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Driving Financial Inclusion
This paper examines India's level of digital access to financial services as compared to other Asian countries. The study also intends to analyse whether COVID-19 has influenced the usage trend of the selected digital payment...
Published by: IGI Global Scientific Publishing
Identification of HSP47 Binding Site on Native Collagen and Its Implications for the Development of HSP47 Inhibitors
Haiyan Cai, Parvathy Sasikumar, Gemma Little, Dominique Bihan, Samir W. Hamaia, Aiwu Zhou, Jonathan M. Gibbins, Richard W. Farndale
Jul 07, 2021
HSP47 (heat shock protein 47) is a collagen-specific molecular chaperone that is essential for procollagen folding and function. Previous studies have shown that HSP47 binding requires a critical Arg residue at the Y position of...
Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.
Arash Yavari, Claire J Stocker, Sahar Ghaffari, Edward T Wargent, Violetta Steeples, Gabor Czibik, Katalin Pinter, Mohamed Bellahcene, Angela Woods, Pablo B Martínez de Morentin, Céline Cansell, Brian YH Lam, André Chuster, Kasparas Petkevicius, Marie-Sophie Nguyen-Tu, Aida Martinez-Sanchez, Timothy J Pullen, Peter L Oliver, Alexander Stockenhuber, Chinh Nguyen, Merzaka Lazdam, Jacqueline F O'Dowd, Parvathy Harikumar, Mónika Tóth, Craig Beall, Theodosios Kyriakou, Julia Parnis, Dhruv Sarma, George Katritsis, Diana DJ Wortmann, Andrew R Harper, Laurence A Brown, Robin Willows, Silvia Gandra, Victor Poncio, Márcio J de Oliveira Figueiredo, Nathan R Qi, Stuart N Peirson, Rory J McCrimmon, Balázs Gereben, László Tretter, Csaba Fekete, Charles Redwood, Giles SH Yeo, Lora K Heisler, Guy A Rutter, Mark A Smith, Dominic J Withers, David Carling, Eduardo B Sternick, Jonathan RS Arch, Michael A Cawthorne, Hugh Watkins, Houman Ashrafian
Sep 03, 2019
Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-activated protein kinase (AMPK) has been proposed...
AMP-Activated Protein Kinases Adiposity Adult aging Agouti-Related Protein Animals Arcuate Nucleus of Hypothalamus Energy Metabolism Enzyme Activation Feeding Behavior Female Heterozygote Humans Hyperphagia Hypothalamus Insulin Insulin-Secreting Cells Male Mice Mitochondria Mutation Neurons obesity Oxidative Phosphorylation Receptors Ghrelin Ribosomes Signal Transduction Transcriptome Up-Regulation