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Results: 78791
Morphology of the earliest reconstructable tetrapod Parmastega aelidae.
The known diversity of tetrapods of the Devonian period has increased markedly in recent decades, but their fossil record consists mostly of tantalizing fragments1-15. The framework for interpreting the morphology and...
An unexpected role reversal
Abstract
In 1862, the collector Pavel Tretyakov made his second visit to Britain, and lent three paintings to the International Exhibition held in London that year. Then aged just thirty, he had...
RP Blakesley
Apr 19, 2017
Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases.
Alvin Djajadikerta, Swati Keshri, Mariana Pavel, Ryan Prestil, Laura Ryan, David C Rubinsztein
Dec 11, 2019
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic contents to lysosomes for degradation. Genetic studies have revealed extensive links between autophagy and neurodegenerative disease, and...
Vinexin contributes to autophagic decline in brain ageing across species.
So Jung Park, Rebecca A Frake, Cansu Karabiyik, Sung Min Son, Farah H Siddiqi, Carla F Bento, Peter Sterk, Mariella Vicinanza, Mariana Pavel, David C Rubinsztein
May 10, 2022
Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments? A Simulation Study.
There is growing interest in Phase I dose-finding studies studying several doses of more than one agent simultaneously. A number of combination dose-finding designs were recently proposed to guide escalation/de-escalation...
Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis.
Mammalian autophagy and the plasma membrane.
Autophagy (literally 'self-eating') is an evolutionarily conserved degradation process where cytoplasmic components are engulfed by vesicles called autophagosomes, which are then delivered to lysosomes, where their contents are...
Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic.
BACKGROUND: Modern designs for dose-finding studies (e.g., model-based designs such as continual reassessment method) have been shown to substantially improve the ability to determine a suitable dose for efficacy testing when...
Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic.
BACKGROUND: Modern designs for dose-finding studies (e.g., model-based designs such as continual reassessment method) have been shown to substantially improve the ability to determine a suitable dose for efficacy testing when...
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Cell type-specific YAP1-WWTR1/TAZ transcriptional responses after autophagy perturbations are determined by levels of α-catenins (CTNNA1 and CTNNA3).
Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments? A Simulation Study
There is growing interest in Phase I dose-finding studies studying several doses of more than one agent simultaneously. A number of combination dose-finding designs were recently proposed to guide escalation/de-escalation...
Porous Nanocrystalline Silicon Supported Bimetallic Pd-Au Catalysts
Dmitriy I Potemkin, Dmitry K Maslov, Konstantin Loponov, Pavel V Snytnikov, Yuri V Shubin, Pavel E Plyusnin, Dmitry A Svintsitskiy, Vladimir A Sobyanin, Alexei A Lapkin
Feb 06, 2019
Bimetallic Pd-Au catalysts were prepared on the porous nanocrystalline silicon (PSi) for the first time. The catalysts were tested in the reaction of direct hydrogen peroxide synthesis and characterized by standard structural...
A Hybrid Hierarchical Heuristic-ACO With Local Search Applied to Travelling Salesman Problem, AS-FA-Ls
The combinatorial optimization problem is attracting research because they have a wide variety of applications ranging from route planning and supply chain optimization to industrial scheduling and the IoT. Solving such problems...
Published by: IGI Global Scientific Publishing
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Label-Free DNA Biosensor using Modified Reduced Graphene Oxide Platform as a DNA Methylation Assay
Eliska Sedlackova, Zuzana Bytesnikova, Eliska Birgusova, Pavel Svec, Amirmansoor Ashrafi, Pedro Estrela, Lukas Richtera
Nov 03, 2020
This work reports using modified reduced graphene oxide (rGO) as a platform for label-free DNA-based electrochemical biosensor as a possible diagnostic tool for DNA methylation assay. The biosensor sensitivity wasenhanced by...
A comparison of various aggregation functions in multi-criteria decision analysis for drug benefit-risk assessment.
Multi-criteria decision analysis is a quantitative approach to the drug benefit-risk assessment which allows for consistent comparisons by summarising all benefits and risks in a single score. The multi-criteria decision...
In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue.
Pedro Silva-Pinheiro, Pavel A Nash, Lindsey Van Haute, Christian D Mutti, Keira Turner, Michal Minczuk
Mar 13, 2022
Mitochondria host key metabolic processes vital for cellular energy provision and are central to cell fate decisions. They are subjected to unique genetic control by both nuclear DNA and their own multi-copy genome -...
A dose-finding design for dual-agent trials with patient-specific doses for one agent with application to an opiate detoxification trial.
There is a growing interest in early phase dose-finding clinical trials studying combinations of several treatments. While the majority of dose finding designs for such setting were proposed for oncology trials, the...
Label-Free DNA Biosensor using Modified Reduced Graphene Oxide Platform as a DNA Methylation Assay
Eliska Sedlackova, Zuzana Bytesnikova, Eliska Birgusova, Pavel Svec, Amirmansoor Ashrafi, Pedro Estrela, Lukas Richtera
Nov 03, 2020
This work reports using modified reduced graphene oxide (rGO) as a platform for label-free DNA-based electrochemical biosensor as a possible diagnostic tool for DNA methylation assay. The biosensor sensitivity wasenhanced by...
Practical implementation of the partial ordering continual reassessment method in a Phase I combination-schedule dose-finding trial.
Pavel Mozgunov, Thomas Jaki, Ioannis Gounaris, Thomas Goddemeier, Anja Victor, Marianna Grinberg
Nov 26, 2022
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue.
Pedro Silva-Pinheiro, Pavel A Nash, Lindsey Van Haute, Christian D Mutti, Keira Turner, Michal Minczuk
Feb 09, 2022
Mitochondria host key metabolic processes vital for cellular energy provision and are central to cell fate decisions. They are subjected to unique genetic control by both nuclear DNA and their own multi-copy genome -...
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