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Results: 149
Investigating Protein Interactions Between PAM-1, CDC-25.1, and the Novel lz6 Suppressor During Oocyte Maturation in C. elegans
Ilyssa Marsh
Jan 01, 0001
Caenorhabditis elegans are transparent nematodes often used as model organisms. PAM-1 is a highly conserved puromycin sensitive aminopeptidase that regulates oocyte maturation and polarity establishment. Mutations in the pam-1...
Published by: Ursinus College
Mitotic spindles in pam-1 mutant embryos of Caenorhabditis elegans
Jasmine Borie
Jan 01, 0001
Caenorhabditis elegans is a transparent nematode ideal for studying early embryonic mechanisms such as mitosis and meiosis. Mitosis is an important process involving the division of cells, and the spindles in mitosis are...
Published by: Ursinus College
Identification of the lz5 Suppressor of pam-1 in Caenorhabditis elegans
Emily M Schleicher
Jan 01, 0001
In C. elegans early embryonic development, the anterior-posterior axis is established. This establishment is created by the sperm-donated centrosome contacting the posterior cortex of the cell, causing a series of events to...
Published by: Ursinus College
Characterizing lz6, a Suppressor of the pam-1 Mutation in C. elegans
AJ Belville
Jan 01, 0001
The gene pam-1 encodes a puromycin-sensitive aminopeptidase that, in mutant form, causes several deleterious phenotypes in C. elegans, including lowered hatch rate and disturbed cytoskeletal and cortical activity around...
Genetics GENE suppressor Caenorhabditis elegans protein DNA Biochemistry, Biophysics, and Structural Biology Life Sciences
Published by: Ursinus College
Genetic Interactions Between PAM-1 and MPF
Quaran Davis
Jan 01, 0001
Caenorhabditis elegans are microscopic worms that are a great model organism for examining genes and proteins involved in the reproductive system because of their fecundity, easy manipulation, and easy to look at gonad. Lyczak's...
Published by: Ursinus College
Locus Determination and Delineation of Suppressors of pam-1 in C. elegans
Zana Lee
Jan 01, 0001
In order for the single celled embryo of C. elegans to develop, they need to have a proper anterior-posterior axis development. A gene that plays an important role in that development is pam-1 which codes for the puromycin...
Published by: Ursinus College
Genetic Interactions of PAM-1 & MPF in Developing Oocytes
Quaran Davis
Jan 01, 0001
Caenorhabditis elegans are microscopic worms that are a great model organism for examining genes and proteins involved in the reproductive system because of their fecundity, easy manipulation, and visible gonad. The Lyczak lab...
Published by: Ursinus College
Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment
Robert T. Jones, Maria Sanchez-Contreras, Isabella Vlisidou, Matthew R. Amos, Guowei Yang, Xavier Munoz-Berbel, Abhishek Upadhyay, Ursula J. Potter, Susan A. Joyce, Todd A. Ciche, A. Toby A. Jenkins, Stefan Bagby, Richard H ffrench-Constant, Nicholas R Waterfield
May 12, 2010
Background: Photorhabdus are Gram-negative nematode-symbiotic and insect-pathogenic bacteria. The species Photorhabdus asymbiotica is able to infect humans as well as insects. We investigated the secreted proteome of a...
Identification and Characterization of pam-1 Suppressor lz4
Timothy J. Litz
Jan 01, 0001
Cell polarization is responsible for proper cell function, axis formation, and viability. In the single-cell Caenorhabditis elegans, anteroposterior polarity is triggered by the sperm donated centrosome contacting the posterior...
Published by: Ursinus College
The Role of MBK-2 and CDK-1 in Oocytes and Early Embryos of pam-1 Mutant C. elegans
Alexa R Alessandrini
Jan 01, 0001
The puromycin-sensitive aminopeptidase, PAM-1, is needed for meiotic exit and anteroposterior axis formation in early Caenorhabditis elegans embryos. PAM-1 is also involved in oocyte maturation and the oocyte-to-embryo...
Published by: Ursinus College
Investigating Interactions Between PAM-1 and the Maturation Promoting Factor in Cell Cycle Regulation in Caenorhabditis elegans
Nareen Babaian
Jan 01, 0001
To develop into mature organisms, fertilized embryos must go through phases of growth, DNA replication, and cell division. The phases together make up the cell cycle, and movement through these phases is facilitated by many...
Published by: Ursinus College
Identifying Suppressor Mutations of the pam-1 Gene in C. elegans
Angela Hong
Jan 01, 0001
In order for the single celled embryo of C. elegans to develop, it must have a proper anterior-posterior axis development. A gene that plays an important role in that development is pam-1 which codes for the puromycin sensitive...
Published by: Ursinus College
Investigating Protein Interactions Between PAM-1, CDC-25.1, and MBK-2 During Oocyte Maturation in C. elegans
Ilyssa Marsh
Jan 01, 0001
Caenorhabditis elegans are transparent nematodes often used as model organisms. Their fully sequenced genome, simple organ systems, and high fecundity make them ideal for studying protein interactions. PAM-1 is a puromycin...
