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Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18 F-GE-180 and comparison with 18 F-FDG and DCE-MRI
Marius de Groot, Neel Patel, Roido Manavaki, Robert L. Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J. Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D. Fryer, Pilar Jimenez-Royo
Dec 22, 2020
Abstract: Purpose: While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be...
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI.
Marius de Groot, Neel Patel, Roido Manavaki, Robert L Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D Fryer, Pilar Jimenez-Royo
Feb 13, 2020
PURPOSE: While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be valuable....
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI.
Marius de Groot, Neel Patel, Roido Manavaki, Robert L Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D Fryer, Pilar Jimenez-Royo
Jan 27, 2020
PURPOSE:While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be valuable....
Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation
α-Synuclein (aSyn) aggregation is an attractive target for therapeutic development fora range of neurodegenerative conditions, collectively termed synucleinopathies. Here,we probe the mechanism of action of a peptide 4554W...
C(sp3)-C(sp3) coupling of non-activated alkyl-iodides with electron-deficient alkenes via visible-light/silane-mediated alkyl-radical formation.
Here, we present a remarkably mild and general initiation protocol for alkyl-radical generation from non-activated alkyl-iodides. An interaction between a silane and an alkyl iodide is excited by irradiation with visible light...
Whole Genome Interpretation for a Family of Five.
Although best practices have emerged on how to analyse and interpret personal genomes, the utility of whole genome screening remains underdeveloped. A large amount of information can be gathered from various types of analyses...
Whole Genome Interpretation for a Family of Five
Although best practices have emerged on how to analyse and interpret personal genomes, the utility of whole genome screening remains underdeveloped. A large amount of information can be gathered from various types of analyses...
Human Stiffness Perception and Learning in Interacting With Compliant Environments.
Humans are capable of adjusting their posture stably when interacting with a compliant surface. Their whole-body motion can be modulated in order to respond to the environment and reach to a stable state. In perceiving an...
Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation
α-Synuclein (aSyn) aggregation is an attractive target for therapeutic development fora range of neurodegenerative conditions, collectively termed synucleinopathies. Here,we probe the mechanism of action of a peptide 4554W...
Factors associated with mobile phone usage to access maternal and child healthcare among women of urban slums in Dhaka, Bangladesh
Sabuj Kanti Mistry, Fahmida Akter, Uday Narayan Yadav, Md Belal Hossain, Amarynth Sichel, Alain B Labrique, Daniel ML Storisteanu
Apr 13, 2021
INTRODUCTION: With the acute shortage of human resources and infrastructure, mobile phones can be a critical tool for accessing health services and strengthening health systems in Bangladesh. Yet, there is a scarcity of evidence...
Human placental renin-angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia-reoxygenation insult.
Lesia O Kurlak, Hiten D Mistry, Tereza Cindrova-Davies, Graham J Burton, Fiona Broughton Pipkin
Oct 30, 2015
N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons.
Adrian J Butcher, Ignacio Torrecilla, Kenneth W Young, Kok Choi Kong, Sharad C Mistry, Andrew R Bottrill, Andrew B Tobin
Aug 20, 2020
Changes in synaptic strength mediated by ionotropic glutamate N-methyl-D-asparate (NMDA) receptors is generally considered to be the molecular mechanism underlying memory and learning. NMDA receptors themselves are subject to...
Amino Acid Sequence Animals Calcium Signaling Calcium-Calmodulin-Dependent Protein Kinase Type 2 Cells Cultured cerebellum Feedback Physiological Mice Mice Knockout Molecular Sequence Data N-Methylaspartate Neuronal Plasticity Neurons Phosphatidylinositols Phosphorylation Receptor Muscarinic M3 Receptors N-Methyl-D-Aspartate Recombinant Fusion Proteins Signal Transduction
Exploring Factors Associated with Women's Willingness to Provide Digital Fingerprints in Accessing Healthcare Services
Sabuj Kanti Mistry, Fahmida Akter, Md Belal Hossain, Md Nazmul Huda, Nafis Md Irfan, Uday Narayan Yadav, Daniel ML Storisteanu, Amit Arora
Jan 06, 2022
Digital fingerprints are increasingly used for patient care and treatment delivery, health system monitoring and evaluation, and maintaining data integrity during health research. Yet, no evidence exists about the use of...
Plasma chitotriosidase activity versus CCL18 level for assessing type I Gaucher disease severity
Tatiana Raskovalova, Patrick B Deegan, Ruby Yang, Elena Pavlova, Jérome Stirnemann, José Labarère, Ari Zimran, Pramod K Mistry, Marc Berger
May 05, 2017
BACKGROUND: Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by deficiency in acid beta-glucosidase. GD exhibits a wide clinical spectrum of disease severity with an unpredictable natural course....
Anemia Biomarkers Chemokines CC Gaucher Disease Hepatomegaly Hexosaminidases Humans Splenomegaly Thrombocytopenia Anemia Biomarkers Chemokines CC Gaucher Disease Hepatomegaly Hexosaminidases Humans Meta-Analysis as Topic Research Design Severity of Illness Index Splenomegaly Systematic Reviews as Topic Thrombocytopenia
Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code.
Adrian J Butcher, Rudi Prihandoko, Kok Choi Kong, Phillip McWilliams, Jennifer M Edwards, Andrew Bottrill, Sharad Mistry, Andrew B Tobin
Aug 20, 2020
G-protein-coupled receptors are hyper-phosphorylated in a process that controls receptor coupling to downstream signaling pathways. The pattern of receptor phosphorylation has been proposed to generate a "bar code" that can be...
