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Results: 83
Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit.
Michael C Lee, Michael S Nahorski, James RF Hockley, Van B Lu, Gillian Ison, Luke A Pattison, Gerard Callejo, Kaitlin Stouffer, Emily Fletcher, Christopher Brown, Ichrak Drissi, Daniel Wheeler, Patrik Ernfors, David Menon, Frank Reimann, Ewan St John Smith, C Geoffrey Woods
Jul 02, 2020
labor pain nociception Pain Kv6.4 quantitative sensory testing DRG neuron exome sequencing Adult Alleles Amino Acid Sequence Analgesics Animals Base Sequence Cell Membrane Cognition Cohort Studies Emotions Female Ganglia Spinal Heterozygote Humans Ion Channel Gating Labor Pain Male Mice Inbred C57BL Models Biological Mutation Nociceptors Pain Threshold Polymorphism Single Nucleotide Potassium Channels Voltage-Gated Pregnancy Protein Multimerization Protein Subunits Sensory Receptor Cells Shab Potassium Channels Subcellular Fractions Uterus
Treatment of posterior circulation stroke
One-fifth of strokes occur in the territory of the posterior circulation, but their management, particularly acute reperfusion therapy and neurointervention procedures for secondary prevention, has received much less attention...
Reducing occupational sitting time in adults with type 2 diabetes
AIM: Understanding barriers and facilitators for limiting occupational sitting and what impact it has on health on those with type 2 diabetes is essential for future trials and intervention development in primary healthcare...
Towards standard electrolytes for sodium-ion batteries
Damien Monti, Erlendur Jonsson, Andrea Boschin, M Rosa Palacín, Alexandre Ponrouch, Patrik Johansson
Nov 05, 2020
The currently emerging sodium-ion battery technology is in need of an optimized standard organic solvent electrolyte based on solid and directly comparable data. With this aim we have made a systematic study of "simple"...
Brain reactivity to emotion persists in NREM sleep and is associated with individual dream recall.
Maëva Moyne, Guillaume Legendre, Luc Arnal, Samika Kumar, Virginie Sterpenich, Margitta Seeck, Didier Grandjean, Sophie Schwartz, Patrik Vuilleumier, Judith Domínguez-Borràs
Mar 20, 2022
The waking brain efficiently detects emotional signals to promote survival. However, emotion detection during sleep is poorly understood and may be influenced by individual sleep characteristics or neural reactivity. Notably...
Graphene for Biosensing Applications in Point-of-Care Testing.
Ioannis Prattis, Ernestine Hui, Patrik Gubeljak, Gabriele S Kaminski Schierle, Antonio Lombardo, Luigi G Occhipinti
Feb 11, 2021
Graphene and graphene-related materials (GRMs) exhibit a unique combination of electronic, optical, and electrochemical properties, which make them ideally suitable for ultrasensitive and selective point-of-care testing (POCT)...
Impact of achievement and change in achievement of lifestyle recommendations in middle-age on risk of the most common potentially preventable cancers.
Juliet A Usher-Smith, Christel Häggström, Patrik Wennberg, Kristina Lindvall, Jean Strelitz, Stephen J Sharp, Simon J Griffin
Jul 07, 2021
Editorial
This is the author accepted manuscript. The final version is available from Frontiers via http://dx.doi.org/
A Physiological-Monitoring Electronic Platform for Cattle Grazing Systems
Ricardo Santos, Fabiana Alves, Patrik Bressan, Ricardo Aguiar, Wellington Santos, Rafael Costa
Jul 01, 2020
In this work, we present a non-invasive electronic platform for physiological data acquisition on cattle grazing systems. The platform can be used for dairy and beef cattle to continuously monitor physiological variables such as...
Published by: IGI Global Scientific Publishing
Para-chloro-2-[18F]fluoroethyl-etomidate
Isabella Silins, Anders Sundin, Patrik Nordeman, Mahabuba Jahan, Sergio Estrada, Azita Monazzam, Mark Lubberink, Franklin Aigbirhio, Per Hellman, Gunnar Antoni
May 21, 2021
Introduction: [11C]Metomidate ([11C]MTO), the methyl ester analogue of etomidate, was developed as a positron emission tomography (PET) radiotracer for adrenocortical tumours and has also been suggested for imaging in primary...
18F-CETO Adrenal masses Adrenal tracer positron emission tomography primary aldosteronism Adrenal Cortex Adrenal Cortex Neoplasms Animals Drug Evaluation Preclinical Etomidate Fluorine Radioisotopes Humans hyperaldosteronism Macaca fascicularis Mice Positron-Emission Tomography Radiopharmaceuticals Rats Tissue Distribution
Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.
