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Results: 38
Detailed analysis of the genetic and epigenetic signatures of iPSC-derived mesodiencephalic dopaminergic neurons.
Reinhard Roessler, Sebastien A Smallwood, Jesse V Veenvliet, Petros Pechlivanoglou, Su-Ping Peng, Koushik Chakrabarty, Marian JA Groot-Koerkamp, R Jeroen Pasterkamp, Evelyn Wesseling, Gavin Kelsey, Erik Boddeke, Marten P Smidt, Sjef Copray
Jun 24, 2019
Induced pluripotent stem cells (iPSCs) hold great promise for in vitro generation of disease-relevant cell types, such as mesodiencephalic dopaminergic (mdDA) neurons involved in Parkinson's disease. Although iPSC-derived...
Photorealistic 3D Models and Interactive Learning Content for a Machine Elements E-Course
Production and industrial engineering are domains that increasingly require a sophisticated and multidisciplinary set of skills. As modern educational mechanisms shift towards more advanced patterns of remote and asynchronous...
Published by: IGI Global Scientific Publishing
A review of the Impact of Blue Space on the Urban Microclimate
The urban heat island (UHI) phenomenon represents a major public health issue and has received great attention due to rapid urbanisation. Blue spaces have long been considered a possible mitigation strategy to ameliorate the...
Blue space climate Cooling Heat island Microclimate Waterbody /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/2300/2311 name=Waste Management and Disposal /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
A review of the Impact of Blue Space on the Urban Microclimate
The urban heat island (UHI) phenomenon represents a major public health issue and has received great attention due to rapid urbanisation. Blue spaces have long been considered a possible mitigation strategy to ameliorate the...
Blue space climate Cooling Heat island Microclimate Waterbody /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/2300/2311 name=Waste Management and Disposal /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Formalization of Ethical Decision Making
As automation in robotics and artificial intelligence is increasing, we will need to automate a growing amount of ethical decision making. However, ethical decision-making raises novel challenges for designers, engineers...
Published by: IGI Global Scientific Publishing
Impact of blue space geometry on urban heat island mitigation
A growing body of literature recognises the importance of nature-based solutions in providing resilience to the effects of climate change by mitigating urban heat islands. However, a knowledge gap exists regarding the...
CFD OpenFOAM RANS Blue space evaporation nature-based solutions water bodies /dk/atira/pure/subjectarea/asjc/1900/1902 name=Atmospheric Science /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Impact of blue space geometry on urban heat island mitigation
A growing body of literature recognises the importance of nature-based solutions in providing resilience to the effects of climate change by mitigating urban heat islands. However, a knowledge gap exists regarding the...
CFD OpenFOAM RANS Blue space evaporation nature-based solutions water bodies /dk/atira/pure/subjectarea/asjc/1900/1902 name=Atmospheric Science /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
A data-driven dynamic repositioning model in bicycle-sharing systems
The new generation of bicycle-sharing is an O2O (online-to-offline) platform service that enables the users to access the bicycle with a smartphone App. This paper proposes a dynamic repositioning model with predicted demand...
Bicycle-sharing data-driven Demand prediction Dynamic repositioning neural network /dk/atira/pure/subjectarea/asjc/1400/1400 name=General Business,Management and Accounting /dk/atira/pure/subjectarea/asjc/2000/2002 name=Economics and Econometrics /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Evaluating the effects of second-dose vaccine-delay policies in European countries
Petros Barmpounakis, Nikolaos Demiris, Ioannis Kontoyiannis, George N Pavlakis, Vana Sypsa
Apr 21, 2022
The results of a simulation-based evaluation of several policies for vaccine rollout are reported, particularly focusing on the effects of delaying the second dose of two-dose vaccines. In the presence of limited vaccine supply...
Evaluating the effects of second-dose vaccine-delay policies in European countries
Petros Barmpounakis, Nikolaos Demiris, Ioannis Kontoyiannis, George N Pavlakis, Vana Sypsa
May 22, 2022
The results of a simulation-based evaluation of several policies for vaccine rollout are reported, particularly focusing on the effects of delaying the second dose of two-dose vaccines. In the presence of limited vaccine supply...
Understanding Product Returns
Quang Huy Duong, Li Zhou, Meng Meng, Truong Van Nguyen, Petros Ieromonachou, Duy Tiep Nguyen
Jan 31, 2022
Product Returns (PR) are an inevitable yet costly process in business, especially in the online marketplace. How to deal with the conundrums has attracted a great deal of attention from both practitioners and researchers. This...
A data-driven dynamic repositioning model in bicycle-sharing systems
The new generation of bicycle-sharing is an O2O (online-to-offline) platform service that enables the users to access the bicycle with a smartphone App. This paper proposes a dynamic repositioning model with predicted demand...
