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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.
Ioanna Ntalla, Lu-Chen Weng, James H Cartwright, Amelia Weber Hall, Gardar Sveinbjornsson, Nathan R Tucker, Seung Hoan Choi, Mark D Chaffin, Carolina Roselli, Michael R Barnes, Borbala Mifsud, Helen R Warren, Caroline Hayward, Jonathan Marten, James J Cranley, Maria Pina Concas, Paolo Gasparini, Thibaud Boutin, Ivana Kolcic, Ozren Polasek, Igor Rudan, Nathalia M Araujo, Maria Fernanda Lima-Costa, Antonio Luiz P Ribeiro, Renan P Souza, Eduardo Tarazona-Santos, Vilmantas Giedraitis, Erik Ingelsson, Anubha Mahajan, Andrew P Morris, Fabiola del Greco M, Luisa Foco, Martin Gögele, Andrew A Hicks, James P Cook, Lars Lind, Cecilia M Lindgren, Johan Sundström, Christopher P Nelson, Muhammad B Riaz, Nilesh J Samani, Gianfranco Sinagra, Sheila Ulivi, Mika Kähönen, Pashupati P Mishra, Nina Mononen, Kjell Nikus, Mark J Caulfield, Anna Dominiczak, Sandosh Padmanabhan, May E Montasser, Jeff R O'Connell, Kathleen Ryan, Alan R Shuldiner, Stefanie Aeschbacher, David Conen, Lorenz Risch, Sébastien Thériault, Nina Hutri-Kähönen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Olli T Raitakari, Catriona LK Barnes, Harry Campbell, Peter K Joshi, James F Wilson, Aaron Isaacs, Jan A Kors, Cornelia M van Duijn, Paul L Huang, Vilmundur Gudnason, Tamara B Harris, Lenore J Launer, Albert V Smith, Erwin P Bottinger, Ruth JF Loos, Girish N Nadkarni, Michael H Preuss, Adolfo Correa, Hao Mei, James Wilson, Thomas Meitinger, Martina Müller-Nurasyid, Annette Peters, Melanie Waldenberger, Massimo Mangino, Timothy D Spector, Michiel Rienstra, Yordi J van de Vegte, Pim van der Harst, Niek Verweij, Stefan Kääb, Katharina Schramm, Moritz F Sinner, Konstantin Strauch, Michael J Cutler, Diane Fatkin, Barry London, Morten Olesen, Dan M Roden, M Benjamin Shoemaker, J Gustav Smith, Mary L Biggs, Joshua C Bis, Jennifer A Brody, Bruce M Psaty, Kenneth Rice, Nona Sotoodehnia, Alessandro De Grandi, Christian Fuchsberger, Cristian Pattaro, Peter P Pramstaller, Ian Ford, J Wouter Jukema, Peter W Macfarlane, Stella Trompet, Marcus Dörr, Stephan B Felix, Uwe Völker, Stefan Weiss, Aki S Havulinna, Antti Jula, Katri Sääksjärvi, Veikko Salomaa, Xiuqing Guo, Susan R Heckbert, Henry J Lin, Jerome I Rotter, Kent D Taylor, Jie Yao, Renée de Mutsert, Arie C Maan, Dennis O Mook-Kanamori, Raymond Noordam, Francesco Cucca, Jun Ding, Edward G Lakatta, Yong Qian, Kirill V Tarasov, Daniel Levy, Honghuang Lin, Christopher H Newton-Cheh, Kathryn L Lunetta, Alison D Murray, David J Porteous, Blair H Smith, Bruno H Stricker, André Uitterlinden, Marten E van den Berg, Jeffrey Haessler, Rebecca D Jackson, Charles Kooperberg, Ulrike Peters, Alexander P Reiner, Eric A Whitsel, Alvaro Alonso, Dan E Arking, Eric Boerwinkle, Georg B Ehret, Elsayed Z Soliman, Christy L Avery, Stephanie M Gogarten, Kathleen F Kerr, Cathy C Laurie, Amanda A Seyerle, Adrienne Stilp, Solmaz Assa, M Abdullah Said, M Yldau van der Ende, Pier D Lambiase, Michele Orini, Julia Ramirez, Stefan Van Duijvenboden, David O Arnar, Daniel F Gudbjartsson, Hilma Holm, Patrick Sulem, Gudmar Thorleifsson, Rosa B Thorolfsdottir, Unnur Thorsteinsdottir, Emelia J Benjamin, Andrew Tinker, Kari Stefansson, Patrick T Ellinor, Yalda Jamshidi, Steven A Lubitz, Patricia B Munroe
Jun 08, 2020
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a...
