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Results: 344
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.
Wei Jiao, Gurnit Atwal, Paz Polak, Rosa Karlic, Edwin Cuppen, PCAWG Tumor Subtypes and Clinical Translation Working Group, Alexandra Danyi, Jeroen de Ridder, Carla van Herpen, Martijn P Lolkema, Neeltje Steeghs, Gad Getz, Quaid D Morris, Lincoln D Stein, PCAWG Consortium
May 14, 2020
In cancer, the primary tumour's organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of...
The difference an end-of-life diagnosis makes
BACKGROUND:Increasing numbers of people die of the frailty and multimorbidity associated with old age, often without receiving an end-of-life diagnosis. Compared to those with a single life-limiting condition such as cancer...
Diverse mutational landscapes in human lymphocytes.
Heather E Machado, Emily Mitchell, Nina F Øbro, Kirsten Kübler, Megan Davies, Daniel Leongamornlert, Alyssa Cull, Francesco Maura, Mathijs A Sanders, Alex TJ Cagan, Craig McDonald, Miriam Belmonte, Mairi S Shepherd, Felipe A Vieira Braga, Robert J Osborne, Krishnaa Mahbubani, Iñigo Martincorena, Elisa Laurenti, Anthony R Green, Gad Getz, Paz Polak, Kourosh Saeb-Parsy, Daniel J Hodson, David G Kent, Peter J Campbell
Sep 10, 2022
The difference an End of Life diagnosis makes
Background
Increasing numbers of people die of the frailty and multimorbidity associated with old age, often without receiving an End-of-Life diagnosis. Compared to those with a single life-limiting condition such as cancer...
Diverse mutational landscapes in human lymphocytes.
Heather E Machado, Emily Mitchell, Nina F Øbro, Kirsten Kübler, Megan Davies, Daniel Leongamornlert, Alyssa Cull, Francesco Maura, Mathijs A Sanders, Alex TJ Cagan, Craig McDonald, Miriam Belmonte, Mairi S Shepherd, Felipe A Vieira Braga, Robert J Osborne, Krishnaa Mahbubani, Iñigo Martincorena, Elisa Laurenti, Anthony R Green, Gad Getz, Paz Polak, Kourosh Saeb-Parsy, Daniel J Hodson, David G Kent, Peter J Campbell
Aug 24, 2022
The lymphocyte genome is prone to many threats, including programmed mutation during differentiation1, antigen-driven proliferation and residency in diverse microenvironments. Here, after developing protocols for expansion of...
Longitudinal effects of clozapine concentration and clozapine to N-desmethylclozapine ratio on cognition
Francesco Dal Santo, Isaac Jarratt-Barnham, Leticia González-Blanco, María Paz García-Portilla, Julio Bobes, Emilio Fernández-Egea
Jan 28, 2020
Assessment of the long-term stability of the polymer of intrinsic microporosity PIM-1 for hydrogen storage applications
Sebastien Rochat, Katarzyna Polak-Kraśna, Mi Tian, Timothy Mays, Christopher Bowen, Andrew Burrows
Jan 01, 2019
Polymers of intrinsic microporosity, such as PIM-1, advantageously combine high surface areas with good processability, which are attractive properties for hydrogen storage applications. Here we address the lack of data on the...
Hydrogen storage long-term stability physisorption Polymer of intrinsic microporosity Porous material Tensile test /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2100/2103 name=Fuel Technology /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Assessment of the long-term stability of the polymer of intrinsic microporosity PIM-1 for hydrogen storage applications
Sebastien Rochat, Katarzyna Polak-Kraśna, Mi Tian, Timothy Mays, Christopher Bowen, Andrew Burrows
Jan 01, 2019
Polymers of intrinsic microporosity, such as PIM-1, advantageously combine high surface areas with good processability, which are attractive properties for hydrogen storage applications. Here we address the lack of data on the...
Hydrogen storage long-term stability physisorption Polymer of intrinsic microporosity Porous material Tensile test /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2100/2103 name=Fuel Technology /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
AFM imaging and nanoindentation of polymer of intrinsic microporosity PIM-1
Katarzyna Polak-Krasna, Carlos Fuhrhop, Sebastien Rochat, Andrew Burrows, Anthimos Georgiadis, Christopher Bowen, Timothy Mays
Sep 14, 2017
Polymers of intrinsic microporosity (PIMs) have promising gas adsorption properties for potential applications such as incorporation into high-pressure hydrogen storage tanks in an effort to increase the storage capacity or...
