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Results: 53
Rule Extraction in Trained Feedforward Deep Neural Networks
Explainability is a key aspect of machine learning, necessary for ensuring transparency and trust in decision-making processes. As machine learning models become more complex, the integration of neural and symbolic approaches...
Published by: IGI Global Scientific Publishing
Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury.
Thomas Geeraerts, Jonathan P Coles, Franklin I Aigbirhio, John D Pickard, David K Menon, Tim D Fryer, Young T Hong
Jun 18, 2018
OBJECTIVE: [(11)C]Flumazenil ([(11)C]FMZ) positron emission tomography (PET) can be used as a measure of neuronal loss. The purpose of this study was to validate reference tissue kinetic modelling of [(11)C]FMZ PET within a...
EMD-based data augmentation method applied to handwriting data for the diagnosis of Essential Tremor using LSTM networks.
José Fernando Adrán Otero, Karmele López-de-Ipina, Oscar Solans Caballer, Pere Marti-Puig, José Ignacio Sánchez-Méndez, Jon Iradi, Alberto Bergareche, Jordi Solé-Casals
Jul 27, 2022
The increasing capacity of today's technology represents great advances in diagnosing diseases using standard procedures supported by computer science. Deep learning techniques are able to extract the characteristics of temporal...
EMD-based data augmentation method applied to handwriting data for the diagnosis of Essential Tremor using LSTM networks.
José Fernando Adrán Otero, Karmele López-de-Ipina, Oscar Solans Caballer, Pere Marti-Puig, José Ignacio Sánchez-Méndez, Jon Iradi, Alberto Bergareche, Jordi Solé-Casals
Sep 02, 2022
The increasing capacity of today's technology represents great advances in diagnosing diseases using standard procedures supported by computer science. Deep learning techniques are able to extract the characteristics of temporal...
What Are Observables in Hamiltonian Einstein–Maxwell Theory?
J. Brian Pitts
Aug 05, 2020
Abstract: Is change missing in Hamiltonian Einstein–Maxwell theory? Given the most common definition of observables (having weakly vanishing Poisson bracket with each first-class constraint), observables are constants of the...
Application of Machine Learning Models for Malware Classification With Real and Synthetic Datasets
Stacking of multiple Machine Learning (ML) classifiers have gained popularity in addressing anomalous data classification along with Deep Learning (DL) algorithms. This study compares traditional ML classifiers, multi-layer...
Published by: IGI Global Scientific Publishing
Outcomes of adjunctive radiation therapy for the treatment of mast cell tumors in dogs and assessment of toxicity
Sarah L Mason, Charles Pittaway, Begona Pons Gil, Onne-Marju Russak, Katie Westlake, Davide Berlato, Jérôme Benoit, Joanna Morris, Jane Margaret Dobson
Oct 21, 2021
BACKGROUND: Radiation therapy is commonly used as an adjunct to incomplete surgical excision in dogs with mast cell tumors (MCT), but the optimal dose and fractionation regimen have yet to be determined. HYPOTHESIS: We assessed...
The case of 'A Rhino Horn'
Oliver Marín-Pena, Olufemi R Ayeni, Marc Tey-Pons, Jesús Mas-Martinez, Pedro Dantas, Vikas Khanduja
Jul 29, 2021
Subspine impingement syndrome by definition involves a prominent antero-inferior iliac spine (AIIS) which can lead to impingement on the femoral neck thereby causing symptoms. We present the case of a 22-year-old...
Published by: Journal of hip preservation surgery
Integrin-Mediated Adhesion in the Unicellular Holozoan Capsaspora owczarzaki.
Helena Parra-Acero, Matija Harcet, Núria Sánchez-Pons, Elena Casacuberta, Nicholas H Brown, Omaya Dudin, Iñaki Ruiz-Trillo
Sep 15, 2020
In animals, cell-matrix adhesions are essential for cell migration, tissue organization, and differentiation, which have central roles in embryonic development [1-6]. Integrins are the major cell surface adhesion receptors...
