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Divergent Metabolomic Signatures of TGFβ2 and TNFα in the Induction of Retinal Epithelial-Mesenchymal Transition.
Divergent Metabolomic Signatures of TGFβ2 and TNFα in the Induction of Retinal Epithelial-Mesenchymal Transition.
Epithelial-mesenchymal transition (EMT) is a dedifferentiation program in which polarized, differentiated epithelial cells lose their cell-cell adhesions and transform into matrix-producing mesenchymal cells. EMT of retinal...
Mitochondria metabolism proliferative vitreoretinopathy Metabolomics age-related macular degeneration Glycolysis OXPHOS epithelial-mesenchymal transition (EMT) retinal pigment epithelium (RPE) tumor necrosis factor-alpha (TNFα) transforming growth factor-beta (TGFβ)
Published by: Metabolites
Disparities in the unmet mental health needs between LGBTQ+ and non-LGBTQ+ populations during COVID-19 in the United States from 21 July 2021 to 9 May 2022.
BACKGROUND: Evidence highlighted the likelihood of unmet mental health needs (UMHNs) among LGBTQ+ than non-LGBTQ+ populations during COVID-19. However, there lacks evidence to accurately answer to what extent the gap was in UMHN...
Mode-localized accelerometer in the nonlinear Duffing regime with 75 ng bias instability and 95 ng/√Hz noise floor.
Hemin Zhang, Milind Pandit, Guillermo Sobreviela, Madan Parajuli, Dongyang Chen, Jiangkun Sun, Chun Zhao, Ashwin A Seshia
Mar 21, 2022
Mode-localized sensors have attracted attention because of their high parametric sensitivity and first-order common-mode rejection to temperature drift. The high-fidelity detection of resonator amplitude is critical to...
Structure of the Chicken Neuron-Glia Cell Adhesion Molecule, Ng-CAM: Origin of the Polypeptides and Relation to the Ig Superfamily
Mark P Burgoon
Jan 01, 0001
The neuron-glia cell adhesion molecule, Ng-CAM, is a cell-surface glycoprotein expressed on neurons and Schwann cells in the chicken nervous system. It is expressed as a group of related components of -200 kD, 135 kD, and 80 kD...
Published by: Rockefeller University
Electrochemical CO
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Reduction with Atomic Iron‐Dispersed on Nitrogen‐Doped Graphene
Chenhao Zhang, Shize Yang, Jingjie Wu, Mingjie Liu, Sadegh Yazdi, Muqing Ren, Junwei Sha, Jun Zhong, Kaiqi Nie, Almaz S Jalilov, Zhenyuan Li, Huaming Li, Boris I Yakobson, Qin Wu, Emilie Ringe, Hui Xu, Pulickel M Ajayan, James M Tour
Nov 20, 2018
Electrochemical reduction of CO2 provides an opportunity to reach a carbon‐neutral energy recycling regime, in which CO2 emissions from fuel use are collected and converted back to fuels. The reduction of CO2 to CO is the first...
Risk factors for excess deaths during lockdown among older users of secondary care mental health services without confirmed COVID-19
Shanquan Chen, Peter B Jones, Benjamin R Underwood, Emilio Fernandez-Egea, Pei Qin, Jonathan R Lewis, Rudolf N Cardinal
Aug 19, 2021
OBJECTIVE: To investigate factors contributing to excess deaths of older patients during the initial 2020 lockdown beyond those attributable to confirmed COVID-19. METHODS: Retrospective cohort study comparing patients treated...
Risk factors for excess deaths during lockdown among older users of secondary care mental health services without confirmed COVID‐19
Shanquan Chen, Peter B. Jones, Benjamin R. Underwood, Emilio Fernandez‐Egea, Pei Qin, Jonathan R. Lewis, Rudolf N. Cardinal
Aug 19, 2021
Published by: International Journal of Geriatric Psychiatry
Rapid prioritisation of topics for rapid evaluation
Katherine Cowan, Naomi J Fulop, Amelia Harshfield, Pei Li Ng, Antiopi Ntouva, Manbinder Sidhu, Jon Sussex, Sonila M Tomini, Holly Walton
Mar 10, 2021
BACKGROUND: Prioritisation processes are widely used in healthcare research and increasingly in social care research. Previous research has recommended using consensus development methods for inclusive research agenda setting....
Facile synthesis of crack-free metal-organic framework films on alumina by a dip-coating route in the presence of polyethylenimine
A facile polyethylenimine (PEI)-assisted dip-coating method allows crack-free films of MIL-101(Cr) and MIL-101(Cr)-NH2 to be prepared on alumina supports. The presence of PEI enhances the selectivity of the films...
Facile synthesis of crack-free metal-organic framework films on alumina by a dip-coating route in the presence of polyethylenimine
A facile polyethylenimine (PEI)-assisted dip-coating method allows crack-free films of MIL-101(Cr) and MIL-101(Cr)-NH2 to be prepared on alumina supports. The presence of PEI enhances the selectivity of the films...
Pressure-stabilized divalent ozonide CaO3 and its impact on Earth's oxygen cycles.
Yanchao Wang, Meiling Xu, Liuxiang Yang, Bingmin Yan, Qin Qin, Xuecheng Shao, Yunwei Zhang, Dajian Huang, Xiaohuan Lin, Jian Lv, Dongzhou Zhang, Huiyang Gou, Ho-Kwang Mao, Changfeng Chen, Yanming Ma
Nov 16, 2020
High pressure can drastically alter chemical bonding and produce exotic compounds that defy conventional wisdom. Especially significant are compounds pertaining to oxygen cycles inside Earth, which hold key to understanding...
