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Results: 150
A kinase-independent function of PAK is crucial for pathogen-mediated actin remodelling.
The p21-activated kinase (PAK) family regulate a multitude of cellular processes, including actin cytoskeleton remodelling. Numerous bacterial pathogens usurp host signalling pathways that regulate actin reorganisation in order...
Complete Genome Sequence of Pseudomonas aeruginosa Reference Strain PAK.
Amy K Cain, Laura M Nolan, Geraldine J Sullivan, Cynthia B Whitchurch, Alain Filloux, Julian Parkhill
Nov 20, 2019
We report the complete genome of Pseudomonas aeruginosa strain PAK, a strain which has been instrumental in the study of a range of P. aeruginosa virulence and pathogenesis factors and has been used for over 50 years as a...
Computing the self-consistent field in Kohn-Sham density functional theory.
A new framework is presented for evaluating the performance of self-consistent field methods in Kohn-Sham density functional theory (DFT). The aims of this work are two-fold. First, we explore the properties of Kohn-Sham DFT as...
Predicting first-episode psychosis patients who will never relapse over 10 years.
Christy LM Hui, William G Honer, Edwin HM Lee, WC Chang, Sherry KW Chan, Emily SM Chen, Edwin PF Pang, Simon SY Lui, Dicky WS Chung, WS Yeung, Roger MK Ng, William TL Lo, Peter B Jones, Pak Sham, Eric YH Chen
Dec 04, 2018
BACKGROUND: Although relapse in psychosis is common, a small proportion of patients will not relapse in the long term. We examined the proportion and predictors of patients who never relapsed in the 10 years following complete...
microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma.
Julja Burchard, Chunsheng Zhang, Angela M Liu, Ronnie TP Poon, Nikki PY Lee, Kwong-Fai Wong, Pak C Sham, Brian Y Lam, Mark D Ferguson, George Tokiwa, Ryan Smith, Brendan Leeson, Rebecca Beard, John R Lamb, Lee Lim, Mao Mao, Hongyue Dai, John M Luk
Aug 08, 2017
Tumorigenesis involves multistep genetic alterations. To elucidate the microRNA (miRNA)-gene interaction network in carcinogenesis, we examined their genome-wide expression profiles in 96 pairs of tumor/non-tumor tissues from...
Animals Carcinoma Hepatocellular Cell Line Tumor Down-Regulation Energy Metabolism Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Genes Mitochondrial Humans Liver Liver Neoplasms Mice Mice Inbred C57BL MicroRNAs Mitochondria RNA Messenger Reproducibility of Results Sequence Homology Nucleic Acid Signal Transduction Survival Analysis Up-Regulation
A prospective, double-blind, pilot, randomized, controlled trial of an "embodied" virtual reality intervention for adults with low back pain
Christopher Eccleston, Emma Fisher, Sammeli Liikkanen, Toni Sarapohja, Carina Stenfors, Satu K. Jääskeläinen, Andrew S.C. Rice, Leena Mattila, Taru Blom, J. Raymond Bratty
Sep 01, 2022
Adults with chronic low back pain, disability, moderate-to-severe pain, and high fear of movement and reinjury were recruited into a trial of a novel, automated, digital therapeutics, virtual reality, psychological...
Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease
Petroula Proitsi, Michelle K Lupton, Latha Velayudhan, Stephen Newhouse, Isabella Fogh, Magda Tsolaki, Makrina Daniilidou, Megan Pritchard, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, Alzheimer's Disease Neuroimaging Initiative, Julie Williams, GERAD1 Consortium, Robert Stewart, Pak Sham, Simon Lovestone, John F Powell
Nov 08, 2018
BACKGROUND: Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking...
Logic of the Powers
Pak Nung Wong
Jul 30, 2021
What global future would ensure hope, justice and peace to the human mankind? In view of a fast evolving post-Covid world order, this volume explores a novel Christian post-colonial approach to global affairs. It examines the...
Published by: Routledge
Techno-Geopolitics
Pak Nung Wong
Sep 24, 2021
Techno-Geopolitics explores contemporary U.S.–China relations and the future of global cyber-security through the prisms of geopolitics and financial-technological competition. It puts forward a new conceptual framework for an...
Published by: Routledge
Open Science, Bandung and Ezekiel
Pak Nung Wong
Nov 07, 2017
To explore a new de-colonial option for the global future, this article grapples with three movements of our time: the ‘Open Science’ movement, the 1955 African-Asian conference and the Non-Aligned Movement, and the post-exilic...
Techno-Geopolitics
Pak Nung Wong
Sep 24, 2021
Techno-Geopolitics explores contemporary U.S.–China relations and the future of global cyber-security through the prisms of geopolitics and financial-technological competition. It puts forward a new conceptual framework for an...
Published by: Routledge
Long-term effects of discontinuation from antipsychotic maintenance following first-episode schizophrenia and related disorders
Christy LM Hui, William G Honer, Edwin HM Lee, Wing Chung Chang, Sherry KW Chan, Emily SM Chen, Edwin PF Pang, Simon SY Lui, Dicky WS Chung, Wai Song Yeung, Roger MK Ng, William TL Lo, Peter B Jones, Pak Sham, Eric YH Chen
May 03, 2018
BACKGROUND: The long-term consequences of discontinuing antipsychotic medication after successful treatment of first-episode psychosis are not well studied. We assess the relation between early maintenance therapy decisions in...
Open Science, Bandung and Ezekiel
Pak Nung Wong
Nov 07, 2017
To explore a new de-colonial option for the global future, this article grapples with three movements of our time: the ‘Open Science’ movement, the 1955 African-Asian conference and the Non-Aligned Movement, and the post-exilic...
On the stoichiometry of zirconium carbide
Claudia Gasparrini, Dhan-Sham Rana, Niccolò Le Brun, Denis Horlait, Christos N. Markides, Ian Farnan, William E. Lee
Apr 14, 2021
Abstract: The dependencies of the enhanced thermomechanical properties of zirconium carbide (ZrCx) with sample purity and stoichiometry are still not understood due to discrepancies in the literature. Multiple researchers have...
Logic of the Powers
Pak Nung Wong
Jul 30, 2021
What global future would ensure hope, justice and peace to the human mankind? In view of a fast evolving post-Covid world order, this volume explores a novel Christian post-colonial approach to global affairs. It examines the...
Published by: Routledge
Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids.
Ali Hashmi, Sham Tlili, Pierre Perrin, Molly Lowndes, Hanna Peradziryi, Joshua M Brickman, Alfonso Martínez Arias, Pierre-François Lenne
May 11, 2022
Shaping the animal body plan is a complex process that involves the spatial organization and patterning of the different germ layers. Recent advances in live imaging have started to unravel the cellular choreography underlying...
A prospective, double-blind, pilot, randomized, controlled trial of an "embodied" virtual reality intervention for adults with low back pain
Christopher Eccleston, Emma Fisher, Sammeli Liikkanen, Toni Sarapohja, Carina Stenfors, Satu K. Jääskeläinen, Andrew S.C. Rice, Leena Mattila, Taru Blom, J. Raymond Bratty
Sep 01, 2022
Adults with chronic low back pain, disability, moderate-to-severe pain, and high fear of movement and reinjury were recruited into a trial of a novel, automated, digital therapeutics, virtual reality, psychological...
The Grizzly, May 7, 2020
How we Spend our Time During COVID-19 Productivity is a Sham
Ursinus College Collegeville Pennsylvania newspaper covid-19 coronavirus cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
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