The case of 'A Rhino Horn'
Oliver Marín-Pena, Olufemi R Ayeni, Marc Tey-Pons, Jesús Mas-Martinez, Pedro Dantas, Vikas Khanduja
Jul 22, 2021
Subspine impingement syndrome by definition involves a prominent antero-inferior iliac spine (AIIS) which can lead to impingement on the femoral neck thereby causing symptoms. We present the case of a 22-year-old...
Smart Tourism Empowered by Artificial Intelligence
Artificial intelligence (AI) is changing the rules of the game in many industries. This case details how the combination of open innovation and artificial intelligence generates new opportunities in the tourism sector....
Published by: IGI Global Scientific Publishing
Physical principles of membrane remodelling during cell mechanoadaptation.
Anita Joanna Kosmalska, Laura Casares, Alberto Elosegui-Artola, Joseph Jose Thottacherry, Roberto Moreno-Vicente, Víctor González-Tarragó, Miguel Ángel Del Pozo, Satyajit Mayor, Marino Arroyo, Daniel Navajas, Xavier Trepat, Nils C Gauthier, Pere Roca-Cusachs
Jan 06, 2020
Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope--the bilayer membrane. However, the fundamental biophysical principles by which the cell...
The EASL–<em>Lancet</em> Commission on liver health in Europe
Tom H Karlsen, Harry Rutter, Patrizia Carrieri, Shira Zelber-Sagi, Eivind Engebretsen, Sharon Hutchinson, Kristin Voigt, Neil Guha, Annalisa Berzigotti, Georg Schomerus, Pere Gines, Maria Buti, Patrizia Burra, Michael P Manns, Aleksander Krag, Sabine Kleinert
Feb 12, 2024
In December, 2021, the first report from the Lancet Commission on liver disease in Europe, a joint project with the European Association for the Study of the Liver (EASL), was published. 1 The Commission explored the harm to...
The EASL–<em>Lancet</em> Commission on liver health in Europe
Tom H Karlsen, Harry Rutter, Patrizia Carrieri, Shira Zelber-Sagi, Eivind Engebretsen, Sharon Hutchinson, Kristin Voigt, Neil Guha, Annalisa Berzigotti, Georg Schomerus, Pere Gines, Maria Buti, Patrizia Burra, Michael P Manns, Aleksander Krag, Sabine Kleinert
Feb 12, 2024
In December, 2021, the first report from the Lancet Commission on liver disease in Europe, a joint project with the European Association for the Study of the Liver (EASL), was published. 1 The Commission explored the harm to...
Zola’s “champ limité de la réalisation”
Nicholas White
Dec 07, 2020
Émile Zola explains the inclusion of the Paris Commune of 1871 in his novel, La Débâcle (1892) in terms of his Naturalist epistemophilia: “Je veux tout mettre, je suis toujours désespéré du champ limité de la réalisation.” But...
Motor cortical output for skilled forelimb movement is selectively distributed across projection neuron classes.
Junchol Park, James W Phillips, Jian-Zhong Guo, Kathleen A Martin, Adam W Hantman, Joshua T Dudman
Apr 09, 2022
The interaction of descending neocortical outputs and subcortical premotor circuits is critical for shaping skilled movements. Two broad classes of motor cortical output projection neurons provide input to many subcortical motor...
Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells.
Joseph Jose Thottacherry, Anita Joanna Kosmalska, Amit Kumar, Amit Singh Vishen, Alberto Elosegui-Artola, Susav Pradhan, Sumit Sharma, Parvinder P Singh, Marta C Guadamillas, Natasha Chaudhary, Ram Vishwakarma, Xavier Trepat, Miguel A Del Pozo, Robert G Parton, Madan Rao, Pramod Pullarkat, Pere Roca-Cusachs, Satyajit Mayor
Jan 06, 2020
Plasma membrane tension regulates many key cellular processes. It is modulated by, and can modulate, membrane trafficking. However, the cellular pathway(s) involved in this interplay is poorly understood. Here we find that...