The Medium-Term Impact of COVID-19 Lockdown on Referrals to Secondary Care Mental Health Services
Shanquan Chen, Rui She, Pei Qin, Anne Kershenbaum, Emilio Fernandez-Egea, Jenny R Nelder, Chuoxin Ma, Jonathan Lewis, Chaoqun Wang, Rudolf N Cardinal
Dec 21, 2020
To date, there is a paucity of information regarding the effect of COVID-19 or lockdown on mental disorders. We aimed to quantify the medium-term impact of lockdown on referrals to secondary care mental health clinical services....
Development of models of care coordination for rare conditions
Holly Walton, Amy Simpson, Angus IG Ramsay, Amy Hunter, Jennifer Jones, Pei Li Ng, Kerry Leeson-Beevers, Lara Bloom, Joe Kai, Maria Kokocinska, Alastair G Sutcliffe, Stephen Morris, Naomi J Fulop
Feb 14, 2022
INTRODUCTION: Improving care coordination for people with rare conditions may help to reduce burden on patients and carers and improve the care that patients receive. We recently developed a taxonomy of different ways of...
The Medium-Term Impact of COVID-19 Lockdown on Referrals to Secondary Care Mental Health Services
Shanquan Chen, Rui She, Pei Qin, Anne Kershenbaum, Emilio Fernandez-Egea, Jenny R. Nelder, Chuoxin Ma, Jonathan Lewis, Chaoqun Wang, Rudolf N. Cardinal
Dec 10, 2020
To date, there is a paucity of information regarding the effect of COVID-19 or lockdown on mental disorders. We aimed to quantify the medium-term impact of lockdown on referrals to secondary care mental health clinical services....
Patients' experiences of, and engagement with, remote home monitoring services for COVID-19 patients
Holly Walton, Cecilia Vindrola-Padros, Nadia E Crellin, Manbinder S Sidhu, Lauren Herlitz, Ian Litchfield, Jo Ellins, Pei Li Ng, Efthalia Massou, Sonila M Tomini, Naomi J Fulop
Aug 07, 2022
INTRODUCTION: Remote home monitoring models were implemented during the COVID-19 pandemic to shorten hospital length of stay, reduce unnecessary hospital admission, readmission and infection and appropriately escalate care....
Developing a taxonomy of care coordination for people living with rare conditions
Holly Walton, Amy Simpson, Angus IG Ramsay, Emma Hudson, Amy Hunter, Jennifer Jones, Pei Li Ng, Kerry Leeson-Beevers, Lara Bloom, Joe Kai, Larissa Kerecuk, Maria Kokocinska, Alastair G Sutcliffe, Stephen Morris, Naomi J Fulop
Apr 21, 2022
BACKGROUND: Improving care coordination is particularly important for individuals with rare conditions (who may experience multiple inputs into their care, across different providers and settings). To develop and evaluate...
Pathogenic mtDNA mutations causing mitochondrial myopathy
Steven A Hardy, Emma L Blakely, Andrew I Purvis, Mariana C Rocha, Syeda Ahmed, Gavin Falkous, Joanna Poulton, Michael R Rose, Olivia O'Mahony, Niamh Bermingham, Charlotte F Dougan, Yi Shiau Ng, Rita Horvath, Doug M Turnbull, Grainne S Gorman, Robert W Taylor
Oct 01, 2019
Pathogenic mitochondrial tRNA (mt-tRNA) gene mutations represent a prominent cause of primary mitochondrial DNA (mtDNA)-related disease despite accounting for only 5%-10% of the mitochondrial genome.(1,2) Although some common...
Development of models of care coordination for rare conditions
Holly Walton, Amy Simpson, Angus IG Ramsay, Amy Hunter, Jennifer Jones, Pei Li Ng, Kerry Leeson-Beevers, Lara Bloom, Joe Kai, Maria Kokocinska, Alastair G Sutcliffe, Stephen Morris, Naomi J Fulop
Mar 18, 2022
INTRODUCTION: Improving care coordination for people with rare conditions may help to reduce burden on patients and carers and improve the care that patients receive. We recently developed a taxonomy of different ways of...
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.
Sonia Baig, Muhammad Shabeer, Ehsan Parvaresh Rizi, Madhur Agarwal, Michelle H Lee, Delicia Shu Qin Ooi, Chelsea Chia, Nweni Aung, Geelyn Ng, Yvonne Teo, Vanna Chhay, Faidon Magkos, Antonio Vidal-Puig, Raymond CS Seet, Sue-Anne Toh
Oct 08, 2020
INTRODUCTION AND OBJECTIVE: Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study...
Characterisation of PALB2 tumours through whole-exome and whole-transcriptomic analyses.
Pei Sze Ng, Jia Wern Pan, Muhammad Mamduh Ahmad Zabidi, Pathmanathan Rajadurai, Cheng Har Yip, Oscar M Reuda, Alison M Dunning, Antonis C Antoniou, Douglas F Easton, Carlos Caldas, Suet-Feung Chin, Soo Hwang Teo
May 13, 2021
Rare protein-truncating variants (PTVs) in PALB2 confer increased risk to breast cancer, but relatively few studies have reported the characteristics of tumours with PALB2 PTVs. In this study, we describe molecular...
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.
Sonia Baig, Muhammad Shabeer, Ehsan Parvaresh Rizi, Madhur Agarwal, Michelle H Lee, Delicia Shu Qin Ooi, Chelsea Chia, Nweni Aung, Geelyn Ng, Yvonne Teo, Vanna Chhay, Faidon Magkos, Antonio Vidal-Puig, Raymond C S Seet, Sue-Anne Toh
Mar 14, 2020
INTRODUCTION AND OBJECTIVE:Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study...
Oxidative Stress Adipocytes Inflammation mononuclear cells myotubes family history of type 2 diabetes
Published by: BMJ open diabetes research & care
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