Sanae Hamanaka, Ayumi Umino, Hideyuki Sato, Tomonari Hayama, Ayaka Yanagida, Naoaki Mizuno, Toshihiro Kobayashi, Mariko Kasai, Fabian Patrik Suchy, Satoshi Yamazaki, Hideki Masaki, Tomoyuki Yamaguchi, Hiromitsu Nakauchi
Dec 13, 2018
In the case of organ transplantation accompanied by vascular anastomosis, major histocompatibility complex mismatched vascular endothelial cells become a target for graft rejection. Production of a rejection-free, transplantable...
blastocyst complementation hematopoietic cells Pluripotent Stem Cells tissue regeneration vascular endothelial cells aging Animals Blastocyst Chimera Endothelial Cells Hematopoietic Stem Cells Induced Pluripotent Stem Cells Mice Inbred C57BL Mice Knockout Neovascularization Physiologic Pericytes Phenotype Platelet Endothelial Cell Adhesion Molecule-1 Vascular Endothelial Growth Factor Receptor-2
Recent Advances in the Development of Stem-Cell-Derived Dopaminergic Neuronal Transplant Therapies for Parkinson's Disease.
Peter A Barbuti, Roger A Barker, Patrik Brundin, Serge Przedborski, Stella M Papa, Lorraine V Kalia, Hideki Mochizuki, MDS Scientific Issues Committee
Mar 17, 2021
The last decade has seen exciting advances in the development of potential stem cell-based therapies for Parkinson's disease (PD), which have used different types of stem cells as starting material. These cells have been...
Cytokinin and Auxin Display Distinct but Interconnected Distribution and Signaling Profiles to Stimulate Cambial Activity.
Juha Immanen, Kaisa Nieminen, Olli-Pekka Smolander, Mikiko Kojima, Juan Alonso Serra, Patrik Koskinen, Jing Zhang, Annakaisa Elo, Ari Pekka Mähönen, Nathaniel Street, Rishikesh P Bhalerao, Lars Paulin, Petri Auvinen, Hitoshi Sakakibara, Ykä Helariutta
Jun 23, 2016
Acute effects of breaking up prolonged sitting on fatigue and cognition
Patrik Wennberg, Carl-Johan Boraxbekk, Michael Wheeler, Bethany Howard, Paddy C Dempsey, Gavin Lambert, Nina Eikelis, Robyn Larsen, Parneet Sethi, Jessica Occleston, Jenny Hernestål-Boman, Kathryn A Ellis, Neville Owen, David W Dunstan
Feb 08, 2019
OBJECTIVES: To compare the acute effects of uninterrupted sitting with sitting interrupted by brief bouts of light-intensity walking on self-reported fatigue, cognition, neuroendocrine biomarkers and cardiometabolic risk markers...
Change in lifestyle behaviors and diabetes risk
Adina L Feldman, Gráinne H Long, Ingegerd Johansson, Lars Weinehall, Eva Fhärm, Patrik Wennberg, Margareta Norberg, Simon J Griffin, Olov Rolandsson
May 05, 2017
Abstract
Background
Promoting positive changes in lifestyle behavior in the whole population may be a feasible and effective approach to reducing type 2 diabetes burden, but the...
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.
Elisa Vergari, Jakob G Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford JB Briant, Margarita V Chibalina, Fiona M Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils JG Rorsman, Ioannis I Spiliotis, Andrei Tarasov, Yanling Wu, Frances M Ashcroft, Patrik Rorsman
Feb 12, 2019
Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by...
Animals Benzhydryl Compounds Blood Glucose Diabetes mellitus Female Glucagon Glucagon-Secreting Cells Glucosides Humans Hypoglycemia Insulin Male Mice Mice Inbred C57BL Mice Knockout Receptor Insulin Receptors Somatostatin Sodium-Glucose Transporter 2 Sodium-Glucose Transporter 2 Inhibitors Somatostatin
Spermatogonia Loss Correlates with LAMA 1 Expression in Human Prepubertal Testes Stored for Fertility Preservation
Magdalena Kurek, Elisabet Åkesson, Masahito Yoshihara, Elizabeth Oliver, Yanhua Cui, Martin Becker, João Pedro Alves-Lopes, Ragnar Bjarnason, Patrik Romerius, Mikael Sundin, Ulrika Norén Nyström, Cecilia Langenskiöld, Hartmut Vogt, Lars Henningsohn, Cecilia Petersen, Olle Söder, Jingtao Guo, Rod T. Mitchell, Kirsi Jahnukainen, Jan-Bernd Stukenborg
Jan 29, 2021
Fertility preservation for male childhood cancer survivors not yet capable of producing mature spermatozoa, relies on experimental approaches such as testicular explant culture. Although the first steps in somatic maturation can...
PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.
Claudia Guida, Sam D Stephen, Michael Watson, Niall Dempster, Pierre Larraufie, Thomas Marjot, Tamsin Cargill, Lisa Rickers, Michael Pavlides, Jeremy Tomlinson, Jeremy FL Cobbold, Chun-Mei Zhao, Duan Chen, Fiona Gribble, Frank Reimann, Richard Gillies, Bruno Sgromo, Patrik Rorsman, John D Ryan, Reshma D Ramracheya
Feb 04, 2020
BACKGROUND: Bariatric surgery leads to early and long-lasting remission of type 2 diabetes (T2D). However, the mechanisms behind this phenomenon remain unclear. Among several factors, gut hormones are thought to be crucial...