[11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.
Luca Passamonti, Patricia Vázquez Rodríguez, Young T Hong, Kieren SJ Allinson, W Richard Bevan-Jones, David Williamson, P Simon Jones, Robert Arnold, Robin J Borchert, Ajenthan Surendranathan, Elijah Mak, Li Su, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Rowe
May 22, 2018
OBJECTIVE: We tested whether in vivo neuroinflammation relates to the distinctive distributions of pathology in Alzheimer disease (AD) and progressive supranuclear palsy (PSP). METHODS: Sixteen patients with symptomatic AD...
Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology.
Alessandra Stangherlin, Joseph L Watson, David C S Wong, Silvia Barbiero, Aiwei Zeng, Estere Seinkmane, Sew Peak Chew, Andrew D Beale, Edward A Hayter, Alina Guna, Alison J Inglis, Marrit Putker, Eline Bartolami, Stefan Matile, Nicolas Lequeux, Thomas Pons, Jason Day, Gerben van Ooijen, Rebecca M Voorhees, David A Bechtold, Emmanuel Derivery, Rachel S Edgar, Peter Newham, John S O'Neill
Nov 22, 2021
Between 6-20% of the cellular proteome is under circadian control and tunes mammalian cell function with daily environmental cycles. For cell viability, and to maintain volume within narrow limits, the daily variation in osmotic...
Published by: Nature Communications
Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology
Alessandra Stangherlin, Joseph L. Watson, David C. S. Wong, Silvia Barbiero, Aiwei Zeng, Estere Seinkmane, Sew Peak Chew, Andrew D. Beale, Edward A. Hayter, Alina Guna, Alison J. Inglis, Marrit Putker, Eline Bartolami, Stefan Matile, Nicolas Lequeux, Thomas Pons, Jason Day, Gerben van Ooijen, Rebecca M. Voorhees, David A. Bechtold, Emmanuel Derivery, Rachel S. Edgar, Peter Newham, John S. O’Neill
Oct 18, 2021
Abstract: Between 6–20% of the cellular proteome is under circadian control and tunes mammalian cell function with daily environmental cycles. For cell viability, and to maintain volume within narrow limits, the daily variation...
Operation of a TCA cycle subnetwork in the mammalian nucleus.
Eleni Kafkia, Amparo Andres-Pons, Kerstin Ganter, Markus Seiler, Tom S Smith, Anna Andrejeva, Paula Jouhten, Filipa Pereira, Catarina Franco, Anna Kuroshchenkova, Sergio Leone, Ritwick Sawarkar, Rebecca Boston, James Thaventhiran, Judith B Zaugg, Kathryn S Lilley, Christophe Lancrin, Martin Beck, Kiran Raosaheb Patil
Oct 01, 2022
Nucleic acid and histone modifications critically depend on the tricarboxylic acid (TCA) cycle for substrates and cofactors. Although a few TCA cycle enzymes have been reported in the nucleus, the corresponding pathways are...
Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology.
Alessandra Stangherlin, Joseph L Watson, David CS Wong, Silvia Barbiero, Aiwei Zeng, Estere Seinkmane, Sew Peak Chew, Andrew D Beale, Edward A Hayter, Alina Guna, Alison J Inglis, Marrit Putker, Eline Bartolami, Stefan Matile, Nicolas Lequeux, Thomas Pons, Jason Day, Gerben van Ooijen, Rebecca M Voorhees, David A Bechtold, Emmanuel Derivery, Rachel S Edgar, Peter Newham, John S O'Neill
Dec 15, 2021
Between 6-20% of the cellular proteome is under circadian control and tunes mammalian cell function with daily environmental cycles. For cell viability, and to maintain volume within narrow limits, the daily variation in osmotic...
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