treatment Outcome
The peroxisomal fatty acid transporter ABCD1/PMP-4 is required in the C. elegans hypodermis for axonal maintenance
Andrea Coppa, Sanjib Guha, Stéphane Fourcade, Janani Parameswaran, Montserrat Ruiz, Ann B Moser, Agatha Schlüter, Michael P Murphy, Jose Miguel Lizcano, Antonio Miranda-Vizuete, Esther Dalfó, Aurora Pujol
Feb 18, 2020
Adrenoleukodystrophy is a neurometabolic disorder caused by a defective peroxisomal ABCD1 transporter of very long-chain fatty acids (VLCFAs). Its pathogenesis is incompletely understood. Here we characterize a nematode model of...
Axonal degeneration Hypodermis Lipid Droplets Mitochondria redox imbalance Peroxisomes X-linked adrenoleukodystrophy ATP Binding Cassette Transporter Subfamily D Member 1 ATP-Binding Cassette Transporters Adrenoleukodystrophy Animals Caenorhabditis elegans Fatty Acids Mice Mice Knockout Subcutaneous Tissue
Microparticle subpopulations are potential markers of disease progression and vascular dysfunction across a spectrum of connective tissue disease
E M McCarthy, D Moreno-Martinez, F L Wilkinson, N J McHugh, I N Bruce, J D Pauling, M Y Alexander, B Parker
Jun 01, 2017
OBJECTIVE: Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). We investigated EMP and PMP numbers across a spectrum of...
Electron Microscopy Characterization of P3 Lines and Laser Scribing-Induced Perovskite Decomposition in Perovskite Solar Modules.
Hybrid metal halide perovskites have emerged as a potential photovoltaic material for low-cost thin film solar cells due to their excellent optoelectronic properties. However, high efficiencies obtained with lab-scale cells are...
Microparticle subpopulations are potential markers of disease progression and vascular dysfunction across a spectrum of connective tissue disease
E M McCarthy, D Moreno-Martinez, F L Wilkinson, N J McHugh, I N Bruce, J D Pauling, M Y Alexander, B Parker
Jun 01, 2017
OBJECTIVE: Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). We investigated EMP and PMP numbers across a spectrum of...
Effectiveness of different accelerated partial breast irradiation techniques for the treatment of breast cancer patients
Gustavo Nader Marta, Jessica Barrett, Gustavo José Martiniano Porfirio, Ana Luiza Cabrera Martimbianco, José Luiz Barbosa Bevilacqua, Philip Poortmans, Rachel Riera
Feb 11, 2019
AIM: This systematic review was conducted to compare the effectiveness of different accelerated partial breast irradiation (APBI) techniques for the treatment of breast cancer patients. BACKGROUND: Numerous (APBI) techniques are...
Preoperative breast radiation therapy
SV Lightowlers, LJ Boersma, A Fourquet, YM Kirova, BV Offersen, P Poortmans, AN Scholten, N Somaiah, CE Coles
Nov 24, 2017
Preoperative breast radiation therapy (RT) is not a new concept, but older studies failed to change practice. More recently, there has been interest in revisiting preoperative RT using modern techniques. This current perspective...
The Financial Impact on Reimbursement of Moderately Hypofractionated Postoperative Radiation Therapy for Breast Cancer
GN Marta, D Ramiah, O Kaidar-Person, A Kirby, C Coles, R Jagsi, T Hijal, G Sancho, Y Zissiadis, J-P Pignol, AY Ho, SH-C Cheng, BV Offersen, I Meattini, P Poortmans
Jan 06, 2021
AIMS: Moderately hypofractionated breast irradiation has been evaluated in several prospective studies, resulting in wide acceptance of shorter treatment protocols for postoperative breast irradiation. Reimbursement for...
