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Results: 28
Predictive evolution of metabolic phenotypes using model-designed environments.
Paula Jouhten, Dimitrios Konstantinidis, Filipa Pereira, Sergej Andrejev, Kristina Grkovska, Sandra Castillo, Payam Ghiachi, Gemma Beltran, Eivind Almaas, Albert Mas, Jonas Warringer, Ramon Gonzalez, Pilar Morales, Kiran R Patil
Nov 05, 2022
Adaptive evolution under controlled laboratory conditions has been highly effective in selecting organisms with beneficial phenotypes such as stress tolerance. The evolution route is particularly attractive when the organisms...
Predictive evolution of metabolic phenotypes using model-designed environments.
Paula Jouhten, Dimitrios Konstantinidis, Filipa Pereira, Sergej Andrejev, Kristina Grkovska, Sandra Castillo, Payam Ghiachi, Gemma Beltran, Eivind Almaas, Albert Mas, Jonas Warringer, Ramon Gonzalez, Pilar Morales, Kiran R Patil
Oct 06, 2022
Adaptive evolution under controlled laboratory conditions has been highly effective in selecting organisms with beneficial phenotypes such as stress tolerance. The evolution route is particularly attractive when the organisms...
A Systematic Literature Review on IT Outsourcing Decision and Future Research Directions
During the recent decades, some academic research on the subject of information technology outsourcing (ITO) decision has appeared in different outlets, which may impede the use of such resources and as a result, repetition of...
Published by: IGI Global Scientific Publishing
Mitochondrial DNA
Abstract: Perturbed mitochondrial bioenergetics constitute a core pillar of cancer-associated metabolic dysfunction. While mitochondrial dysfunction in cancer may result from myriad biochemical causes, a historically neglected...
Mitochondrial Genome Engineering
In recent years mitochondrial DNA (mtDNA) has transitioned to greater prominence across diverse areas of biology and medicine. The recognition of mitochondria as a major biochemical hub, contributions of mitochondrial...
CRISPR/Cas9 RNA import mitoTALEN Mitochondria mtDNA mtZFN Animals Biolistics Biological Transport CRISPR-Cas Systems DNA Mitochondrial Dependovirus Endodeoxyribonucleases Gene Editing Genetic Vectors Genome Mitochondrial Mammals Mitochondria Polyribonucleotide Nucleotidyltransferase RNA Guide Kinetoplastida Transcription Activator-Like Effector Nucleases Transcription Factors
A New Tsunami Hazard Assessment for Eastern Makran Subduction Zone by Considering Splay Faults and Applying Stochastic Modeling
Tsunami hazard imposed by possible rupture of splay faults is important as it may significantly intensify tsunami heights locally. The Makran Subduction Zone (MSZ) in the northwestern Indian Ocean can generate large thrust...
earthquake Makran subduction zone splay faults stochastic source model tsunami hazard /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
A New Tsunami Hazard Assessment for Eastern Makran Subduction Zone by Considering Splay Faults and Applying Stochastic Modeling
Tsunami hazard imposed by possible rupture of splay faults is important as it may significantly intensify tsunami heights locally. The Makran Subduction Zone (MSZ) in the northwestern Indian Ocean can generate large thrust...
earthquake Makran subduction zone splay faults stochastic source model tsunami hazard /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
Robot-Assisted Fracture Surgery
The design of medical devices is a complex and crucial process to ensure patient safety. It has been shown that improperly designed devices lead to errors and associated accidents and costs. A key element for a successful design...
Robot-Assisted Fracture Surgery
The design of medical devices is a complex and crucial process to ensure patient safety. It has been shown that improperly designed devices lead to errors and associated accidents and costs. A key element for a successful design...
Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations.
Hanne Hoitzing, Payam A Gammage, Lindsey Van Haute, Michal Minczuk, Iain G Johnston, Nick S Jones
Sep 11, 2019
The dynamics of the cellular proportion of mutant mtDNA molecules is crucial for mitochondrial diseases. Cellular populations of mitochondria are under homeostatic control, but the details of the control mechanisms involved...
Exploring the Impact of Terminators on Transgene Expression in Chlamydomonas reinhardtii with a Synthetic Biology Approach
Katrin Geisler, Mark A. Scaife, Paweł M. Mordaka, Andre Holzer, Eleanor V. Tomsett, Payam Mehrshahi, Gonzalo I. Mendoza Ochoa, Alison G. Smith
Sep 15, 2021
Chlamydomonas reinhardtii has many attractive features for use as a model organism for both fundamental studies and as a biotechnological platform. Nonetheless, despite the many molecular tools and resources that have been...
NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction.