Exploring Factors Associated with Women's Willingness to Provide Digital Fingerprints in Accessing Healthcare Services
Sabuj Kanti Mistry, Fahmida Akter, Md Belal Hossain, Md Nazmul Huda, Nafis Md Irfan, Uday Narayan Yadav, Daniel ML Storisteanu, Amit Arora
Feb 10, 2022
Digital fingerprints are increasingly used for patient care and treatment delivery, health system monitoring and evaluation, and maintaining data integrity during health research. Yet, no evidence exists about the use of...
On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination
Endre J. Szili, Bhagirath Ghimire, Bethany Lee Patenall, Mohammed Rohaim, Dharmit Mistry, Adrian Fellows, Muhammad Munir, A. Toby A. Jenkins, Robert D. Short
Aug 02, 2021
Antibiotics are commonly used as the first line of defense in the treatment of infectious diseases. However, the rise of antimicrobial resistance (AMR) is rendering many antibiotics less effective. Consequently, effective...
On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination
Endre J. Szili, Bhagirath Ghimire, Bethany Lee Patenall, Mohammed Rohaim, Dharmit Mistry, Adrian Fellows, Muhammad Munir, A. Toby A. Jenkins, Robert D. Short
Aug 02, 2021
Antibiotics are commonly used as the first line of defense in the treatment of infectious diseases. However, the rise of antimicrobial resistance (AMR) is rendering many antibiotics less effective. Consequently, effective...
An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes.
Austin D-E Swafford, Joanna MM Howson, Lucy J Davison, Chris Wallace, Deborah J Smyth, Helen Schuilenburg, Meeta Maisuria-Armer, Trupti Mistry, Michael J Lenardo, John A Todd
Feb 08, 2021
OBJECTIVE: IKZF1 encoding Ikaros, an essential regulator of lymphopoiesis and immune homeostasis, has been implicated in the development of childhood acute lymphoblastic leukemia (C-ALL). Because recent genome-wide association...
Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.
Susan W Robinson, Julie-Myrtille Bourgognon, Jereme G Spiers, Carlo Breda, Susanna Campesan, Adrian Butcher, Giovanna R Mallucci, David Dinsdale, Nobuhiro Morone, Raj Mistry, Tim M Smith, Maria Guerra-Martin, RA John Challiss, Flaviano Giorgini, Joern R Steinert
Jul 18, 2018
Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as...
Adaptor Proteins Vesicular Transport Aldehyde Oxidoreductases Animals Brain Cyclic GMP Drosophila Proteins Drosophila melanogaster Glutamate-Cysteine Ligase Glutathione Larva Nerve Tissue Proteins Neuromuscular Junction Neurotransmitter Agents Nitric oxide Phenotype Prenylation Protein Processing Post-Translational SNARE Proteins Synaptic Transmission Synaptic Vesicles
Fostering autonomous motivation, physical activity and cardiorespiratory fitness in rheumatoid arthritis
Peter C Rouse, Jet J C S Veldhuijzen Van Zanten, George S Metsios, Nikos Ntoumanis, Chen-an Yu, Yiannis Koutedakis, Sally A M Fenton, Joanna Coast, Hema Mistry, George D Kitas, Joan L Duda
Dec 19, 2014
BACKGROUND: People with rheumatoid arthritis are at greater risk of morbidity and mortality from cardiovascular disease than the general population. Sustained physical activity increases cardio-respiratory fitness and reduces...
Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a longitudinal population cohort study.
Alexander Richards, John Horwood, Joseph Boden, Martin Kennedy, Ruth Sellers, Lucy Riglin, Sumit Mistry, Hannah Jones, Daniel J Smith, Stanley Zammit, Michael Owen, Michael C O'Donovan, Gordon T Harold
Jul 03, 2020
BACKGROUND: Studies involving clinically recruited samples show that genetic liability to schizophrenia overlaps with that for several psychiatric disorders including bipolar disorder, major depression and, in a population...
Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I
Zoe A Stephenson, Robert F Harvey, Kenneth R Pryde, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy EH Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst, Barrie Kellam, Anne E Willis
Jun 26, 2020
Disruption of mitochondrial function selectively targets tumour cells that are dependent on oxidative phosphorylation. However, due to their high energy demands, cardiac cells are disproportionately targeted by mitochondrial...
Fostering autonomous motivation, physical activity and cardiorespiratory fitness in rheumatoid arthritis
Peter C Rouse, Jet J C S Veldhuijzen Van Zanten, George S Metsios, Nikos Ntoumanis, Chen-an Yu, Yiannis Koutedakis, Sally A M Fenton, Joanna Coast, Hema Mistry, George D Kitas, Joan L Duda
Dec 19, 2014
BACKGROUND: People with rheumatoid arthritis are at greater risk of morbidity and mortality from cardiovascular disease than the general population. Sustained physical activity increases cardio-respiratory fitness and reduces...
Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I.
Zoe A Stephenson, Robert F Harvey, Kenneth R Pryde, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy EH Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst, Barrie Kellam, Anne E Willis
Jun 04, 2020
Biochemistry cancer biology cardiac liability chemical biology human Mitochondria toxicophore Adenosine Triphosphate Antineoplastic Agents Cell Death Cell Line Cell Proliferation Electron Transport Complex I Gene Expression Regulation Humans Mitochondria Mitochondria Heart Myocytes Cardiac Oxazoles Oxidative Phosphorylation Protein Binding Receptor ErbB-2 Triazoles
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