The use of moderately hypofractionated post-operative radiation therapy for breast cancer in clinical practice
Gustavo Nader Marta, Charlotte Coles, Orit Kaidar-Person, Icro Meattini, Tarek Hijal, Yvonne Zissiadis, Jean-Philippe Pignol, Duvern Ramiah, Alice Y Ho, Skye Hung-Chun Cheng, Gemma Sancho, Birgitte Vrou Offersen, Philip Poortmans
Dec 22, 2020
Post-operative radiation therapy (RT) reduces loco-regional recurrence rates and mortality in most patients with non-metastatic breast cancer. The aim of this critical review is to provide an overview of the applicability of...
Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members, including the LDL receptor and LRP6.
Michael P Weekes, Robin Antrobus, Suzanne Talbot, Simon Hör, Nikol Simecek, Duncan L Smith, Stuart Bloor, Felix Randow, Paul J Lehner
May 29, 2019
The endoplasmic reticulum chaperone gp96 is required for the cell surface expression of a narrow range of proteins, including toll-like receptors (TLRs) and integrins. To identify a more comprehensive repertoire of proteins...
Animals Antigens CD Cell Line Cell Membrane Chromatography High Pressure Liquid Down-Regulation Integrins Low Density Lipoprotein Receptor-Related Protein-6 Membrane Glycoproteins Membrane Proteins Mice Peptide Fragments Protein Interaction Mapping Proteomics Receptors LDL Tandem Mass Spectrometry Toll-Like Receptors
The 2018 assisi think tank meeting on breast cancer
Meritxell Arenas, Ugur Selek, Orit Kaidar-Person, Elisabetta Perrucci, Angel Montero Luis, Liesbeth Boersma, Charlotte Coles, Birgitte Offersen, Icro Meattini, Yasemin Bölükbaşı, Maria Cristina Leonardi, Raphael Pfeffer, Bruno Cutuli, Cristiana Vidali, Pierfrancesco Franco, Vassilis Kouloulias, Valeria Masiello, Sofia Rivera, Céline Bourgier, Antonella Ciabattoni, Valentina Lancellotta, Lurdes Trigo, Vincenzo Valentini, Philip Poortmans, Cynthia Aristei
Jun 24, 2020
We report on the second Assisi Think Tank Meeting (ATTM) on breast cancer which was held under the auspices of the European Society for RadioTherapy & Oncology (ESTRO). In discussing in-depth current evidence and practice it was...
Breast Cancer Breast reconstruction De-escalating therapy Ductal carcinoma in situ Hypofractionation neoadjuvant chemotherapy Partial breast irradiation Post-mastectomy radiation therapy Radiation therapy Breast Neoplasms Carcinoma Intraductal Noninfiltrating Humans Mastectomy Mastectomy Segmental Radiotherapy Adjuvant
The use of bolus in postmastectomy radiation therapy for breast cancer
Hannah M Dahn, Liesbeth J Boersma, Dirk de Ruysscher, Icro Meattini, Birgitte V Offersen, Jean-Philippe Pignol, Cynthia Aristei, Yazid Belkacemi, Dori Benjamin, Nuran Bese, Charlotte E Coles, Pierfrancesco Franco, Alice Ho, Sandra Hol, Reshma Jagsi, Anna M Kirby, Livia Marrazzo, Gustavo N Marta, Meena S Moran, Alan M Nichol, Henrik D Nissen, Vratislav Strnad, Yvonne E Zissiadis, Philip Poortmans, Orit Kaidar-Person
Jul 12, 2021
PURPOSE: Post mastectomy radiation therapy (PMRT) reduces locoregional recurrence (LRR) and breast cancer mortality for selected patients. Bolus overcomes the skin-sparing effect of external-beam radiotherapy, ensuring adequate...