AFM imaging and nanoindentation of polymer of intrinsic microporosity PIM-1
Katarzyna Polak-Krasna, Carlos Fuhrhop, Sebastien Rochat, Andrew Burrows, Anthimos Georgiadis, Christopher Bowen, Timothy Mays
Sep 14, 2017
Polymers of intrinsic microporosity (PIMs) have promising gas adsorption properties for potential applications such as incorporation into high-pressure hydrogen storage tanks in an effort to increase the storage capacity or...
Current Status of Cell-Based Therapies for Vitiligo.
Anna Domaszewska-Szostek, Agnieszka Polak, Monika Słupecka-Ziemilska, Marta Krzyżanowska, Monika Puzianowska-Kuźnicka
Mar 28, 2023
Vitiligo is a chronic pigmentary disease with complex etiology, the signs of which are caused by the destruction of melanocytes in the epidermis, leading to the lack of melanin pigment responsible for skin coloration. The...
Keratinocytes Melanocytes Cell transplantation vitiligo melanogenesis cell-based therapies epidermis Humans Hypopigmentation Treatment Outcome
Published by: International journal of molecular sciences
Current Status of Cell-Based Therapies for Vitiligo.
Anna Domaszewska-Szostek, Agnieszka Polak, Monika Słupecka-Ziemilska, Marta Krzyżanowska, Monika Puzianowska-Kuźnicka
Mar 06, 2023
Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa.
Samuel Terkper Ahuno, Anna-Lisa Doebley, Thomas U Ahearn, Joel Yarney, Nicholas Titiloye, Nancy Hamel, Ernest Adjei, Joe-Nat Clegg-Lamptey, Lawrence Edusei, Baffour Awuah, Xiaoyu Song, Verna Vanderpuye, Mustapha Abubakar, Maire Duggan, Daniel G Stover, Kofi Nyarko, John MS Bartlett, Francis Aitpillah, Daniel Ansong, Kevin L Gardner, Felix Andy Boateng, Anne M Bowcock, Carlos Caldas, William D Foulkes, Seth Wiafe, Beatrice Wiafe-Addai, Montserrat Garcia-Closas, Alexander Kwarteng, Gavin Ha, Jonine D Figueroa, Paz Polak, Ghana Breast Health Study Team
Oct 19, 2021
Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana...
Influence of secondary sources in the Brief Negative Symptom Scale.
Devi Treen, George Savulich, Gisela Mezquida, Maria Paz García-Portilla, Alba Toll, Clemente García-Rizo, Leticia García-Álvarez, Daniel Bergé, Julio Bobes, Miguel bernardo, Emilio Fernandez-Egea, Anna Mané
Nov 23, 2018
A transposable element insertion is associated with an alternative life history strategy.
Alyssa Woronik, Kalle Tunström, Michael W Perry, Ramprasad Neethiraj, Constanti Stefanescu, Maria de la Paz Celorio-Mancera, Oskar Brattström, Jason Hill, Philipp Lehmann, Reijo Käkelä, Christopher W Wheat
Dec 22, 2020
Animals Butterflies CRISPR-Cas Systems Color DNA Transposable Elements Female Gene Editing Gene Expression Profiling Gene Expression Regulation Developmental Genetic Loci Homeodomain Proteins Life History Traits Male Pigmentation Pigments Biological Reproduction Sex Factors whole genome sequencing Wings Animal
Obstetric Phenotypes in the Heterogeneity of Schizophrenia.
Gisela Mezquida, Emilio Fernandez-Egea, Devi Treen, Anna Mané, Daniel Bergé, George Savulich, Leticia Garcia-Alvarez, Paz García-Portilla, Julio Bobes, Miguel bernardo, Clemente Garcia-Rizo
Dec 03, 2018
A transposable element insertion is associated with an alternative life history strategy.
Alyssa Woronik, Kalle Tunström, Michael W Perry, Ramprasad Neethiraj, Constanti Stefanescu, Maria de la Paz Celorio-Mancera, Oskar Brattström, Jason Hill, Philipp Lehmann, Reijo Käkelä, Christopher W Wheat
Jan 27, 2020
Tradeoffs affect resource allocation during development and result in fitness consequences that drive the evolution of life history strategies. Yet despite their importance, we know little about the mechanisms underlying life...
