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Evidence for violations of Weak Cosmic Censorship in black hole
collisions in higher dimensions
We study collisions of boosted rotating black holes in $D=6$ and 7 spacetime
dimensions with a non-zero impact parameter. We find that there exists an open
set of initial conditions such that the intermediate state of the...
Linking Individual and Collective Contests through Noise Level and Sharing Rules
We propose the use of Nitzan’s (1991) sharing rule in collective contests as a tractable way of modelling individual contests. This proposal (i) tractably introduces noise in Tullock contests when no closed form solution in pure...
Linking Individual and Collective Contests through Noise Level and Sharing Rules
We propose the use of Nitzan’s (1991) sharing rule in collective contests as a tractable way of modelling individual contests. This proposal (i) tractably introduces noise in Tullock contests when no closed form solution in pure...
Silencing of StRIK in potato suggests a role in periderm related to RNA processing and stress
Pau Boher, Marçal Soler, Sandra Fernández-Piñán, Xènia Torrent, Sebastian Y. Müller, Krystyna A. Kelly, Olga Serra, Mercè Figueras
Sep 08, 2021
Abstract: Background: The periderm is a protective barrier crucial for land plant survival, but little is known about genetic factors involved in its development and regulation. Using a transcriptomic approach in the cork oak...
FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in embryonic stem cells.
Cell fate decision Dynamic systems Embryonic Stem Cells GATA factor Live cell imaging Preimplantation development Animals Biomarkers Cell Differentiation Cell Lineage Cells Cultured Endoderm Fibroblast Growth Factors GATA4 Transcription Factor Gene Expression Regulation Germ Layers Luminescent Proteins MAP Kinase Signaling System Mice Models Biological Mouse embryonic stem cells
Deep Learning Hybrid Models for COVID-19 Prediction
COVID-19 is a highly contagious virus. Blood test is one of effective methods for COVID-19 diagnosis. However, the issues of blood test are time-consuming and lack of medical staff. In this paper, four deep learning hybrid...
Published by: IGI Global Scientific Publishing
An ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time.
Katie Abley, Pau Formosa-Jordan, Hugo Tavares, Emily YT Chan, Mana Afsharinafar, Ottoline Leyser, James CW Locke
Jun 03, 2021
Genetically identical plants growing in the same conditions can display heterogeneous phenotypes. Here we use Arabidopsis seed germination time as a model system to examine phenotypic variability and its underlying mechanisms....
An ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time.
Katie Abley, Pau Formosa-Jordan, Hugo Tavares, Emily YT Chan, Mana Afsharinafar, Ottoline Leyser, James CW Locke
Jul 05, 2021
Genetically identical plants growing in the same conditions can display heterogeneous phenotypes. Here we use Arabidopsis seed germination time as a model system to examine phenotypic variability and its underlying mechanisms....
germination variability ABA GA Systems Biology Computational Biology quantitative genetics plant biology Mathematical modelling A. thaliana
Published by: eLife
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Jie Zheng, Valeriia Haberland, Denis Baird, Venexia Walker, Philip C Haycock, Mark R Hurle, Alex Gutteridge, Pau Erola, Yi Liu, Shan Luo, Jamie Robinson, Tom G Richardson, James R Staley, Benjamin Elsworth, Stephen Burgess, Benjamin B Sun, John Danesh, Heiko Runz, Joseph C Maranville, Hannah M Martin, James Yarmolinsky, Charles Laurin, Michael V Holmes, Jimmy Z Liu, Karol Estrada, Rita Santos, Linda McCarthy, Dawn Waterworth, Matthew R Nelson, George Davey Smith, Adam S Butterworth, Gibran Hemani, Robert A Scott, Tom R Gaunt
Jun 17, 2020
Silencing of StRIK in potato suggests a role in periderm related to RNA processing and stress.
Pau Boher, Marçal Soler, Sandra Fernández-Piñán, Xènia Torrent, Sebastian Y Müller, Krystyna A Kelly, Olga Serra, Mercè Figueras
Dec 24, 2022
BACKGROUND: The periderm is a protective barrier crucial for land plant survival, but little is known about genetic factors involved in its development and regulation. Using a transcriptomic approach in the cork oak (Q. suber)...
flowering Kh-domain Rna-binding Protein Potato Tuber Periderm Rna Regulation Rs2-interacting Kh Protein Arabidopsis Cell Nucleus DNA Transposable Elements Flowers Gene Expression Regulation Plant Gene Regulatory Networks Gene Silencing Plant Proteins Plant Tubers Plants Genetically Modified RNA Plant Solanum tuberosum Stress Physiological
An ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time
Katie Abley, Pau Formosa-Jordan, Hugo Tavares, Emily YT Chan, Mana Afsharinafar, Ottoline Leyser, James CW Locke
Jun 04, 2021
Genetically identical plants growing in the same conditions can display heterogeneous phenotypes. Here we use Arabidopsis seed germination time as a model system to examine phenotypic variability and its underlying mechanisms....