Combined quantitative measures of ER, PR, HER2, and KI67 provide more prognostic information than categorical combinations in luminal breast cancer.
Mustapha Abubakar, Jonine Figueroa, H Raza Ali, Fiona Blows, Jolanta Lissowska, Carlos Caldas, Douglas F Easton, Mark E Sherman, Montserrat Garcia-Closas, Mitch Dowsett, Paul D Pharoah
Mar 28, 2019
Although most women with luminal breast cancer do well on endocrine therapy alone, some will develop fatal recurrence thereby necessitating the need to prospectively determine those for whom additional cytotoxic therapy will be...
Linear induction motors with modular winding primaries and wound rotor secondaries
Linear induction motors commonly use double layer windings, which produce good sinusoidal travelling fields, but have relatively bulky end windings and use either half-filled slots or overhanging coil sides at the ends of the...
Crystal and molecular structure of bis(di-<em>n-</em>propylammonium) dioxalatodiphenylstannate, [<em>n</em>-Pr<sub>2</sub>NH<sub>2</sub>]<sub>2</sub>[(C<sub>2</sub>O<sub>4</sub>)<sub>2</sub>SnPh<sub>2</sub>]
The title compound [n-Pr2NH2]2[(C2O4)2SnPh2] (1) has been synthesized by allowing Ph2SnCl2 to react with...
Crystal and molecular structure of bis(di-<em>n-</em>propylammonium) dioxalatodiphenylstannate, [<em>n</em>-Pr<sub>2</sub>NH<sub>2</sub>]<sub>2</sub>[(C<sub>2</sub>O<sub>4</sub>)<sub>2</sub>SnPh<sub>2</sub>]
The title compound [n-Pr2NH2]2[(C2O4)2SnPh2] (1) has been synthesized by allowing Ph2SnCl2 to react with...
Key issues for participatory research in the design and implementation of humanitarian assistance
Ilja Ormel, Jon Salsberg, Matthew Hunt, Alison Doucet, Lisa Hinton, Ann C Macaulay, Susan Law
Nov 26, 2020
BACKGROUND: Participatory approaches that engage affected populations are increasingly applied in humanitarian health programs in concert with emerging accountability frameworks and the rapid growth of research in these...
Pulmonary rehabilitation referral and uptake from primary care for people living with COPD
Frances Early, Patricia Mary Wilson, Christi Deaton, Ian Wellwood, Hena Wali Haque, Sarah Emma Fox, Azka Yousaf, Oliver D Meysner, James R Ward, Sally J Singh, Jonathan Paul Fuld
Mar 25, 2020
Healthcare service and patient barriers contribute to low referral to and uptake of pulmonary rehabilitation (PR). Solutions should support skilled clinician-patient conversations and span primary care-PR boundaries to prevent...
Published by: ERJ open research
Understanding the Influences of COPD Patient's Capability on the Uptake of Pulmonary Rehabilitation in the UK Through an Inclusive Design Approach.
Yuanyuan Liu, Terry Dickerson, Frances Early, Jonathan Fuld, Chen Jiang, P John Clarkson
Jul 28, 2021
Background
Pulmonary rehabilitation (PR) is recommended for patients with COPD to improve their symptoms and quality of life. However, in the UK, only one in ten of those who need PR receive it and this might be...
Understanding the Influences of COPD Patient's Capability on the Uptake of Pulmonary Rehabilitation in the UK Through an Inclusive Design Approach.
Yuanyuan Liu, Terry Dickerson, Frances Early, Jonathan Fuld, Chen Jiang, P John Clarkson
Apr 20, 2021
BACKGROUND: Pulmonary rehabilitation (PR) is recommended for patients with COPD to improve their symptoms and quality of life. However, in the UK, only one in ten of those who need PR receive it and this might be inaccessible to...