C. elegans oocyte maturation pam-1 CDC-25.1 MBK-2 Biology developmental biology Genetics Life Sciences
Published by: Ursinus College
Identification of the lz5 Suppressor of pam-1 in C. elegans
Robin Alsher
Jan 01, 0001
Polarity establishment is an essential process in C. elegans embryonic development, and occurs prior to the first cell division. This process is initiated when the sperm-donated centrosome makes contact and triggers changes in...
C. elegans polarity pam-1 RNAi suppressor wee-1.3 Biochemistry Biochemistry, Biophysics, and Structural Biology Life Sciences Molecular Biology Molecular genetics
Published by: Ursinus College
Investigating the Interaction Between PAM-1 and WEE-1.3 During Meiosis in C. elegans
Sophie Lear
Jan 01, 0001
PAM-1 is a puromycin sensitive aminopeptidase responsible for cleaving amino acids from the N-terminus of unknown target proteins. In our model system, a microscopic nematode known as C. elegans, functional PAM-1 is required for...
Published by: Ursinus College
Investigating Interactions Between Proteins PAM-1 and WEE-1.3 in Regulating the Cell Cycle in Caenorhabditis elegans
Nareen Babaian
Jan 01, 0001
In order to develop into mature organisms, fertilized embryos must go through growth, DNA replication, and cell division. These phases together make up the cell cycle, and movement through the phases is facilitated by many...
Published by: Ursinus College
Development of the support needs after ICU (SNAC) questionnaire.
Brenda O'Neill, Mark Linden, Pam Ramsay, Alia Darweish Medniuk, Joanne Outtrim, Judy King, Bronagh Blackwood
Aug 13, 2021
The Effect of the lz6 Suppressor on Polarity and Meiotic Cell Cycle Progression of Caenorhabditis elegans Puromycin-Sensitive Aminopeptidase (pam-1) Mutants
Brooke Adams
Jan 01, 0001
Puromycin-sensitive aminopeptidases (PSAs) are M1 family metalloproteases that regulate the cell cycle, fertility, and embryogenesis in many organisms. The PSA homolog found in the nematode Caenorhabditis elegans is known as...
C. elegans Puromycin sensitive aminopeptidase (PSA) pam-1 Biochemistry Biochemistry, Biophysics, and Structural Biology Life Sciences Molecular Biology
Published by: Ursinus College
The Relationship Between pam-1 and wee-1.3(lz5) in Mitosis of C. elegans
Sarah Bell
Jan 01, 0001
This research is focused on part of the cell cycle that involves the first cell division, otherwise known as mitosis. Regulation of mitosis is very important as mistakes can cause problems such as uncontrolled cell division...
Published by: Ursinus College
Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment
Robert T. Jones, Maria Sanchez-Contreras, Isabella Vlisidou, Matthew R. Amos, Guowei Yang, Xavier Munoz-Berbel, Abhishek Upadhyay, Ursula J. Potter, Susan A. Joyce, Todd A. Ciche, A. Toby A. Jenkins, Stefan Bagby, Richard H ffrench-Constant, Nicholas R Waterfield
May 12, 2010
Background: Photorhabdus are Gram-negative nematode-symbiotic and insect-pathogenic bacteria. The species Photorhabdus asymbiotica is able to infect humans as well as insects. We investigated the secreted proteome of a...
Location and Characterization of the lz2 Suppressor of pam-1 in C. elegans
Alyse N. Brewer
Jan 01, 0001
In a single-celled Caenorhabditis elegans, the anterior posterior axis is established when the sperm-donated centrosome meets the posterior cortex, which is fundamental for proper development. pam-1 encodes for the protein...
Cell Polarity C. elegans suppressors anterior posterior axis snp mapping Biology developmental biology Life Sciences
Published by: Ursinus College
The Connection Between Cytoskeletal Proteins and pam-1 Mutants
AJ Belville
Jan 01, 0001
Proper development of the one-cell embryo in the nematode C. elegans depends on polarization along the anterior-posterior axis. The actin cytoskeleton is critical to this process, and mutation in the gene pam-1 results in...
pam-1 Caenorhabditis elegans pfn-1 ani-1 RNAi Cytoskeleton Biochemistry Biochemistry, Biophysics, and Structural Biology Life Sciences Molecular Biology
Published by: Ursinus College
Investigating the Interaction Between PAM-1 and WEE-1.3 During Meiosis in C. elegans
Sophie Lear
Jan 01, 0001
PAM-1 is a puromycin sensitive aminopeptidase responsible for cleaving the amino acid from the N-terminus of unknown target proteins. In our model system, a microscopic nematode known as C. elegans, functional PAM-1 is required...
Published by: Ursinus College
Investigating the Effect of the wee-1.3 and pam-1 Mutations on Meiosis in C. elegans
PAM-1 is a puromycin sensitive aminopeptidase responsible for cleaving the amino acid from the N-terminus of unknown target proteins. In our model system, a microscopic nematode known as C. elegans, functional PAM-1 is required...
Published by: Ursinus College
Identification and Phenotypic Analysis of the lz5 Suppressor of the pam-1 Mutation in C. elegans
Dorothy A Benton
Jan 01, 0001
The anterior-posterior axis in the C. elegans embryo is set up in the one-cell embryo stage and results in an asymmetric cell division, creating two differently sized daughter cells. One of the genes involved in axis...
Published by: Ursinus College
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