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Results: 43
Effectiveness of quality improvement collaboratives in UK surgical settings and barriers and facilitators influencing their implementation
Outcomes of Surgery for Patients with Peripheral Arterial Disease During the COVID-19 Pandemic in the United Kingdom
Panagiota Birmpili, Qiuju Li, Amundeep S Johal, Sam Waton, Eleanor Atkins, Jonathan R Boyle, Ian Chetter, Robin Williams, Arun D Pherwani, David A Cromwell
Mar 16, 2023
OBJECTIVE: There is limited information on changes in the patterns of care and outcomes for patients who had vascular procedures after the first wave of the COVID-19 pandemic. The aim of this population based study was to...
Investigation of drug partition kinetics to fat in simulated fed state gastric conditions based on drug properties
The presence of fat in the gastric environment can affect the pharmacokinetic behaviour of drugs with mechanisms which have not been yet fully understood. The objective of the current study was to assess the drug partition to...
Investigation of drug partition kinetics to fat in simulated fed state gastric conditions based on drug properties
The presence of fat in the gastric environment can affect the pharmacokinetic behaviour of drugs with mechanisms which have not been yet fully understood. The objective of the current study was to assess the drug partition to...
Type II ancient compact solutions to the Yamabe flow
We construct new type II ancient compact solutions to the Yamabe flow. Our solutions are rotationally symmetric and converge, as t → -∞, to a tower of two spheres. Their curvature operator changes sign. We allow two...
The predictive value of abnormal P-wave axis for the detection of incident atrial fibrillation
Rahul Kumar Chattopadhyay, Panagiota Anna Chousou, Trisha Mukherjee, Peter John Pugh, Vassilios S Vassiliou
Jan 04, 2023
INTRODUCTION: There is growing interest in the prediction of incident atrial fibrillation (AF). The 12-lead electrocardiogram (ECG) has been a particularly rich target for possible prediction strategies. PURPOSE: The P-wave axis...
Internet of Things in E-Government
E-government can greatly benefit by the use of IoT, enabling the creation of new innovative services or the transformation and enhancement of current ones, which are informed by smart devices and real-time data. The adoption of...
Published by: IGI Global Scientific Publishing
Biopharmaceutical aspects and implications of excipient variability in drug product performance
Implementation of Quality by Design approaches in pharmaceutical industry requires a sound understanding of the parameters triggering final product variability. Excipients, although generally regarded as inert components, are of...
Affinity of Lipophilic Drugs to Mixed Lipid Aggregates in Simulated Gastrointestinal Fluids
Mixed lipid aggregates, comprising of bile salts and phospholipids, present in the small intestine assist in drug solubilization and subsequent drug dissolution and absorption through the intestinal epithelium. The increased...
Scientific, sustainability and regulatory challenges of cultured meat
Mark Post, Shulamit Levenberg, David Kaplan, Nicholas Genovese, Jianan Fu, Chris Bryant, Nicole Negowetti, Karin Verzijden, Panagiota Moutsatsou
Jul 31, 2020
Cellular agriculture is an emerging branch of biotechnology that aims to address issues associated with the environmental impact, animal welfare and sustainability challenges of conventional animal farming for meat production....
Benefits of support groups for patients living with implantable cardioverter defibrillators
Katie H Sanders, Panagiota Anna Chousou, Kathryn Carver, Peter J Pugh, Hans Degens, May Azzawi
Nov 17, 2022
BACKGROUND: Patients with implantable cardioverter defibrillators (ICD) experience anxiety, depression and reduced quality of life (QoL). OBJECTIVES: This mixed-methods systematic review evaluates whether ICD support groups have...
Type II ancient compact solutions to the Yamabe flow
We construct new type II ancient compact solutions to the Yamabe flow. Our solutions are rotationally symmetric and converge, as t → -∞, to a tower of two spheres. Their curvature operator changes sign. We allow two...
Biopharmaceutical aspects and implications of excipient variability in drug product performance
Implementation of Quality by Design approaches in pharmaceutical industry requires a sound understanding of the parameters triggering final product variability. Excipients, although generally regarded as inert components, are of...
The organization of RNA contacts by PTB for regulation of FAS splicing.
Ian Mickleburgh, Panagiota Kafasla, Dmitry Cherny, Miriam Llorian, Stephen Curry, Richard J Jackson, Christopher WJ Smith
Jul 08, 2014
An Evaluation of the Effectiveness of Labor Market Integration Policies in EU Member States Using PROMETHEE
From an economic point of view, the rational response towards migration is the labor market integration of immigrants. Within the above framework, several actions have been developed by the European Union member states over the...