Silencing of StRIK in potato suggests a role in periderm related to RNA processing and stress.
Pau Boher, Marçal Soler, Sandra Fernández-Piñán, Xènia Torrent, Sebastian Y Müller, Krystyna A Kelly, Olga Serra, Mercè Figueras
Oct 08, 2021
BACKGROUND: The periderm is a protective barrier crucial for land plant survival, but little is known about genetic factors involved in its development and regulation. Using a transcriptomic approach in the cork oak (Q. suber)...
flowering Rna Regulation Kh-domain Rna-binding Protein Potato Tuber Periderm Rs2-interacting Kh Protein Cell Nucleus Plants Genetically Modified Arabidopsis Flowers Plant Tubers Plant Proteins DNA Transposable Elements RNA Plant Gene Expression Regulation Plant Gene Silencing Solanum tuberosum Gene Regulatory Networks Stress Physiological
Macroevolutionary dynamics of nectar spurs, a key evolutionary innovation.
Mario Fernández-Mazuecos, José Luis Blanco-Pastor, Ana Juan, Pau Carnicero, Alan Forrest, Marisa Alarcón, Pablo Vargas, Beverley J Glover
Jan 13, 2020
Progress and prospects of thermo-mechanical energy storage—a critical review
Andreas V Olympios, Joshua D McTigue, Pau Farres-Antunez, Alessio Tafone, Alessandro Romagnoli, Yongliang Li, Yulong Ding, Wolf-Dieter Steinmann, Liang Wang, Haisheng Chen, Christos N Markides
Mar 12, 2021
Abstract: The share of electricity generated by intermittent renewable energy sources is increasing (now at 26% of global electricity generation) and the requirements of affordable, reliable and secure energy supply designate...
Progress and prospects of thermo-mechanical energy storage—a critical review
Andreas V Olympios, Joshua D McTigue, Pau Farres-Antunez, Alessio Tafone, Alessandro Romagnoli, Yongliang Li, Yulong Ding, Wolf-Dieter Steinmann, Liang Wang, Haisheng Chen, Christos N Markides
Mar 12, 2021
Abstract: The share of electricity generated by intermittent renewable energy sources is increasing (now at 26% of global electricity generation) and the requirements of affordable, reliable and secure energy supply designate...
Extent and mechanism of phase separation during the extrusion of calcium phosphate pastes.
Rory O'Neill, Helen O McCarthy, Eoin Cunningham, Edgar Montufar, Maria-Pau Ginebra, D Ian Wilson, Alex Lennon, Nicholas Dunne
Dec 03, 2020
The aim of this study was to increase understanding of the mechanism and dominant drivers influencing phase separation during ram extrusion of calcium phosphate (CaP) paste for orthopaedic applications. The liquid content of...
Development of Generalized QSAR Models for Predicting Cytotoxicity and Genotoxicity of Metal Oxides Nanoparticles
Pravin Ambure, Arantxa Ballesteros, Francisco Huertas, Pau Camilleri, Stephen Barigye, Rafael Gozalbes
Oct 01, 2020
In recent years, nanomaterials have gained tremendous attention due to their wide variety of industrial applications including food packaging, consumer products, nanomedicines, etc. The fascinating properties of nanoparticles...
Published by: IGI Global Scientific Publishing
Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition
Pau B. Esparza-Moltó, Inés Romero-Carramiñana, Cristina Núñez de Arenas, Marta P. Pereira, Noelia Blanco, Beatriz Pardo, Georgina R. Bates, Carla Sánchez-Castillo, Rafael Artuch, Michael P. Murphy, José A. Esteban, José M. Cuezva
May 25, 2021
The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the production of ATP, cellular signaling, and fate. It is regulated by the ATPase inhibitory factor 1 (IF1), which is highly abundant in...
Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition.
Pau B Esparza-Moltó, Inés Romero-Carramiñana, Cristina Núñez de Arenas, Marta P Pereira, Noelia Blanco, Beatriz Pardo, Georgina R Bates, Carla Sánchez-Castillo, Rafael Artuch, Michael P Murphy, José A Esteban, José M Cuezva
May 24, 2021
The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the production of ATP, cellular signaling, and fate. It is regulated by the ATPase inhibitory factor 1 (IF1), which is highly abundant in...
