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Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics
Min Ju, Toby S Scott-ward, Jia Liu, Pissared Khuituan, Hongyu Li, Zhiwei Cai, Stephen M Husbands, David N Sheppard
Jan 01, 2014
Background and Purpose Loop diuretics are widely used to inhibit the Na+, K+, 2Cl- co-transporter, but they also inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl - channel. Here, we investigated the...
Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics
Min Ju, Toby S Scott-ward, Jia Liu, Pissared Khuituan, Hongyu Li, Zhiwei Cai, Stephen M Husbands, David N Sheppard
Jan 01, 2014
Background and Purpose Loop diuretics are widely used to inhibit the Na+, K+, 2Cl- co-transporter, but they also inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl - channel. Here, we investigated the...