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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.
Ioanna Ntalla, Lu-Chen Weng, James H Cartwright, Amelia Weber Hall, Gardar Sveinbjornsson, Nathan R Tucker, Seung Hoan Choi, Mark D Chaffin, Carolina Roselli, Michael R Barnes, Borbala Mifsud, Helen R Warren, Caroline Hayward, Jonathan Marten, James J Cranley, Maria Pina Concas, Paolo Gasparini, Thibaud Boutin, Ivana Kolcic, Ozren Polasek, Igor Rudan, Nathalia M Araujo, Maria Fernanda Lima-Costa, Antonio Luiz P Ribeiro, Renan P Souza, Eduardo Tarazona-Santos, Vilmantas Giedraitis, Erik Ingelsson, Anubha Mahajan, Andrew P Morris, Fabiola del Greco M, Luisa Foco, Martin Gögele, Andrew A Hicks, James P Cook, Lars Lind, Cecilia M Lindgren, Johan Sundström, Christopher P Nelson, Muhammad B Riaz, Nilesh J Samani, Gianfranco Sinagra, Sheila Ulivi, Mika Kähönen, Pashupati P Mishra, Nina Mononen, Kjell Nikus, Mark J Caulfield, Anna Dominiczak, Sandosh Padmanabhan, May E Montasser, Jeff R O'Connell, Kathleen Ryan, Alan R Shuldiner, Stefanie Aeschbacher, David Conen, Lorenz Risch, Sébastien Thériault, Nina Hutri-Kähönen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Olli T Raitakari, Catriona LK Barnes, Harry Campbell, Peter K Joshi, James F Wilson, Aaron Isaacs, Jan A Kors, Cornelia M van Duijn, Paul L Huang, Vilmundur Gudnason, Tamara B Harris, Lenore J Launer, Albert V Smith, Erwin P Bottinger, Ruth JF Loos, Girish N Nadkarni, Michael H Preuss, Adolfo Correa, Hao Mei, James Wilson, Thomas Meitinger, Martina Müller-Nurasyid, Annette Peters, Melanie Waldenberger, Massimo Mangino, Timothy D Spector, Michiel Rienstra, Yordi J van de Vegte, Pim van der Harst, Niek Verweij, Stefan Kääb, Katharina Schramm, Moritz F Sinner, Konstantin Strauch, Michael J Cutler, Diane Fatkin, Barry London, Morten Olesen, Dan M Roden, M Benjamin Shoemaker, J Gustav Smith, Mary L Biggs, Joshua C Bis, Jennifer A Brody, Bruce M Psaty, Kenneth Rice, Nona Sotoodehnia, Alessandro De Grandi, Christian Fuchsberger, Cristian Pattaro, Peter P Pramstaller, Ian Ford, J Wouter Jukema, Peter W Macfarlane, Stella Trompet, Marcus Dörr, Stephan B Felix, Uwe Völker, Stefan Weiss, Aki S Havulinna, Antti Jula, Katri Sääksjärvi, Veikko Salomaa, Xiuqing Guo, Susan R Heckbert, Henry J Lin, Jerome I Rotter, Kent D Taylor, Jie Yao, Renée de Mutsert, Arie C Maan, Dennis O Mook-Kanamori, Raymond Noordam, Francesco Cucca, Jun Ding, Edward G Lakatta, Yong Qian, Kirill V Tarasov, Daniel Levy, Honghuang Lin, Christopher H Newton-Cheh, Kathryn L Lunetta, Alison D Murray, David J Porteous, Blair H Smith, Bruno H Stricker, André Uitterlinden, Marten E van den Berg, Jeffrey Haessler, Rebecca D Jackson, Charles Kooperberg, Ulrike Peters, Alexander P Reiner, Eric A Whitsel, Alvaro Alonso, Dan E Arking, Eric Boerwinkle, Georg B Ehret, Elsayed Z Soliman, Christy L Avery, Stephanie M Gogarten, Kathleen F Kerr, Cathy C Laurie, Amanda A Seyerle, Adrienne Stilp, Solmaz Assa, M Abdullah Said, M Yldau van der Ende, Pier D Lambiase, Michele Orini, Julia Ramirez, Stefan Van Duijvenboden, David O Arnar, Daniel F Gudbjartsson, Hilma Holm, Patrick Sulem, Gudmar Thorleifsson, Rosa B Thorolfsdottir, Unnur Thorsteinsdottir, Emelia J Benjamin, Andrew Tinker, Kari Stefansson, Patrick T Ellinor, Yalda Jamshidi, Steven A Lubitz, Patricia B Munroe
Jun 08, 2020
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a...