Bicycle-sharing data-driven Demand prediction Dynamic repositioning neural network /dk/atira/pure/subjectarea/asjc/1400/1400 name=General Business,Management and Accounting /dk/atira/pure/subjectarea/asjc/2000/2002 name=Economics and Econometrics /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Required Project Designers' Attributes as Perceived by Male and Female Engineers
Project designer (PD) personality defines the way PDs cooperate with the project team, make decisions, and influence the project performance. The current research focused on identifying attributes associated with successful PDs...
Published by: IGI Global Scientific Publishing
Understanding Product Returns
Quang Huy Duong, Li Zhou, Meng Meng, Truong Van Nguyen, Petros Ieromonachou, Duy Tiep Nguyen
Jan 31, 2022
Product Returns (PR) are an inevitable yet costly process in business, especially in the online marketplace. How to deal with the conundrums has attracted a great deal of attention from both practitioners and researchers. This...
Epidemiology of ATTRV30M neuropathy in Cyprus and the modifier effect of complement C1q on the age of disease onset.
Savanna Andreou, Elena Panayiotou, Kyriaki Michailidou, Panayiota Pirpa, Andreas Hadjisavvas, Adonis El Salloukh, Daniel Barnes, Antonis Antoniou, Petros Agathangelou, Katia Papastavrou, Kyproula Christodoulou, George A Tanteles, Theodoros Kyriakides
Jan 31, 2019
BACKGROUND: ATTRV30M amyloidosis is a lethal autosomal dominant sensorimotor and autonomic neuropathy caused by amyloid deposition composed of aggregated misfolded TTR monomers with the V30M mutation. The age of onset in...
Tricuspid regurgitation and the right ventricle in risk stratification and timing of intervention.
Bushra S Rana, Shaun Robinson, Rajeevan Francis, Mark Toshner, Martin J Swaans, Sharad Agarwal, Ravi de Silva, Amer A Rana, Petros Nihoyannopoulos
Apr 12, 2019
Tricuspid regurgitation natural history and treatment remains poorly understood. Right ventricular function is a key factor in determining prognosis, timing for intervention and longer-term outcome. The right ventricle is a thin...
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson
May 31, 2018
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was...
HIF transcription factors VEGF angiogenesis cytotoxic T cells Hypoxia Immunotherapy Animals Breast Neoplasms CD8-Positive T-Lymphocytes Cell Line Tumor Cells Cultured Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Mice Knockout Neoplasms Experimental Neovascularization Pathologic T-Lymphocytes Cytotoxic Vascular Endothelial Growth Factor A
Evaluation of the sensitivity of R1ρ MRI to pH and macromolecular density.
Syed O Ali, Petros Fessas, Joshua D Kaggie, Fulvio Zaccagna, Gavin Houston, Scott Reid, Martin J Graves, Ferdia A Gallagher
Feb 21, 2019
The tumor microenvironment is characteristically acidic and this extracellular acidosis is known to play a role in carcinogenesis and metastasis and can affect tumor chemosensitivity and radiosensitivity. Intracellular pH has...
MRI R(1)ρ T(1)ρ Tumor Microenvironment pH basal ganglia Brain Brain Ischemia Brain Mapping Contrast Media Gadolinium Gray Matter Healthy Volunteers Humans Hydrogen-Ion Concentration Macromolecular Substances Magnetic Resonance Imaging Male Neoplasm Metastasis Neoplasms Phantoms imaging Reproducibility of Results Sensitivity and Specificity stroke Tumor Microenvironment Young Adult
Management of primary hypothyroidism
Onyebuchi Okosieme, Jackie Gilbert, Prakash Abraham, Kristien Boelaert, Colin Dayan, Mark Gurnell, Graham Leese, Christopher McCabe, Petros Perros, Vicki Smith, Graham Williams, Mark Vanderpump
Mar 18, 2019
The management of primary hypothyroidism with levothyroxine (L-T4) is simple, effective and safe, and most patients report improved well-being on initiation of treatment. However, a proportion of individuals continue to suffer...
Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.
Petros A Tyrakis, Marie E Yurkovich, Marco Sciacovelli, Evangelia K Papachristou, Hannah R Bridges, Edoardo Gaude, Alexander Schreiner, Clive D'Santos, Judy Hirst, Juan Hernandez-Fernaud, Roger Springett, John R Griffiths, Christian Frezza
May 22, 2018
Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding its role in tumorigenesis, the effects of FH loss on mitochondrial...
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.
Petros A Tyrakis, Asis Palazon, David Macias, Kian L Lee, Anthony T Phan, Pedro Veliça, Jia You, Grace S Chia, Jingwei Sim, Andrew Doedens, Alice Abelanet, Colin E Evans, John R Griffiths, Lorenz Poellinger, Ananda W Goldrath, Randall S Johnson
Dec 14, 2016
R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both...
Animals CD8-Positive T-Lymphocytes Cell Differentiation DNA DNA Methylation Dioxygenases Glutarates Histones Homeostasis Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Ketoglutaric Acids Lymphocyte Activation Lysine Mice Oxygen Protein Stability Receptors Antigen T-Cell Von Hippel-Lindau Tumor Suppressor Protein
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