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Results: 1671
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K Garwood, T McLaughlin, C Garwood, S Joens, N Morrison, CF Taylor, K Carroll, C Evans, AD Whetton, S Hart, D Stead, Z Yin, AJP Brown, A Hesketh, K Chater, L Hansson, M Mewissen, P Ghazal, J Howard, KS Lilley, SJ Gaskell, A Brass, SJ Hubbard, SG Oliver, NW Paton
Jun 16, 2011
Abstract Background Proteomics is rapidly evolving into a high-throughput technology, in which substantial and systematic studies are conducted on samples from a wide range of physiological, developmental, or pathological...
Animals Arabidopsis Proteins Bacterial Proteins Candida albicans Candida glabrata Computational Biology Database Management Systems Databases Protein Fungal Proteins Helminth Proteins Jejunal Diseases Mice Proteins Proteomics Saccharomyces cerevisiae Proteins Software Design Streptomyces coelicolor Trichinella spiralis Trichinellosis
Compact zinc finger base editors that edit mitochondrial or nuclear DNA in vitro and in vivo.
DddA-derived cytosine base editors (DdCBEs) use programmable DNA-binding TALE repeat arrays, rather than CRISPR proteins, a split double-stranded DNA cytidine deaminase (DddA), and a uracil glycosylase inhibitor to mediate...
In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue.
Pedro Silva-Pinheiro, Pavel A Nash, Lindsey Van Haute, Christian D Mutti, Keira Turner, Michal Minczuk
Feb 09, 2022
Mitochondria host key metabolic processes vital for cellular energy provision and are central to cell fate decisions. They are subjected to unique genetic control by both nuclear DNA and their own multi-copy genome -...
In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue.
Pedro Silva-Pinheiro, Pavel A Nash, Lindsey Van Haute, Christian D Mutti, Keira Turner, Michal Minczuk
Mar 13, 2022
Mitochondria host key metabolic processes vital for cellular energy provision and are central to cell fate decisions. They are subjected to unique genetic control by both nuclear DNA and their own multi-copy genome -...
Chromosomal painting in Charadrius collaris Vieillot, 1818 and Vanellus chilensis Molina, 1782 and an analysis of chromosomal signatures in Charadriiformes.
Melquizedec Luiz Silva Pinheiro, Cleusa Yoshiko Nagamachi, Talita Fernanda Augusto Ribas, Cristovam Guerreiro Diniz, Patricia Caroline Mary O Brien, Malcolm Andrew Ferguson-Smith, Fengtang Yang, Julio Cesar Pieczarka
Sep 10, 2022
Charadriiformes represent one of the largest orders of birds; members of this order are diverse in morphology, behavior and reproduction, making them an excellent model for studying evolution. It is accepted that the avian...
DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.
Pedro Silva-Pinheiro, Carlos Pardo-Hernández, Aurelio Reyes, Lisa Tilokani, Anup Mishra, Raffaele Cerutti, Shuaifeng Li, Dieu-Hien Rozsivalova, Sebastian Valenzuela, Sukru A Dogan, Bradley Peter, Patricio Fernández-Silva, Aleksandra Trifunovic, Julien Prudent, Michal Minczuk, Laurence Bindoff, Bertil Macao, Massimo Zeviani, Maria Falkenberg, Carlo Viscomi
Jun 25, 2021
Mutations in POLG, encoding POLγA, the catalytic subunit of the mitochondrial DNA polymerase, cause a spectrum of disorders characterized by mtDNA instability. However, the molecular pathogenesis of POLG-related diseases is...
Chromosomal painting of the sandpiper (Actitis macularius) detects several fissions for the Scolopacidae family (Charadriiformes).
Melquizedec Luiz Silva Pinheiro, Cleusa Yoshiko Nagamachi, Talita Fernanda Augusto Ribas, Cristovam Guerreiro Diniz, Patricia Caroline Mary O Brien, Malcolm Andrew Ferguson-Smith, Fengtang Yang, Julio Cesar Pieczarka
Jan 22, 2021
BACKGROUND: The Scolopacidae family (Suborder Scolopaci, Charadriiformes) is composed of sandpipers and snipes; these birds are long-distance migrants that show great diversity in their behavior and habitat use. Cytogenetic...
Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput.
Ludimila Dias Almeida, Ali Salim Faraj Silva, Daniel Calixto Mota, Adrielle Ayumi Vasconcelos, Antônio Pedro Camargo, Gabriel Silva Pires, Monique Furlan, Helena Martins Ribeiro da Cunha Freire, Angélica Hollunder Klippel, Suélen Fernandes Silva, Cleslei Fernando Zanelli, Marcelo Falsarella Carazzolle, Stephen G Oliver, Elizabeth Bilsland
Jan 28, 2022
Saccharomyces cerevisiae drug efflux drug transport drug uptake genetic interactions nonessential transporter double-deletion library plasma membrane transporter xenobiotics Yeast ATP-Binding Cassette Transporters Antifungal Agents Biological Transport Gene Deletion Gene Library High-Throughput Screening Assays Monosaccharide Transport Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins xenobiotics
Chromosomal painting in Charadrius collaris Vieillot, 1818 and Vanellus chilensis Molina, 1782 and an analysis of chromosomal signatures in Charadriiformes.