Understanding influences on the uptake of pulmonary rehabilitation in the East of England
INTRODUCTION: 1.2 million people in the UK have chronic obstructive pulmonary disease (COPD) that causes breathlessness, difficulty with daily activities, infections and hospitalisation. Pulmonary rehabilitation (PR), a...
ERα-36 regulates progesterone receptor activity in breast cancer
Henri-Philippe Konan, Loay Kassem, Soleilmane Omarjee, Ausra Surmieliova-Garnès, Julien Jacquemetton, Elodie Cascales, Amélie Rezza, Olivier Trédan, Isabelle Treilleux, Coralie Poulard, Muriel Le Romancer
Jun 06, 2020
Abstract: Background: Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR), respectively, are largely involved in the development of...
Validation and optimisation of a touchscreen progressive ratio test of motivation in male rats.
Jonathan M Hailwood, Christopher J Heath, Trevor W Robbins, Lisa M Saksida, Timothy J Bussey
Sep 20, 2018
RATIONALE: Across species, effort-related motivation can be assessed by testing behaviour under a progressive ratio (PR) schedule of reinforcement. However, to date, PR tasks for rodents have been available using traditional...
End turn leakage reactance of concentrated modular winding stators
When considering common methods of calculating the end turn reactance of concentrated modular windings, significant effects are seen due to the presence of core iron that are not accounted for in many methods. Experimental study...
Linear induction motors with modular winding primaries and wound rotor secondaries
Linear induction motors commonly use double layer windings, which produce good sinusoidal travelling fields, but have relatively bulky end windings and use either half-filled slots or overhanging coil sides at the ends of the...
End turn leakage reactance of concentrated modular winding stators
When considering common methods of calculating the end turn reactance of concentrated modular windings, significant effects are seen due to the presence of core iron that are not accounted for in many methods. Experimental study...
Impact of Rocket Launch and Space Debris Air Pollutant Emissions on Stratospheric Ozone and Global Climate.
Detailed examination of the impact of modern space launches on the Earth's atmosphere is crucial, given booming investment in the space industry and an anticipated space tourism era. We develop air pollutant emissions...
Novel Fast Operating Moving Coil Actuator with Compensation Coil for HVDC Circuit Breakers
DC circuit breakers are major enabling components for multi-terminal HVDC systems. Their key design targets are operating speed and efficiency. This paper proposes a novel moving coil actuator using a compensation coil...
Understanding Product Returns
Quang Huy Duong, Li Zhou, Meng Meng, Truong Van Nguyen, Petros Ieromonachou, Duy Tiep Nguyen
Jan 31, 2022
Product Returns (PR) are an inevitable yet costly process in business, especially in the online marketplace. How to deal with the conundrums has attracted a great deal of attention from both practitioners and researchers. This...
The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.
Zongling Ji, Hisham Mohammed, Aaron Webber, Jenna Ridsdale, Namshik Han, Jason S Carroll, Andrew D Sharrocks
Apr 23, 2019
There are numerous forkhead transcription factors in mammalian cells but we know little about the molecular functions of the majority of these. FOXK2 is a ubiquitously expressed family member suggesting an important function...
The role of photon recycling in perovskite light-emitting diodes
Changsoon Cho, Baodan Zhao, Gregory D. Tainter, Jung-Yong Lee, Richard H. Friend, Dawei Di, Felix Deschler, Neil C. Greenham
Jan 29, 2021
Abstract: Perovskite light-emitting diodes have recently broken the 20% barrier for external quantum efficiency. These values cannot be explained with classical models for optical outcoupling. Here, we analyse the role of photon...
ERα-36 regulates progesterone receptor activity in breast cancer.
Henri-Philippe Konan, Loay Kassem, Soleilmane Omarjee, Ausra Surmieliova-Garnès, Julien Jacquemetton, Elodie Cascales, Amélie Rezza, Olivier Trédan, Isabelle Treilleux, Coralie Poulard, Muriel Le Romancer
May 20, 2021
BACKGROUND: Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR), respectively, are largely involved in the development of breast cancer...
Novel Fast Operating Moving Coil Actuator with Compensation Coil for HVDC Circuit Breakers
DC circuit breakers are major enabling components for multi-terminal HVDC systems. Their key design targets are operating speed and efficiency. This paper proposes a novel moving coil actuator using a compensation coil...
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