The Assisi Think Tank Meeting Survey of post-mastectomy radiation therapy in ductal carcinoma in situ
A Montero-Luis, C Aristei, I Meattini, M Arenas, L Boersma, C Bourgier, C Coles, B Cutuli, L Falcinelli, O Kaidar-Person, MC Leonardi, B Offersen, F Marazzi, S Rivera, L Tagliaferri, V Tombolini, C Vidali, V Valentini, P Poortmans
May 16, 2019
BACKGROUND: Risk factors for local recurrence after mastectomy in ductal carcinoma in situ (DCIS) emerged as a grey area during the second "Assisi Think Tank Meeting" (ATTM) on Breast Cancer. AIM: To review practice patterns of...
Breast Cancer Ductal carcinoma in situ Hypofractionation Post-mastectomy radiotherapy Survey Breast Neoplasms Carcinoma Intraductal Noninfiltrating Dose Fractionation Radiation Female Humans Mastectomy Middle Aged Neoplasm Recurrence Local Radiation Oncology Radiotherapy Adjuvant Risk Factors Surveys and Questionnaires
The cost-effectiveness of alternative vaccination strategies for polyvalent meningococcal vaccines in Burkina Faso
Reza Yaesoubi, Caroline Trotter, Caroline Colijn, Maziar Yaesoubi, Anaïs Colombini, Stephen Resch, Paul A Kristiansen, F Marc LaForce, Ted Cohen
Feb 27, 2018
BACKGROUND: The introduction of a conjugate vaccine for serogroup A Neisseria meningitidis has dramatically reduced disease in the African meningitis belt. In this context, important questions remain about the performance of...
Oncoplastic breast consortium recommendations for mastectomy and whole breast reconstruction in the setting of post-mastectomy radiation therapy.
Walter Paul Weber, Jane Shaw, Andrea Pusic, Lynda Wyld, Monica Morrow, Tari King, Zoltán Mátrai, Jörg Heil, Florian Fitzal, Shelley Potter, Isabel T Rubio, Maria-Joao Cardoso, Oreste Davide Gentilini, Viviana Galimberti, Virgilio Sacchini, Emiel JT Rutgers, John Benson, Tanir M Allweis, Martin Haug, Regis R Paulinelli, Tibor Kovacs, Yves Harder, Bahadir M Gulluoglu, Eduardo Gonzalez, Andree Faridi, Elisabeth Elder, Peter Dubsky, Jens-Uwe Blohmer, Vesna Bjelic-Radisic, Mitchel Barry, Susanne Dieroff Hay, Kimberly Bowles, James French, Roland Reitsamer, Rupert Koller, Peter Schrenk, Daniela Kauer-Dorner, Jorge Biazus, Fabricio Brenelli, Jaime Letzkus, Ramon Saccilotto, Sarianna Joukainen, Susanna Kauhanen, Ulla Karhunen-Enckell, Juergen Hoffmann, Ulrich Kneser, Thorsten Kühn, Michalis Kontos, Ekaterini Christina Tampaki, Moshe Carmon, Tal Hadar, Giuseppe Catanuto, Carlos A Garcia-Etienne, Linetta Koppert, Pedro F Gouveia, Jakob Lagergren, Tor Svensjö, Nadia Maggi, Elisabeth A Kappos, Fabienne D Schwab, Liliana Castrezana, Daniel Steffens, Janna Krol, Christoph Tausch, Andreas Günthert, Michael Knauer, Maria C Katapodi, Susanne Bucher, Nik Hauser, Christian Kurzeder, Rosine Mucklow, Pelagia G Tsoutsou, Atakan Sezer, Güldeniz Karadeniz Çakmak, Hasan Karanlik, Patricia Fairbrother, Laszlo Romics, Giacomo Montagna, Cicero Urban, Melanie Walker, Silvia C Formenti, Guenther Gruber, Frank Zimmermann, Daniel Rudolf Zwahlen, Sherko Kuemmel, Mahmoud El-Tamer, Marie Jeanne Vrancken Peeters, Orit Kaidar-Person, Michael Gnant, Philip Poortmans, Jana de Boniface
May 09, 2022