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Results: 188
Modeling arterial pulse waves in healthy aging
Peter H Charlton, Jorge Mariscal Harana, Samuel Vennin, Ye Li, Phil Chowienczyk, Jordi Alastruey
Sep 11, 2020
The arterial pulse wave (PW) is a rich source of information on cardiovascular (CV) health. It is widely measured by both consumer and clinical devices. However, the physical determinants of the PW are not yet fully understood...
Progressive tauopathy in P301S tau transgenic mice is associated with a functional deficit of the olfactory system.
Intracellular SERS nanoprobes for distinction of different neuronal cell types.
Distinction between closely related and morphologically similar cells is difficult by conventional methods especially without labeling. Using nuclear-targeted gold nanoparticles (AuNPs) as intracellular probes we demonstrate the...
Antidopaminergic treatment is associated with reduced chorea and irritability but impaired cognition in Huntington’s disease (Enroll-HD)
Objectives: Alterations in dopamine neurotransmission underlie some of the clinical features of Huntington’s disease (HD) and as such are a target for therapeutic intervention, especially for the treatment of chorea and some...
Published by: BMJ Publishing Group
Lysophosphatidic Acid and Hematopoiesis
Vertebrate hematopoiesis is a complex physiological process that is tightly regulated by intracellular signaling and extracellular microenvironment. In recent decades, breakthroughs in lineage-tracing technologies and lipidomics...
Serum Raman spectroscopy as a diagnostic tool in patients with Huntington's disease.
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an abnormal CAG expansion in exon 1 of the huntingtin (HTT) gene. Given its genetic basis it is possible to study patients both in the...
Published by: Chemical science
Serum Raman spectroscopy as a diagnostic tool in patients with Huntington's disease.
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an abnormal CAG expansion in exon 1 of the huntingtin (HTT) gene. Given its genetic basis it is possible to study patients both in the...
Antidopaminergic treatment is associated with reduced chorea and irritability but impaired cognition in Huntington’s disease (Enroll-HD)
Objectives: Alterations in dopamine neurotransmission underlie some of the clinical features of Huntington’s disease (HD) and as such are a target for therapeutic intervention, especially for the treatment of chorea and some...
Published by: BMJ Publishing Group
Female entrepreneurship in patriarchal society
This study explores the lived experience of female entrepreneurs in Kazakhstan to understand their motivations and challenges in light of the limited research availability on female entrepreneurship in a transitional and...
challenges female entrepreneurs institutional theory motivation patriarchal society transitional context /dk/atira/pure/subjectarea/asjc/1400/1403 name=Business and International Management /dk/atira/pure/subjectarea/asjc/1400/1408 name=Strategy and Management /dk/atira/pure/sustainabledevelopmentgoals/gender_equality name=SDG 5 - Gender Equality
Therapeutic Potential of Astrocyte Transplantation.
Cell transplantation is an attractive treatment strategy for a variety of brain disorders, as it promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of astrocytes has come into light...
Female entrepreneurship in patriarchal society
This study explores the lived experience of female entrepreneurs in Kazakhstan to understand their motivations and challenges in light of the limited research availability on female entrepreneurship in a transitional and...
challenges female entrepreneurs institutional theory motivation patriarchal society transitional context /dk/atira/pure/subjectarea/asjc/1400/1403 name=Business and International Management /dk/atira/pure/subjectarea/asjc/1400/1408 name=Strategy and Management /dk/atira/pure/sustainabledevelopmentgoals/gender_equality name=SDG 5 - Gender Equality
Therapeutic Potential of Astrocyte Transplantation.
Cell transplantation is an attractive treatment strategy for a variety of brain disorders, as it promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of astrocytes has come into light...
A novel neuroprotective therapy for Parkinson's disease using a viral noncoding RNA that protects mitochondrial complex I activity.
Wei-Li Kuan, Emma Poole, Michael Fletcher, Sharon Karniely, Pam Tyers, Mark Wills, Roger A Barker, John H Sinclair
Nov 16, 2017
Parkinson's disease (PD) is a neurodegenerative disorder that results in the loss of nigrostriatal dopamine neurons. The etiology of this cell loss is unknown, but it involves abnormalities in mitochondrial function. In this...
Animals Cell Death Cell Line Cytomegalovirus Disease Models Animal Dopaminergic Neurons Electron Transport Complex I Enzyme Activation HEK293 Cells Humans Injections Intravenous Male Mitochondria Neuroprotective Agents Neurotoxins Parkinson Disease Peptides RNA transport RNA Untranslated RNA Viral Rats Rats Sprague-Dawley Substantia Nigra
Modelling the natural history of Huntington's disease progression.
The Cambridge Crime Harm Index
The logic of simply summing crimes of all kind into a single total has long been challenged as misleading. All crimes are not created equal. Counting them as if they are fosters distortion of risk assessments, resource...
Linear response of east Greenland's tidewater glaciers to ocean/atmosphere warming.
Predicting the retreat of tidewater outlet glaciers forms a major obstacle to forecasting the rate of mass loss from the Greenland Ice Sheet. This reflects the challenges of modeling the highly dynamic, topographically complex...
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