A mouse model of the 15q13.3 microdeletion syndrome shows prefrontal neurophysiological dysfunctions and attentional impairment.
Simon RO Nilsson, Pau Celada, Kim Fejgin, Jonas Thelin, Jacob Nielsen, Noemí Santana, Christopher J Heath, Peter H Larsen, Vibeke Nielsen, Brianne A Kent, Lisa M Saksida, Tine B Stensbøl, Trevor W Robbins, Jesper F Bastlund, Timothy J Bussey, Francesc Artigas, Michael Didriksen
Mar 01, 2016
15q13.3 animal model Chrna7 Cognition Copy number variation neurophysiology Prefrontal Cortex Animals Attention Deficit Disorder with Hyperactivity Behavior Animal Chromosome Deletion Chromosome Disorders Chromosomes Human Pair 15 Disease Models Animal Evoked Potentials Auditory Extinction Psychological GABA Antagonists Gene Deletion Humans Intellectual Disability Interneurons Male Mice Mice Inbred C57BL Prefrontal Cortex Pyramidal Cells Pyridazines Reaction Time Receptors GABA-A Reversal Learning Schizophrenia Schizophrenic Psychology Seizures
Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition.
Pau B Esparza-Moltó, Inés Romero-Carramiñana, Cristina Núñez de Arenas, Marta P Pereira, Noelia Blanco, Beatriz Pardo, Georgina R Bates, Carla Sánchez-Castillo, Rafael Artuch, Michael P Murphy, José A Esteban, José M Cuezva
Jun 13, 2021
The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the production of ATP, cellular signaling, and fate. It is regulated by the ATPase inhibitory factor 1 (IF1), which is highly abundant in...
Published by: PLoS biology
Mapping the serum proteome to neurological diseases using whole genome sequencing.
Grace Png, Andrei Barysenka, Linda Repetto, Pau Navarro, Xia Shen, Maik Pietzner, Eleanor Wheeler, Nicholas Wareham, Claudia Langenberg, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Anders Mälarstig, James F Wilson, Arthur Gilly, Eleftheria Zeggini
Dec 15, 2021
Despite the increasing global burden of neurological disorders, there is a lack of effective diagnostic and therapeutic biomarkers. Proteins are often dysregulated in disease and have a strong genetic component. Here, we carry...
Mapping the serum proteome to neurological diseases using whole genome sequencing.
Grace Png, Andrei Barysenka, Linda Repetto, Pau Navarro, Xia Shen, Maik Pietzner, Eleanor Wheeler, Nicholas J Wareham, Claudia Langenberg, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Anders Mälarstig, James F Wilson, Arthur Gilly, Eleftheria Zeggini
Jan 28, 2022
Despite the increasing global burden of neurological disorders, there is a lack of effective diagnostic and therapeutic biomarkers. Proteins are often dysregulated in disease and have a strong genetic component. Here, we carry...
Alzheimer Disease Biomarkers Cohort Studies Gene Expression Gene Ontology Genetic Predisposition to Disease Genome Human Humans Membrane Glycoproteins Mendelian Randomization Analysis Molecular Sequence Annotation Parkinson Disease Proteome Quantitative Trait Loci Scavenger Receptors Class A Schizophrenia Sialic Acid Binding Ig-like Lectin 3 whole genome sequencing
Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types
Simone Ecker, Lu Chen, Vera Pancaldi, Frederik O Bagger, José M Fernández, Enrique Carrillo de Santa Pau, David Juan, Alice L Mann, Stephen Watt, Francesco P Casale, Nikos Sidiropoulos, Nicolas Rapin, Angelika Merkel, Hendrik G Stunnenberg, Oliver Stegle, Mattia Frontini, Kate Downes, Tomi Pastinen, Taco W Kuijpers, Daniel Rico, Alfonso Valencia, Stephan Beck, Nicole Soranzo, Dirk S Paul
Jan 27, 2017
Abstract
Background
A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and...
Operational Decision-Making on Desalination Plants
Fatima Dargam, Erhard Perz, Stefan Bergmann, Ekaterina Rodionova, Pedro Sousa, Francisco Souza, Tiago Matias, Juan Ortiz, Abraham Esteve-Nuñez, Pau Rodenas, Patricia Bonachela
Dec 05, 2022
This paper describes some of the work carried out within the Horizon 2020 project MIDES (MIcrobial DESalination for low energy drinking water), which is developing the world's largest demonstration of a low-energy sys-tem to...
Published by: IGI Global Scientific Publishing
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