Published by: IGI Global Scientific Publishing
Applications of DSSs in Irrigation and Production Planning in Agriculture
Jason Papathanasiou, Georgios Tsaples, Thomas Bournaris, Basil Manos, Panagiota Digkoglou
Jul 01, 2021
Agricultural management has become an increasingly complex endeavor. As a result, there is the need to generate knowledge from information that can guide practice, and in that aspect, decision support systems (DSSs) can...
Published by: IGI Global Scientific Publishing
Affinity of Lipophilic Drugs to Mixed Lipid Aggregates in Simulated Gastrointestinal Fluids
Mixed lipid aggregates, comprising of bile salts and phospholipids, present in the small intestine assist in drug solubilization and subsequent drug dissolution and absorption through the intestinal epithelium. The increased...
The predictive value of abnormal P-wave axis for the detection of incident atrial fibrillation
Rahul Kumar Chattopadhyay, Panagiota Anna Chousou, Trisha Mukherjee, Peter John Pugh, Vassilios S Vassiliou
Dec 08, 2022
INTRODUCTION: There is growing interest in the prediction of incident atrial fibrillation (AF). The 12-lead electrocardiogram (ECG) has been a particularly rich target for possible prediction strategies. PURPOSE: The P-wave axis...
A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2
Panagiota Vardaka, Teresa Lozano, Christopher Bot, Jonathan Ellery, Sarah K. Whiteside, Charlotte J. Imianowski, Stuart Farrow, Simon Walker, Hanneke Okkenhaug, Jie Yang, Klaus Okkenhaug, Paula Kuo, Rahul Roychoudhuri
Nov 03, 2020
Abstract: Whereas effector CD4+ and CD8+ T cells promote immune activation and can drive clearance of infections and cancer, CD4+ regulatory T (Treg) cells suppress their function, contributing to both immune homeostasis and...
Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study
Adam Naguib, James C Cooke, Lisa Happerfield, Lucy Kerr, Laura J Gay, Robert N Luben, Richard Y Ball, Panagiota N Mitrou, Alison McTaggart, Mark J Arends
Jun 16, 2011
Adenocarcinoma Aged Aged 80 and over Class I Phosphatidylinositol 3-Kinases Colonic Neoplasms DNA Mutational Analysis Disease Progression Female Gene Expression Regulation Neoplastic Genetic Association Studies Humans Immunohistochemistry Male Middle Aged Mutation PTEN Phosphohydrolase Phosphatidylinositol 3-Kinases Proto-Oncogene Mas Sex Factors Surveys and Questionnaires
A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2.
Panagiota Vardaka, Teresa Lozano, Christopher Bot, Jonathan Ellery, Sarah K Whiteside, Charlotte J Imianowski, Stuart Farrow, Simon Walker, Hanneke Okkenhaug, Jie Yang, Klaus Okkenhaug, Paula Kuo, Rahul Roychoudhuri
Oct 15, 2020
Whereas effector CD4+ and CD8+ T cells promote immune activation and can drive clearance of infections and cancer, CD4+ regulatory T (Treg) cells suppress their function, contributing to both immune homeostasis and cancer...
Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuits.
John Apergis-Schoute, Panagiota Iordanidou, Cedric Faure, Sonia Jego, Cornelia Schöne, Teemu Aitta-Aho, Antoine Adamantidis, Denis Burdakov
May 11, 2015
GABA hypocretin Hypothalamus melanin-concentrating hormone optogenetics orexin Animals Calcium Channelrhodopsins Excitatory Amino Acid Antagonists Hypothalamic Area Lateral Hypothalamic Hormones In Vitro Techniques Intracellular Signaling Peptides and Proteins Luminescent Proteins Lysine Melanins Membrane Potentials Mice Nerve Net Neural Inhibition Neurons Neuropeptides Optogenetics Orexins Patch-Clamp Techniques Pituitary Hormones Signal Transduction Transduction Genetic gamma-Aminobutyric Acid
Scientific, sustainability and regulatory challenges of cultured meat
Mark Post, Shulamit Levenberg, David Kaplan, Nicholas Genovese, Jianan Fu, Chris Bryant, Nicole Negowetti, Karin Verzijden, Panagiota Moutsatsou
Jul 31, 2020
Cellular agriculture is an emerging branch of biotechnology that aims to address issues associated with the environmental impact, animal welfare and sustainability challenges of conventional animal farming for meat production....
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