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DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.
Pedro Silva-Pinheiro, Carlos Pardo-Hernández, Aurelio Reyes, Lisa Tilokani, Anup Mishra, Raffaele Cerutti, Shuaifeng Li, Dieu-Hien Rozsivalova, Sebastian Valenzuela, Sukru A Dogan, Bradley Peter, Patricio Fernández-Silva, Aleksandra Trifunovic, Julien Prudent, Michal Minczuk, Laurence Bindoff, Bertil Macao, Massimo Zeviani, Maria Falkenberg, Carlo Viscomi
Jun 25, 2021
Mutations in POLG, encoding POLγA, the catalytic subunit of the mitochondrial DNA polymerase, cause a spectrum of disorders characterized by mtDNA instability. However, the molecular pathogenesis of POLG-related diseases is...
DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.
Pedro Silva-Pinheiro, Carlos Pardo-Hernández, Aurelio Reyes, Lisa Tilokani, Anup Mishra, Raffaele Cerutti, Shuaifeng Li, Dieu-Hien Rozsivalova, Sebastian Valenzuela, Sukru A Dogan, Bradley Peter, Patricio Fernández-Silva, Aleksandra Trifunovic, Julien Prudent, Michal Minczuk, Laurence Bindoff, Bertil Macao, Massimo Zeviani, Maria Falkenberg, Carlo Viscomi
Jun 06, 2021
Mutations in POLG, encoding POLγA, the catalytic subunit of the mitochondrial DNA polymerase, cause a spectrum of disorders characterized by mtDNA instability. However, the molecular pathogenesis of POLG-related diseases is...
Published by: Nucleic Acids Research
The Unbearable Lightness of Bones
B Epps
Jan 10, 2017
Focusing on two documentary films by Patricio Guzmán, $\textit{Chile, Obstinate Memory}$ (1997) and, especially, $\textit{Nostalgia of the Light}$ (2010), this paper examines some of the relations between neoliberal violence...
Variations of geometric invariant quotients for pairs, a computational approach
We study GIT compactifications of pairs formed by a hypersurface and a hyperplane. We provide a general setting to characterize all polarizations which give rise to different GIT quotients. Furthermore, we describe a finite...
Variations of geometric invariant quotients for pairs, a computational approach
We study GIT compactifications of pairs formed by a hypersurface and a hyperplane. We provide a general setting to characterize all polarizations which give rise to different GIT quotients. Furthermore, we describe a finite...
The Effect of Vanes and Blades on Ingress in Gas Turbines
This paper presents experimental and computational results using a 1.5-stage test rig designed to investigate the effects of ingress through a double radial overlap rim-seal. The effect of the vanes and blades on ingress was...
"As Seen on TV"
Maria de la luz Matus-Mendoza
Aug 01, 2013
This paper reports on the usage of the Spanish subjunctive in televised media. Silva-Corvahin (1994) and Lavandera (1983) have researched the subjunctive extensively though without consideration of the language as used on...
Published by: Atlantic Provinces Linguistic Association
"As Seen on TV"
Maria de la luz Matus-Mendoza
Aug 01, 2013
This paper reports on the usage of the Spanish subjunctive in televised media. Silva-Corvahin (1994) and Lavandera (1983) have researched the subjunctive extensively though without consideration of the language as used on...
Published by: Atlantic Provinces Linguistic Association
Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput.
Ludimila Dias Almeida, Ali Salim Faraj Silva, Daniel Calixto Mota, Adrielle Ayumi Vasconcelos, Antônio Pedro Camargo, Gabriel Silva Pires, Monique Furlan, Helena Martins Ribeiro da Cunha Freire, Angélica Hollunder Klippel, Suélen Fernandes Silva, Cleslei Fernando Zanelli, Marcelo Falsarella Carazzolle, Stephen G Oliver, Elizabeth Bilsland
Jan 28, 2022
Saccharomyces cerevisiae drug efflux drug transport drug uptake genetic interactions nonessential transporter double-deletion library plasma membrane transporter xenobiotics Yeast ATP-Binding Cassette Transporters Antifungal Agents Biological Transport Gene Deletion Gene Library High-Throughput Screening Assays Monosaccharide Transport Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins xenobiotics
Mismatch between midline shift and hematoma thickness as a prognostic factor of mortality in patients sustaining acute subdural hematoma
Matheus Rodrigues de Souza, Caroline Ferreira Fagundes, Davi Jorge Fontoura Solla, Gustavo Carlos Lucena da Silva, Rafaela Borin Barreto, Manoel Jacobsen Teixeira, Robson Luis Oliveira de Amorim, Angelos G Kolias, Daniel Godoy, Wellingson Silva Paiva
May 26, 2021
Background: Acute subdural hematoma (ASDH) is a traumatic lesion commonly found secondary to traumatic brain injury. Radiological findings on CT, such as hematoma thickness (HT) and structures midline shift (MLS), have an...
Five Seniors Earn President's Award on May 5 for Academic Excellence
Winthrop University
Jan 01, 0001
Quick Facts
President Dan Mahony recognized Kathryn Taylor Burt of Wilmington, North Carolina, in the morning ceremony, held for the College of Visual and Performing Arts and the College of Arts and Sciences. In the afternoon...