De Finetti and Savage on the normative relevance of imprecise reasoning
This paper examines the claim that de Finetti and Savage completely rejected the notion of indeterminate, as distinct from imprecise, probabilities. It argues that their examination of imprecise reasoning refers both to...
Flexibility defines structure in crystals of amphiphilic DNA nanostars.
DNA nanostructures with programmable shape and interactions can be used as building blocks for the self-assembly of crystalline materials with prescribed nanoscale features, holding a vast technological potential. Structural...
Combined quantitative measures of ER, PR, HER2, and KI67 provide more prognostic information than categorical combinations in luminal breast cancer.
Mustapha Abubakar, Jonine Figueroa, H Raza Ali, Fiona Blows, Jolanta Lissowska, Carlos Caldas, Douglas F Easton, Mark E Sherman, Montserrat Garcia-Closas, Mitch Dowsett, Paul D Pharoah
Mar 28, 2019
Although most women with luminal breast cancer do well on endocrine therapy alone, some will develop fatal recurrence thereby necessitating the need to prospectively determine those for whom additional cytotoxic therapy will be...
Key issues for participatory research in the design and implementation of humanitarian assistance
Ilja Ormel, Jon Salsberg, Matthew Hunt, Alison Doucet, Lisa Hinton, Ann C Macaulay, Susan Law
Nov 26, 2020
BACKGROUND: Participatory approaches that engage affected populations are increasingly applied in humanitarian health programs in concert with emerging accountability frameworks and the rapid growth of research in these...
Pulmonary rehabilitation referral and uptake from primary care for people living with COPD
Frances Early, Patricia Mary Wilson, Christi Deaton, Ian Wellwood, Hena Wali Haque, Sarah Emma Fox, Azka Yousaf, Oliver D Meysner, James R Ward, Sally J Singh, Jonathan Paul Fuld
Mar 25, 2020
Healthcare service and patient barriers contribute to low referral to and uptake of pulmonary rehabilitation (PR). Solutions should support skilled clinician-patient conversations and span primary care-PR boundaries to prevent...
Published by: ERJ open research
Crystal and molecular structure of bis(di-<em>n-</em>propylammonium) dioxalatodiphenylstannate, [<em>n</em>-Pr<sub>2</sub>NH<sub>2</sub>]<sub>2</sub>[(C<sub>2</sub>O<sub>4</sub>)<sub>2</sub>SnPh<sub>2</sub>]
The title compound [n-Pr2NH2]2[(C2O4)2SnPh2] (1) has been synthesized by allowing Ph2SnCl2 to react with...
Crystal and molecular structure of bis(di-<em>n-</em>propylammonium) dioxalatodiphenylstannate, [<em>n</em>-Pr<sub>2</sub>NH<sub>2</sub>]<sub>2</sub>[(C<sub>2</sub>O<sub>4</sub>)<sub>2</sub>SnPh<sub>2</sub>]
The title compound [n-Pr2NH2]2[(C2O4)2SnPh2] (1) has been synthesized by allowing Ph2SnCl2 to react with...
Understanding the Influences of COPD Patient's Capability on the Uptake of Pulmonary Rehabilitation in the UK Through an Inclusive Design Approach.
Yuanyuan Liu, Terry Dickerson, Frances Early, Jonathan Fuld, Chen Jiang, P John Clarkson
Jul 28, 2021
Background
Pulmonary rehabilitation (PR) is recommended for patients with COPD to improve their symptoms and quality of life. However, in the UK, only one in ten of those who need PR receive it and this might be...
Understanding the Influences of COPD Patient's Capability on the Uptake of Pulmonary Rehabilitation in the UK Through an Inclusive Design Approach.
Yuanyuan Liu, Terry Dickerson, Frances Early, Jonathan Fuld, Chen Jiang, P John Clarkson
Apr 20, 2021
BACKGROUND: Pulmonary rehabilitation (PR) is recommended for patients with COPD to improve their symptoms and quality of life. However, in the UK, only one in ten of those who need PR receive it and this might be inaccessible to...
Understanding influences on the uptake of pulmonary rehabilitation in the East of England
INTRODUCTION: 1.2 million people in the UK have chronic obstructive pulmonary disease (COPD) that causes breathlessness, difficulty with daily activities, infections and hospitalisation. Pulmonary rehabilitation (PR), a...
Thermodynamics of Melting in Colloids and Helium
Abstract Enhanced fluctuations pervade a phase near a transition point. This phenomenon was observed in recent simulations of polyhedral particles, where rod-shaped vacancy defects diffused...