Spermatogonia Loss Correlates with LAMA 1 Expression in Human Prepubertal Testes Stored for Fertility Preservation.
Magdalena Kurek, Elisabet Åkesson, Masahito Yoshihara, Elizabeth Oliver, Yanhua Cui, Martin Becker, João Pedro Alves-Lopes, Ragnar Bjarnason, Patrik Romerius, Mikael Sundin, Ulrika Norén Nyström, Cecilia Langenskiöld, Hartmut Vogt, Lars Henningsohn, Cecilia Petersen, Olle Söder, Jingtao Guo, Rod T Mitchell, Kirsi Jahnukainen, Jan-Bernd Stukenborg
Apr 09, 2021
Fertility preservation for male childhood cancer survivors not yet capable of producing mature spermatozoa, relies on experimental approaches such as testicular explant culture. Although the first steps in somatic maturation can...
Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta-cells.
Elisa Vergari, Geoffrey Denwood, Albert Salehi, Quan Zhang, Julie Adam, Ahmed Alrifaiy, Ingrid Wernstedt Asterholm, Anna Benrick, Margarita V Chibalina, Lena Eliasson, Claudia Guida, Thomas G Hill, Alexander Hamilton, Reshma Ramracheya, Frank Reimann, Nils JG Rorsman, Ioannis Spilliotis, Andrei I Tarasov, Jonathan N Walker, Patrik Rorsman, Linford JB Briant
Jan 23, 2020
Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting α-, insulin-producing β- and somatostatin-releasing δ-cells1. Somatostatin is a powerful paracrine inhibitor of...
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.
Makoto Shigeto, Reshma Ramracheya, Andrei I Tarasov, Chae Young Cha, Margarita V Chibalina, Benoit Hastoy, Koenraad Philippaert, Thomas Reinbothe, Nils Rorsman, Albert Salehi, William R Sones, Elisa Vergari, Cathryn Weston, Julia Gorelik, Masashi Katsura, Viacheslav O Nikolaev, Rudi Vennekens, Manuela Zaccolo, Antony Galione, Paul RV Johnson, Kohei Kaku, Graham Ladds, Patrik Rorsman
Nov 19, 2015
The European NAFLD Registry
Timothy Hardy, Kristy Wonders, Ramy Younes, Guruprasad P Aithal, Rocio Aller, Michael Allison, Pierre Bedossa, Fay Betsou, Jerome Boursier, M Julia Brosnan, Alastair Burt, Jeremy Cobbold, Helena Cortez-Pinto, Chris P Day, Jean-Francois Dufour, Mattias Ekstedt, Sven Francque, Stephen Harrison, Luca Miele, Patrik Nasr, George Papatheodoridis, Salvatore Petta, Dina Tiniakos, Richard Torstenson, Luca Valenti, Adriaan G Holleboom, Hannele Yki-Jarvinen, Andreas Geier, Manuel Romero-Gomez, Vlad Ratziu, Elisabetta Bugianesi, Jörn M Schattenberg, Quentin M Anstee, LITMUS Consortium
Dec 16, 2020
Non-Alcoholic Fatty Liver Disease (NAFLD), a progressive liver disease that is closely associated with obesity, type 2 diabetes, hypertension and dyslipidaemia, represents an increasing global public health challenge. There is...
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.
Hamdi Mbarek, Stacy Steinberg, Dale R Nyholt, Scott D Gordon, Michael B Miller, Allan F McRae, Jouke Jan Hottenga, Felix R Day, Gonneke Willemsen, Eco J de Geus, Gareth E Davies, Hilary C Martin, Brenda W Penninx, Rick Jansen, Kerrie McAloney, Jacqueline M Vink, Jaakko Kaprio, Robert Plomin, Tim D Spector, Patrik K Magnusson, Bruno Reversade, R Alan Harris, Kjersti Aagaard, Ragnar P Kristjansson, Isleifur Olafsson, Gudmundur Ingi Eyjolfsson, Olof Sigurdardottir, William G Iacono, Cornelis B Lambalk, Grant W Montgomery, Matt McGue, Ken K Ong, John RB Perry, Nicholas G Martin, Hreinn Stefánsson, Kari Stefánsson, Dorret I Boomsma
May 17, 2016
Disease modification and biomarker development in Parkinson disease
Alberto J Espay, Lorraine V Kalia, Ziv Gan-Or, Caroline H Williams-Gray, Philippe L Bedard, Steven M Rowe, Francesca Morgante, Alfonso Fasano, Benjamin Stecher, Marcelo A Kauffman, Matthew J Farrer, Chris S Coffey, Michael A Schwarzschild, Todd Sherer, Ronald B Postuma, Antonio P Strafella, Andrew B Singleton, Roger A Barker, Karl Kieburtz, C Warren Olanow, Andres Lozano, Jeffrey H Kordower, Jesse M Cedarbaum, Patrik Brundin, David G Standaert, Anthony E Lang
Jan 09, 2020
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