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Results: 76
Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature.
Andrew Scott, Michael B Powner, Pranita Gandhi, Claire Clarkin, David H Gutmann, Randall S Johnson, Napoleone Ferrara, Marcus Fruttiger
Mar 13, 2020
Vascular endothelial growth factor (VEGF) plays a critical role in normal development as well as retinal vasculature disease. During retinal vascularization, VEGF is most strongly expressed by not yet vascularized retinal...
Decorrelated Deep Neural Networks: Learning Bias Invariant & Scanner Independent Features, and Causal relationships Using a novel deep learning methods based on Distance Correlation
Pranita Patil
Jan 01, 0001
Advancements in deep learning or deep neural networks have made it possible to reach expert-level performance in a variety of applications, even in challenging situations. However, a central challenge in all deep learning, as...
Published by: Harrisburg University of Science and Technology
A Study of Small Volume Plasma Exchange in Guillain Barre Syndrome Patients Admitted in Gandhi Hospital
Introduction: Guillain Barre Syndrome (GBS) or Acute Polyradiculoneuritis is an acute, diffuse post-infective- disorder of the nervous system involving the spinal roots, the peripheral nerves and occasionally the cranial nerves....
Published by: IJHS Medical Association
A Study of Small Volume Plasma Exchange in Guillain Barre Syndrome Patients Admitted in Gandhi Hospital
Introduction: Guillain Barre Syndrome (GBS) or Acute Polyradiculoneuritis is an acute, diffuse post-infective- disorder of the nervous system involving the spinal roots, the peripheral nerves and occasionally the cranial nerves....
Published by: IJHS Medical Association
Extracting Signal from the Noisy Environment of an Ecosystem
Emily Wefelmeyer, Pranita Pramod Patil, Sridhar Reddy Ravula, Kevin M Purcell, Ziyuan Huang, Igor Pilja
Jan 01, 0001
The collection and storage of environmental and ecological data by researchers, government agencies and stewardship groups over the last decade has been remarkable. The proportional challenge to this data accretion lies in...
Data analysis Data Science Decision Making ecological system GAM Generalized additive models analysis Environmental Sciences
Published by: Harrisburg University of Science and Technology
Early Insights for Atmospheric Retrievals of Exoplanets Using JWST Transit Spectroscopy
Abstract
We have entered the era of the James Webb Space Telescope (JWST). We use the first JWST transmission spectrum of the hot Saturn-mass exoplanet, WASP-39 b, obtained with...
Genetic study of the Arctic CPT1A variant suggests that its effect on fatty acid levels is modulated by traditional Inuit diet.
Ninna Senftleber, Marit Eika Jørgensen, Emil Jørsboe, Fumiaki Imamura, Nita Gandhi Forouhi, Christina Lytken Larsen, Peter Bjerregaard, Torben Hansen, Anders Albrechtsen
Jun 23, 2020
Axillary Surgery Following Neoadjuvant Chemotherapy - Multidisciplinary Guidance From the Association of Breast Surgery, Faculty of Clinical Oncology of the Royal College of Radiologists, UK Breast Cancer Group, National Coordinating Committee for Breast Pathology and British Society of Breast Radiology.
AIMS: These multidisciplinary guidelines aim to provide clinically helpful, evidence-based recommendations on the surgical management of the axilla in patients who have received neo-adjuvant chemotherapy for early breast cancer....
Detection of titanium oxide in the atmosphere of a hot Jupiter.
Elyar Sedaghati, Henri MJ Boffin, Ryan J MacDonald, Siddharth Gandhi, Nikku Madhusudhan, Neale P Gibson, Mahmoudreza Oshagh, Antonio Claret, Heike Rauer
May 21, 2018
As an exoplanet transits its host star, some of the light from the star is absorbed by the atoms and molecules in the planet's atmosphere, causing the planet to seem bigger; plotting the planet's observed size as a function of...
Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
Marija Iljina, Laura Tosatto, Minee L Choi, Jason C Sang, Yu Ye, Craig D Hughes, Clare E Bryant, Sonia Gandhi, David Klenerman
Dec 04, 2017
MAVIDOS Maternal Vitamin D Osteoporosis Study
Nicholas C Harvey, Kassim Javaid, Nicholas Bishop, Stephen Kennedy, Aris T Papageorghiou, Robert Fraser, Saurabh V Gandhi, Inez Schoenmakers, Ann Prentice, Cyrus Cooper
Feb 29, 2012
Absorptiometry Photon Administration Oral Age Factors Biomarkers Bone Density Bone and Bones Child Preschool Cholecalciferol Dietary Supplements Double-Blind Method England Female Gestational Age Humans Infant Infant Newborn Osteoporosis Pregnancy Pregnancy Complications Research Design Treatment Outcome vitamin D Vitamin D Deficiency
Ultrasensitive Measurement of Ca(2+) Influx into Lipid Vesicles Induced by Protein Aggregates.
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
Aug 04, 2017
To quantify and characterize the potentially toxic protein aggregates associated with neurodegenerative diseases, a high-throughput assay based on measuring the extent of aggregate-induced Ca(2+) entry into individual lipid...
Optical Structural Analysis of Individual α-Synuclein Oligomers.
Juan A Varela, Margarida Rodrigues, Suman De, Patrick Flagmeier, Sonia Gandhi, Christopher M Dobson, David Klenerman, Steven F Lee
Mar 19, 2018
Small aggregates of misfolded proteins play a key role in neurodegenerative disorders. Such species have proved difficult to study due to the lack of suitable methods capable of resolving these heterogeneous aggregates, which...
Correction to 'Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species'.
Lisa-Maria Needham, Judith Weber, James WB Fyfe, Omaru M Kabia, Dung T Do, Ewa Klimont, Yu Zhang, Margarida Rodrigues, Christopher M Dobson, Sonia Gandhi, Sarah E Bohndiek, Thomas N Snaddon, Steven F Lee
Sep 20, 2018
[This corrects the article DOI: 10.1098/rsos.171399.].
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death.
Craig Hughes, Minee L Choi, Jee-Hyun Yi, Seung-Chan Kim, Anna Drews, Peter St George-Hyslop, Clare Bryant, Sonia Gandhi, Kwangwook Cho, David Klenerman
Jan 20, 2020
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
Mathew H Horrocks, Steven F Lee, Sonia Gandhi, Nadia K Magdalinou, Serene W Chen, Michael J Devine, Laura Tosatto, Magnus Kjaergaard, Joseph S Beckwith, Henrik Zetterberg, Marija Iljina, Nunilo Cremades, Christopher M Dobson, Nicholas W Wood, David Klenerman
Jan 26, 2016
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death.
Craig Hughes, Minee L Choi, Jee-Hyun Yi, Seung-Chan Kim, Anna Drews, Peter St George-Hyslop, Clare Bryant, Sonia Gandhi, Kwangwook Cho, David Klenerman
Mar 25, 2020
Published by: Communications biology
Latent Cytomegalovirus-Driven Recruitment of Activated CD4+ T Cells Promotes Virus Reactivation
Sarah E. Jackson, Kevin C. Chen, Ian J. Groves, George X. Sedikides, Amar Gandhi, Charlotte J. Houldcroft, Emma L. Poole, Inmaculada Montanuy, Gavin M. Mason, Georgina Okecha, Matthew B. Reeves, John H. Sinclair, Mark R. Wills
Apr 26, 2021
Human cytomegalovirus (HCMV) infection is not cleared by the initial immune response but persists for the lifetime of the host, in part due to its ability to establish a latent infection in cells of the myeloid lineage. HCMV has...
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.
Marija Iljina, Gonzalo A Garcia, Mathew H Horrocks, Laura Tosatto, Minee L Choi, Kristina A Ganzinger, Andrey Y Abramov, Sonia Gandhi, Nicholas W Wood, Nunilo Cremades, Christopher M Dobson, Tuomas PJ Knowles, David Klenerman
Feb 04, 2016
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Alpha synuclein aggregation drives ferroptosis
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Feb 09, 2021
Abstract: Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death...
$\textit{Chandra}$ X-ray observations of the hyper-luminous infrared galaxy IRAS F15307+3252
J Hlavacek-Larrondo, P Gandhi, MT Hogan, M-L Gendron-Marsolais, AC Edge, AC Fabian, HR Russell, K Iwasawa, M Mezcua
Feb 01, 2017
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.
Craig D Hughes, Minee L Choi, Mina Ryten, Lee Hopkins, Anna Drews, Juan A Botía, Maria Iljina, Margarida Rodrigues, Sarah A Gagliano, Sonia Gandhi, Clare Bryant, David Klenerman
Oct 03, 2018
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