Published by: Winthrop University
The Effect of Vanes and Blades on Ingress in Gas Turbines
This paper presents experimental and computational results using a 1.5-stage test rig designed to investigate the effects of ingress through a double radial overlap rim-seal. The effect of the vanes and blades on ingress was...
Experimental and Computational Investigation of Flow Instabilities in Turbine Rim Seals
Josh Horwood, Fabian Patricio Hualca Tigsilema, James Scobie, Mike Wilson, Carl Sangan, Gary Lock
Jan 01, 2019
In high-pressure turbines, cool air is purged through rim seals at the periphery of wheel-spaces between the stator and rotor disks. The purge suppresses the ingress of hot gas from the annulus but superfluous use is...
/dk/atira/pure/subjectarea/asjc/2100/2104 name=Nuclear Energy and Engineering /dk/atira/pure/subjectarea/asjc/2100/2103 name=Fuel Technology /dk/atira/pure/subjectarea/asjc/2200/2202 name=Aerospace Engineering /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
Re-Ingestion of Upstream Egress in a 1.5-Stage Gas Turbine Rig
James Scobie, Fabian Patricio Hualca, Marios Patinios, Carl Sangan, John Owen, Gary Lock
Jul 31, 2018
n gas turbines, rim seals are fitted at the periphery of stator and rotor discs to minimize the purge flow required to seal the wheel-space between the discs. Ingestion (or ingress) of hot mainstream gases through rim seals is a...
Experimental and Computational Investigation of Flow Instabilities in Turbine Rim Seals
Josh Horwood, Fabian Patricio Hualca Tigsilema, James Scobie, Mike Wilson, Carl Sangan, Gary Lock
Jan 01, 2019
In high-pressure turbines, cool air is purged through rim seals at the periphery of wheel-spaces between the stator and rotor disks. The purge suppresses the ingress of hot gas from the annulus but superfluous use is...
/dk/atira/pure/subjectarea/asjc/2100/2104 name=Nuclear Energy and Engineering /dk/atira/pure/subjectarea/asjc/2100/2103 name=Fuel Technology /dk/atira/pure/subjectarea/asjc/2200/2202 name=Aerospace Engineering /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
Mismatch between midline shift and hematoma thickness as a prognostic factor of mortality in patients sustaining acute subdural hematoma.
Matheus Rodrigues de Souza, Caroline Ferreira Fagundes, Davi Jorge Fontoura Solla, Gustavo Carlos Lucena da Silva, Rafaela Borin Barreto, Manoel Jacobsen Teixeira, Robson Luis Oliveira de Amorim, Angelos G Kolias, Daniel Godoy, Wellingson Silva Paiva
Jul 09, 2021
BACKGROUND: Acute subdural hematoma (ASDH) is a traumatic lesion commonly found secondary to traumatic brain injury. Radiological findings on CT, such as hematoma thickness (HT) and structures midline shift (MLS), have an...
Flow Instabilities in Gas Turbine Chute Seals
Joshua Horwood, Fabian Patricio Hualca Tigsilema, Michael Wilson, James Scobie, Carl Sangan, Gary Lock, Johan Dahlqvist, Jens Fridh
Feb 29, 2020
The ingress of hot annulus gas into stator-rotor cavities is an important topic to engine designers. Rim-seals reduce the pressurised purge required to protect highly-stressed components. This paper describes an experimental and...
Re-Ingestion of Upstream Egress in a 1.5-Stage Gas Turbine Rig
James Scobie, Fabian Patricio Hualca, Marios Patinios, Carl Sangan, John Owen, Gary Lock
Jul 31, 2018
n gas turbines, rim seals are fitted at the periphery of stator and rotor discs to minimize the purge flow required to seal the wheel-space between the discs. Ingestion (or ingress) of hot mainstream gases through rim seals is a...
Adjectival Agreement in Middle and Early Modern Welsh Native and Translated Prose
This paper investigates adjectival agreement in a group of Middle Welsh native prose texts and a sample of translations from around the end of the Middle Welsh period and the beginning of the Early Modern period. It presents a...
Vaginal Microbiota Diversity in Response to Lipopolysaccharide in Gilts Housed Under Three Housing Systems.
Luana Alves, Francisco José de Novais, Arthur Nery da Silva, Michelle Silva Araujo, Thiago Bernardino, Germana Vizzotto Osowski, Ricardo Zanella, Matthew Lee Settles, Mark A Holmes, Heidge Fukumasu, Vera Letticie de Azevedo Ruiz, Adroaldo José Zanella
Apr 22, 2022
The United Kingdom and European Union have banned crates for pregnant sows. However, animals are kept in a restrictive environment for up to four weeks after mating, leading to stress and different responses of the animals'...
A new remote predictor of wave reflection based on runup asymmetry
Rafael Almar, Chris Blenkinsopp, Luis Pedro Almeida, Patricio A. Catalán, Erwin Bergsma, Rodrigo Cienfuegos, Nguyen Trung Viet
Feb 05, 2019
Reflected waves account for a significant part of the nearshore energy budget and influence incoming waves, nearshore circulation and sediment transport. The use of swash parameters to estimate wave reflection is investigated...
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