ERα-36 regulates progesterone receptor activity in breast cancer
Henri-Philippe Konan, Loay Kassem, Soleilmane Omarjee, Ausra Surmieliova-Garnès, Julien Jacquemetton, Elodie Cascales, Amélie Rezza, Olivier Trédan, Isabelle Treilleux, Coralie Poulard, Muriel Le Romancer
Jun 06, 2020
Abstract: Background: Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR), respectively, are largely involved in the development of...
Validation and optimisation of a touchscreen progressive ratio test of motivation in male rats.
Jonathan M Hailwood, Christopher J Heath, Trevor W Robbins, Lisa M Saksida, Timothy J Bussey
Sep 20, 2018
RATIONALE: Across species, effort-related motivation can be assessed by testing behaviour under a progressive ratio (PR) schedule of reinforcement. However, to date, PR tasks for rodents have been available using traditional...
The Ursinus Weekly, April 27, 1931
Dr. Felmuth speaker at Chapel Friday I. N. A. convention held at Brooklyn St. Paul Brotherhood holds annual banquet Interclass track meet won by the seniors Bear nine breaks even in week's play New Varsity Club to be...
Ursinus College Collegeville Pennsylvania newspaper William G. Felmuth tennis baseball student government Carl Vernon Tower track team debate team YMCA YWCA May Day pageant cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.
Zongling Ji, Hisham Mohammed, Aaron Webber, Jenna Ridsdale, Namshik Han, Jason S Carroll, Andrew D Sharrocks
Apr 23, 2019
There are numerous forkhead transcription factors in mammalian cells but we know little about the molecular functions of the majority of these. FOXK2 is a ubiquitously expressed family member suggesting an important function...
Understanding Product Returns
Quang Huy Duong, Li Zhou, Meng Meng, Truong Van Nguyen, Petros Ieromonachou, Duy Tiep Nguyen
Jan 31, 2022
Product Returns (PR) are an inevitable yet costly process in business, especially in the online marketplace. How to deal with the conundrums has attracted a great deal of attention from both practitioners and researchers. This...
ERα-36 regulates progesterone receptor activity in breast cancer.
Henri-Philippe Konan, Loay Kassem, Soleilmane Omarjee, Ausra Surmieliova-Garnès, Julien Jacquemetton, Elodie Cascales, Amélie Rezza, Olivier Trédan, Isabelle Treilleux, Coralie Poulard, Muriel Le Romancer
May 20, 2021
BACKGROUND: Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR), respectively, are largely involved in the development of breast cancer...
The role of photon recycling in perovskite light-emitting diodes
Changsoon Cho, Baodan Zhao, Gregory D. Tainter, Jung-Yong Lee, Richard H. Friend, Dawei Di, Felix Deschler, Neil C. Greenham
Jan 29, 2021
Abstract: Perovskite light-emitting diodes have recently broken the 20% barrier for external quantum efficiency. These values cannot be explained with classical models for optical outcoupling. Here, we analyse the role of photon...
Gene Correction Recovers Phagocytosis in Retinal Pigment Epithelium Derived from Retinitis Pigmentosa-Human-Induced Pluripotent Stem Cells.
Ana Artero-Castro, Kathleen Long, Andrew Bassett, Almudena Ávila-Fernandez, Marta Cortón, Antonio Vidal-Puig, Pavla Jendelova, Francisco Javier Rodriguez-Jimenez, Eleonora Clemente, Carmen Ayuso, Slaven Erceg
Feb 21, 2021
Hereditary retinal dystrophies (HRD) represent a significant cause of blindness, affecting mostly retinal pigment epithelium (RPE) and photoreceptors (PRs), and currently suffer from a lack of effective treatments. Highly...
RPE Retinitis Pigmentosa gene correction Induced Pluripotent Stem Cells Cell Differentiation Cell Line Gene Editing Gene Expression Regulation Humans Induced Pluripotent Stem Cells Mutation Phagocytosis Retinal Photoreceptor Cell Outer Segment Retinal Pigment Epithelium Retinitis Pigmentosa c-Mer Tyrosine Kinase
Oxygen responses within the nucleus accumbens are associated with individual differences in effort exertion in rats.
Jonathan M Hailwood, Gary Gilmour, Trevor W Robbins, Lisa M Saksida, Timothy J Bussey, Hugh M Marston, Francois Gastambide
Nov 16, 2018
Goal-directed motivated behaviour is crucial for everyday life. Such behaviour is often measured, in rodents, under a progressive ratio (PR) schedule of reinforcement. Previous studies have identified a few brain structures...
Heresy and forfeiture in marian England
PR Cavill
Oct 02, 2014
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