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
Wei Jiao, Rosa Karlic, Edwin Cuppen, Alexandra Danyi, Jeroen de Ridder, Carla van Herpen, Martijn P. Lolkema, Neeltje Steeghs, Quaid Morris, Fatima Al-Shahrour, Gurnit Atwal, Peter J. Bailey, Andrew V. Biankin, Paul C. Boutros, Peter J. Campbell, David K. Chang, Susanna L. Cooke, Vikram Deshpande, Bishoy M. Faltas, William C. Faquin, Levi Garraway, Gad Getz, Sean M. Grimmond, Syed Haider, Katherine A. Hoadley, Vera B. Kaiser, Rosa Karlić, Mamoru Kato, Kirsten Kübler, Alexander J. Lazar, Constance H. Li, David N. Louis, Adam Margolin, Sancha Martin, Hardeep K. Nahal-Bose, G. Petur Nielsen, Serena Nik-Zainal, Larsson Omberg, Christine P’ng, Marc D. Perry, Paz Polak, Esther Rheinbay, Mark A. Rubin, Colin A. Semple, Dennis C. Sgroi, Tatsuhiro Shibata, Reiner Siebert, Jaclyn Smith, Lincoln D. Stein, Miranda D. Stobbe, Ren X. Sun, Kevin Thai, Derek W. Wright, Chin-Lee Wu, Ke Yuan, Junjun Zhang
Feb 04, 2021
Abstract: In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary....
Short Children with CHARGE Syndrome
Helmuth G Dörr, Margaret Boguszewski, Jovanna Dahlgren, David Dunger, Mitchell E Geffner, Anita C Hokken-Koelega, Anders Lindberg, Michel Polak, Raoul Rooman, KIGS International Board
Jul 28, 2015
Solvent Sorption-Induced Actuation of Composites Based on a Polymer of Intrinsic Microporosity
Katarzyna Polak-Kraśna, Mi Tian, Sebastien Rochat, Nicholas Gathercole, Chenggang Yuan, Zhe Hao, Min Pan, Andrew Burrows, Tim Mays, Chris Bowen
Feb 12, 2021
Materials that are capable of actuation in response to a variety of external stimuli are of significant interest for applications in sensors, soft robotics, and biomedical devices. Here, we present a class of actuators using...
The effect of early life events on glucose levels in first-episode psychosis.
Clemente Garcia-Rizo, Bibiana Cabrera, Miquel Bioque, Gisela Mezquida, Antonio Lobo, Ana Gonzalez-Pinto, Covadonga M Diaz-Caneja, Iluminada Corripio, Eduard Vieta, Inmaculada Baeza, Maria Paz Garcia-Portilla, Miguel Gutierrez-Fraile, Roberto Rodriguez-Jimenez, Marina Garriga, Emilio Fernandez-Egea, Miguel bernardo, PEPs GROUP
Dec 19, 2022
Solvent Sorption-Induced Actuation of Composites Based on a Polymer of Intrinsic Microporosity
Katarzyna Polak-Kraśna, Mi Tian, Sebastien Rochat, Nicholas Gathercole, Chenggang Yuan, Zhe Hao, Min Pan, Andrew Burrows, Tim Mays, Chris Bowen
Feb 12, 2021
Materials that are capable of actuation in response to a variety of external stimuli are of significant interest for applications in sensors, soft robotics, and biomedical devices. Here, we present a class of actuators using...
Manipulating molecules with strong coupling
Daniel Polak, Rahul Jayaprakash, Thomas P Lyons, Luis Á Martínez-Martínez, Anastasia Leventis, Kealan J Fallon, Harriet Coulthard, David G Bossanyi, Kyriacos Georgiou, Anthony J Petty Ii, John Anthony, Hugo Bronstein, Joel Yuen-Zhou, Alexander I Tartakovskii, Jenny Clark, Andrew J Musser
Apr 19, 2020
Exciton-polaritons are quasiparticles with mixed photon and exciton character that demonstrate rich quantum phenomena, novel optoelectronic devices and the potential to modify chemical properties of materials. Organic materials...
Estimating the Potential for Conservation and Farming in the Amazon and Cerrado under Four Policy Scenarios
Since 2013, clearing rates have rapidly increased in the Amazon and Cerrado biomes. This acceleration has raised questions about the efficacy of current regional public and private conservation policies that seek to...
Amintas Brandão Jr., Lisa Rausch, América Paz Durán, Ciniro Costa Jr., Seth A Spawn, Holly K Gibbs
Feb 11, 2020
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