Melquizedec Luiz Silva Pinheiro, Cleusa Yoshiko Nagamachi, Talita Fernanda Augusto Ribas, Cristovam Guerreiro Diniz, Patricia Caroline Mary O Brien, Malcolm Andrew Ferguson-Smith, Fengtang Yang, Julio Cesar Pieczarka
Aug 10, 2022
Charadriiformes represent one of the largest orders of birds; members of this order are diverse in morphology, behavior and reproduction, making them an excellent model for studying evolution. It is accepted that the avian...
DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.
Pedro Silva-Pinheiro, Carlos Pardo-Hernández, Aurelio Reyes, Lisa Tilokani, Anup Mishra, Raffaele Cerutti, Shuaifeng Li, Dieu-Hien Rozsivalova, Sebastian Valenzuela, Sukru A Dogan, Bradley Peter, Patricio Fernández-Silva, Aleksandra Trifunovic, Julien Prudent, Michal Minczuk, Laurence Bindoff, Bertil Macao, Massimo Zeviani, Maria Falkenberg, Carlo Viscomi
Jun 06, 2021
Mutations in POLG, encoding POLγA, the catalytic subunit of the mitochondrial DNA polymerase, cause a spectrum of disorders characterized by mtDNA instability. However, the molecular pathogenesis of POLG-related diseases is...
Published by: Nucleic Acids Research
Quantifying moment redistribution in FRP-strengthened RC beams
Consideration of moment redistribution (MR) in the design of continuous reinforced concrete (RC) beams results in an efficient and economical design. Adding fibre-reinforced polymer (FRP) materials to RC structures to enhance...
Species fractionation in atomic chains from mechanically stretched alloys.
Bettini et al (2006 Nat. Nanotechnol. 1 182-5) reported the first experimental realization of linear atomic chains (LACs) composed of different atoms (Au and Ag). The different contents of Au and Ag were observed in the chains...
Prediction of capacity for moment redistribution in FRP-strengthened continuous RC T-beams
Due to the premature debonding of fiber-reinforced polymer (FRP) materials which results in a reduction in 14 ductility, the problem of how to exploit moment redistribution (MR) in FRP-strengthened continuous 15 reinforced...
Quantifying moment redistribution in FRP-strengthened RC beams
Consideration of moment redistribution (MR) in the design of continuous reinforced concrete (RC) beams results in an efficient and economical design. Adding fibre-reinforced polymer (FRP) materials to RC structures to enhance...
Prediction of capacity for moment redistribution in FRP-strengthened continuous RC T-beams
Due to the premature debonding of fiber-reinforced polymer (FRP) materials which results in a reduction in 14 ductility, the problem of how to exploit moment redistribution (MR) in FRP-strengthened continuous 15 reinforced...
Chromosome painting in Glyphorynchus spirurus (Vieillot, 1819) detects a new fission in Passeriformes.
Talita Fernanda Augusto Ribas, Cleusa Yoshiko Nagamachi, Alexandre Aleixo, Melquizedec Luiz Silva Pinheiro, Patricia Caroline Mary O Brien, Malcolm Andrew Ferguson-Smith, Fengtang Yang, Pablo Suarez, Julio Cesar Pieczarka
Nov 22, 2018
Glyphorynchus spirurus (GSP), also called the Wedge-billed Woodcreeper (Furnariidae) has an extensive distribution in the Americas, including the Atlantic coast of Brazil. Nevertheless, there is no information about its...
Resonant wave interactions in the equatorial waveguide
Weakly nonlinear interactions among equatorial waves have been explored in this paper using the adiabatic version of the equatorial β-plane primitive equations in isobaric coordinates. Assuming rigid lid vertical boundary...
Resonant wave interactions in the equatorial waveguide
Weakly nonlinear interactions among equatorial waves have been explored in this paper using the adiabatic version of the equatorial β-plane primitive equations in isobaric coordinates. Assuming rigid lid vertical boundary...
Rethinking the Informal and Criminal Economy from a Global Commodity Chain Perspective
Rosana Pinheiro Machado
Jun 11, 2018
The criminalization of Chinese counterfeit goods in the global market calls for a fresh approach to understanding well‐established binary distinctions such as legal/illegal, licit/illicit, and formal/informal. Based on a...
Cyanogenesis in Arthropods
Chemical defences are key components in insect⁻plant interactions, as insects continuously learn to overcome plant defence systems by, e.g., detoxification, excretion or sequestration. Cyanogenic glucosides are natural products...
Active Textile Fabrics from Weaving Liquid Crystalline Elastomer Filaments.
Pedro ES Silva, Xueyan Lin, Maija Vaara, Mithila Mohan, Jaana Vapaavuori, Eugene M Terentjev
Feb 25, 2023
Active fabrics, responding autonomously to environmental changes, are the "Holy Grail" of the development of smart textiles. Liquid crystal elastomers (LCEs) promise to be the base materials for large-stroke reversible...
Objectively Measured Physical Activity Reduces the Risk of Mortality among Brazilian Older Adults.
Renata M Bielemann, Andrea Z LaCroix, Andréa D Bertoldi, Elaine Tomasi, Flávio F Demarco, Maria Cristina Gonzalez, Pedro Augusto Crespo da Silva, Andrea Wendt, Inácio Crochemore Mohnsam da Silva, Soren Brage, Ulf Ekelund, Michael Pratt
Jan 27, 2021
OBJECTIVES: Use of objectively measured physical activity (PA) in older adults to assess relationship between PA and risk of all-causes mortality is scarce. This study evaluated the associations of PA based on accelerometry and...
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