Edoardo Gaude, Christina Schmidt, Payam A Gammage, Aurelien Dugourd, Thomas Blacker, Sew Peak Chew, Julio Saez-Rodriguez, John S O'Neill, Gyorgy Szabadkai, Michal Minczuk, Christian Frezza
Apr 05, 2018
The bioenergetics and molecular determinants of the metabolic response to mitochondrial dysfunction are incompletely understood, in part due to a lack of appropriate isogenic cellular models of primary mitochondrial defects....
GAPDH MDH1 NADH cancer metabolism cell migration Glycolysis malate-aspartate shuttle MITOCHONDRIAL DYSFUNCTION Mitochondrial Metabolism reductive carboxylation Bone Neoplasms Cell Movement Citric Acid Cycle Cytosol DNA Mitochondrial Energy Metabolism Female Glucose Glutamine Glycolysis Humans Malate Dehydrogenase Mitochondria NAD Osteosarcoma Oxidation-Reduction Tumor Cells Cultured
Thiamine metabolism genes in diatoms are not regulated by thiamine despite the presence of predicted riboswitches.
Marcel Llavero-Pasquina, Katrin Geisler, Andre Holzer, Payam Mehrshahi, Gonzalo I Mendoza-Ochoa, Shelby A Newsad, Matthew P Davey, Alison G Smith
Jul 01, 2022
Heterozygous SSBP1 start loss mutation co-segregates with hearing loss and the m.1555A>G mtDNA variant in a large multigenerational family.
Peter J Kullar, Aurora Gomez-Duran, Payam A Gammage, Caterina Garone, Michal Minczuk, Zoe Golder, Janet Wilson, Julio Montoya, Sanna Häkli, Mikko Kärppä, Rita Horvath, Kari Majamaa, Patrick F Chinnery
Apr 26, 2018
The m.1555A>G mtDNA variant causes maternally inherited deafness, but the reasons for the highly variable clinical penetrance are not known. Exome sequencing identified a heterozygous start loss mutation in SSBP1, encoding the...
Genetics Hearing Mitochondrial Diseases muscle disease neurodegeneration Adolescent Child Child Preschool DNA Mutational Analysis DNA-Binding Proteins Electron Transport Complex II Electron Transport Complex IV Family Health Female FIBROBLASTS Hearing Loss Heterozygote Humans Infant Male Mitochondrial Diseases Mitochondrial Proteins Mitochondrial Proton-Translocating ATPases Muscle Skeletal Mutation Young Adult
Responses of a Newly Evolved Auxotroph of Chlamydomonas to B12 Deprivation.
Freddy Bunbury, Katherine E Helliwell, Payam Mehrshahi, Matthew P Davey, Deborah L Salmon, Andre Holzer, Nicholas Smirnoff, Alison G Smith
Mar 03, 2020
The corrinoid B12 is synthesized only by prokaryotes yet is widely required by eukaryotes as an enzyme cofactor. Microalgae have evolved B12 dependence on multiple occasions, and we previously demonstrated that experimental...
Exploring the Impact of Terminators on Transgene Expression in Chlamydomonas reinhardtii with a Synthetic Biology Approach.
Katrin Geisler, Mark A Scaife, Paweł M Mordaka, Andre Holzer, Eleanor V Tomsett, Payam Mehrshahi, Gonzalo I Mendoza Ochoa, Alison G Smith
Oct 01, 2021
Chlamydomonas reinhardtii has many attractive features for use as a model organism for both fundamental studies and as a biotechnological platform. Nonetheless, despite the many molecular tools and resources that have been...
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery.
Viktoriya Peeva, Daniel Blei, Genevieve Trombly, Sarah Corsi, Maciej J Szukszto, Pedro Rebelo-Guiomar, Payam A Gammage, Alexei P Kudin, Christian Becker, Janine Altmüller, Michal Minczuk, Gábor Zsurka, Wolfram S Kunz
Jul 17, 2018
Emerging gene therapy approaches that aim to eliminate pathogenic mutations of mitochondrial DNA (mtDNA) rely on efficient degradation of linearized mtDNA, but the enzymatic machinery performing this task is presently unknown....
Base Sequence CRISPR-Cas Systems DNA Breaks Double-Stranded DNA Cleavage DNA Helicases DNA Polymerase gamma DNA Replication DNA Mitochondrial Deoxyribonucleases Type II Site-Specific Electron Transport Complex IV Exodeoxyribonucleases Gene Editing Genetic Therapy HEK293 Cells Humans Mitochondria Recombinant Fusion Proteins
Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.
Payam A Gammage, Edoardo Gaude, Lindsey Van Haute, Pedro Rebelo-Guiomar, Christopher B Jackson, Joanna Rorbach, Marcin L Pekalski, Alan J Robinson, Marine Charpentier, Jean-Paul Concordet, Christian Frezza, Michal Minczuk
Sep 09, 2016
Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
Simonetta Andreazza, Colby L. Samstag, Alvaro Sanchez-Martinez, Erika Fernandez-Vizarra, Aurora Gomez-Duran, Juliette J. Lee, Roberta Tufi, Michael J. Hipp, Elizabeth K. Schmidt, Thomas J. Nicholls, Payam A. Gammage, Patrick F. Chinnery, Michal Minczuk, Leo J. Pallanck, Scott R. Kennedy, Alexander J. Whitworth
Jul 22, 2020
Abstract: Somatic mutations in the mitochondrial genome (mtDNA) have been linked to multiple disease conditions and to ageing itself. In Drosophila, knock-in of a proofreading deficient mtDNA polymerase (POLG) generates high...
Development of Novel Riboswitches for Synthetic Biology in the Green Alga Chlamydomonas.
Payam Mehrshahi, Ginnie Trinh DT Nguyen, Aleix Gorchs Rovira, Andrew Sayer, Marcel Llavero-Pasquina, Michelle Lim Huei Sin, Elliot J Medcalf, Gonzalo I Mendoza-Ochoa, Mark A Scaife, Alison G Smith
Jun 01, 2020
Alternative translation initiation augments the human mitochondrial proteome.
Lawrence Kazak, Aurelio Reyes, Anna L Duncan, Joanna Rorbach, Stuart R Wood, Gloria Brea-Calvo, Payam A Gammage, Alan J Robinson, Michal Minczuk, Ian J Holt
Nov 13, 2017
Alternative translation initiation (ATI) is a mechanism of producing multiple proteins from a single transcript, which in some cases regulates trafficking of proteins to different cellular compartments, including mitochondria....
Amino Acid Sequence Animals Cell Line Tumor Codon Initiator DNA Helicases DNA Polymerase gamma DNA Mitochondrial DNA-Binding Proteins DNA-Directed DNA Polymerase Humans Mice Mitochondria Mitochondrial Proteins Molecular Sequence Data Mutation Peptide Chain Initiation Translational Poly(A)-Binding Proteins Polynucleotide Adenylyltransferase Protein Isoforms Protein Transport Proteome
Exploring the Impact of Terminators on Transgene Expression in <i>Chlamydomonas reinhardtii</i> with a Synthetic Biology Approach.
Katrin Geisler, Mark A Scaife, Paweł M Mordaka, Andre Holzer, Eleanor V Tomsett, Payam Mehrshahi, Gonzalo I Mendoza Ochoa, Alison G Smith
Oct 29, 2021
Chlamydomonas reinhardtii has many attractive features for use as a model organism for both fundamental studies and as a biotechnological platform. Nonetheless, despite the many molecular tools and resources that have...
Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.
Payam A Gammage, Carlo Viscomi, Marie-Lune Simard, Ana SH Costa, Edoardo Gaude, Christopher A Powell, Lindsey Van Haute, Beverly J McCann, Pedro Rebelo-Guiomar, Raffaele Cerutti, Lei Zhang, Edward J Rebar, Massimo Zeviani, Christian Frezza, James B Stewart, Michal Minczuk
Nov 05, 2018
Mutations of the mitochondrial genome (mtDNA) underlie a substantial portion of mitochondrial disease burden. These disorders are currently incurable and effectively untreatable, with heterogeneous penetrance, presentation and...
Birth of a Photosynthetic Chassis
Pierre Crozet, Francisco J Navarro, Felix Willmund, Payam Mehrshahi, Kamil Bakowski, Kyle J Lauersen, Maria-Esther Pérez-Pérez, Pascaline Auroy, Aleix Gorchs Rovira, Susana Sauret-Gueto, Justus Niemeyer, Benjamin Spaniol, Jasmine Theis, Raphael Trösch, Lisa-Desiree Westrich, Konstantinos Vavitsas, Thomas Baier, Wolfgang Hübner, Felix de Carpentier, Mathieu Cassarini, Antoine Danon, Julien Henri, Christophe H Marchand, Marcello de Mia, Kevin Sarkissian, David C Baulcombe, Gilles Peltier, José-Luis Crespo, Olaf Kruse, Poul-Erik Jensen, Michael Schroda, Alison G Smith, Stéphane D Lemaire
Nov 15, 2018
Microalgae are regarded as promising organisms to develop innovative concepts based on their photosynthetic capacity that offers more sustainable production than heterotrophic hosts. However, to realize their potential as green...
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